FI931384L - Vattenloesliga kamptothecinanaloger, processer och foerfaranden - Google Patents

Vattenloesliga kamptothecinanaloger, processer och foerfaranden Download PDF

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Publication number
FI931384L
FI931384L FI931384A FI931384A FI931384L FI 931384 L FI931384 L FI 931384L FI 931384 A FI931384 A FI 931384A FI 931384 A FI931384 A FI 931384A FI 931384 L FI931384 L FI 931384L
Authority
FI
Finland
Prior art keywords
vattenloesliga
kamptothecinanaloger
processer
och foerfaranden
foerfaranden
Prior art date
Application number
FI931384A
Other languages
English (en)
Finnish (fi)
Other versions
FI931384A7 (fi
FI931384A0 (fi
Inventor
Joseph Marian Fortunak
Antonietta Rose Mastrocola
Mark Mellinger
Jeffery Lee Wood
Patrick Lee Burk
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of FI931384A7 publication Critical patent/FI931384A7/fi
Publication of FI931384A0 publication Critical patent/FI931384A0/fi
Publication of FI931384L publication Critical patent/FI931384L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI931384A 1990-09-28 1991-09-23 Vattenloesliga kamptothecinanaloger, processer och foerfaranden FI931384L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28
PCT/US1991/006888 WO1992005785A1 (en) 1990-09-28 1991-09-23 Water soluble camptothecin analogues, processes and methods

Publications (3)

Publication Number Publication Date
FI931384A7 FI931384A7 (fi) 1993-03-26
FI931384A0 FI931384A0 (fi) 1993-03-26
FI931384L true FI931384L (fi) 1993-03-26

Family

ID=24358879

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931384A FI931384L (fi) 1990-09-28 1991-09-23 Vattenloesliga kamptothecinanaloger, processer och foerfaranden

Country Status (24)

Country Link
US (1) US5734056A (cs)
EP (1) EP0547165B1 (cs)
JP (1) JP2848958B2 (cs)
CN (1) CN1033509C (cs)
AT (1) ATE186461T1 (cs)
AU (1) AU664830B2 (cs)
CA (1) CA2090967C (cs)
CZ (1) CZ51593A3 (cs)
DE (1) DE69131775T2 (cs)
DK (1) DK0547165T3 (cs)
ES (1) ES2137932T3 (cs)
FI (1) FI931384L (cs)
GR (1) GR3031823T3 (cs)
HU (1) HUT70024A (cs)
IE (1) IE913402A1 (cs)
IL (1) IL99571A (cs)
NO (1) NO931153L (cs)
NZ (1) NZ239947A (cs)
PT (1) PT99109B (cs)
SI (1) SI9111599A (cs)
SK (1) SK283693B6 (cs)
WO (1) WO1992005785A1 (cs)
YU (1) YU159991A (cs)
ZA (1) ZA917748B (cs)

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* Cited by examiner, † Cited by third party
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US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
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US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
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WO1997019085A1 (en) * 1995-11-22 1997-05-29 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
GB9601779D0 (en) * 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
WO2004055020A1 (en) * 2002-12-16 2004-07-01 Council Of Scientific And Industrial Research Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones
CN100372854C (zh) * 2003-03-31 2008-03-05 科学与工业研究委员会 从10-羟基-20-(s)-喜树碱制备托泊替康的方法
JP5270091B2 (ja) * 2003-05-12 2013-08-21 サイノファーム シンガポール ピーティーイー リミテッド ７−アルキル−１０−ヒドロキシ−２０（ｓ）−カンプトテシンを調製するためのプロセス
CZ298934B6 (cs) * 2003-08-26 2008-03-12 Pliva- Lachema A.S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
AR046579A1 (es) * 2003-11-12 2005-12-14 Smithkline Beecham Corp Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
WO2006016203A1 (en) * 2004-08-09 2006-02-16 Shilpa Medicare Limited An improved process for the preparation of irinotecan hydrochloride trihydrate
NZ554677A (en) * 2004-11-05 2010-08-27 Samyang Corp Pharmaceutical formulation for increasing solubility of 10-hydroxycamptothecin compounds in non-aqueous polar solvents
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
WO2007011962A2 (en) * 2005-07-18 2007-01-25 Bipar Sciences, Inc. Treatment of cancer
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US7547785B2 (en) 2005-12-26 2009-06-16 Dr. Reddy's Laboratories Limited Process for preparing topotecan
US20070259031A1 (en) * 2006-04-26 2007-11-08 The Regents Of The University Of California Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
PE20080695A1 (es) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
CA2655257A1 (en) * 2006-06-12 2008-12-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
CA2662517A1 (en) * 2006-09-05 2008-03-13 Jerome Moore Treatment of cancer
CN101534836B (zh) * 2006-09-05 2011-09-28 彼帕科学公司 Parp抑制剂在制备治疗肥胖症的药物中的用途
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US7977483B2 (en) 2007-04-11 2011-07-12 Scinopharm Taiwan, Ltd. Process for making topotecan
JP2011500684A (ja) * 2007-10-19 2011-01-06 バイパー サイエンシズ，インコーポレイティド ベンゾピロン系ｐａｒｐ阻害剤を用いる癌の処置方法および組成物
CA2703489A1 (en) 2007-10-23 2009-04-30 Banyu Pharmaceutical Co., Ltd. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
SG185952A1 (en) * 2007-11-12 2012-12-28 Bipar Sciences Inc Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents
JP2011503071A (ja) * 2007-11-12 2011-01-27 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる子宮がん及び卵巣がんの治療
ITMI20072268A1 (it) 2007-12-04 2009-06-05 Antibioticos Spa Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione
WO2009073869A1 (en) * 2007-12-07 2009-06-11 Bipar Sciences, Inc. Treatment of cancer with combinations of topoisomerase inhibitors and parp inhibitors
CN101450949B (zh) * 2007-12-07 2011-10-05 上海龙翔生物医药开发有限公司 一种10-羟基喜树碱的化学半合成工艺
CN102046634B (zh) 2008-05-29 2013-04-24 日本迈科洛生物制药有限公司 喜树碱衍生物的制备方法
WO2010098367A1 (en) 2009-02-25 2010-09-02 Banyu Pharmaceutical Co.,Ltd. Pyrimidopyrimidoindazole derivative
WO2010101734A1 (en) 2009-03-06 2010-09-10 Merck Sharp & Dohme Corp. Combination cancer therapy with an akt inhibitor and other anticancer agents
US8709420B2 (en) 2010-12-17 2014-04-29 Glaxosmithkline Intellectual Property Limited Pharmaceutical combination of pazopanib and topotecan to treat neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human
JP2014504638A (ja) 2011-02-01 2014-02-24 グラクソスミスクライン インテレクチュアル プロパティ リミテッド 組合せ
CN103145720B (zh) * 2013-02-20 2015-09-30 上海北卡医药技术有限公司 一种10-羟基喜树碱的一水合物的制备方法
EP2881396A1 (en) * 2013-12-03 2015-06-10 Synbias Pharma AG Method for the synthesis of irinotecan
JP6732967B2 (ja) * 2016-03-08 2020-07-29 チェン ラブ アンド カンパニー リミテッド ライアビリティ カンパニー 人体のｐＨレベルを酸性からよりアルカリ性に上げるための薬草製剤
US12029736B2 (en) 2020-02-25 2024-07-09 Mediboston Limited Camptothecin derivatives and conjugates thereof
EP4522183A2 (en) 2022-05-11 2025-03-19 Celgene Corporation Methods and uses related to t cell therapy and production of same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
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JPS5842192B2 (ja) * 1974-05-18 1983-09-17 フセソユ−ズヌイ ナウチノ イスレドワ−チエレスキ− ヒミコ フアルマツエフチチエスキ− インスチツ−ト イメ−ニ エス オルジヨニキ−ゼ ５− オキシ −６− アミノメチルベンゾフランノ ユウドウタイノ セイホウ
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPS5946284A (ja) * 1982-09-10 1984-03-15 Yakult Honsha Co Ltd １１−ニトロカンプトテシン誘導体およびその製造法
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds

Also Published As

Publication number Publication date
SI9111599A (sl) 1998-02-28
AU664830B2 (en) 1995-12-07
JP2848958B2 (ja) 1999-01-20
HUT70024A (en) 1995-09-28
FI931384A7 (fi) 1993-03-26
FI931384A0 (fi) 1993-03-26
SK283693B6 (sk) 2003-12-02
EP0547165A4 (cs) 1994-03-30
GR3031823T3 (en) 2000-02-29
WO1992005785A1 (en) 1992-04-16
PT99109A (pt) 1992-08-31
CN1033509C (zh) 1996-12-11
NZ239947A (en) 1994-07-26
NO931153D0 (no) 1993-03-26
EP0547165B1 (en) 1999-11-10
CA2090967C (en) 2007-02-06
CN1062731A (zh) 1992-07-15
CZ51593A3 (en) 1994-01-19
PT99109B (pt) 1999-02-26
HU9300878D0 (en) 1993-06-28
DK0547165T3 (da) 2000-03-27
YU159991A (sh) 1994-06-10
IL99571A0 (en) 1992-08-18
ES2137932T3 (es) 2000-01-01
US5734056A (en) 1998-03-31
IE913402A1 (en) 1992-04-08
CA2090967A1 (en) 1992-03-29
NO931153L (no) 1993-03-26
ATE186461T1 (de) 1999-11-15
DE69131775T2 (de) 2000-04-20
SK25993A3 (en) 1993-07-07
AU8739991A (en) 1992-04-28
JPH06501476A (ja) 1994-02-17
IL99571A (en) 2000-08-31
ZA917748B (en) 1992-09-30
EP0547165A1 (en) 1993-06-23
HK1012283A1 (en) 1999-07-30
DE69131775D1 (de) 1999-12-16

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