FI73218B - Foerfarande foer framstaellning av nya farmakologiskt verksamma tieno/3,2-c/pyridinderivat. - Google Patents

Foerfarande foer framstaellning av nya farmakologiskt verksamma tieno/3,2-c/pyridinderivat. Download PDF

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Publication number
FI73218B
FI73218B FI832543A FI832543A FI73218B FI 73218 B FI73218 B FI 73218B FI 832543 A FI832543 A FI 832543A FI 832543 A FI832543 A FI 832543A FI 73218 B FI73218 B FI 73218B
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FI
Finland
Prior art keywords
formula
group
derivative
thieno
pyridyl
Prior art date
Application number
FI832543A
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English (en)
Finnish (fi)
Other versions
FI832543A0 (fi
FI832543L (fi
FI73218C (sv
Inventor
Jean-Pierre Maffrand
Daniel Aubert
Claude Ferrand
Original Assignee
Sanofi Sa
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Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of FI832543A0 publication Critical patent/FI832543A0/fi
Publication of FI832543L publication Critical patent/FI832543L/fi
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Publication of FI73218B publication Critical patent/FI73218B/fi
Publication of FI73218C publication Critical patent/FI73218C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)

Claims (12)

1. Förfarande för framställning av farmakologiskt verksamma tieno/3,2-c/pyridinderivat med formeln
0 Y I (Il *XT0 x' i vilken formel Y är en OH-grupp eller en OR-grupp, där R är en lägre alkylradikal med rak eller förgrenad kedja, eller Y är en grupp Xr2 i vilken formel Ri och R2 vardera oberoende av varandra är väte eller en lägre alkylgrupp med rak eller förgrenad kedja, eller och R2 tillsammans och med den kväveatom tili vilken de är anslutna bildar en heterocykel, säsom en pyrrolidin-, morfolin, piperidin-, eller piperazinring, som kan vara subs-tituerad med en benzylradikal, och X är väte, en halogen eller en lägre alkylradikal, och deras additionssalter med farmaceu-tiskt acceptabla oorganiska eller organiska syror, ifall Y är en OR-grupp eller N eller med mineralbaser, ifall Y är OH, kännetecknat därav, att estrar med formeln (I), där Y är en OR-grupp, fram-ställs genom kondensering av 4,5,6,7-tetrahydro-tieno/3,2-c/-pyridin med följande formel oCj 25 7321 8 med ett cx-klorfenylacetat med formeln 0 ^ 0-R "'"'0 x' (III) i vilken formel R och X betecknar detsamma som ovan definie-rats, och eventuellt syran med formeln (I), där Y är OH som erhällits genom förtvälning av dessa estrar, omvandlas, eventuellt efter aktivering, till en amid eller en ester med formeln (I) genom behandling med en amin D HN \R R2 i vilken formel och R2 betecknar detsamma som ovan definie-rats, eller med en alkohol R-OH, där R betecknar detsamma som ovan definierats.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att kondenseringsreaktionen mellan tienopyridinen med formeln (II) och estern med formeln (III) utförs i närvaro av ett alkalimetallkarbonat i ett inert lösningsmedel vid tempe-raturer mellan 60 °C och lösningsmedlets kokpunkt.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att förtvälningen av estern med formeln (I) där R är metyl eller etyl, utförs med en alkalimetallhydroxid i ett hydroalkoholiskt lösningsmedel vid temperaturer mellan rums-temperatur och lösningsmedlets kokpunkt.
4. Förfarande enligt patentkravet 1, kännetecknat därav, att syran med formeln (I) aktiveras med etylkloroformi-at i närvaro av trietylamin vid temperaturer mellan -5 °c och 0 °C i ett inert lösningsmedel, säsom kloroform, 1,2-dimetoxi-etan eller tetrahydrofuran.
FI832543A 1982-07-13 1983-07-12 Förfarande för framställning av nya farmakologiskt verksamma tieno/3,2 -c/pyridinderivat. FI73218C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8212599A FR2530247B1 (fr) 1982-07-13 1982-07-13 Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR8212599 1982-07-13

Publications (4)

Publication Number Publication Date
FI832543A0 FI832543A0 (fi) 1983-07-12
FI832543L FI832543L (fi) 1984-01-14
FI73218B true FI73218B (fi) 1987-05-29
FI73218C FI73218C (sv) 1987-09-10

Family

ID=9276096

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832543A FI73218C (sv) 1982-07-13 1983-07-12 Förfarande för framställning av nya farmakologiskt verksamma tieno/3,2 -c/pyridinderivat.

Country Status (33)

Country Link
US (1) US4529596A (sv)
EP (1) EP0099802B1 (sv)
JP (1) JPS5927895A (sv)
KR (1) KR870001270B1 (sv)
AT (1) ATE25384T1 (sv)
AU (1) AU554358B2 (sv)
CA (1) CA1194875A (sv)
CS (1) CS246062B2 (sv)
DD (1) DD211351A5 (sv)
DE (1) DE3369683D1 (sv)
DK (1) DK157552C (sv)
DZ (1) DZ558A1 (sv)
EG (1) EG16540A (sv)
ES (1) ES523943A0 (sv)
FI (1) FI73218C (sv)
FR (1) FR2530247B1 (sv)
GR (1) GR79592B (sv)
HU (1) HU187111B (sv)
IE (1) IE55895B1 (sv)
IL (1) IL69049A (sv)
MA (1) MA19843A1 (sv)
MX (1) MX9203264A (sv)
NO (1) NO159725C (sv)
NZ (1) NZ204874A (sv)
OA (1) OA07491A (sv)
PH (1) PH19375A (sv)
PL (1) PL142272B1 (sv)
PT (1) PT77018B (sv)
SG (1) SG95287G (sv)
SU (1) SU1272994A3 (sv)
UA (1) UA7142A1 (sv)
YU (2) YU44384B (sv)
ZA (1) ZA834705B (sv)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
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ZA834705B (en) 1984-03-28
SU1272994A3 (ru) 1986-11-23
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PL142272B1 (en) 1987-10-31
FR2530247B1 (fr) 1986-05-16
FI832543A0 (fi) 1983-07-12
FI832543L (fi) 1984-01-14
KR840005448A (ko) 1984-11-12
IL69049A (en) 1986-03-31
EP0099802B1 (fr) 1987-02-04
US4529596A (en) 1985-07-16
EP0099802A1 (fr) 1984-02-01
NZ204874A (en) 1986-01-24
EG16540A (en) 1990-12-30
YU45291B (en) 1992-05-28
FI73218C (sv) 1987-09-10
SG95287G (en) 1990-11-23
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DD211351A5 (de) 1984-07-11
AU554358B2 (en) 1986-08-21
NO159725B (no) 1988-10-24
IL69049A0 (en) 1983-10-31
ATE25384T1 (de) 1987-02-15
MA19843A1 (fr) 1984-04-01
PH19375A (en) 1986-04-02
HU187111B (en) 1985-11-28
NO832530L (no) 1984-01-16
PL242965A1 (en) 1984-07-16
PT77018A (fr) 1983-08-01
UA7142A1 (uk) 1995-06-30
DK157552C (da) 1990-06-11
DE3369683D1 (en) 1987-03-12
CS528183A2 (en) 1985-12-16
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MX9203264A (es) 1992-07-01
NO159725C (no) 1989-02-01
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OA07491A (fr) 1985-03-31
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ES8403901A1 (es) 1984-04-01
PT77018B (fr) 1986-01-24
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YU197485A (en) 1986-10-31
CS246062B2 (en) 1986-10-16
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