FI76785B - Foerfarande foer framstaellning av bensamidoderivat. - Google Patents
Foerfarande foer framstaellning av bensamidoderivat. Download PDFInfo
- Publication number
- FI76785B FI76785B FI820544A FI820544A FI76785B FI 76785 B FI76785 B FI 76785B FI 820544 A FI820544 A FI 820544A FI 820544 A FI820544 A FI 820544A FI 76785 B FI76785 B FI 76785B
- Authority
- FI
- Finland
- Prior art keywords
- group
- lower alkyl
- formula
- compound
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Claims (3)
1. Pörfarande för framställning av ett terapeutiskt använd- bart benzamidderivat med formeln
2. R OA (/ Λ-CONHCH -L J I \-J 2 N 1^ > 2 I 3 R OA R 1 2 eller dess fysiologiskt aktiva salt, i vilken formel R och R är lika eller olika och vardera är en väteatom, halogenatom, läg- 3 re alkylgrupp eller acylgrupp, R är en lägre alkylgrupp, alke- nylgrupp eller bensylgrupp som eventuellt är substituerad med fluor, klor, brom, trifluormetyl, lägre alkyl eller lägre alkoxi, 1 2 A och A är lika eller olika och vardera är en väteatom, lägre alkylgrupp eller acylgrupp, förutsatt att ätminstone den andra av grupper A och A är en lägre alkylgrupp, och vidare 1 2 förutsatt att när A och A är samma lägre alkylgrupp och 3 12 R är etyl, är R eller R eller bada valda ur gruppen lägre alkyl eller acyl, varvid acylgrupperna i formeln I är grupper al-kyl-CO-, väri alkylen är en rak eller grenkedjad alkylgrupp med 1-5 kolatomer, kännetecknat av att förfarandet omfattar a) en reaktion av en förening med formeln
2. R OA M < )-co-z 1 \ 2 R OA 12 1 2 i vilken formel R , R , A och A betecknar detsamma som ovan och -CO-Z är en reaktiv grupp, som kan reagera med en amino-grupp sä att en amidgrupp bildas, med en sadan förening, som har formeln 72 7 6 7 8 5 H N-CH N - 2 2 | I 3 R 3 i vilken formel R betecknar detsamma som ovan sa att en för-ening enligt formeln I bildas, eller b) dealkylering av en förening med formeln
2. R OA O-C0NHCH2“^
2 I
3 R OA R 12 3 i vilken formel R , R och R betecknar detsamma som ovan, 1' 2' och A och A är en lägre alkylgrupp, med en protonsyra eller en Lewis-syra sä att en förening med formeln I bildas, i vil-1 / 2 ken formel A och/eller A är en väteatom och den andra, om nödvändigt, är en lägre alkylgrupp, eller c) en reaktion av en förening med formeln r/ π A V^ONHCH -1. hJ ' 2 I 3 OA R 3 1 2 i vilken formel R , A och A betecknar detsamma som ovan, med en halogen eller halogen-dioxankomplex eller med en acylhalid med en Lewis-syra som katalysator, eller med en alkylhalid med en Lewis-syra som katalysator, eller med trikloracetonitril eller cyanohalid i närvaro av en Lewis-syrakatalysator sä, att en förening enligt formeln I bildas, väri R och/eller R är en ha-logenatom, acylgrupp eller lägre alkylgrupp, och den andra, om nödvändigt, en väteatom, eller
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI864866A FI864866A (fi) | 1981-03-11 | 1986-11-28 | Mellanprodukter foer framstaellning av vaerdefulla bentsamidoderivater. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8101536 | 1981-03-11 | ||
| SE8101536A SE8101536L (sv) | 1981-03-11 | 1981-03-11 | Bensamid-derivat |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI820544L FI820544L (fi) | 1982-09-12 |
| FI76785B true FI76785B (fi) | 1988-08-31 |
| FI76785C FI76785C (sv) | 1988-12-12 |
Family
ID=20343304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI820544A FI76785C (sv) | 1981-03-11 | 1982-02-18 | Förfarande för framställning av bensamidoderivat |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4789683A (sv) |
| EP (1) | EP0060235B1 (sv) |
| JP (1) | JPS57159762A (sv) |
| KR (1) | KR890001375B1 (sv) |
| AT (1) | ATE17346T1 (sv) |
| AU (1) | AU553041B2 (sv) |
| BG (4) | BG41126A3 (sv) |
| CA (1) | CA1167457A (sv) |
| CS (1) | CS266310B2 (sv) |
| CY (1) | CY1440A (sv) |
| DD (1) | DD201886A5 (sv) |
| DE (1) | DE3268354D1 (sv) |
| DK (1) | DK159968C (sv) |
| ES (4) | ES8307742A1 (sv) |
| FI (1) | FI76785C (sv) |
| GR (1) | GR75892B (sv) |
| HK (1) | HK66288A (sv) |
| HU (1) | HU186042B (sv) |
| IE (1) | IE52608B1 (sv) |
| IL (1) | IL65035A0 (sv) |
| MY (1) | MY8600526A (sv) |
| NO (1) | NO156286C (sv) |
| NZ (1) | NZ199925A (sv) |
| PH (1) | PH19661A (sv) |
| PL (4) | PL135699B1 (sv) |
| PT (1) | PT74563B (sv) |
| RO (4) | RO86082B (sv) |
| SE (1) | SE8101536L (sv) |
| SU (4) | SU1156593A3 (sv) |
| ZA (1) | ZA821017B (sv) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205135D0 (sv) * | 1982-09-09 | 1982-09-09 | Astra Laekemedel Ab | Benzamido-derivatives |
| SE8400478D0 (sv) * | 1984-01-31 | 1984-01-31 | Astra Laekemedel Ab | Oxysalicylamido derivatives |
| US5240957A (en) * | 1984-01-31 | 1993-08-31 | Astra Lakemedel Akteibolag | Oxysalicylamido derivatives |
| FR2578539B1 (fr) * | 1985-03-08 | 1987-09-04 | Therapeutiques Ste Monega Et | Nouveaux benzamides de l'acide 2,4,6-trimethoxybenzoique, leur procede de preparation et leur utilisation |
| SE8503054D0 (sv) * | 1985-06-19 | 1985-06-19 | Astra Laekemedel Ab | Catecholcarboxamides |
| GB8708833D0 (en) * | 1987-04-13 | 1987-05-20 | Lilly S A E | Organic compounds |
| EP0320630A1 (en) * | 1987-11-19 | 1989-06-21 | The Vanderbilt University | Enantiometric iodobenzamides |
| GB8823042D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| GB8823040D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| GB8823041D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| US5248817A (en) * | 1991-07-15 | 1993-09-28 | Merck & Co., Inc. | Process for aromatic bromination |
| US5446147A (en) * | 1992-04-03 | 1995-08-29 | Trustees Of The University Of Pennsylvania | Fluorinated and iodinated dopamine agents |
| DK72693D0 (da) * | 1993-06-18 | 1993-06-18 | Lundbeck & Co As H | Compounds |
| JP4275819B2 (ja) * | 1999-09-17 | 2009-06-10 | 飯田 秀博 | デメチルラクロプライドの非求核性酸塩およびこれを用いる［ｃ−１１］ラクロプライドの製造法 |
| DK178705B1 (en) * | 2015-07-07 | 2016-11-28 | Silversnow Aps | A heat pump system using water as the thermal fluid |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
| FR5916M (sv) * | 1966-01-21 | 1968-05-06 | ||
| BE695272A (sv) * | 1967-03-09 | 1967-09-11 | ||
| CH507938A (fr) * | 1968-08-01 | 1971-05-31 | Ile De France | Procédé de préparation de benzamides hétérocycliques |
| US3793030A (en) * | 1971-09-02 | 1974-02-19 | Ricoh Kk | Process for producing diazotype light-sensitive material |
| US3914418A (en) * | 1971-09-02 | 1975-10-21 | Merck & Co Inc | Methods of controlling liver fluke infections |
| US3862139A (en) * | 1972-06-23 | 1975-01-21 | Delmar Chem | Heterocyclic benzamide compounds |
| IT1070992B (it) * | 1973-12-21 | 1985-04-02 | Italfarmaco Spa | Processo per la preparazione della i etil 2 2 metossi 5 sulfamoil benzamidometil pirrolidina |
| CH605793A5 (sv) * | 1974-03-05 | 1978-10-13 | Ile De France | |
| FR2294698A1 (fr) * | 1974-12-18 | 1976-07-16 | Synthelabo | Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment |
| IE42210B1 (en) * | 1974-12-18 | 1980-06-18 | Synthelabo | 2-methoxy-benzamide derivatives |
| US4172143A (en) * | 1974-12-18 | 1979-10-23 | Synthelabo | 2-Methoxy-benzamide derivatives |
| JPS5319447A (en) * | 1976-08-07 | 1978-02-22 | Igeta Seikou Kk | Manufacture of endless wire rope |
| NZ186175A (en) * | 1977-01-27 | 1980-03-05 | Shionogi & Co | Meta-sulphonamidobenzamide derivatives |
| FR2440946A2 (fr) * | 1978-01-20 | 1980-06-06 | Ile De France | Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement |
| SE411118B (sv) * | 1978-03-23 | 1979-12-03 | Astra Laekemedel Ab | Ett forfarande for framstellning av 2,6-dialkoxibensamider med terapentiska egenskaper |
| FR2438650A1 (fr) * | 1978-10-11 | 1980-05-09 | Ile De France | N-(1-methyl 2-pyrrolidinyl methyl) 2,3-dimethoxy 5-methylsulfamoyl benzamide et ses derives, leurs methodes de preparation et leur application dans le traitement des troubles du bas appareil urinaire |
-
1981
- 1981-03-11 SE SE8101536A patent/SE8101536L/sv not_active Application Discontinuation
-
1982
- 1982-02-16 ZA ZA821017A patent/ZA821017B/xx unknown
- 1982-02-17 IL IL65035A patent/IL65035A0/xx not_active IP Right Cessation
- 1982-02-18 FI FI820544A patent/FI76785C/sv not_active IP Right Cessation
- 1982-02-22 PH PH26897A patent/PH19661A/en unknown
- 1982-02-24 CA CA000396996A patent/CA1167457A/en not_active Expired
- 1982-03-05 DE DE8282850041T patent/DE3268354D1/de not_active Expired
- 1982-03-05 AU AU81160/82A patent/AU553041B2/en not_active Ceased
- 1982-03-05 AT AT82850041T patent/ATE17346T1/de not_active IP Right Cessation
- 1982-03-05 NZ NZ199925A patent/NZ199925A/en unknown
- 1982-03-05 EP EP82850041A patent/EP0060235B1/en not_active Expired
- 1982-03-08 CS CS821568A patent/CS266310B2/cs unknown
- 1982-03-09 DD DD82237995A patent/DD201886A5/de not_active IP Right Cessation
- 1982-03-10 JP JP57036685A patent/JPS57159762A/ja active Granted
- 1982-03-10 SU SU823402586A patent/SU1156593A3/ru active
- 1982-03-10 BG BG8569819A patent/BG41126A3/xx unknown
- 1982-03-10 RO RO111177A patent/RO86082B/ro unknown
- 1982-03-10 RO RO111178A patent/RO86083B1/ro unknown
- 1982-03-10 PT PT74563A patent/PT74563B/pt not_active IP Right Cessation
- 1982-03-10 BG BG8569817A patent/BG41124A3/xx unknown
- 1982-03-10 ES ES510278A patent/ES8307742A1/es not_active Expired
- 1982-03-10 BG BG8569818A patent/BG41125A3/xx unknown
- 1982-03-10 IE IE544/82A patent/IE52608B1/en not_active IP Right Cessation
- 1982-03-10 RO RO106862A patent/RO82956B/ro unknown
- 1982-03-10 RO RO111176A patent/RO86081B/ro unknown
- 1982-03-10 HU HU82748A patent/HU186042B/hu not_active IP Right Cessation
- 1982-03-10 DK DK103782A patent/DK159968C/da not_active IP Right Cessation
- 1982-03-10 NO NO820762A patent/NO156286C/no unknown
- 1982-03-10 BG BG8255733A patent/BG39976A3/xx unknown
- 1982-03-11 PL PL1982240321A patent/PL135699B1/pl unknown
- 1982-03-11 PL PL1982240323A patent/PL135700B1/pl unknown
- 1982-03-11 GR GR67553A patent/GR75892B/el unknown
- 1982-03-11 PL PL1982240322A patent/PL136457B1/pl unknown
- 1982-03-11 PL PL1982235397A patent/PL135475B1/pl unknown
- 1982-03-11 KR KR8201046A patent/KR890001375B1/ko active
-
1983
- 1983-01-20 SU SU833543243A patent/SU1241986A3/ru active
- 1983-01-20 SU SU3543299A patent/SU1261561A3/ru active
- 1983-01-20 SU SU833543247A patent/SU1355122A3/ru active
- 1983-03-01 ES ES520193A patent/ES8401459A1/es not_active Expired
- 1983-03-01 ES ES520194A patent/ES520194A0/es active Granted
- 1983-03-01 ES ES520192A patent/ES520192A0/es active Granted
-
1985
- 1985-01-08 US US06/689,502 patent/US4789683A/en not_active Expired - Fee Related
-
1986
- 1986-12-30 MY MY526/86A patent/MY8600526A/xx unknown
-
1988
- 1988-08-25 HK HK662/88A patent/HK66288A/xx not_active IP Right Cessation
-
1989
- 1989-03-10 CY CY1440A patent/CY1440A/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI76785B (fi) | Foerfarande foer framstaellning av bensamidoderivat. | |
| JP6574918B1 (ja) | 複素環化合物およびその用途 | |
| KR102604975B1 (ko) | (s)-7-(1-아크릴로일피페리딘-4-일)-2-(4-페녹시페닐)-4,5,6,7-테트라-하이드로피라졸로 [1,5-a] 피리미딘-3-카르복스아미드의 제조 및 그 용도 | |
| KR101282464B1 (ko) | 나트륨 채널 조절제로서의 프롤린아미드 유도체 | |
| JPS6058751B2 (ja) | プロリン関連化合物ならびにその製法 | |
| DE1595915A1 (de) | Verfahren zur Herstellung von heterocyclischen Benzamiden | |
| TW201731838A (zh) | 做為布魯頓式酪胺酸激酶（ｂｔｋ）抑制劑之雜芳族化合物 | |
| BRPI0610034A2 (pt) | composto, agente de icremento do transporte de açúcar, agente hipoglicêmico, agente para prevenção e/ou tratamento de uma doença, medicamento, composição farmacêutica , uso do composto, e, método de preparação para o composto | |
| AU2007287338A1 (en) | Piperidine derivatives | |
| JP6340103B2 (ja) | ベンゾチアゾロン化合物 | |
| JP2022537103A (ja) | 多発性硬化症のようなｃｎｓ障害を治療するためのｇｐｒ１７モジュレーターとしてのｎ‐（フェニル）‐インドール‐３‐スルホンアミド誘導体及び関連化合物 | |
| BRPI0808758A2 (pt) | Derivados de benzamida e processo para o preparo dos mesmos | |
| JP2020097526A (ja) | 複素環化合物 | |
| JPS6169774A (ja) | 新規なトリプタミン誘導体 | |
| JPWO2007032371A1 (ja) | 摂食調節剤としてのオキシインドール誘導体 | |
| DE3590241T (de) | Neues Arzneimittel und dessen Herstellung | |
| EP1904442B1 (en) | Histamine h3 receptor agents, preparation and therapeutic uses | |
| RU2162470C2 (ru) | 2,7-замещенные производные октагидропирроло[1,2-а]пиразина, способ лечения, фармацевтическая композиция, промежуточные соединения | |
| DE69828998T2 (de) | Indolderivate verwendbar zur behandlung von u.a. osteoporosis | |
| CN108069942A (zh) | 苯酞吡唑酮类偶联物、其制备方法和用途 | |
| SE431869B (sv) | Forfarande for framstellning av n-(1-cyklohexyl-3-pyrrolidinyl)-bensamider med antiemetisk verkan | |
| US7662836B2 (en) | Indazole having analgesic activity | |
| TW202204343A (zh) | 經取代之３－苯氧基氮雜環丁烷－１－基－吡 | |
| JP3637974B2 (ja) | ピロリジン誘導体 | |
| US9303019B2 (en) | Amino-pyrroline derivatives, and use thereof in the prevention and/or treatment of metabolic syndrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: ASTRA LAEKEMEDEL AKTIEBOLAG |