ES477154A1 - Procedimiento para la obtencion de preparados farmaceuticos activos contra infecciones bacterianas. - Google Patents
Procedimiento para la obtencion de preparados farmaceuticos activos contra infecciones bacterianas.Info
- Publication number
- ES477154A1 ES477154A1 ES477154A ES477154A ES477154A1 ES 477154 A1 ES477154 A1 ES 477154A1 ES 477154 A ES477154 A ES 477154A ES 477154 A ES477154 A ES 477154A ES 477154 A1 ES477154 A1 ES 477154A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- denotes hydrogen
- optionally substituted
- denotes
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedimiento para la obtención de preparados farmacéuticos activos contra infecciones bacterianas, caracterizado porque se preparar, en primer lugar, un derivado de cefem de la fórmula general I **fórmula** en la que R1 significa hidrógeno, un grupo alcohilo, acilo, arilsulfonilo o alcohilsulfonilo eventualmente sustituido o un grupo protector amino, conocido por la química de los péptidos, R2 significa hidrógeno, un grupo alcohilo, ciclo-alcohilo, alquenilo, alquinilo, acilo, arilo, aralcohilo, arilsulfonilo, alcohilsulfonilo o heterocícliclo, eventualmente sustituido, R3 significa hidrógeno, un grupo éster o un catión, R4 significa hidrógeno, un grupo alcohiloxi inferior o un grupo transformable en éste, X significa un grupos SO en configuración R o s, o un grupo SO2, A significa hidrógeno, un grupo alcohiloxi o alqueniloxi, eventualmente sustituido, halógeno o un grupo -CH2Y, en el que Y representa hidrógeno, halógeno o el radical de un compuesto nucleófilo y en el que el grupo R2O estáen posición "sin" para lo cual se oxidan en el azufre del anillo cefem
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2716677A DE2716677C2 (de) | 1977-04-15 | 1977-04-15 | Cephemderivate und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES477154A1 true ES477154A1 (es) | 1979-12-01 |
Family
ID=6006350
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES468666A Expired ES468666A1 (es) | 1977-04-15 | 1978-04-10 | Procedimiento para la preparacion de derivados de cefem. |
ES477153A Expired ES477153A1 (es) | 1977-04-15 | 1979-01-25 | Procedimiento para la preparacion de derivados de cefem. |
ES477154A Expired ES477154A1 (es) | 1977-04-15 | 1979-01-25 | Procedimiento para la obtencion de preparados farmaceuticos activos contra infecciones bacterianas. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES468666A Expired ES468666A1 (es) | 1977-04-15 | 1978-04-10 | Procedimiento para la preparacion de derivados de cefem. |
ES477153A Expired ES477153A1 (es) | 1977-04-15 | 1979-01-25 | Procedimiento para la preparacion de derivados de cefem. |
Country Status (30)
Country | Link |
---|---|
US (1) | US4399131A (es) |
JP (1) | JPS6052756B2 (es) |
AT (1) | AT367426B (es) |
AU (1) | AU526333B2 (es) |
BE (1) | BE866038A (es) |
CA (1) | CA1161836A (es) |
CH (1) | CH643558A5 (es) |
CS (1) | CS208748B2 (es) |
DD (1) | DD138423A5 (es) |
DE (1) | DE2716677C2 (es) |
DK (1) | DK163244C (es) |
ES (3) | ES468666A1 (es) |
FI (1) | FI66188C (es) |
FR (1) | FR2387234B1 (es) |
GB (1) | GB1603212A (es) |
GR (1) | GR71190B (es) |
HK (1) | HK28983A (es) |
HU (1) | HU184145B (es) |
IE (1) | IE46535B1 (es) |
IL (1) | IL54503A0 (es) |
IT (1) | IT1095578B (es) |
LU (1) | LU79439A1 (es) |
NL (1) | NL7804019A (es) |
NO (1) | NO781322L (es) |
NZ (1) | NZ186968A (es) |
OA (1) | OA05939A (es) |
PT (1) | PT67906B (es) |
SE (1) | SE447384B (es) |
YU (1) | YU87378A (es) |
ZA (1) | ZA782168B (es) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE878433A (fr) * | 1978-08-31 | 1980-02-25 | Fujisawa Pharmaceutical Co | Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne |
BE878514A (fr) * | 1978-09-04 | 1980-02-29 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne |
PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
US4409217A (en) * | 1977-03-14 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
AU520269B2 (en) * | 1977-03-14 | 1982-01-21 | Fujisawa Pharmaceutical Co., Ltd. | Cephem and cepham compounds |
US4496562A (en) * | 1977-03-14 | 1985-01-29 | Fujisawa Pharmaceutical Co., Ltd. | 7-Substituted-3-cephem-4-carboxylic acid esters |
FR2410655A1 (fr) * | 1977-12-05 | 1979-06-29 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR2432521A1 (fr) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR2421907A1 (fr) * | 1978-04-07 | 1979-11-02 | Roussel Uclaf | Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments |
AR228726A1 (es) | 1978-05-26 | 1983-04-15 | Glaxo Group Ltd | Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato |
DE2822861A1 (de) * | 1978-05-26 | 1979-11-29 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
US4341775A (en) * | 1978-09-11 | 1982-07-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4237128A (en) * | 1979-04-12 | 1980-12-02 | E. R. Squibb & Sons, Inc. | 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides |
US4331666A (en) | 1979-05-11 | 1982-05-25 | Farmitalia Carlo Erba S.P.A. | 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid |
US4275062A (en) * | 1979-09-19 | 1981-06-23 | E. R. Squibb & Sons, Inc. | Aminothiazolyl ureido sulfoxide cephalosporins |
US4271157A (en) | 1980-02-28 | 1981-06-02 | E. R. Squibb & Sons, Inc. | Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins |
US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
US4349672A (en) * | 1979-11-29 | 1982-09-14 | Hoffmann-La Roche Inc. | Cephalosporin derivatives |
FR2476087A1 (fr) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
DE3006888A1 (de) * | 1980-02-23 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
US4252802A (en) | 1980-03-13 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins |
FR2479229B1 (fr) * | 1980-03-26 | 1986-01-17 | Clin Midy | Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives |
IT1141286B (it) * | 1980-04-17 | 1986-10-01 | Dob Far Spa | Esteri delle desacetossi cefalosporine loro sali e procedimenti per il loro ottenimento |
FR2501209B1 (fr) * | 1981-03-03 | 1986-07-04 | Sanofi Sa | Nouveaux derives des cephalosporines et medicaments antibiotiques contenant lesdits derives |
GR75706B (es) * | 1980-06-30 | 1984-08-02 | Sanofi Sa | |
JPS5756486A (en) * | 1980-08-11 | 1982-04-05 | Fujisawa Pharmaceut Co Ltd | Novel cephem compound or its salt, their preparation and prophylactic or remedy for microbism containing the same as active ingredient |
US4443444A (en) * | 1980-08-11 | 1984-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4416879A (en) | 1980-09-08 | 1983-11-22 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
JPS6011917B2 (ja) * | 1981-04-09 | 1985-03-28 | 山之内製薬株式会社 | 新規なセファロスポリン化合物 |
DE3118732A1 (de) * | 1981-05-12 | 1982-12-02 | Hoechst Ag, 6000 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
JPS5849382A (ja) * | 1981-09-18 | 1983-03-23 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物 |
EP0187355A1 (en) | 1981-09-23 | 1986-07-16 | E.R. Squibb & Sons, Inc. | Process for preparing beta-lactam antibiotics |
JPS5862181A (ja) * | 1981-10-07 | 1983-04-13 | Dai Ichi Seiyaku Co Ltd | セフアロスポリン誘導体 |
FR2516515A1 (fr) * | 1981-11-16 | 1983-05-20 | Sanofi Sa | Nouveaux derives de pyridinium thiomethyl cephalosporines, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR2517309A1 (fr) * | 1981-12-01 | 1983-06-03 | Sanofi Sa | Nouveaux derives de cephalosporines substitues en position 3 par un groupe heterocycle thiomethyl; procede de preparation desdits composes et compositions pharmaceutiques en contenant |
PH19163A (en) * | 1982-04-06 | 1986-01-16 | Daiichi Seiyaku Co | Cephalosporin derivatives |
US4500526A (en) * | 1982-06-28 | 1985-02-19 | Bristol-Myers Company | Cephalosporin derivatives |
NL8302309A (nl) * | 1982-06-30 | 1984-01-16 | Glaxo Group Ltd | Cefalosporinen, preparaten die ze bevatten, en werkwijzen voor de bereiding daarvan. |
US4616081A (en) * | 1982-07-07 | 1986-10-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Cephalosporin compounds |
FR2530248A1 (fr) * | 1982-07-13 | 1984-01-20 | Sanofi Sa | Nouveaux derives des cephalosporines, leur procede de preparation et medicaments antibiotiques contenant lesdits derives |
US4459405A (en) * | 1982-11-16 | 1984-07-10 | Eli Lilly And Company | Desacetylcephalosporin sulfones |
US4477660A (en) * | 1982-11-16 | 1984-10-16 | Eli Lilly And Company | 7-(S)-Acylaminocephalosporin sulfones and process |
US4608373A (en) * | 1982-12-13 | 1986-08-26 | Yamanouchi Pharmaceutical Co., Ltd. | Cephem compounds |
US4547371A (en) * | 1983-04-18 | 1985-10-15 | Merck & Co., Inc. | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents |
US5132301A (en) * | 1983-05-02 | 1992-07-21 | Merck & Co., Inc. | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents |
FR2546520B1 (fr) * | 1983-05-27 | 1985-08-30 | Sanofi Sa | Nouveaux composes antibiotiques derives des cephalosporines |
DE150507T1 (de) * | 1983-12-29 | 1987-02-26 | Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
JPS60142987A (ja) * | 1983-12-29 | 1985-07-29 | Mochida Pharmaceut Co Ltd | セフアロスポリン誘導体 |
US4785090A (en) * | 1984-02-23 | 1988-11-15 | Meiji Seika Kaisha, Ltd. | Cephalosporin derivatives |
US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
ZW11586A1 (en) * | 1985-07-01 | 1987-12-30 | Hoffmann La Roche | Bicyclic compounds |
FR2586020B2 (fr) | 1985-08-09 | 1988-10-14 | Roussel Uclaf | Nouveaux derives de l'acide 1-dethia 2-thia cephalosporanique, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant |
US4684722A (en) * | 1986-01-06 | 1987-08-04 | E. R. Squibb & Sons, Inc. | Monosulfactams |
ZA874696B (en) | 1986-07-03 | 1988-01-04 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Acyl derivatives |
US5147871A (en) * | 1986-07-03 | 1992-09-15 | Hoffmann La-Roche, Inc. | Anti-bacterial cephalosporin compounds |
US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
JPS63132893A (ja) * | 1986-11-25 | 1988-06-04 | Mochida Pharmaceut Co Ltd | 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤 |
US5428163A (en) * | 1986-12-31 | 1995-06-27 | Mills; Randell L. | Prodrugs for selective drug delivery |
DE3809561A1 (de) * | 1988-03-22 | 1989-10-05 | Hoechst Ag | Ester der 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroxyiminoacetamido)-3-methoxymethyl-3-cephem-4-carbonsaeure, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen |
US5336768A (en) * | 1988-05-24 | 1994-08-09 | Hoffmann-La Roche Inc. | Antibacterial cephalosporin compounds |
CS273349B2 (en) * | 1988-03-31 | 1991-03-12 | Hoffmann La Roche | Method of cephalosporin's new derivatives production |
GB9104238D0 (en) * | 1990-03-16 | 1991-04-17 | Ici Pharma | 3-tetrazolylthiomethyl cephalosporin antibiotics |
ATE123034T1 (de) * | 1990-03-24 | 1995-06-15 | Lucky Ltd | Cephalosporinzwischenverbindungen, verfahren zu ihrer herstellung sowie zur herstellung ihrer endprodukte. |
JPH0626344U (ja) * | 1992-08-27 | 1994-04-08 | 武盛 豊永 | ソフトタッチ電話器 |
US5811419A (en) * | 1996-01-16 | 1998-09-22 | Hoffmann-La Roche Inc. | Isooxacephem-derivatives |
DE19607960A1 (de) * | 1996-03-01 | 1997-09-04 | Hoechst Schering Agrevo Gmbh | Verfahren zur Herstellung von Ketonoximether durch Boronsäurekupplung |
US5883247A (en) * | 1996-06-10 | 1999-03-16 | Hoffmann-La Roche Inc. | Preparation of cephem and isooxacephem derivatives |
WO2001095944A2 (en) * | 2000-06-12 | 2001-12-20 | Mills Randell L | Photocleavable prodrugs for selective drug delivery |
US20050080260A1 (en) * | 2003-04-22 | 2005-04-14 | Mills Randell L. | Preparation of prodrugs for selective drug delivery |
EP1660506A4 (en) * | 2003-08-25 | 2009-02-25 | Revaax Pharmaceuticals Llc | ORAL NEUROTHERAPEUTIC CEFAZOLINE COMPOSITIONS |
US7908037B2 (en) * | 2009-03-27 | 2011-03-15 | General Electric Company | Pre-programmed energy management ballast or driver |
AU2015308350B2 (en) | 2014-08-29 | 2020-03-05 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1389194A (en) | 1971-01-29 | 1975-04-03 | Glaxo Lab Ltd | Antibiotics |
US3926957A (en) * | 1971-01-29 | 1975-12-16 | Glaxo Lab Ltd | Penicillin antibiotics |
US3971778A (en) * | 1972-05-12 | 1976-07-27 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position |
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
US3932385A (en) * | 1971-05-14 | 1976-01-13 | Glaxo Laboratories Limited | Penicillins having a 6β-(α-etherified oximino) acylamido group |
GB1442993A (en) * | 1972-07-18 | 1976-07-21 | Gist Brocades Nv | Penicillin and cephalosporin r-sulphoxides |
US4075337A (en) * | 1972-07-18 | 1978-02-21 | Gist-Brocades N.V. | Methods of combatting bacterial infections in warm-blooded animal with cephalsporin R-sulfoxide |
US4020058A (en) * | 1974-10-03 | 1977-04-26 | Glaxo Laboratories Limited | Improvements in or relating to cephalosporin antibiotics |
JPS5168589A (es) * | 1974-12-06 | 1976-06-14 | Shionogi Seiyaku Kk | |
US4203899A (en) * | 1974-12-19 | 1980-05-20 | Takeda Chemical Industries, Ltd. | Thiazolylacetamido compounds |
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
CA1088049A (en) | 1975-06-03 | 1980-10-21 | Takashi Masugi | 3-substituted-7-substituted alkanamido-3-cephem-4- carboxylic acid compounds and processes for preparation thereof |
DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
US4237128A (en) * | 1979-04-12 | 1980-12-02 | E. R. Squibb & Sons, Inc. | 7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides |
US4252802A (en) * | 1980-03-13 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins |
-
1977
- 1977-04-15 DE DE2716677A patent/DE2716677C2/de not_active Expired
-
1978
- 1978-04-10 ES ES468666A patent/ES468666A1/es not_active Expired
- 1978-04-12 CH CH394178A patent/CH643558A5/de not_active IP Right Cessation
- 1978-04-12 YU YU00873/78A patent/YU87378A/xx unknown
- 1978-04-12 DD DD78204752A patent/DD138423A5/xx unknown
- 1978-04-12 IT IT22244/78A patent/IT1095578B/it active
- 1978-04-13 IL IL54503A patent/IL54503A0/xx not_active IP Right Cessation
- 1978-04-13 FI FI781131A patent/FI66188C/fi not_active IP Right Cessation
- 1978-04-13 SE SE7804185A patent/SE447384B/sv not_active IP Right Cessation
- 1978-04-13 AU AU35071/78A patent/AU526333B2/en not_active Expired
- 1978-04-13 NZ NZ186968A patent/NZ186968A/xx unknown
- 1978-04-14 CS CS782443A patent/CS208748B2/cs unknown
- 1978-04-14 CA CA000301193A patent/CA1161836A/en not_active Expired
- 1978-04-14 DK DK162878A patent/DK163244C/da not_active IP Right Cessation
- 1978-04-14 FR FR7811069A patent/FR2387234B1/fr not_active Expired
- 1978-04-14 IE IE736/78A patent/IE46535B1/en not_active IP Right Cessation
- 1978-04-14 ZA ZA00782168A patent/ZA782168B/xx unknown
- 1978-04-14 LU LU79439A patent/LU79439A1/de unknown
- 1978-04-14 HU HU78HO2063A patent/HU184145B/hu not_active IP Right Cessation
- 1978-04-14 AT AT0263278A patent/AT367426B/de not_active IP Right Cessation
- 1978-04-14 OA OA56469A patent/OA05939A/xx unknown
- 1978-04-14 NO NO781322A patent/NO781322L/no unknown
- 1978-04-14 NL NL7804019A patent/NL7804019A/xx not_active Application Discontinuation
- 1978-04-14 PT PT67906A patent/PT67906B/pt unknown
- 1978-04-15 GR GR55989A patent/GR71190B/el unknown
- 1978-04-15 JP JP53043813A patent/JPS6052756B2/ja not_active Expired
- 1978-04-17 BE BE186834A patent/BE866038A/xx not_active IP Right Cessation
- 1978-04-17 GB GB14990/78A patent/GB1603212A/en not_active Expired
-
1979
- 1979-01-25 ES ES477153A patent/ES477153A1/es not_active Expired
- 1979-01-25 ES ES477154A patent/ES477154A1/es not_active Expired
-
1980
- 1980-05-05 US US06/146,780 patent/US4399131A/en not_active Expired - Lifetime
-
1983
- 1983-08-18 HK HK289/83A patent/HK28983A/xx unknown
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