DE69714698D1 - Endothelin-antagonisten - Google Patents

Endothelin-antagonisten

Info

Publication number
DE69714698D1
DE69714698D1 DE69714698T DE69714698T DE69714698D1 DE 69714698 D1 DE69714698 D1 DE 69714698D1 DE 69714698 T DE69714698 T DE 69714698T DE 69714698 T DE69714698 T DE 69714698T DE 69714698 D1 DE69714698 D1 DE 69714698D1
Authority
DE
Germany
Prior art keywords
endothelin antagonists
alpha
chain
carbon atoms
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69714698T
Other languages
English (en)
Other versions
DE69714698T2 (de
Inventor
Ryuji Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Original Assignee
Sucampo GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo GmbH filed Critical Sucampo GmbH
Application granted granted Critical
Publication of DE69714698D1 publication Critical patent/DE69714698D1/de
Publication of DE69714698T2 publication Critical patent/DE69714698T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S502/00—Catalyst, solid sorbent, or support therefor: product or process of making
    • Y10S502/50—Stabilized
    • Y10S502/503—Crush strength

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69714698T 1996-06-10 1997-06-04 Endothelin-antagonisten Expired - Lifetime DE69714698T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14716696 1996-06-10
JP1019197 1997-01-23
PCT/JP1997/001892 WO1997047595A1 (fr) 1996-06-10 1997-06-04 Antagoniste de l'endotheline

Publications (2)

Publication Number Publication Date
DE69714698D1 true DE69714698D1 (de) 2002-09-19
DE69714698T2 DE69714698T2 (de) 2002-12-05

Family

ID=26345421

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69714698T Expired - Lifetime DE69714698T2 (de) 1996-06-10 1997-06-04 Endothelin-antagonisten

Country Status (14)

Country Link
US (2) US6242485B1 (de)
EP (1) EP0857718B1 (de)
JP (1) JP3187438B2 (de)
KR (1) KR19990036322A (de)
CN (3) CN101085756B (de)
AT (1) ATE222237T1 (de)
CA (1) CA2229183C (de)
DE (1) DE69714698T2 (de)
DK (1) DK0857718T3 (de)
ES (1) ES2182088T3 (de)
NO (1) NO980553L (de)
PT (1) PT857718E (de)
TW (1) TW418188B (de)
WO (1) WO1997047595A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69832513T2 (de) * 1997-09-09 2006-07-13 Duke University Aromatische c16-c20-substituierte tetrahydro-prostaglandinen verwendbar wie fp agoniste
EP1012137B1 (de) * 1997-09-09 2002-11-06 The Procter & Gamble Company Aromatische c16-c20-substituierte tetrahydro-prostaglandine und ihre verwendung als prostaglandin f agonisten
US5977173A (en) * 1997-09-09 1999-11-02 Wos; John August Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists
CA2279267C (en) 1997-11-28 2010-01-12 R-Tech Ueno, Ltd. Use of 15-ketoprostaglandin e compounds as endothelin antagonist
NZ513825A (en) 1999-03-05 2001-09-28 Procter & Gamble C 16 unsaturated FP-selective prostaglandins analogs
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
KR100867295B1 (ko) * 2001-05-18 2008-11-06 수캄포 아게 하제 조성물
WO2003020283A2 (en) * 2001-08-29 2003-03-13 Novartis Ag Method for treating diabetic retinopathy
BR0212233A (pt) 2001-08-31 2004-10-05 Sucampo Ag Abridor de canal de cloreto
AR037524A1 (es) * 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
EP1545608A4 (de) 2002-06-28 2006-09-13 Centocor Inc Ch1-deletierte säugetier-mimetikörper, zusammensetzungen, verfahren und anwendungen
CA2502439C (en) * 2002-10-23 2011-11-22 Sucampo Ag Prostaglandin compounds for the treatment of obesity
AU2003292556B2 (en) 2002-12-27 2009-09-10 Sucampo Ag Derivatives of prostaglandins for treating abdominal discomfort
US8337891B2 (en) * 2003-07-03 2012-12-25 Sucampo Ag Enteric coated composition comprising prostaglandin analogs as chloride channel opener
TWI348386B (en) * 2003-08-12 2011-09-11 R Tech Ueno Ltd Composition and method for promoting hair growth
JP5222462B2 (ja) 2003-08-21 2013-06-26 スキャンポ・アーゲー 眼科用組成物
JP4690814B2 (ja) * 2004-08-02 2011-06-01 株式会社アールテック・ウエノ プロスタグランジン誘導体の製造法
CN101146541B (zh) 2005-01-27 2012-04-11 苏坎波公司 用于治疗中枢神经系统疾病的方法和组合物
KR20160120809A (ko) 2005-03-04 2016-10-18 수캄포 아게 말초 혈관 질환 치료를 위한 방법 및 조성물
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
DK1864666T3 (da) * 2005-03-31 2012-10-29 Asahi Glass Co Ltd Beskyttelsesmiddel til en retinal neuronal celle indeholdende prostaglandin-F2-alfa-derivat som aktiv ingrediens
EP1871380B1 (de) * 2005-04-12 2011-10-19 Sucampo AG Kombinierte verwendung einer prostaglandin-verbindung und eines protonenpumpenhemmers zur behandlung von magen-darm-erkrankungen
US8026393B2 (en) 2006-01-24 2011-09-27 Sucampo Ag Soft-gelatin capsule formulation
MX2008009652A (es) 2006-01-24 2008-11-06 R Tech Ueno Ltd Composicion farmaceutica que comprende un compuesto biciclico y metodo para estabilizar el compuesto biciclico.
WO2007091697A2 (en) * 2006-02-07 2007-08-16 R-Tech Ueno, Ltd. Method for preparing prostaglandin derivative
KR101382922B1 (ko) 2006-03-13 2014-04-08 가부시키가이샤 아루떼꾸 우에노 수성 조성물
SG174050A1 (en) * 2006-04-13 2011-09-29 Actelion Pharmaceuticals Ltd Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
US8871752B2 (en) 2008-02-19 2014-10-28 Sucampo Ag Method for modulating stem cell growth
CA2639240A1 (en) * 2008-08-29 2010-02-28 Alphora Research Inc. Prostaglandin synthesis and intermediates for use therein
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
US8609729B2 (en) 2009-04-15 2013-12-17 Sucampo Ag Method for treating macular degeneration
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US9084815B2 (en) * 2009-09-16 2015-07-21 Sucampo Ag Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
EP2694077A4 (de) 2011-04-07 2015-01-21 Sucampo Ag Verfahren zur behandlung von asthenopie
RU2648474C2 (ru) 2011-08-05 2018-03-26 Сукампо Аг Способ лечения шизофрении
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
US20150057351A1 (en) 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
GB201418567D0 (en) * 2014-10-20 2014-12-03 Syngenta Participations Ag Improvements in or relating to organic compounds
WO2016203317A1 (en) 2015-06-19 2016-12-22 Sucampo Ag Pharmaceutical compositions comprising fatty acid derivative

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853951A (en) * 1971-07-14 1974-12-10 American Cyanamid Co Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone
US4018811A (en) * 1972-02-11 1977-04-19 American Cyanamid Company 3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
CA1027118A (en) * 1972-04-03 1978-02-28 Martin J. Weiss 3-alkyl-2-(6-carboxyhexyl) cyclopentanones and esters and salts thereof
US3981868A (en) * 1973-05-31 1976-09-21 American Cyanamid Company Derivatives of 9-oxo-13-trans-prostenoic acid amides
US3974195A (en) * 1974-10-02 1976-08-10 The Upjohn Company 2A,2B-Dihomo-15-alkyl-PGF2.sub.α analogs
US4026909A (en) * 1975-07-14 1977-05-31 The Upjohn Company Cis-13-PGF2.sub.α analogs
US4166187A (en) * 1977-04-11 1979-08-28 The Upjohn Company 9-deoxy-9-methylene-16-phenyl-5,6-didehydro-pgf2 or 4,4,5,5-tetradehydro-pgf1 compounds
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
US5140271A (en) 1989-12-26 1992-08-18 Texaco Inc. Watercut means and method with debris reducing test cell
US5292754A (en) * 1990-03-08 1994-03-08 Shionogi & Co., Ltd. Treatment for hypertension or glaucoma in eyes
TW224942B (de) * 1990-04-04 1994-06-11 Adka Ueno Kk
BE1004080A6 (fr) * 1990-04-18 1992-09-22 Centre Rech Metallurgique Procede pour le controle automatique de la qualite d'un composant de carrosserie automobile.
CA2046069C (en) * 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
JPH07113012B2 (ja) * 1991-01-29 1995-12-06 株式会社アールテック・ウエノ 新規１５−ケト−プロスタグランジン類
DE69213057T2 (de) * 1991-03-14 1997-01-09 Ueno Seiyaku Oyo Kenkyujo Kk Stimulierung von Wundheilung mit 15-Keto-prostaglandinverbindungen

Also Published As

Publication number Publication date
AU3047897A (en) 1998-01-07
CA2229183C (en) 2008-11-04
CN102126998A (zh) 2011-07-20
WO1997047595A1 (fr) 1997-12-18
CN102126998B (zh) 2013-06-12
NO980553L (no) 1998-04-07
US6452039B1 (en) 2002-09-17
ES2182088T3 (es) 2003-03-01
CN101085756B (zh) 2011-03-02
CN100337632C (zh) 2007-09-19
CN101085756A (zh) 2007-12-12
ATE222237T1 (de) 2002-08-15
EP0857718A4 (de) 1999-07-28
TW418188B (en) 2001-01-11
EP0857718A1 (de) 1998-08-12
CA2229183A1 (en) 1997-12-18
EP0857718B1 (de) 2002-08-14
US6242485B1 (en) 2001-06-05
CN1198737A (zh) 1998-11-11
PT857718E (pt) 2002-11-29
NO980553D0 (no) 1998-02-09
DK0857718T3 (da) 2002-12-16
AU716176B2 (en) 2000-02-17
KR19990036322A (ko) 1999-05-25
DE69714698T2 (de) 2002-12-05
JP3187438B2 (ja) 2001-07-11

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