JP2013537187A5 - - Google Patents
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- Publication number
- JP2013537187A5 JP2013537187A5 JP2013527738A JP2013527738A JP2013537187A5 JP 2013537187 A5 JP2013537187 A5 JP 2013537187A5 JP 2013527738 A JP2013527738 A JP 2013527738A JP 2013527738 A JP2013527738 A JP 2013527738A JP 2013537187 A5 JP2013537187 A5 JP 2013537187A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- syngeneic
- subject
- respect
- isolated population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 48
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 12
- 230000001939 inductive effect Effects 0.000 claims 9
- 208000024908 graft versus host disease Diseases 0.000 claims 8
- 210000001165 lymph node Anatomy 0.000 claims 8
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 7
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 7
- 238000002054 transplantation Methods 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000008029 eradication Effects 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 1
- 102100033467 L-selectin Human genes 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38071610P | 2010-09-08 | 2010-09-08 | |
| US61/380,716 | 2010-09-08 | ||
| PCT/IL2011/000727 WO2012032526A2 (en) | 2010-09-08 | 2011-09-08 | Use of anti third party central memory t cells for anti-leukemia/lymphoma treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013537187A JP2013537187A (ja) | 2013-09-30 |
| JP2013537187A5 true JP2013537187A5 (enExample) | 2014-10-16 |
| JP5977238B2 JP5977238B2 (ja) | 2016-08-24 |
Family
ID=45002090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527738A Active JP5977238B2 (ja) | 2010-09-08 | 2011-09-08 | 抗白血病／リンパ腫処置のための抗第三者セントラルメモリーｔ細胞の使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9421228B2 (enExample) |
| EP (1) | EP2613801B1 (enExample) |
| JP (1) | JP5977238B2 (enExample) |
| KR (1) | KR101788826B1 (enExample) |
| CN (2) | CN103282047B (enExample) |
| BR (1) | BR112013005756A2 (enExample) |
| CA (1) | CA2810632C (enExample) |
| ES (1) | ES2589678T3 (enExample) |
| HU (1) | HUE031063T2 (enExample) |
| IL (1) | IL225102A (enExample) |
| MX (1) | MX357746B (enExample) |
| PL (1) | PL2613801T3 (enExample) |
| PT (1) | PT2613801T (enExample) |
| SG (1) | SG188473A1 (enExample) |
| WO (1) | WO2012032526A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010049935A1 (en) | 2008-10-30 | 2010-05-06 | Yeda Research And Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| ES2589678T3 (es) | 2010-09-08 | 2016-11-15 | Yeda Research And Development Co. Ltd. | Uso de linfocitos T de memoria central anti-terceros para el tratamiento anti-leucemia/linfoma |
| CN104906139B (zh) * | 2011-01-10 | 2020-10-23 | 小利兰·斯坦福大学托管委员会 | 异源造血干细胞移植的增强 |
| SG11201400513PA (en) | 2011-09-08 | 2014-06-27 | Yeda Res & Dev | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| JP6142142B2 (ja) * | 2012-04-10 | 2017-06-07 | 株式会社リンフォテック | メモリーｔ細胞を主成分とするリンパ球細胞群の製造方法 |
| AU2016291825B2 (en) * | 2015-07-16 | 2022-08-11 | Yeda Research And Development Co. Ltd. | Genetically modified anti-third party central memory T cells and use of same in immunotherapy |
| EP3475414B1 (en) | 2016-06-27 | 2025-03-26 | Yeda Research and Development Co. Ltd | Veto cells generated from memory t cells |
| US10751368B2 (en) | 2017-01-18 | 2020-08-25 | Yeda Research And Development Co. Ltd. | Methods of transplantation and disease treatment |
| ES3064681T3 (en) | 2017-01-18 | 2026-04-28 | Yeda Res & Dev | Genetically modified veto cells and use of same in immunotherapy |
| CN118662615A (zh) * | 2017-03-15 | 2024-09-20 | 浩康生物系统公司 | 用于造血干细胞移植的组合物和方法 |
| BR112022008700A2 (pt) * | 2019-11-05 | 2022-07-19 | Yeda Res & Dev | Método para tratar ou prevenir uma doença falciforme, e, transplante de células hematopoiéticas imaturas e uma quantidade terapeuticamente eficaz de uma população isolada de células anti-terceiros não indutoras de doença do enxerto versus hospedeiro |
| AU2020379319A1 (en) * | 2019-11-05 | 2022-06-23 | Yeda Research And Development Co. Ltd. | Use of veto cells in treatment of T cell mediated autoimmune diseases |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US5599703A (en) | 1993-10-28 | 1997-02-04 | The United States Of America As Represented By The Secretary Of The Navy | In vitro amplification/expansion of CD34+ stem and progenitor cells |
| US6803036B1 (en) | 1998-03-03 | 2004-10-12 | University Of Southern California | Use of cytokines, cells and mitogens to inhibit graft versus host disease |
| AU2101600A (en) | 1998-12-24 | 2000-07-31 | Novartis Ag | Porcine cells incapable of expressing cd40 antigen, for xenotransplantation |
| US6544506B2 (en) | 2000-01-05 | 2003-04-08 | Yeda Research & Development Co. Ltd. | Veto cells effective in preventing graft rejection and devoid of graft versus host potential |
| ATE460475T1 (de) | 2000-04-11 | 2010-03-15 | Univ Southern California | Methode zur verhinderung der transplantatabstossung unter verwendung von tgf- beta zur induktion von t-suppressorzellen |
| US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
| CA2630062C (en) | 2000-07-03 | 2014-10-14 | Bristol-Myers Squibb Company | Methods for treating graft versus host disease and immune disorders associated with rejection using a soluble ctla4 molecule |
| US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
| WO2002043651A2 (en) | 2000-11-30 | 2002-06-06 | Yeda Research And Development Co. Ltd. | Methods of utilizing cultured non-gvhd inducing t lymphocytes to treat disease |
| ATE390931T1 (de) | 2001-05-23 | 2008-04-15 | Bristol Myers Squibb Co | Verfahren zum schützen eines allogenen inseltransplantats mit löslichen ctla4- mutationsmolekülen |
| US20030147859A1 (en) | 2001-06-18 | 2003-08-07 | Yair Reisner | Methods of utilizing cultured hematopoietic progenitor cells for inducing immunological tolerance |
| NZ545314A (en) | 2003-08-04 | 2009-03-31 | Bristol Myers Squibb Co | Methods for treating cardiovascular disease using a soluble CTLA4 molecule |
| KR100845354B1 (ko) | 2004-03-26 | 2008-07-09 | 화이자 프로덕츠 인코포레이티드 | 항－ｃｔｌａ－4 항체의 용도 |
| WO2006041763A1 (en) | 2004-10-04 | 2006-04-20 | Novartis Ag | Renin inhibitors for treating transplantation induced diseases |
| EP1814580B1 (en) | 2004-11-24 | 2016-08-10 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
| PL1868635T3 (pl) | 2005-04-06 | 2017-10-31 | Bristol Myers Squibb Co | Metody leczenia zaburzeń immunologicznych związanych z transplantacją narządów rozpuszczalnymi zmutowanymi cząsteczkami CTLA4 |
| EP2514315A3 (en) * | 2005-08-24 | 2012-11-07 | Yeda Research and Development Co. Ltd. | Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance |
| GB0605217D0 (en) | 2006-03-15 | 2006-04-26 | Novartis Ag | Method and compositions for assessing acute rejection |
| GB0606776D0 (en) | 2006-04-03 | 2006-05-10 | Novartis Pharma Ag | Predictive biomarkers for chronic allograft nephropathy |
| WO2010019935A2 (en) * | 2008-08-15 | 2010-02-18 | Brijen Biotech, Llc | Refinery process to produce biofuels and bioenergy products from home and municipal solid waste |
| US8200915B2 (en) | 2008-08-22 | 2012-06-12 | Cadence Design Systems, Inc. | Management of very large streaming data sets for efficient writes and reads to and from persistent storage |
| WO2010049935A1 (en) | 2008-10-30 | 2010-05-06 | Yeda Research And Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| EP2614083A2 (en) | 2010-09-08 | 2013-07-17 | Yeda Research and Development Co. Ltd | An immunosuppressive drug combination for a stable and long term engraftment |
| ES2589678T3 (es) | 2010-09-08 | 2016-11-15 | Yeda Research And Development Co. Ltd. | Uso de linfocitos T de memoria central anti-terceros para el tratamiento anti-leucemia/linfoma |
| SG11201400513PA (en) | 2011-09-08 | 2014-06-27 | Yeda Res & Dev | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
-
2011
- 2011-09-08 ES ES11773325.3T patent/ES2589678T3/es active Active
- 2011-09-08 SG SG2013017439A patent/SG188473A1/en unknown
- 2011-09-08 CA CA2810632A patent/CA2810632C/en active Active
- 2011-09-08 KR KR1020137008892A patent/KR101788826B1/ko active Active
- 2011-09-08 EP EP11773325.3A patent/EP2613801B1/en active Active
- 2011-09-08 HU HUE11773325A patent/HUE031063T2/en unknown
- 2011-09-08 WO PCT/IL2011/000727 patent/WO2012032526A2/en not_active Ceased
- 2011-09-08 PL PL11773325.3T patent/PL2613801T3/pl unknown
- 2011-09-08 PT PT117733253T patent/PT2613801T/pt unknown
- 2011-09-08 CN CN201180053858.9A patent/CN103282047B/zh active Active
- 2011-09-08 JP JP2013527738A patent/JP5977238B2/ja active Active
- 2011-09-08 BR BR112013005756-4A patent/BR112013005756A2/pt not_active Application Discontinuation
- 2011-09-08 MX MX2013002668A patent/MX357746B/es active IP Right Grant
- 2011-09-08 CN CN201610307275.9A patent/CN105907713A/zh active Pending
- 2011-09-08 US US13/821,255 patent/US9421228B2/en active Active
-
2013
- 2013-03-07 IL IL225102A patent/IL225102A/en active IP Right Grant
-
2016
- 2016-08-22 US US15/242,666 patent/US20160354410A1/en not_active Abandoned
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