FI62821C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara hydroxamsyror - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara hydroxamsyror Download PDF

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Publication number
FI62821C
FI62821C FI770859A FI770859A FI62821C FI 62821 C FI62821 C FI 62821C FI 770859 A FI770859 A FI 770859A FI 770859 A FI770859 A FI 770859A FI 62821 C FI62821 C FI 62821C
Authority
FI
Finland
Prior art keywords
crl
mice
solution
mol
compound
Prior art date
Application number
FI770859A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI770859A (es
FI62821B (fi
Inventor
Louis Lafon
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of FI770859A publication Critical patent/FI770859A/fi
Priority to FI821215A priority Critical patent/FI71313C/fi
Priority to FI821213A priority patent/FI65236C/fi
Priority to FI821214A priority patent/FI69624C/fi
Application granted granted Critical
Publication of FI62821B publication Critical patent/FI62821B/fi
Publication of FI62821C publication Critical patent/FI62821C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/56—Radicals substituted by sulfur atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
FI770859A 1976-03-23 1977-03-18 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara hydroxamsyror FI62821C (fi)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI821215A FI71313C (fi) 1976-03-23 1982-04-06 Analogifoerfarande foer framstaellning av terapeutiskt anvaendbar 2-(1-fenylbensimidazolyl)acetohydroxamsyra
FI821213A FI65236C (fi) 1976-03-23 1982-04-06 Analogifoerfarande foer framstaellning av nya terapeutiskt anvaendbara arylsulfinylacetohydroxamsyror
FI821214A FI69624C (fi) 1976-03-23 1982-04-06 Analogifoerfarande foer framstaellning av nya terapeutiskt anvaendbara acetohydroxamsyror

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1171076 1976-03-23
GB11710/76A GB1574822A (en) 1976-03-23 1976-03-23 Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
GB629877 1977-02-15
GB629877 1977-02-15

Publications (3)

Publication Number Publication Date
FI770859A FI770859A (es) 1977-09-24
FI62821B FI62821B (fi) 1982-11-30
FI62821C true FI62821C (fi) 1983-03-10

Family

ID=26240593

Family Applications (1)

Application Number Title Priority Date Filing Date
FI770859A FI62821C (fi) 1976-03-23 1977-03-18 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara hydroxamsyror

Country Status (25)

Country Link
US (7) US4122186A (es)
JP (1) JPS52144601A (es)
AT (5) AT356078B (es)
AU (1) AU516473B2 (es)
BE (1) BE852738A (es)
CA (2) CA1120928A (es)
CH (1) CH620894A5 (es)
CS (1) CS200511B2 (es)
DD (1) DD129645A5 (es)
DE (1) DE2711451A1 (es)
DK (1) DK171197B1 (es)
ES (1) ES457105A1 (es)
FI (1) FI62821C (es)
FR (4) FR2345430A1 (es)
GB (1) GB1574822A (es)
IE (1) IE44721B1 (es)
IL (1) IL51705A (es)
LU (1) LU76989A1 (es)
NL (1) NL188801C (es)
NO (4) NO144420C (es)
NZ (1) NZ183616A (es)
PH (1) PH16271A (es)
PT (1) PT66300B (es)
SE (4) SE432420B (es)
SU (1) SU689617A3 (es)

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US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
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US7842835B2 (en) * 2003-07-07 2010-11-30 Georgetown University Histone deacetylase inhibitors and methods of use thereof
EP1644323B1 (en) * 2003-07-07 2015-03-18 Georgetown University Histone deacetylase inhibitors and methods of use thereof
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7378426B2 (en) * 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US20090264384A1 (en) * 2004-11-01 2009-10-22 Nuada, Inc. Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
WO2007134169A2 (en) * 2006-05-10 2007-11-22 Nuada, Llc Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof
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KR101288781B1 (ko) 2006-06-28 2013-07-22 암젠 인크 글리신 수송자-1 억제제
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BRPI0718089A2 (pt) * 2006-10-28 2013-11-05 Methylgene Inc Composto, uso do composto, composição, e, métodos para inibir histona desacetilase e para tratar uma doença de expansão da poliglutamina
US8242174B2 (en) 2007-02-01 2012-08-14 Panthera Biopharma Llc Hydroxamic acid derivatives of aniline useful as therapeutic agents for treating anthrax poisoning
FR2957492B1 (fr) * 2010-03-18 2013-08-16 Rhodia Operations Nouvelles utilisations de composes de type esteramide
CN101982459A (zh) * 2010-10-21 2011-03-02 山东华尔康生物技术有限公司 乙酰氧肟酸的制备工艺
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US11993575B1 (en) 2023-12-29 2024-05-28 King Faisal University Ethyl [4,4-bis(4-bromophenyl)-2,5-dioxoimidazolidin-1-yl]acetate as an antimicrobial compound
US11970462B1 (en) 2024-01-03 2024-04-30 King Faisal University Ethyl 3-[4,4-bis(4-chlorophenyl)-2,5-dioxoimidazolidin-1-yl]propanoate as an antimicrobial compound

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Also Published As

Publication number Publication date
AT361932B (de) 1981-04-10
ATA839878A (de) 1980-09-15
NO146431B (no) 1982-06-21
FR2453158A1 (fr) 1980-10-31
NZ183616A (en) 1979-03-28
NO803336L (no) 1977-09-26
US4209523A (en) 1980-06-24
ATA501480A (de) 1983-08-15
SE8302171L (sv) 1983-04-19
US4183951A (en) 1980-01-15
NO771006L (no) 1977-09-26
US4151300A (en) 1979-04-24
US4152458A (en) 1979-05-01
JPS52144601A (en) 1977-12-02
IL51705A (en) 1982-09-30
FI770859A (es) 1977-09-24
SE458605B (sv) 1989-04-17
ES457105A1 (es) 1978-10-16
AT356078B (de) 1980-04-10
IE44721B1 (en) 1982-03-10
IL51705A0 (en) 1977-05-31
DD129645A5 (de) 1978-02-01
ATA193077A (de) 1979-09-15
NO144420B (no) 1981-05-18
US4225617A (en) 1980-09-30
NL188801C (nl) 1992-10-01
FI62821B (fi) 1982-11-30
SE7703263L (sv) 1977-09-24
US4122186A (en) 1978-10-24
DE2711451A1 (de) 1977-10-06
FR2453148B1 (es) 1983-12-02
BE852738A (fr) 1977-09-22
AU516473B2 (en) 1981-06-04
CA1120928A (en) 1982-03-30
CA1130301A (en) 1982-08-24
GB1574822A (en) 1980-09-10
SU689617A3 (ru) 1979-09-30
PH16271A (en) 1983-08-25
NO152972C (no) 1985-12-27
NL7703168A (nl) 1977-09-27
SE8302173D0 (sv) 1983-04-19
ATA840078A (de) 1980-11-15
SE432420B (sv) 1984-04-02
AT374191B (de) 1984-03-26
FR2345430B1 (es) 1982-07-23
IE44721L (en) 1977-09-23
DK171197B1 (da) 1996-07-22
DK126677A (da) 1977-09-24
SE8302173L (sv) 1983-04-19
NO803338L (no) 1977-09-26
AT362793B (de) 1981-06-10
ATA839978A (de) 1980-02-15
NO145881C (no) 1982-06-16
AU2334477A (en) 1978-09-21
DE2711451C2 (es) 1990-05-10
NO146431C (no) 1982-09-29
FR2453133A1 (fr) 1980-10-31
NO145881B (no) 1982-03-08
SE8302172D0 (sv) 1983-04-19
FR2453133B1 (es) 1984-04-06
NO144420C (no) 1981-08-26
PT66300A (fr) 1977-04-01
US4209524A (en) 1980-06-24
LU76989A1 (es) 1977-07-18
FR2345430A1 (fr) 1977-10-21
SE452155B (sv) 1987-11-16
SE8302171D0 (sv) 1983-04-19
NO152972B (no) 1985-09-16
SE456992B (sv) 1988-11-21
CS200511B2 (en) 1980-09-15
SE8302172L (sv) 1983-04-19
NO803337L (no) 1977-09-26
PT66300B (pt) 1978-08-10
FR2453148A1 (fr) 1980-10-31
FR2453158B1 (es) 1982-08-06
JPS628424B2 (es) 1987-02-23
CH620894A5 (es) 1980-12-31
AT358556B (de) 1980-09-25

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