ATE229539T1 - Verfahren zur anreichung des verhältnisses der r- epimers von 16,17-acetal derivate von 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.- triol-3,20-dionen - Google Patents

Verfahren zur anreichung des verhältnisses der r- epimers von 16,17-acetal derivate von 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.- triol-3,20-dionen

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Publication number
ATE229539T1
ATE229539T1 AT97942897T AT97942897T ATE229539T1 AT E229539 T1 ATE229539 T1 AT E229539T1 AT 97942897 T AT97942897 T AT 97942897T AT 97942897 T AT97942897 T AT 97942897T AT E229539 T1 ATE229539 T1 AT E229539T1
Authority
AT
Austria
Prior art keywords
alpha
triol
acyloxy
dionene
pregan
Prior art date
Application number
AT97942897T
Other languages
English (en)
Inventor
Hermann Amschler
Dieter Flockerzi
Beate Schmidt
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE229539T1 publication Critical patent/ATE229539T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97942897T 1996-09-03 1997-08-29 Verfahren zur anreichung des verhältnisses der r- epimers von 16,17-acetal derivate von 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.- triol-3,20-dionen ATE229539T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung
PCT/EP1997/004716 WO1998009982A1 (en) 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives

Publications (1)

Publication Number Publication Date
ATE229539T1 true ATE229539T1 (de) 2002-12-15

Family

ID=7804358

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97942897T ATE229539T1 (de) 1996-09-03 1997-08-29 Verfahren zur anreichung des verhältnisses der r- epimers von 16,17-acetal derivate von 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.- triol-3,20-dionen

Country Status (18)

Country Link
US (1) US6787533B1 (de)
EP (1) EP0929566B1 (de)
JP (1) JP3807509B2 (de)
AT (1) ATE229539T1 (de)
AU (1) AU736840B2 (de)
CA (1) CA2264863C (de)
CL (1) CL2004001297A1 (de)
CY (2) CY2454B1 (de)
CZ (1) CZ298789B6 (de)
DE (2) DE19635498A1 (de)
DK (1) DK0929566T3 (de)
EE (1) EE03927B1 (de)
ES (1) ES2188984T3 (de)
HU (1) HU228766B1 (de)
IL (1) IL128535A (de)
PL (1) PL186063B1 (de)
PT (1) PT929566E (de)
WO (1) WO1998009982A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
EA006231B1 (ru) 2000-11-10 2005-10-27 Алтана Фарма Аг Способ получения 16,17-[(циклогексилметилен)бис(окси)]-11,21-дигидроксипрегна-1,4-диен-3,20-диона или его 21-изобутирата транскетализацией
AU2003291634A1 (en) 2002-10-08 2004-05-04 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
AU2003293833B2 (en) 2002-12-12 2009-10-01 Covis Pharma B.V. Combination medicament
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
PL1670482T5 (pl) 2003-09-16 2022-10-03 Covis Pharma Gmbh Zastosowanie cyklezonidu w leczeniu chorób układu oddechowego
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
EP1869064A2 (de) * 2005-11-02 2007-12-26 Sicor, Inc. Verbessertes verfahren zur herstellung von ciclesonid
CA2637815A1 (en) * 2006-02-08 2007-08-16 Sicor Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
CA2663737A1 (en) 2006-09-19 2008-03-27 Cipla Limited Processes for the preparation of ciclesonide and its crystal form
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
EP2262823B1 (de) * 2008-03-13 2013-01-23 Farmabios S.p.A. Verfahren zur herstellung von pregnanderivaten
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
SG10202001787QA (en) 2016-06-02 2020-04-29 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
CA3082356A1 (en) 2017-12-01 2019-06-06 Abbvie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

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US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (de) * 1972-05-19 1975-08-18 Bofors Ab
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
CN1062869C (zh) * 1993-04-02 2001-03-07 比克·古尔顿·劳姆贝尔格化学公司 新型脱氢皮质醇衍生物
WO1995024416A1 (de) 1994-03-09 1995-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue silylverbindungen und ihre verwendung

Also Published As

Publication number Publication date
WO1998009982A1 (en) 1998-03-12
CZ72799A3 (cs) 1999-09-15
JP2000517330A (ja) 2000-12-26
CL2004001297A1 (es) 2005-04-15
DK0929566T3 (da) 2003-04-07
CZ298789B6 (cs) 2008-01-30
AU736840B2 (en) 2001-08-02
HUP9904127A2 (hu) 2000-04-28
IL128535A (en) 2003-07-06
CY2009010I1 (el) 2010-07-28
DE19635498A1 (de) 1998-03-26
EE9900079A (et) 1999-10-15
CA2264863A1 (en) 1998-03-12
EP0929566B1 (de) 2002-12-11
PL331699A1 (en) 1999-08-02
DE69717836D1 (de) 2003-01-23
AU4456797A (en) 1998-03-26
US6787533B1 (en) 2004-09-07
EE03927B1 (et) 2002-12-16
PL186063B1 (pl) 2003-09-30
JP3807509B2 (ja) 2006-08-09
DE69717836T2 (de) 2003-09-18
ES2188984T3 (es) 2003-07-01
CY2009010I2 (el) 2010-07-28
HUP9904127A3 (en) 2001-02-28
HU228766B1 (hu) 2013-05-28
PT929566E (pt) 2003-04-30
CA2264863C (en) 2007-07-31
CY2454B1 (en) 2005-06-03
EP0929566A1 (de) 1999-07-21
IL128535A0 (en) 2000-01-31

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