EE03927B1 - Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod - Google Patents

Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod

Info

Publication number
EE03927B1
EE03927B1 EEP199900079A EE9900079A EE03927B1 EE 03927 B1 EE03927 B1 EE 03927B1 EE P199900079 A EEP199900079 A EE P199900079A EE 9900079 A EE9900079 A EE 9900079A EE 03927 B1 EE03927 B1 EE 03927B1
Authority
EE
Estonia
Prior art keywords
mixture
pregna
dione
cyclohexylmethylene
oxopropoxy
Prior art date
Application number
EEP199900079A
Other languages
English (en)
Other versions
EE9900079A (et
Inventor
Amschler Hermann
Flockerzi Dieter
Gutterer Beate
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7804358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03927(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of EE9900079A publication Critical patent/EE9900079A/et
Publication of EE03927B1 publication Critical patent/EE03927B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EEP199900079A 1996-09-03 1997-08-29 Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod EE03927B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung
PCT/EP1997/004716 WO1998009982A1 (en) 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives

Publications (2)

Publication Number Publication Date
EE9900079A EE9900079A (et) 1999-10-15
EE03927B1 true EE03927B1 (et) 2002-12-16

Family

ID=7804358

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900079A EE03927B1 (et) 1996-09-03 1997-08-29 Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod

Country Status (18)

Country Link
US (1) US6787533B1 (et)
EP (1) EP0929566B1 (et)
JP (1) JP3807509B2 (et)
AT (1) ATE229539T1 (et)
AU (1) AU736840B2 (et)
CA (1) CA2264863C (et)
CL (1) CL2004001297A1 (et)
CY (2) CY2454B1 (et)
CZ (1) CZ298789B6 (et)
DE (2) DE19635498A1 (et)
DK (1) DK0929566T3 (et)
EE (1) EE03927B1 (et)
ES (1) ES2188984T3 (et)
HU (1) HU228766B1 (et)
IL (1) IL128535A (et)
PL (1) PL186063B1 (et)
PT (1) PT929566E (et)
WO (1) WO1998009982A1 (et)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
CA2430196C (en) 2000-11-10 2010-01-26 Altana Pharma Ag Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
WO2004033478A2 (en) 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
JP4755495B2 (ja) 2002-12-12 2011-08-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 組合せ医薬品
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
PT1670482E (pt) 2003-09-16 2014-03-12 Takeda Gmbh Utilização de ciclesonida para o tratamento de doenças respiratórias
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
EP1869064A2 (en) * 2005-11-02 2007-12-26 Sicor, Inc. Improved process for the preparation of ciclesonide
WO2007092574A2 (en) * 2006-02-08 2007-08-16 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
JP2010503722A (ja) * 2006-09-19 2010-02-04 シプラ・リミテッド シクレソニドとその結晶変異体の調製方法
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
WO2009112557A2 (en) * 2008-03-13 2009-09-17 Farmabios S.P.A. Process for the preparation of pregnane derivatives
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
KR20220119529A (ko) 2016-06-02 2022-08-29 애브비 인코포레이티드 글루코코르티코이드 수용체 작용제 및 이의 면역접합체
ES2877659T3 (es) 2017-12-01 2021-11-17 Abbvie Inc Agonista del receptor de glucocorticoides y sus inmunoconjugados
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (et) * 1972-05-19 1975-08-18 Bofors Ab
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
US5733901A (en) 1993-04-02 1998-03-31 Byk Gulden Lomberg Chemische Fabrik Gmbh Prednisolone derivatives
AU697541B2 (en) 1994-03-09 1998-10-08 Takeda Gmbh Novel silyl compounds and their use

Also Published As

Publication number Publication date
CL2004001297A1 (es) 2005-04-15
DE69717836D1 (de) 2003-01-23
AU736840B2 (en) 2001-08-02
IL128535A (en) 2003-07-06
ES2188984T3 (es) 2003-07-01
EP0929566A1 (en) 1999-07-21
HU228766B1 (hu) 2013-05-28
CZ72799A3 (cs) 1999-09-15
HUP9904127A3 (en) 2001-02-28
CY2009010I1 (el) 2010-07-28
PT929566E (pt) 2003-04-30
US6787533B1 (en) 2004-09-07
HUP9904127A2 (hu) 2000-04-28
DE19635498A1 (de) 1998-03-26
PL186063B1 (pl) 2003-09-30
CY2009010I2 (el) 2010-07-28
CY2454B1 (en) 2005-06-03
EP0929566B1 (en) 2002-12-11
PL331699A1 (en) 1999-08-02
CZ298789B6 (cs) 2008-01-30
EE9900079A (et) 1999-10-15
JP3807509B2 (ja) 2006-08-09
DK0929566T3 (da) 2003-04-07
IL128535A0 (en) 2000-01-31
WO1998009982A1 (en) 1998-03-12
CA2264863C (en) 2007-07-31
AU4456797A (en) 1998-03-26
DE69717836T2 (de) 2003-09-18
ATE229539T1 (de) 2002-12-15
CA2264863A1 (en) 1998-03-12
JP2000517330A (ja) 2000-12-26

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