KR102391259B1 - 포유류 세포 배양물을 회수하는 방법 - Google Patents

포유류 세포 배양물을 회수하는 방법 Download PDF

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KR102391259B1
KR102391259B1 KR1020177000136A KR20177000136A KR102391259B1 KR 102391259 B1 KR102391259 B1 KR 102391259B1 KR 1020177000136 A KR1020177000136 A KR 1020177000136A KR 20177000136 A KR20177000136 A KR 20177000136A KR 102391259 B1 KR102391259 B1 KR 102391259B1
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cell culture
cells
permeate
bioreactor
cell
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KR20170015464A (ko
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체탄 고우다
션 콜
니콜 사보
헨리 린
조나단 룰
타말라 타말링감
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암젠 인크
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
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    • C12P21/00—Preparation of peptides or proteins
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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
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    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
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    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
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    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
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    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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    • C12N2511/00—Cells for large scale production
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    • C12N2523/00—Culture process characterised by temperature

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  • Computer Hardware Design (AREA)
  • Water Supply & Treatment (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020177000136A 2014-06-04 2015-06-04 포유류 세포 배양물을 회수하는 방법 Active KR102391259B1 (ko)

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KR1020227013515A KR102598799B1 (ko) 2014-06-04 2015-06-04 포유류 세포 배양물을 회수하는 방법

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US201462007588P 2014-06-04 2014-06-04
US62/007,588 2014-06-04
PCT/US2015/034297 WO2015188009A1 (en) 2014-06-04 2015-06-04 Methods for harvesting mammalian cell cultures

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KR1020227013515A Active KR102598799B1 (ko) 2014-06-04 2015-06-04 포유류 세포 배양물을 회수하는 방법

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EP (4) EP3521440B1 (enExample)
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CN (1) CN106687575B (enExample)
AU (5) AU2015269365A1 (enExample)
BR (2) BR112016028285B1 (enExample)
CA (2) CA2951046C (enExample)
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PL (2) PL3152317T3 (enExample)
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SG (2) SG10202113019XA (enExample)
SI (2) SI3926051T1 (enExample)
TR (1) TR201900776T4 (enExample)
WO (1) WO2015188009A1 (enExample)
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