FI3926051T3 - Menetelmiä nisäkässoluviljelmien keräämiseksi - Google Patents

Menetelmiä nisäkässoluviljelmien keräämiseksi Download PDF

Info

Publication number
FI3926051T3
FI3926051T3 FIEP21179944.0T FI21179944T FI3926051T3 FI 3926051 T3 FI3926051 T3 FI 3926051T3 FI 21179944 T FI21179944 T FI 21179944T FI 3926051 T3 FI3926051 T3 FI 3926051T3
Authority
FI
Finland
Prior art keywords
recombinant protein
cell culture
bioreactor
molecular weight
hollow fiber
Prior art date
Application number
FIEP21179944.0T
Other languages
English (en)
Finnish (fi)
Inventor
Chetan Goudar
Sean Cole
Nicole Sabo
Henry Lin
Jonathan Craig Lull
Tharmala Tharmalingam
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53433304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI3926051(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of FI3926051T3 publication Critical patent/FI3926051T3/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Computer Hardware Design (AREA)
  • Water Supply & Treatment (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FIEP21179944.0T 2014-06-04 2015-06-04 Menetelmiä nisäkässoluviljelmien keräämiseksi FI3926051T3 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462007588P 2014-06-04 2014-06-04

Publications (1)

Publication Number Publication Date
FI3926051T3 true FI3926051T3 (fi) 2024-06-18

Family

ID=53433304

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP21179944.0T FI3926051T3 (fi) 2014-06-04 2015-06-04 Menetelmiä nisäkässoluviljelmien keräämiseksi

Country Status (25)

Country Link
US (3) US11384378B2 (enExample)
EP (4) EP3521440B1 (enExample)
JP (3) JP6695814B2 (enExample)
KR (2) KR102391259B1 (enExample)
CN (1) CN106687575B (enExample)
AU (5) AU2015269365A1 (enExample)
BR (2) BR112016028285B1 (enExample)
CA (2) CA2951046C (enExample)
CL (2) CL2016003096A1 (enExample)
CY (1) CY1121217T1 (enExample)
DK (2) DK3152317T3 (enExample)
EA (2) EA202192126A3 (enExample)
ES (3) ES2709994T3 (enExample)
FI (1) FI3926051T3 (enExample)
HU (2) HUE066803T2 (enExample)
IL (3) IL249150B (enExample)
LT (2) LT3152317T (enExample)
MX (3) MX384212B (enExample)
PL (2) PL3152317T3 (enExample)
PT (2) PT3926051T (enExample)
SG (2) SG10202113019XA (enExample)
SI (2) SI3926051T1 (enExample)
TR (1) TR201900776T4 (enExample)
WO (1) WO2015188009A1 (enExample)
ZA (1) ZA201608303B (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014130872A2 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
ES2717927T3 (es) 2013-02-22 2019-06-26 Genzyme Corp Procedimientos de cultivo por perfusión de microportadores y usos de los mismos
TW202204596A (zh) 2014-06-06 2022-02-01 美商健臻公司 灌注培養方法及其用途
TWI707949B (zh) 2014-06-09 2020-10-21 美商健臻公司 種子罐培養法（ｓｅｅｄ ｔｒａｉｎ ｐｒｏｃｅｓｓｅｓ）及其用途
CA3225136A1 (en) 2014-12-22 2016-06-30 Genzyme Corporation Methods of culturing a mammalian cell
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR20230080504A (ko) * 2016-07-25 2023-06-07 리플리겐 코포레이션 교번 접선 유동식의 신속한 수확
JP7043125B2 (ja) * 2016-10-28 2022-03-29 旭化成メディカル株式会社 連続培養における有用物質の回収方法
CN107964037A (zh) * 2017-05-16 2018-04-27 浙江海隆生物科技有限公司 基于cho细胞表达系统的重组猪瘟e2蛋白的纯化方法及应用
WO2018229802A1 (en) * 2017-06-16 2018-12-20 Ge Healthcare Bio-Sciences Ab Method for predicting outcome of and modelling of a process in a bioreactor
US10987636B2 (en) 2017-08-31 2021-04-27 Massachusetts Institute Of Technology Filtration systems and methods for manufacturing biologically-produced products
EP3692358A1 (en) * 2017-10-06 2020-08-12 Lonza Ltd Automated control of cell culture using raman spectroscopy
WO2019084410A1 (en) * 2017-10-26 2019-05-02 Repligen Corporation MICRO-ALTERNATIVE TANGENTIALLY FLOWING INFUSION FILTER, TREATMENT CONTAINER, AND METHODS OF USING THE SAME
CA3083124A1 (en) 2017-11-20 2019-05-23 Lonza Ltd. Process and system for propagating cell cultures while preventing lactate accumulation
CN111868249B (zh) * 2018-03-19 2024-06-18 富士胶片株式会社 生产物的制造方法
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
RS65472B1 (sr) * 2018-07-03 2024-05-31 Bristol Myers Squibb Co Postupak proizvodnje rekombinantnih proteina
CA3118398A1 (en) * 2018-11-02 2020-05-07 WuXi Biologics Ireland Limited Cell culture process by intensified perfusion with continuous harvest and without cell bleeding
KR102910209B1 (ko) * 2018-12-21 2026-01-09 제넨테크, 인크. 세포사멸에 내성인 세포주를 사용한 폴리펩티드 생산 방법
SG11202106609WA (en) * 2018-12-31 2021-07-29 Repligen Corp Filter for mammalian cell culture perfusion and clarification with hydrophobic hollow fiber
US20210047605A1 (en) * 2019-08-13 2021-02-18 Repligen Corporation Control systems and methods for automated clarification of cell culture with high solids content
CN114901794B (zh) 2019-11-15 2026-05-01 隆萨有限公司 用于生产接种物的过程和系统
US20220389363A1 (en) * 2020-01-10 2022-12-08 Lonza Walkersville, Inc. Filter Apparatus and Method for Purifying Biological Processes and Cell Populations
WO2021143699A1 (en) * 2020-01-15 2021-07-22 Wuxi Biologics (Shanghai) Co. Ltd. An apparatus and a method for continuously harvesting a biological substance produced by a cultured cell
CN111808797A (zh) * 2020-07-28 2020-10-23 湖南赛诺生物科技股份有限公司 Necrostatin-1的应用及促进新生猪胰岛细胞成熟的制剂
EP3985097A1 (en) * 2020-10-14 2022-04-20 Sartorius Stedim Biotech GmbH A method and system for configuring and/or setup of a downstream process for processing a biomass
JP2023546736A (ja) * 2020-10-15 2023-11-07 エージーシー バイオロジクス，インコーポレーテッド 二重容器接線流濾過による連続的高細胞密度培養
US20220119759A1 (en) * 2020-10-19 2022-04-21 Emd Millipore Corporation Cascade Tangential Flow Filtration Systems for Perfusion of Cell Culture
US20220268785A1 (en) * 2021-02-19 2022-08-25 Northwestern University Facile sample preparation for quantitative single-cell proteomics
US20240174966A1 (en) * 2021-02-25 2024-05-30 Securecell Ag Fluid sampling system for biotechnological applications, operating method and use thereof
FR3126713A1 (fr) * 2021-09-08 2023-03-10 Erypharm Procédé de production de cellules de culture à haute densité
CN114317392A (zh) * 2021-12-27 2022-04-12 无锡药明生物技术股份有限公司 优化细胞培养的方法
AU2023228549A1 (en) * 2022-03-01 2024-10-17 Biosanapharma B.V. Continuous manufacturing of a biological substance with process traceability
WO2023200918A1 (en) * 2022-04-14 2023-10-19 Terasaki Institute For Biomedical Innovation Systems and methods for recycling growth factors and other components
WO2023205075A1 (en) * 2022-04-22 2023-10-26 Coopersurgical, Inc. Methods of culturing umbilical cord mesenchymal stem cells
JP2025531130A (ja) 2022-09-16 2025-09-19 アムジエン・インコーポレーテツド 灌流培養物から生成物を回収する方法
WO2024173685A1 (en) * 2023-02-15 2024-08-22 The Board Of Trustees Of The Leland Stanford Junior University Metabolic selection for glycogen-storing cells in vitro
JPWO2024248118A1 (enExample) 2023-05-31 2024-12-05
IL324973A (en) 2023-06-20 2026-01-01 Amgen Inc Chromatography methods and reuse of chromatography media
WO2025184296A1 (en) * 2024-02-29 2025-09-04 Nature's Toolbox, Inc. In vitro rna production and purification system and methods of use thereof

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5223428A (en) 1982-12-14 1993-06-29 Baxter International Inc. Method for in vitro culture of mammalian cells
AU588819B2 (en) 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
US4968607A (en) 1987-11-25 1990-11-06 Immunex Corporation Interleukin-1 receptors
US5075222A (en) 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
JP2507552B2 (ja) * 1988-08-29 1996-06-12 株式会社ニッショー 細胞培養産生物の取出しおよび培地の交換方法
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
US4937196A (en) 1989-08-18 1990-06-26 Brunswick Corporation Membrane bioreactor system
US5395760A (en) 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
DE59010908D1 (de) 1989-09-12 2000-08-10 Hoffmann La Roche TNF-bindende Proteine
US6204363B1 (en) 1989-10-16 2001-03-20 Amgen Inc. Stem cell factor
US5272064A (en) 1989-12-19 1993-12-21 Amgen Inc. DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof
US5149792A (en) 1989-12-19 1992-09-22 Amgen Inc. Platelet-derived growth factor B chain analogs
US5378612A (en) 1990-05-11 1995-01-03 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Culture medium for production of recombinant protein
US5350683A (en) 1990-06-05 1994-09-27 Immunex Corporation DNA encoding type II interleukin-1 receptors
WO1991018982A1 (en) 1990-06-05 1991-12-12 Immunex Corporation Type ii interleukin-1 receptors
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
ATE240394T1 (de) 1992-10-23 2003-05-15 Immunex Corp Methoden zur herstellung löslicher, oligomerer proteine
US5554512A (en) 1993-05-24 1996-09-10 Immunex Corporation Ligands for flt3 receptors
US5981713A (en) 1994-10-13 1999-11-09 Applied Research Systems Ars Holding N.V. Antibodies to intereleukin-1 antagonists
US5721121A (en) 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
KR100510234B1 (ko) 1995-06-29 2005-11-25 임뮤넥스 코포레이션 세포소멸을 유도하는 시토킨
US6613544B1 (en) 1995-12-22 2003-09-02 Amgen Inc. Osteoprotegerin
US6096728A (en) 1996-02-09 2000-08-01 Amgen Inc. Composition and method for treating inflammatory diseases
US6271349B1 (en) 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US6337072B1 (en) 1998-04-03 2002-01-08 Hyseq, Inc. Interleukin-1 receptor antagonist and recombinant production thereof
US6068775A (en) * 1998-04-13 2000-05-30 Circe Biomedical, Inc. Removal of agent from cell suspension
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
AU1920301A (en) 1999-11-17 2001-05-30 Immunex Corporation Receptor activator of nf-kappa b
US6544424B1 (en) 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
PE20011338A1 (es) 2000-05-26 2002-01-13 Bristol Myers Squibb Co Moleculas mutantes de ctla4 solubles
EP1325127B1 (en) 2000-10-02 2009-03-11 Novo Nordisk Health Care AG Method for the production of vitamin k-dependent proteins
US20040185535A1 (en) 2003-03-21 2004-09-23 Giles Wilson Industrial-scale serum-free production of recombinant FVII in mammalian cells
US7198940B2 (en) 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
CA2451955C (en) * 2001-06-26 2015-09-29 Abgenix, Inc. Antibodies to opgl
CA2491992A1 (en) 2002-07-09 2004-01-15 Baxter International, Inc. Animal protein free media for cultivation of cells
CN104178491B (zh) * 2002-09-06 2018-07-03 安姆根有限公司 治疗性人抗-il-1r1单克隆抗体
AU2003300276B2 (en) * 2002-12-23 2010-07-01 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
DE10312765A1 (de) 2003-03-21 2004-09-30 Bayer Technology Services Gmbh Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung
US20050100965A1 (en) * 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
WO2005070954A1 (ja) * 2004-01-21 2005-08-04 Toray Industries, Inc. 分画装置および分画方法
EP1720972B1 (en) 2004-03-05 2014-01-08 DSM IP Assets B.V. Process for cell culturing by continuous perfusion and alternating tangential flow
US7422875B2 (en) 2004-07-20 2008-09-09 Board Of Regents Of The University Of Nebraska Compositions and methods for increasing protein production
US8053238B2 (en) 2005-10-31 2011-11-08 Unhwa Corporation Isolated population of plant single cells and method of preparing the same
BRPI0714347A2 (pt) * 2006-07-14 2013-05-07 Dsm Ip Assets Bv processo aperfeiÇoado para o cultivo de cÉlulas
US20080206819A1 (en) 2006-08-21 2008-08-28 Mary Tsao Intensified Perfusion Production Method
MX353340B (es) 2006-09-13 2018-01-09 Abbvie Inc Mejoras de cultivos celulares.
WO2008154014A2 (en) 2007-06-11 2008-12-18 Amgen Inc. A method for culturing mammalian cells to improve recombinant protein production
EP2014760A1 (en) 2007-06-13 2009-01-14 CMC Biopharmaceuticals A/S A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process
DE602008006410D1 (de) 2007-06-15 2011-06-01 Amgen Inc Verfahren zur behandlung von zellkulturmedien für die verwendung in einem bioreaktor
EP2188371B1 (en) * 2007-08-09 2017-12-20 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
CA2709890A1 (en) 2007-12-27 2009-07-09 Andre Giovagnoli Cell culture processes
DE102008051574A1 (de) 2008-10-14 2010-04-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung von Interferon-beta und deren Varianten
HUE026210T2 (en) 2008-11-12 2016-05-30 Baxalta Inc Procedure for serum-free, insulin-free VII. factor
KR101574056B1 (ko) 2009-07-31 2015-12-02 백스터 인터내셔널 인코포레이티드 Ａｄａｍｔｓ 단백질 발현을 위한 세포 배양 배지
CN104928336B (zh) * 2009-10-26 2020-05-08 弗·哈夫曼-拉罗切有限公司 用于生产糖基化免疫球蛋白的方法
EP2516623B1 (fr) 2009-12-23 2016-10-05 Sanofi Pasteur Procede de culture de cellules adherentes
CN103298538B (zh) * 2010-08-25 2017-05-10 瑞普利根公司 流体过滤系统
CN103347595B (zh) * 2011-02-10 2016-01-20 克鲁塞尔荷兰公司 气动交变压力膜细胞分离系统
JP2014506482A (ja) 2011-02-23 2014-03-17 アムジエン・インコーポレーテツド Ｕｖｃ露光のための細胞培養培地およびそれに関連した方法
WO2012145682A1 (en) 2011-04-21 2012-10-26 Amgen Inc. A method for culturing mammalian cells to improve recombinant protein production
CA2835053C (en) 2011-05-13 2020-07-07 Octapharma Ag A method of increasing the productivity of eucaryotic cells in the production of recombinant fviii
KR101662412B1 (ko) 2011-07-01 2016-10-04 암젠 인크 포유동물 세포 배양
JP2014526265A (ja) 2011-09-16 2014-10-06 アムジエン・インコーポレーテツド 細胞培養物のフィードバック制御を伴わない予めプログラムされた連続供給
WO2013063298A1 (en) 2011-10-26 2013-05-02 Amgen Inc. Methods of reducing or eliminating protein modification and degradation arising from exposure to uv light
US10955291B2 (en) 2012-03-15 2021-03-23 Amgen Inc. Methods of determining exposure to UV light
US10481164B2 (en) 2012-03-26 2019-11-19 Amgen Inc. Method for using light scattering in real time to directly monitor and control impurity removal in purification processes
WO2014022102A1 (en) 2012-08-01 2014-02-06 Amgen Inc. Methods of using anti-apoptotic compounds to modulate one or more properties of a cell culture
TWI637057B (zh) 2012-11-09 2018-10-01 拜爾沙納有限公司 具交替生物反應器用途之不連續進料批次製程
PL2735326T3 (pl) 2012-11-26 2017-08-31 Gambro Lundia Ab Układ wspomagania wątroby
ES2842350T3 (es) * 2013-03-19 2021-07-13 Cmc Biologics As Un procedimiento para la producción de un producto (por ejemplo, polipéptido) en un proceso de fermentación de cultivo celular continuo

Also Published As

Publication number Publication date
ZA201608303B (en) 2023-06-28
AU2022224699A1 (en) 2022-09-22
ES2980493T3 (es) 2024-10-01
CY1121217T1 (el) 2020-05-29
CA2951046C (en) 2023-06-13
MX384212B (es) 2025-03-14
US20170114381A1 (en) 2017-04-27
LT3926051T (lt) 2024-06-10
HUE042277T2 (hu) 2019-06-28
SG10202113019XA (en) 2021-12-30
HUE066803T2 (hu) 2024-09-28
AU2020294155A1 (en) 2021-01-28
IL249150A0 (en) 2017-01-31
IL294430A (en) 2022-09-01
US20220136025A1 (en) 2022-05-05
IL249150B (en) 2022-09-01
JP2022126811A (ja) 2022-08-30
MX2021008142A (es) 2021-08-11
EA202192126A3 (ru) 2022-03-31
AU2015269365A1 (en) 2016-12-15
MX2021008143A (es) 2021-08-11
SG11201610143VA (en) 2017-01-27
KR20220054903A (ko) 2022-05-03
JP2020124207A (ja) 2020-08-20
CL2016003096A1 (es) 2017-11-03
EP4372078A2 (en) 2024-05-22
WO2015188009A1 (en) 2015-12-10
ES2709994T3 (es) 2019-04-22
MX2016015944A (es) 2017-08-15
EP4372078A3 (en) 2024-09-04
EA039148B1 (ru) 2021-12-10
WO2015188009A9 (en) 2017-01-26
PT3926051T (pt) 2024-06-20
PL3152317T3 (pl) 2019-08-30
PT3152317T (pt) 2019-04-18
SI3152317T1 (sl) 2019-03-29
US11427848B2 (en) 2022-08-30
US11384378B2 (en) 2022-07-12
AU2024267090A1 (en) 2024-12-19
US20220356502A1 (en) 2022-11-10
CN106687575A (zh) 2017-05-17
AU2019203538A1 (en) 2019-06-06
KR102598799B1 (ko) 2023-11-07
CN106687575B (zh) 2021-04-30
BR112016028285A2 (pt) 2018-06-26
EP3152317B1 (en) 2019-01-02
BR122018011329A2 (pt) 2019-09-10
AU2019203538B2 (en) 2020-10-08
JP2017519497A (ja) 2017-07-20
EP3152317A1 (en) 2017-04-12
JP7097404B2 (ja) 2022-07-07
JP6695814B2 (ja) 2020-05-20
EP3521440B1 (en) 2022-02-09
SI3926051T1 (sl) 2024-06-28
CA2951046A1 (en) 2015-12-10
EA201692498A1 (ru) 2017-05-31
ES2909630T3 (es) 2022-05-09
BR112016028285B1 (pt) 2023-02-23
EP3521440A1 (en) 2019-08-07
EA202192126A2 (ru) 2021-11-30
IL294430B2 (en) 2025-08-01
US12195779B2 (en) 2025-01-14
DK3926051T3 (da) 2024-06-10
IL319240A (en) 2025-04-01
TR201900776T4 (tr) 2019-02-21
CA3195249A1 (en) 2015-12-10
JP7377316B2 (ja) 2023-11-09
EP3926051A1 (en) 2021-12-22
CL2019001641A1 (es) 2019-10-25
KR20170015464A (ko) 2017-02-08
IL294430B1 (en) 2025-04-01
PL3926051T3 (pl) 2024-08-26
DK3152317T3 (en) 2019-04-08
EP3926051B1 (en) 2024-05-08
LT3152317T (lt) 2019-03-12
AU2022224699B2 (en) 2024-08-29
AU2020294155B2 (en) 2022-07-28
KR102391259B1 (ko) 2022-04-26

Similar Documents

Publication Publication Date Title
JP2017519497A5 (enExample)
RU2015143439A (ru) Способы формирования банка клеток высокой плотности
JP2016039817A5 (enExample)
JP2013027385A5 (enExample)
MX386767B (es) Filtración de virus de medio de cultivo celular.
WO2011091248A8 (en) High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
MX2013010737A (es) Novedosos metodos de purificacion de proteinas.
CO2019011204A2 (es) Clarificación de cultivos celulares
KR102789449B1 (ko) 미립자 동결건조된 혈소판 용해물 조성물
GB2526957A (en) System and method to efficiently clean a blood filter
RU2015109997A (ru) Способ получения капсульного полисахарида с пневмококковым серотипом
FI3325612T3 (fi) Menetelmiä ja kompositioita kantasolutransplantaatiota varten
JP2016500260A5 (enExample)
CN104357389A (zh) 一种改良的人脐血来源调节性t细胞扩增培养基及其使用方法
HK1220224A1 (zh) 蛋白纯化的新颖方法
WO2013044023A3 (en) Citrus tristeza virus based vectors for foreign gene/s expression
RU2014133168A (ru) Способ получения химического вещества
WO2016168871A3 (de) Verfahren zur gewinnung, insbesondere zum ernten, von algen und mikroorganismen
AR082289A1 (es) Metodo para estabilizar una bebida fermentada con levaduras
BRPI0914805B8 (pt) método para replicar vírus em uma cultura de células scldk, processo para adaptar células cldk dependentes do substrato para desenvolvimento em suspensão, método para propagar continuamente células scldk em suspensão, e, composição
EP4410970A3 (en) Efficient cell culture system for hepatitis c virus genotype 6a
RU2013140871A (ru) Способ восстановления костных дефектов трубчатых костей критической величины
RU2012123195A (ru) Способ выделения низкомолекулярных пептидов
JP2017532977A5 (enExample)
AR080008A1 (es) Drenaje y recarga de un bioreactor con microportadores