JP2013027385A5 - - Google Patents
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- Publication number
- JP2013027385A5 JP2013027385A5 JP2012021972A JP2012021972A JP2013027385A5 JP 2013027385 A5 JP2013027385 A5 JP 2013027385A5 JP 2012021972 A JP2012021972 A JP 2012021972A JP 2012021972 A JP2012021972 A JP 2012021972A JP 2013027385 A5 JP2013027385 A5 JP 2013027385A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- blood
- cell population
- amplifying
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000000822 natural killer cell Anatomy 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 6
- 230000003321 amplification Effects 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 210000000601 blood cell Anatomy 0.000 claims 3
- 210000004700 fetal blood Anatomy 0.000 claims 3
- 210000005259 peripheral blood Anatomy 0.000 claims 3
- 239000011886 peripheral blood Substances 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000005087 mononuclear cell Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 210000004504 adult stem cell Anatomy 0.000 claims 1
- 238000002617 apheresis Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012021972A JP5572863B2 (ja) | 2011-06-24 | 2012-02-03 | Ｎｋ細胞の増幅方法 |
| PCT/JP2012/065718 WO2012176796A1 (ja) | 2011-06-24 | 2012-06-20 | Ｎｋ細胞の増幅方法 |
| US14/129,143 US9404083B2 (en) | 2011-06-24 | 2012-06-20 | Method for amplifying NK cells |
| AU2012274478A AU2012274478B2 (en) | 2011-06-24 | 2012-06-20 | Method for amplifying NK cells |
| KR1020147001579A KR101963920B1 (ko) | 2011-06-24 | 2012-06-20 | Nk 세포의 증폭 방법 |
| HK14103574.2A HK1190432B (en) | 2011-06-24 | 2012-06-20 | Method for amplifying nk cells |
| MYPI2013004630A MY161389A (en) | 2011-06-24 | 2012-06-20 | Method for amplifying nk cells |
| CN201280031188.5A CN103620022B (zh) | 2011-06-24 | 2012-06-20 | Nk细胞的扩增方法 |
| EP12801859.5A EP2725100B1 (en) | 2011-06-24 | 2012-06-20 | Method for amplifying nk cells |
| CA2840161A CA2840161C (en) | 2011-06-24 | 2012-06-20 | Method for amplifying nk cells |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011140725 | 2011-06-24 | ||
| JP2011140725 | 2011-06-24 | ||
| JP2012021972A JP5572863B2 (ja) | 2011-06-24 | 2012-02-03 | Ｎｋ細胞の増幅方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014011951A Division JP5989016B2 (ja) | 2011-06-24 | 2014-01-27 | Ｎｋ細胞の増幅方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013027385A JP2013027385A (ja) | 2013-02-07 |
| JP2013027385A5 true JP2013027385A5 (enExample) | 2013-12-12 |
| JP5572863B2 JP5572863B2 (ja) | 2014-08-20 |
Family
ID=47422628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012021972A Active JP5572863B2 (ja) | 2011-06-24 | 2012-02-03 | Ｎｋ細胞の増幅方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9404083B2 (enExample) |
| EP (1) | EP2725100B1 (enExample) |
| JP (1) | JP5572863B2 (enExample) |
| KR (1) | KR101963920B1 (enExample) |
| CN (1) | CN103620022B (enExample) |
| AU (1) | AU2012274478B2 (enExample) |
| CA (1) | CA2840161C (enExample) |
| MY (1) | MY161389A (enExample) |
| WO (1) | WO2012176796A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5511039B1 (ja) * | 2013-05-22 | 2014-06-04 | 国立大学法人九州大学 | Ｎｋ細胞の調製方法 |
| JP6164650B2 (ja) * | 2014-01-20 | 2017-07-19 | 国立大学法人九州大学 | Ｎｋ細胞の調製方法 |
| WO2015132415A1 (en) * | 2014-03-07 | 2015-09-11 | Emercell Sas | Pooled nk cells from ombilical cord blood and their uses for the treatment of cancer and chronic infectious disease |
| KR101697473B1 (ko) | 2014-11-26 | 2017-01-18 | 주식회사 녹십자랩셀 | T 세포를 이용한 자연살해세포의 배양방법 |
| US12398371B2 (en) | 2015-01-27 | 2025-08-26 | Korea Research Institute Of Bioscience | Method for mass producing natural killer cell and use of natural killer cell obtained by the method as anti-cancer agent |
| WO2016122014A1 (ko) * | 2015-01-27 | 2016-08-04 | 한국생명공학연구원 | 자연살해세포의 대량생산 방법 및 상기 방법으로 수득된 자연살해세포의 항암제로서의 용도 |
| CN106222141B (zh) * | 2016-10-17 | 2018-10-19 | 湖南丰晖生物科技有限公司 | Nk细胞培养液和细胞培养方法 |
| JP6647240B2 (ja) | 2017-05-12 | 2020-02-14 | 米満 吉和 | 高活性ｎｋ細胞、およびその利用 |
| CN110662834B (zh) | 2017-05-26 | 2023-09-12 | Gc细胞治疗 | 使用转化的t细胞培养自然杀伤细胞的方法 |
| KR102765799B1 (ko) * | 2018-02-01 | 2025-02-13 | 주식회사 엔케이맥스 | Cd56+ 자연살해세포를 포함하는 항암용 조성물 |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| WO2019152663A1 (en) * | 2018-02-01 | 2019-08-08 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| JP6543375B1 (ja) | 2018-03-27 | 2019-07-10 | 株式会社ガイアバイオメディシン | ケモカインレセプターと細胞接着分子を発現するｃｄ３陰性細胞の集団、およびその利用 |
| CN110628714B (zh) * | 2018-06-21 | 2023-03-28 | 精准生技股份有限公司 | 用于体外扩增自然杀手细胞及自然杀手t细胞的无血清细胞培养液 |
| CN109161527A (zh) * | 2018-09-25 | 2019-01-08 | 深圳市五零生命科技有限公司 | 一种高效的nk细胞扩增方法 |
| EP3892721A4 (en) * | 2018-11-14 | 2022-08-31 | GC Cell Corporation | METHOD FOR CULTIVATING NATURAL KILLER CELLS DERIVED FROM UMBILICAL CORD BLOOD USING TRANSFORMED T LYMPHOCYTES |
| WO2020152661A1 (ja) | 2019-01-21 | 2020-07-30 | 株式会社ガイアバイオメディシン | Ｎｋ細胞を含む細胞集団の製造方法 |
| JP6838750B2 (ja) | 2019-01-21 | 2021-03-03 | 株式会社ガイアバイオメディシン | Ｎｋ細胞を含む細胞集団の製造方法 |
| KR102234394B1 (ko) * | 2019-03-08 | 2021-03-31 | 신지섭 | 타가면역세포배양방법, 그 방법으로 얻어진 면역세포배양액 및 이를 포함하는 면역세포치료제 |
| KR102216710B1 (ko) * | 2019-03-27 | 2021-02-17 | 신지섭 | Nk세포배양배지용 첨가조성물, 상기 첨가조성물을 이용한 nk세포배양방법 및 상기 배양방법으로 얻어진 피부트러블개선용 화장료조성물 |
| JP6697611B2 (ja) * | 2019-05-20 | 2020-05-20 | 米満 吉和 | 高活性ｎｋ細胞、およびその利用 |
| CN111154721B (zh) * | 2020-01-14 | 2023-10-17 | 深圳格泰赛尔生物科技有限公司 | Nk细胞扩增方法 |
| US20230040477A1 (en) * | 2020-01-19 | 2023-02-09 | Board Of Regents, The University Of Texas System | T-cell death associated gene 8 (tdag8) modulation to enhance cellular cancer therapies |
| US12486492B2 (en) | 2020-03-05 | 2025-12-02 | Korea Research Institute Of Bioscience | Method for producing memory-like NK cells with ability to express higher levels of NCRs, cytotoxicity, and IFN-γ than NK cells in human peripheral blood |
| EP4263600A1 (en) | 2020-12-18 | 2023-10-25 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| WO2023081813A1 (en) | 2021-11-05 | 2023-05-11 | St. Jude Children's Research Hospital, Inc. | Zip cytokine receptors |
| EP4536687A1 (en) | 2022-06-08 | 2025-04-16 | St. Jude Children's Research Hospital, Inc. | Disruption of kdm4a in t cells to enhance immunotherapy |
| WO2024059787A1 (en) | 2022-09-16 | 2024-03-21 | St. Jude Children's Research Hospital, Inc. | Disruption of asxl1 in t cells to enhance immunotherapy |
| WO2025022372A1 (ja) * | 2023-07-21 | 2025-01-30 | 株式会社ガイアバイオメディシン | 細胞集団の製造方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030068306A1 (en) * | 2001-09-14 | 2003-04-10 | Dilber Mehmet Sirac | Medium |
| US7544355B2 (en) * | 2002-03-13 | 2009-06-09 | Universita Degli Studi Di Perugia | Methods and compositions for allogeneic transplantation |
| AU2003294930B2 (en) | 2002-12-23 | 2008-12-04 | Innate Pharma | Pharmaceutical compositions having an effect on the proliferation of NK cells and a method using the same |
| US7435596B2 (en) * | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| WO2006050270A2 (en) * | 2004-11-02 | 2006-05-11 | The Government Of The United States Of America As Represented By The Secretary Department Of Health & Human Services | Compositions and methods for treating hyperproliferative disorders |
| CA2645042A1 (en) | 2006-03-06 | 2007-09-13 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Autologous natural killer cells and lymphodepleting chemotherapy for the treatment of cancer |
| JP2007297292A (ja) | 2006-04-28 | 2007-11-15 | Kyorin Pharmaceut Co Ltd | １−アルコキシイソキノリン誘導体又はその水和物の製造方法 |
| JP4275680B2 (ja) | 2006-04-28 | 2009-06-10 | 裕 照沼 | リンパ球の活性・増殖に係る培養方法 |
| WO2008023874A1 (en) * | 2006-08-23 | 2008-02-28 | Binex Co., Ltd. | Manufacturing method of activated lymphocytes for immunotherapy |
| JP4861420B2 (ja) | 2006-08-28 | 2012-01-25 | 久光製薬株式会社 | 爪用貼付剤 |
| JP2010220479A (ja) * | 2007-06-15 | 2010-10-07 | Medeinetto:Kk | Ｎｋ細胞の培養方法及びｎｋ細胞の利用 |
| AU2008307633C1 (en) * | 2007-09-28 | 2015-04-30 | Celularity Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| DK2279253T3 (en) * | 2008-04-09 | 2017-02-13 | Maxcyte Inc | Construction and application of therapeutic compositions of freshly isolated cells |
| KR101133185B1 (ko) * | 2008-07-29 | 2012-04-06 | 서울대학교병원 | 자연살해세포의 증식방법 |
| JP2012521215A (ja) * | 2009-03-26 | 2012-09-13 | アヴァリス・アクチエボラーグ | Ｎｋ細胞の増殖 |
| CN102597223B (zh) * | 2009-09-11 | 2017-05-10 | 宝生物工程株式会社 | 生产天然杀伤细胞的方法 |
| EP2519239B1 (en) | 2009-12-29 | 2017-03-08 | Gamida Cell Ltd. | Methods for enhancing natural killer cell proliferation and activity |
| JP2011239701A (ja) | 2010-05-14 | 2011-12-01 | Tella Inc | 樹状細胞の培養方法 |
| KR101039843B1 (ko) | 2010-08-30 | 2011-06-09 | 주식회사 엔케이바이오 | 자기활성화 림프구 배양용 배지 조성물 및 이를 이용한 자기활성화 림프구 배양방법 |
| JP5840876B2 (ja) | 2011-06-24 | 2016-01-06 | テラ株式会社 | Ｎｋ細胞を増幅するための組成物及び方法 |
-
2012
- 2012-02-03 JP JP2012021972A patent/JP5572863B2/ja active Active
- 2012-06-20 CA CA2840161A patent/CA2840161C/en active Active
- 2012-06-20 KR KR1020147001579A patent/KR101963920B1/ko active Active
- 2012-06-20 CN CN201280031188.5A patent/CN103620022B/zh active Active
- 2012-06-20 EP EP12801859.5A patent/EP2725100B1/en active Active
- 2012-06-20 WO PCT/JP2012/065718 patent/WO2012176796A1/ja not_active Ceased
- 2012-06-20 US US14/129,143 patent/US9404083B2/en active Active
- 2012-06-20 MY MYPI2013004630A patent/MY161389A/en unknown
- 2012-06-20 AU AU2012274478A patent/AU2012274478B2/en active Active
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