ES2188984T3 - Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas. - Google Patents

Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas.

Info

Publication number
ES2188984T3
ES2188984T3 ES97942897T ES97942897T ES2188984T3 ES 2188984 T3 ES2188984 T3 ES 2188984T3 ES 97942897 T ES97942897 T ES 97942897T ES 97942897 T ES97942897 T ES 97942897T ES 2188984 T3 ES2188984 T3 ES 2188984T3
Authority
ES
Spain
Prior art keywords
derivatives
epimeros
16alfa
aciloxi
pregnano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97942897T
Other languages
English (en)
Inventor
Hermann Amschler
Dieter Flockerzi
Beate Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7804358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2188984(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of ES2188984T3 publication Critical patent/ES2188984T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION DESCRBE UN PROCEDIMIENTO DE ENRIQUECIMIENTO DE COMPUESTOS DE FORMULA (I), DONDE R 1 Y R 2 SON TAL Y COMO SE DEFINEN EN LA DESCRIPCION, MEDIANTE CRISTALIZACION FRACCIONADA
ES97942897T 1996-09-03 1997-08-29 Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas. Expired - Lifetime ES2188984T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung

Publications (1)

Publication Number Publication Date
ES2188984T3 true ES2188984T3 (es) 2003-07-01

Family

ID=7804358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97942897T Expired - Lifetime ES2188984T3 (es) 1996-09-03 1997-08-29 Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas.

Country Status (18)

Country Link
US (1) US6787533B1 (es)
EP (1) EP0929566B1 (es)
JP (1) JP3807509B2 (es)
AT (1) ATE229539T1 (es)
AU (1) AU736840B2 (es)
CA (1) CA2264863C (es)
CL (1) CL2004001297A1 (es)
CY (2) CY2454B1 (es)
CZ (1) CZ298789B6 (es)
DE (2) DE19635498A1 (es)
DK (1) DK0929566T3 (es)
EE (1) EE03927B1 (es)
ES (1) ES2188984T3 (es)
HU (1) HU228766B1 (es)
IL (1) IL128535A (es)
PL (1) PL186063B1 (es)
PT (1) PT929566E (es)
WO (1) WO1998009982A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
DE60142920D1 (de) * 2000-11-10 2010-10-07 Nycomed Gmbh Verfahren zur herstellung von 16,17-ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy-pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation
US20040235811A1 (en) 2002-10-08 2004-11-25 Sepracor Inc. Fatty acid modified forms of glucocorticoids
CA2508692C (en) 2002-12-12 2012-04-03 Altana Pharma Ag Combination medicament
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
WO2005025578A1 (en) 2003-09-16 2005-03-24 Altana Pharma Ag Use of ciclesonide for the treatment of respiratory diseases
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
US20070135398A1 (en) * 2005-11-02 2007-06-14 Pierluigi Rossetto Process for the preparation of ciclesonide
WO2007092574A2 (en) * 2006-02-08 2007-08-16 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
US8158780B2 (en) * 2006-09-19 2012-04-17 Cipla Limited Processes for the preparation of ciclesonide and its crystal modification
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
CA2714653A1 (en) * 2008-03-13 2009-09-17 Farmabios S.P.A. Process for the preparation of pregnane derivatives
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
SG10202001787QA (en) 2016-06-02 2020-04-29 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
US10772970B2 (en) 2017-12-01 2020-09-15 Abbvie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (es) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
JP3333210B2 (ja) * 1993-04-02 2002-10-15 ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規プレドニソロン誘導体および該化合物を含有する薬剤
WO1995024416A1 (de) * 1994-03-09 1995-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue silylverbindungen und ihre verwendung

Also Published As

Publication number Publication date
EP0929566A1 (en) 1999-07-21
CA2264863C (en) 2007-07-31
EE03927B1 (et) 2002-12-16
WO1998009982A1 (en) 1998-03-12
JP3807509B2 (ja) 2006-08-09
IL128535A (en) 2003-07-06
US6787533B1 (en) 2004-09-07
DE19635498A1 (de) 1998-03-26
DK0929566T3 (da) 2003-04-07
CL2004001297A1 (es) 2005-04-15
JP2000517330A (ja) 2000-12-26
DE69717836T2 (de) 2003-09-18
ATE229539T1 (de) 2002-12-15
PL331699A1 (en) 1999-08-02
DE69717836D1 (de) 2003-01-23
IL128535A0 (en) 2000-01-31
CY2009010I1 (el) 2010-07-28
HU228766B1 (hu) 2013-05-28
CZ72799A3 (cs) 1999-09-15
CY2009010I2 (el) 2010-07-28
PL186063B1 (pl) 2003-09-30
CZ298789B6 (cs) 2008-01-30
AU736840B2 (en) 2001-08-02
CY2454B1 (en) 2005-06-03
EP0929566B1 (en) 2002-12-11
PT929566E (pt) 2003-04-30
HUP9904127A3 (en) 2001-02-28
HUP9904127A2 (hu) 2000-04-28
CA2264863A1 (en) 1998-03-12
EE9900079A (et) 1999-10-15
AU4456797A (en) 1998-03-26

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