FI960400L - Menetelmä iopamidolin kiteyttämiseksi - Google Patents

Menetelmä iopamidolin kiteyttämiseksi Download PDF

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Publication number
FI960400L
FI960400L FI960400A FI960400A FI960400L FI 960400 L FI960400 L FI 960400L FI 960400 A FI960400 A FI 960400A FI 960400 A FI960400 A FI 960400A FI 960400 L FI960400 L FI 960400L
Authority
FI
Finland
Prior art keywords
iopamidol
crystallization
Prior art date
Application number
FI960400A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI960400A7 (fi
FI960400A0 (fi
Inventor
Marco Villa
Maurizio Paiocchi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI931720A external-priority patent/IT1257001B/it
Priority claimed from ITMI940760 external-priority patent/IT1269339B/it
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of FI960400A7 publication Critical patent/FI960400A7/fi
Publication of FI960400A0 publication Critical patent/FI960400A0/fi
Publication of FI960400L publication Critical patent/FI960400L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI960400A 1993-07-30 1994-07-22 Menetelmä iopamidolin kiteyttämiseksi FI960400L (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI931720A IT1257001B (it) 1993-07-30 1993-07-30 Processo per la cristalizzazione dello iopamidolo
ITMI940760 IT1269339B (it) 1994-04-20 1994-04-20 Processo per la cristallizzazione dello iopamidolo
PCT/EP1994/002415 WO1995004031A1 (en) 1993-07-30 1994-07-22 Process for the crystallization of iopamidol

Publications (3)

Publication Number Publication Date
FI960400A7 FI960400A7 (fi) 1996-01-29
FI960400A0 FI960400A0 (fi) 1996-01-29
FI960400L true FI960400L (fi) 1996-01-29

Family

ID=26331032

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960400A FI960400L (fi) 1993-07-30 1994-07-22 Menetelmä iopamidolin kiteyttämiseksi

Country Status (29)

Country Link
US (3) US5571941A (de)
JP (1) JP3299045B2 (de)
KR (1) KR100355211B1 (de)
CN (1) CN1035940C (de)
AT (1) AT404832B (de)
AU (1) AU690138B2 (de)
BE (1) BE1008403A4 (de)
CA (1) CA2128942C (de)
CH (1) CH686783A5 (de)
CZ (1) CZ289300B6 (de)
DE (1) DE4426818A1 (de)
DK (1) DK172074B1 (de)
ES (1) ES2102312B1 (de)
FI (1) FI960400L (de)
FR (1) FR2708601B1 (de)
GB (1) GB2280436B (de)
GR (1) GR940100366A (de)
HU (1) HU217023B (de)
IE (1) IE80675B1 (de)
IL (1) IL110391A (de)
NL (1) NL194272C (de)
NO (1) NO304226B1 (de)
NZ (1) NZ271632A (de)
PT (1) PT101554B (de)
RU (1) RU2135462C1 (de)
SE (1) SE9402595L (de)
SI (1) SI9420046B (de)
WO (1) WO1995004031A1 (de)
ZA (1) ZA945472B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
EP0842141A1 (de) * 1995-07-04 1998-05-20 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Verfahren zur herstellung von iopamidol unter mitverwendung von c1-c5 monoalkylether vom c2-c10 alkylenglycol
AU708195B2 (en) * 1995-09-08 1999-07-29 Bracco International B.V. Process for the crystallization from water of (S)-N,N'-bis{2-hydroxy-1-(hydroxymethyl)ethyl}-5-{(2-hydroxy -1-oxopropyl)amino}-2,4,6-triiodo-1,3-benzendicarboxamide
PT101919B (pt) * 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
AU1455397A (en) * 1997-02-11 1998-08-26 Bracco International B.V. Process for the crystallization from a linear or branched (c5-c6) alcohol or their mixtures of (s)-n,n'-bis{2-hydroxy-1- (hydroxymethyl)ethyl}-5-{ (2-hydroxy-1-oxopropyl)amino}-2,4,6- triiodo-1,3-benzendicarboxamide
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
KR20000031642A (ko) * 1998-11-09 2000-06-05 강재헌 이오파미돌의 결정화 방법
US6265610B1 (en) 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6803485B2 (en) 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
IT1319671B1 (it) 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
NO20043305D0 (no) * 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
DE102005059191B4 (de) * 2005-12-05 2008-02-07 Bayer Schering Pharma Ag Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen
KR100976097B1 (ko) * 2008-12-05 2010-08-16 주식회사 대웅제약 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
JP2012522796A (ja) * 2009-04-02 2012-09-27 アラーガン インコーポレイテッド プロスタグランジンｅレセプター拮抗薬
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
DE102012104679A1 (de) 2011-05-30 2012-12-06 Westfälische Wilhelms-Universität Münster Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli
HUE039458T2 (hu) 2012-12-19 2019-01-28 Ge Healthcare As Röntgen kontrasztanyagok tisztítása
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (de) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
EP0365541B1 (de) * 1987-05-22 1992-08-12 BRACCO S.p.A. Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesäure-derivate
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol

Also Published As

Publication number Publication date
NZ271632A (en) 1997-07-27
ES2102312A1 (es) 1997-07-16
SE9402595L (sv) 1995-01-31
HUP9774567A2 (en) 1997-01-28
PT101554A (pt) 1995-05-04
US5571941A (en) 1996-11-05
CA2128942C (en) 2003-07-15
GB9414912D0 (en) 1994-09-14
JPH07145125A (ja) 1995-06-06
PT101554B (pt) 2000-01-31
NL194272B (nl) 2001-07-02
AU690138B2 (en) 1998-04-23
NO960376L (no) 1996-01-29
KR960703842A (ko) 1996-08-31
IE940609A1 (en) 1995-02-08
ES2102312B1 (es) 1998-04-01
HU217023B (hu) 1999-11-29
DE4426818A1 (de) 1995-02-02
DK172074B1 (da) 1997-10-13
FI960400A7 (fi) 1996-01-29
NL9401229A (nl) 1995-02-16
FI960400A0 (fi) 1996-01-29
FR2708601B1 (fr) 1995-12-08
NO304226B1 (no) 1998-11-16
NL194272C (nl) 2001-11-05
DK89294A (da) 1995-01-31
US6506938B1 (en) 2003-01-14
AT404832B (de) 1999-03-25
NO960376D0 (no) 1996-01-29
BE1008403A4 (fr) 1996-05-07
IE80675B1 (en) 1998-11-18
CZ289300B6 (cs) 2001-12-12
SE9402595D0 (sv) 1994-07-29
FR2708601A1 (fr) 1995-02-10
AU7532194A (en) 1995-02-28
WO1995004031A1 (en) 1995-02-09
GR940100366A (en) 1996-03-31
ATA150594A (de) 1998-07-15
GB2280436A (en) 1995-02-01
JP3299045B2 (ja) 2002-07-08
HU9600191D0 (en) 1996-11-28
CZ183194A3 (en) 1995-02-15
SI9420046A (en) 1996-10-31
ZA945472B (en) 1995-03-03
CH686783A5 (it) 1996-06-28
CA2128942A1 (en) 1995-01-31
IL110391A (en) 1998-12-06
RU2135462C1 (ru) 1999-08-27
GB2280436B (en) 1997-08-13
SI9420046B (sl) 2003-10-31
CN1035940C (zh) 1997-09-24
IL110391A0 (en) 1994-10-21
KR100355211B1 (ko) 2003-04-10
USRE36433E (en) 1999-12-07
CN1128020A (zh) 1996-07-31

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