FI66188C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara s-oxider och -dioxider av 7-(2-(2-aminotiazol-4-yl)-2-oxiimino-acetamido)-cef-3-em-4-karboxylsyraderivat - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara s-oxider och -dioxider av 7-(2-(2-aminotiazol-4-yl)-2-oxiimino-acetamido)-cef-3-em-4-karboxylsyraderivat Download PDF

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Publication number
FI66188C
FI66188C FI781131A FI781131A FI66188C FI 66188 C FI66188 C FI 66188C FI 781131 A FI781131 A FI 781131A FI 781131 A FI781131 A FI 781131A FI 66188 C FI66188 C FI 66188C
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FI
Finland
Prior art keywords
ppm
acid
group
aminothiazol
formula
Prior art date
Application number
FI781131A
Other languages
English (en)
Finnish (fi)
Other versions
FI66188B (fi
FI781131A (fi
Inventor
Walter Duerckheimer
Eberhard Ehlers
Hubert Selinger
Elmar Schrinner
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI781131A publication Critical patent/FI781131A/fi
Publication of FI66188B publication Critical patent/FI66188B/fi
Application granted granted Critical
Publication of FI66188C publication Critical patent/FI66188C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI781131A 1977-04-15 1978-04-13 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara s-oxider och -dioxider av 7-(2-(2-aminotiazol-4-yl)-2-oxiimino-acetamido)-cef-3-em-4-karboxylsyraderivat FI66188C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2716677 1977-04-15
DE2716677A DE2716677C2 (de) 1977-04-15 1977-04-15 Cephemderivate und Verfahren zu ihrer Herstellung

Publications (3)

Publication Number Publication Date
FI781131A FI781131A (fi) 1978-10-16
FI66188B FI66188B (fi) 1984-05-31
FI66188C true FI66188C (fi) 1984-09-10

Family

ID=6006350

Family Applications (1)

Application Number Title Priority Date Filing Date
FI781131A FI66188C (fi) 1977-04-15 1978-04-13 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara s-oxider och -dioxider av 7-(2-(2-aminotiazol-4-yl)-2-oxiimino-acetamido)-cef-3-em-4-karboxylsyraderivat

Country Status (30)

Country Link
US (1) US4399131A (fr)
JP (1) JPS6052756B2 (fr)
AT (1) AT367426B (fr)
AU (1) AU526333B2 (fr)
BE (1) BE866038A (fr)
CA (1) CA1161836A (fr)
CH (1) CH643558A5 (fr)
CS (1) CS208748B2 (fr)
DD (1) DD138423A5 (fr)
DE (1) DE2716677C2 (fr)
DK (1) DK163244C (fr)
ES (3) ES468666A1 (fr)
FI (1) FI66188C (fr)
FR (1) FR2387234B1 (fr)
GB (1) GB1603212A (fr)
GR (1) GR71190B (fr)
HK (1) HK28983A (fr)
HU (1) HU184145B (fr)
IE (1) IE46535B1 (fr)
IL (1) IL54503A0 (fr)
IT (1) IT1095578B (fr)
LU (1) LU79439A1 (fr)
NL (1) NL7804019A (fr)
NO (1) NO781322L (fr)
NZ (1) NZ186968A (fr)
OA (1) OA05939A (fr)
PT (1) PT67906B (fr)
SE (1) SE447384B (fr)
YU (1) YU87378A (fr)
ZA (1) ZA782168B (fr)

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BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
US4409217A (en) * 1977-03-14 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
ZA781502B (en) * 1977-03-14 1979-09-26 Fujisawa Pharmaceutical Co New cephem and cepham compounds and processes for preparation thereof
US4496562A (en) * 1977-03-14 1985-01-29 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted-3-cephem-4-carboxylic acid esters
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2822861A1 (de) * 1978-05-26 1979-11-29 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
AR228726A1 (es) 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
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US4271157A (en) 1980-02-28 1981-06-02 E. R. Squibb & Sons, Inc. Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
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US4349672A (en) * 1979-11-29 1982-09-14 Hoffmann-La Roche Inc. Cephalosporin derivatives
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DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
US4252802A (en) 1980-03-13 1981-02-24 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
FR2479229B1 (fr) * 1980-03-26 1986-01-17 Clin Midy Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives
IT1141286B (it) * 1980-04-17 1986-10-01 Dob Far Spa Esteri delle desacetossi cefalosporine loro sali e procedimenti per il loro ottenimento
GR75711B (fr) * 1980-06-30 1984-08-02 Sanofi Sa
FR2501209B1 (fr) * 1981-03-03 1986-07-04 Sanofi Sa Nouveaux derives des cephalosporines et medicaments antibiotiques contenant lesdits derives
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS5756486A (en) * 1980-08-11 1982-04-05 Fujisawa Pharmaceut Co Ltd Novel cephem compound or its salt, their preparation and prophylactic or remedy for microbism containing the same as active ingredient
US4416879A (en) * 1980-09-08 1983-11-22 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
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DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
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EP0187355A1 (fr) 1981-09-23 1986-07-16 E.R. Squibb & Sons, Inc. Procédé de préparation d'antibiotiques bêta-lactames
JPS5862181A (ja) * 1981-10-07 1983-04-13 Dai Ichi Seiyaku Co Ltd セフアロスポリン誘導体
FR2516515A1 (fr) * 1981-11-16 1983-05-20 Sanofi Sa Nouveaux derives de pyridinium thiomethyl cephalosporines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2517309A1 (fr) * 1981-12-01 1983-06-03 Sanofi Sa Nouveaux derives de cephalosporines substitues en position 3 par un groupe heterocycle thiomethyl; procede de preparation desdits composes et compositions pharmaceutiques en contenant
PH19163A (en) * 1982-04-06 1986-01-16 Daiichi Seiyaku Co Cephalosporin derivatives
US4500526A (en) * 1982-06-28 1985-02-19 Bristol-Myers Company Cephalosporin derivatives
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FR2530248A1 (fr) * 1982-07-13 1984-01-20 Sanofi Sa Nouveaux derives des cephalosporines, leur procede de preparation et medicaments antibiotiques contenant lesdits derives
US4477660A (en) * 1982-11-16 1984-10-16 Eli Lilly And Company 7-(S)-Acylaminocephalosporin sulfones and process
US4459405A (en) * 1982-11-16 1984-07-10 Eli Lilly And Company Desacetylcephalosporin sulfones
US4608373A (en) * 1982-12-13 1986-08-26 Yamanouchi Pharmaceutical Co., Ltd. Cephem compounds
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US5132301A (en) * 1983-05-02 1992-07-21 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
FR2546520B1 (fr) * 1983-05-27 1985-08-30 Sanofi Sa Nouveaux composes antibiotiques derives des cephalosporines
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
KR920004820B1 (ko) * 1984-02-23 1992-06-18 메이지제과 주식회사 새로운 세팔로스포린 유도체의 제조방법
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
FR2586020B2 (fr) 1985-08-09 1988-10-14 Roussel Uclaf Nouveaux derives de l'acide 1-dethia 2-thia cephalosporanique, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
US4684722A (en) * 1986-01-06 1987-08-04 E. R. Squibb & Sons, Inc. Monosulfactams
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Also Published As

Publication number Publication date
LU79439A1 (de) 1978-11-28
AU3507178A (en) 1979-10-18
ES468666A1 (es) 1980-12-16
GR71190B (fr) 1983-04-11
FR2387234A1 (fr) 1978-11-10
FI66188B (fi) 1984-05-31
NO781322L (no) 1978-10-17
NZ186968A (en) 1981-04-24
GB1603212A (en) 1981-11-18
BE866038A (fr) 1978-10-17
DK163244C (da) 1992-06-29
YU87378A (en) 1983-01-21
ES477153A1 (es) 1979-07-01
ES477154A1 (es) 1979-12-01
DK162878A (da) 1978-10-16
FI781131A (fi) 1978-10-16
JPS53130691A (en) 1978-11-14
CS208748B2 (en) 1981-09-15
AT367426B (de) 1982-07-12
PT67906A (fr) 1978-05-01
IE46535B1 (en) 1983-07-13
CA1161836A (fr) 1984-02-07
US4399131A (en) 1983-08-16
DK163244B (da) 1992-02-10
IT7822244A0 (it) 1978-04-12
IL54503A0 (en) 1978-07-31
IE780736L (en) 1978-10-15
HK28983A (en) 1983-08-26
DE2716677C2 (de) 1985-10-10
HU184145B (en) 1984-07-30
OA05939A (fr) 1981-06-30
ZA782168B (en) 1979-03-28
AU526333B2 (en) 1983-01-06
DD138423A5 (de) 1979-10-31
ATA263278A (de) 1981-11-15
NL7804019A (nl) 1978-10-17
DE2716677A1 (de) 1978-10-26
SE7804185L (sv) 1978-10-16
SE447384B (sv) 1986-11-10
JPS6052756B2 (ja) 1985-11-21
CH643558A5 (de) 1984-06-15
PT67906B (pt) 1994-01-14
FR2387234B1 (fr) 1985-09-13
IT1095578B (it) 1985-08-10

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MM Patent lapsed
MM Patent lapsed

Owner name: HOECHST AKTIENGESELLSCHAFT