FI2557517T3 - Nukleiinihapposekvenssiepätasapainon määrittäminen - Google Patents

Nukleiinihapposekvenssiepätasapainon määrittäminen Download PDF

Info

Publication number
FI2557517T3
FI2557517T3 FIEP12180122.9T FI12180122T FI2557517T3 FI 2557517 T3 FI2557517 T3 FI 2557517T3 FI 12180122 T FI12180122 T FI 12180122T FI 2557517 T3 FI2557517 T3 FI 2557517T3
Authority
FI
Finland
Prior art keywords
nucleic acid
acid sequences
amount
several
biological sample
Prior art date
Application number
FIEP12180122.9T
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Inventor
Yuk-Ming Dennis Lo
Rossa Wai Kwun Chiu
Kwan Chee Chan
Benny Chung Ying Zee
Ka Chun Chong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39798126&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI2557517(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Application granted granted Critical
Publication of FI2557517T3 publication Critical patent/FI2557517T3/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G01N2800/385—Congenital anomalies
    • G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FIEP12180122.9T 2007-07-23 2008-07-23 Nukleiinihapposekvenssiepätasapainon määrittäminen FI2557517T3 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95143807P 2007-07-23 2007-07-23

Publications (1)

Publication Number Publication Date
FI2557517T3 true FI2557517T3 (fi) 2022-11-30

Family

ID=39798126

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP12180122.9T FI2557517T3 (fi) 2007-07-23 2008-07-23 Nukleiinihapposekvenssiepätasapainon määrittäminen

Country Status (26)

Country Link
US (12) US8706422B2 (enExample)
EP (15) EP3067807A1 (enExample)
JP (17) JP5519500B2 (enExample)
KR (24) KR102222378B1 (enExample)
CN (11) CN101971178B (enExample)
AU (1) AU2008278839B2 (enExample)
BR (1) BRPI0814670B8 (enExample)
CA (10) CA2693081C (enExample)
CY (3) CY1114773T1 (enExample)
DK (6) DK2514842T3 (enExample)
EA (6) EA202192446A1 (enExample)
ES (7) ES2441807T5 (enExample)
FI (1) FI2557517T3 (enExample)
HK (2) HK1199067A1 (enExample)
HR (5) HRP20251164T3 (enExample)
HU (3) HUE030510T2 (enExample)
IL (2) IL203311A (enExample)
LT (2) LT2557520T (enExample)
MX (3) MX346069B (enExample)
NZ (2) NZ582702A (enExample)
PL (4) PL2183693T5 (enExample)
PT (3) PT2183693E (enExample)
SG (1) SG183062A1 (enExample)
SI (4) SI2557520T1 (enExample)
WO (2) WO2009013492A1 (enExample)
ZA (1) ZA201000524B (enExample)

Families Citing this family (299)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8024128B2 (en) 2004-09-07 2011-09-20 Gene Security Network, Inc. System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data
DE602005009324D1 (de) 2005-04-06 2008-10-09 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
EP2477029A1 (en) * 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US20070178501A1 (en) * 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US20070027636A1 (en) * 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US8515679B2 (en) 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
EP1984738A2 (en) 2006-01-11 2008-10-29 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
SI2385143T1 (sl) 2006-02-02 2016-11-30 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Neinvazivni genetski presejalni test ploda z digitalno analizo
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
KR102222378B1 (ko) 2007-07-23 2021-03-04 더 차이니즈 유니버시티 오브 홍콩 핵산 서열 불균형의 결정
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
WO2009105531A1 (en) * 2008-02-19 2009-08-27 Gene Security Network, Inc. Methods for cell genotyping
US8709726B2 (en) * 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
DE102008019132A1 (de) * 2008-04-16 2009-10-22 Olympus Life Science Research Europa Gmbh Verfahren zur quantitativen Bestimmung der Kopienzahl einer vorbestimmten Sequenz in einer Probe
US20110092763A1 (en) * 2008-05-27 2011-04-21 Gene Security Network, Inc. Methods for Embryo Characterization and Comparison
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US20110178719A1 (en) * 2008-08-04 2011-07-21 Gene Security Network, Inc. Methods for Allele Calling and Ploidy Calling
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
AU2015202167B2 (en) * 2008-09-20 2017-12-21 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
CA2737643C (en) * 2008-09-20 2020-10-06 Hei-Mun Fan Noninvasive diagnosis of fetal aneuploidy by sequencing
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CA2778926C (en) 2009-10-26 2018-03-27 Lifecodexx Ag Means and methods for non-invasive diagnosis of chromosomal aneuploidy
WO2011053790A2 (en) * 2009-10-30 2011-05-05 Fluidigm Corporation Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis
HUE061110T2 (hu) * 2009-11-05 2023-05-28 Univ Hong Kong Chinese Magzati genomelemzés anyai biológiai mintából
GB2488289A (en) 2009-11-06 2012-08-22 Univ Leland Stanford Junior Non-invasive diagnosis of graft rejection in organ transplant patients
WO2011054936A1 (en) 2009-11-06 2011-05-12 The Chinese University Of Hong Kong Size-based genomic analysis
WO2011074960A1 (en) * 2009-12-17 2011-06-23 Keygene N.V. Restriction enzyme based whole genome sequencing
EP2516680B1 (en) * 2009-12-22 2016-04-06 Sequenom, Inc. Processes and kits for identifying aneuploidy
AU2015204302B2 (en) * 2010-01-19 2017-10-05 Verinata Health, Inc. Method for determining copy number variations
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
CA2786565C (en) 2010-01-19 2017-04-25 Verinata Health, Inc. Partition defined detection methods
AU2015203579B2 (en) * 2010-01-19 2017-12-21 Verinata Health, Inc. Sequencing methods and compositions for prenatal diagnoses
WO2012135730A2 (en) * 2011-03-30 2012-10-04 Verinata Health, Inc. Method for verifying bioassay samples
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
EP2848704B1 (en) 2010-01-19 2018-08-29 Verinata Health, Inc Sequencing methods for prenatal diagnoses
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
EP2513341B1 (en) * 2010-01-19 2017-04-12 Verinata Health, Inc Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US20110312503A1 (en) * 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
AU2011210255B2 (en) 2010-01-26 2014-11-20 Medicover Public Co Ltd Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies
EP4484577A3 (en) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digital analyte analysis
CN102753703B (zh) * 2010-04-23 2014-12-24 深圳华大基因健康科技有限公司 胎儿染色体非整倍性的检测方法
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
WO2013052557A2 (en) * 2011-10-03 2013-04-11 Natera, Inc. Methods for preimplantation genetic diagnosis by sequencing
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
SG186787A1 (en) * 2010-07-23 2013-02-28 Esoterix Genetic Lab Llc Identification of differentially represented fetal or maternal genomic regions and uses thereof
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US20130040375A1 (en) * 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20120077185A1 (en) * 2010-08-06 2012-03-29 Tandem Diagnostics, Inc. Detection of genetic abnormalities and infectious disease
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US20120034603A1 (en) * 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
DK2604700T3 (en) * 2010-08-13 2015-11-02 Bgi Genomics Co Ltd METHOD OF ANALYSIS OF CELL CHROMOSOMES
WO2012040387A1 (en) 2010-09-24 2012-03-29 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
CN103534591B (zh) * 2010-10-26 2016-04-06 利兰·斯坦福青年大学托管委员会 通过测序分析进行的非侵入性胎儿遗传筛选
KR101891847B1 (ko) * 2010-11-30 2018-08-24 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
EP2649199A2 (en) 2010-12-07 2013-10-16 Stanford University Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale
CA2821906C (en) 2010-12-22 2020-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
CN103459614B (zh) * 2011-01-05 2015-12-02 香港中文大学 胎儿性染色体的非侵入性产前基因分型
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US20120190021A1 (en) * 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
US10131947B2 (en) * 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
EP3760731A1 (en) * 2011-02-09 2021-01-06 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CA2824387C (en) 2011-02-09 2019-09-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
CA3252077A1 (en) * 2011-02-24 2025-03-20 The Chinese University Of Hong Kong Molecular testing of multiple pregnancies
US20140087962A1 (en) * 2011-03-22 2014-03-27 Life Technologies Corporation Identification of Linkage Using Multiplex Digital PCR
US9260753B2 (en) 2011-03-24 2016-02-16 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
RS57837B1 (sr) 2011-04-12 2018-12-31 Verinata Health Inc Razrešavanje genomskih frakcija upotrebom broja kopija polimorfizama
GB2484764B (en) 2011-04-14 2012-09-05 Verinata Health Inc Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
CA2834218C (en) 2011-04-29 2021-02-16 Sequenom, Inc. Quantification of a minority nucleic acid species using inhibitory oligonucleotides
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
RU2589681C2 (ru) 2011-06-29 2016-07-10 БиДжиАй Дженомикс Ко., Лтд. Неинвазивное обнаружение генетической аномалии плода
SG10201605398QA (en) * 2011-06-30 2016-08-30 Univ Singapore Foetal nucleated red blood cell detection
US20130157875A1 (en) * 2011-07-20 2013-06-20 Anthony P. Shuber Methods for assessing genomic instabilities
CA2840418C (en) * 2011-07-26 2019-10-29 Verinata Health, Inc. Method for determining the presence or absence of different aneuploidies in a sample
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US20130110407A1 (en) * 2011-09-16 2013-05-02 Complete Genomics, Inc. Determining variants in genome of a heterogeneous sample
JP5964432B2 (ja) * 2011-09-21 2016-08-03 ビージーアイ ダイアグノーシス カンパニー リミテッドＢｇｉ Ｄｉａｇｎｏｓｉｓ Ｃｏ．， Ｌｔｄ． 単細胞染色体の非整倍数性を確定する方法及びシステム
WO2013052913A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2624686T3 (es) 2011-10-11 2017-07-17 Sequenom, Inc. Métodos y procesos para la evaluación no invasiva de variaciones genéticas
CN102329876B (zh) * 2011-10-14 2014-04-02 深圳华大基因科技有限公司 一种测定待检测样本中疾病相关核酸分子的核苷酸序列的方法
BR112014009269A8 (pt) 2011-10-18 2017-06-20 Multiplicom N V diagnóstico de aneuploidia cromossômica fetal
WO2013062856A1 (en) 2011-10-27 2013-05-02 Verinata Health, Inc. Set membership testers for aligning nucleic acid samples
EP2602733A3 (en) * 2011-12-08 2013-08-14 Koninklijke Philips Electronics N.V. Biological cell assessment using whole genome sequence and oncological therapy planning using same
AU2013209499B2 (en) 2012-01-20 2018-05-10 Sequenom, Inc. Diagnostic processes that factor experimental conditions
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9892230B2 (en) * 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
PL2831279T3 (pl) * 2012-03-26 2023-12-04 The Johns Hopkins University Szybkie wykrywanie aneuploidii
AU2013245272B2 (en) 2012-04-06 2018-04-05 The Chinese University Of Hong Kong Noninvasive prenatal diagnosis of fetal trisomy by allelic ratio analysis using targeted massively parallel sequencing
CA3209140A1 (en) * 2012-04-19 2013-10-24 The Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
DK3663409T3 (da) 2012-05-21 2021-12-13 Sequenom Inc Fremgangsmåder og processer til ikke-invasiv bedømmelse af genetiske variationer
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
CA2874343C (en) 2012-05-21 2021-11-09 Fluidigm Corporation Single-particle analysis of particle populations
US11261494B2 (en) * 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140093873A1 (en) * 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014015269A1 (en) 2012-07-19 2014-01-23 Ariosa Diagnostics, Inc. Multiplexed sequential ligation-based detection of genetic variants
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP4036247B1 (en) 2012-09-04 2024-04-10 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
LT3354747T (lt) 2012-09-20 2021-04-12 The Chinese University Of Hong Kong Neinvazinis naviko metilomos nustatymas iš plazmos
EP2900837A4 (en) * 2012-09-26 2016-06-01 Agency Science Tech & Res BIOMARKERS FOR THE PRENATAL DIAGNOSIS OF THE DOWN SYNDROME
WO2014055790A2 (en) 2012-10-04 2014-04-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3026124A1 (en) * 2012-10-31 2016-06-01 Genesupport SA Non-invasive method for detecting a fetal chromosomal aneuploidy
US10643738B2 (en) 2013-01-10 2020-05-05 The Chinese University Of Hong Kong Noninvasive prenatal molecular karyotyping from maternal plasma
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN105229168B (zh) * 2013-02-20 2020-07-17 生物纳米基因有限公司 纳米流体中分子的表征
WO2014133369A1 (ko) * 2013-02-28 2014-09-04 주식회사 테라젠이텍스 유전체 서열분석을 이용한 태아 염색체 이수성의 진단 방법 및 장치
US10240199B2 (en) * 2013-02-28 2019-03-26 The Chinese University Of Hong Kong Maternal plasma transcriptome analysis by massively parallel RNA sequencing
US20130189684A1 (en) 2013-03-12 2013-07-25 Sequenom, Inc. Quantification of cell-specific nucleic acid markers
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
EP2971100A1 (en) 2013-03-13 2016-01-20 Sequenom, Inc. Primers for dna methylation analysis
EP2971126B1 (en) 2013-03-15 2018-11-07 The Chinese University Of Hong Kong Determining fetal genomes for multiple fetus pregnancies
LT2981921T (lt) 2013-04-03 2023-02-27 Sequenom, Inc. Neinvazinio genetinių variacijų vertinimo būdai ir procesai
WO2014182726A2 (en) 2013-05-07 2014-11-13 Sequenom, Inc. Genetic markers for macular degeneration disorder treatment
WO2014190286A2 (en) 2013-05-24 2014-11-27 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3663414B1 (en) * 2013-06-13 2023-11-22 Roche Diagnostics GmbH Statistical analysis for non-invasive y chromosome aneuploidy determination
KR102784584B1 (ko) 2013-06-21 2025-03-19 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
WO2015006932A1 (zh) * 2013-07-17 2015-01-22 深圳华大基因科技有限公司 一种染色体非整倍性检测方法及装置
US10174375B2 (en) 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10964409B2 (en) * 2013-10-04 2021-03-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN111863131A (zh) 2013-10-07 2020-10-30 塞昆纳姆股份有限公司 用于非侵入性评估染色体改变的方法和过程
CA2928185C (en) * 2013-10-21 2024-01-30 Verinata Health, Inc. Method for improving the sensitivity of detection in determining copy number variations
CN105765076B (zh) * 2013-12-17 2019-07-19 深圳华大基因股份有限公司 一种染色体非整倍性检测方法及装置
SG10201804519RA (en) 2013-12-28 2018-07-30 Guardant Health Inc Methods and systems for detecting genetic variants
US11365447B2 (en) 2014-03-13 2022-06-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP3957749A1 (en) 2014-04-21 2022-02-23 Natera, Inc. Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples
RU2602366C2 (ru) * 2014-05-21 2016-11-20 Общество С Ограниченной Ответственностью "Тестген" Способ получения днк-праймеров и зондов для малоинвазивной пренатальной пцр-диагностики трисомии 21-й хромосомы у плода по крови беременной женщины и диагностический набор для ее осуществления
KR101663171B1 (ko) * 2014-05-27 2016-10-14 이원 다이애그노믹스 게놈센타(주) 다운증후군 진단을 위한 바이오마커 및 그의 용도
EP3149199B1 (en) 2014-05-30 2020-03-25 Verinata Health, Inc. Detecting, optionally fetal, sub-chromosomal aneuploidies and copy number variations
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
KR20160003547A (ko) * 2014-07-01 2016-01-11 바이오코아 주식회사 디지털 ｐｃｒ을 이용하여 임부의 혈액 또는 혈장으로부터 태아의 유전자 정보를 분석하는 방법
WO2016010401A1 (ko) * 2014-07-18 2016-01-21 에스케이텔레콘 주식회사 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법
KR20160010277A (ko) * 2014-07-18 2016-01-27 에스케이텔레콤 주식회사 산모의 무세포 dna의 차세대 서열분석을 통한 태아의 단일유전자 유전변이의 예측방법
TWI895765B (zh) * 2014-07-18 2025-09-01 香港中文大學 Dna混合物中之組織甲基化模式分析
US20160026759A1 (en) * 2014-07-22 2016-01-28 Yourgene Bioscience Detecting Chromosomal Aneuploidy
KR102696857B1 (ko) 2014-07-25 2024-08-19 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
EP3175000B1 (en) 2014-07-30 2020-07-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN107750277B (zh) 2014-12-12 2021-11-09 维里纳塔健康股份有限公司 使用无细胞dna片段大小来确定拷贝数变化
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US10319463B2 (en) 2015-01-23 2019-06-11 The Chinese University Of Hong Kong Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations
CA2976303A1 (en) 2015-02-10 2016-08-18 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
CN104789466B (zh) * 2015-05-06 2018-03-13 安诺优达基因科技(北京)有限公司 检测染色体非整倍性的试剂盒和装置
CN104789686B (zh) * 2015-05-06 2018-09-07 浙江安诺优达生物科技有限公司 检测染色体非整倍性的试剂盒和装置
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US10395759B2 (en) 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
ES2990200T3 (es) 2015-05-22 2024-11-29 Medicover Public Co Ltd Análisis paralelo múltiplex de regiones genómicas blanco para análisis prenatales no invasivos
CN104951671B (zh) * 2015-06-10 2017-09-19 东莞博奥木华基因科技有限公司 基于单样本外周血检测胎儿染色体非整倍性的装置
EP3822367A1 (en) * 2015-06-24 2021-05-19 Oxford BioDynamics PLC Detection processes using sites of chromosome interaction
AU2016293025A1 (en) 2015-07-13 2017-11-02 Agilent Technologies Belgium Nv System and methodology for the analysis of genomic data obtained from a subject
EP3118323A1 (en) 2015-07-13 2017-01-18 Cartagenia N.V. System and methodology for the analysis of genomic data obtained from a subject
CN108138233B (zh) 2015-07-20 2022-08-26 香港中文大学 Dna混合物中组织的单倍型的甲基化模式分析
HUE057821T2 (hu) 2015-07-23 2022-06-28 Univ Hong Kong Chinese Sejtmentes DNS fragmentációs mintázatának elemzése
IL285795B (en) 2015-08-12 2022-07-01 Univ Hong Kong Chinese Single-molecule sequencing of plasma dna
EP3347466B9 (en) 2015-09-08 2024-06-26 Cold Spring Harbor Laboratory Genetic copy number determination using high throughput multiplex sequencing of smashed nucleotides
WO2017049180A1 (en) 2015-09-18 2017-03-23 Agena Bioscience, Inc. Methods and compositions for the quantitation of mitochondrial nucleic acid
WO2017051996A1 (ko) * 2015-09-24 2017-03-30 에스케이텔레콤 주식회사 비침습적 태아 염색체 이수성 판별 방법
CN105132572B (zh) * 2015-09-25 2018-03-02 邯郸市康业生物科技有限公司 一种无创产前筛查21‑三体综合征试剂盒
KR101848438B1 (ko) * 2015-10-29 2018-04-13 바이오코아 주식회사 디지털 pcr을 이용한 산전진단 방법
CN117174167A (zh) 2015-12-17 2023-12-05 夸登特健康公司 通过分析无细胞dna确定肿瘤基因拷贝数的方法
GB201522665D0 (en) * 2015-12-22 2016-02-03 Premaitha Ltd Detection of chromosome abnormalities
KR101817180B1 (ko) * 2016-01-20 2018-01-10 이원다이애그노믹스(주) 염색체 이상 판단 방법
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
AU2017218149B2 (en) 2016-02-12 2020-09-03 Regeneron Pharmaceuticals, Inc. Methods and systems for detection of abnormal karyotypes
JP7280044B2 (ja) 2016-04-15 2023-05-23 ナテラ， インコーポレイテッド 肺癌の検出方法
WO2017192589A1 (en) 2016-05-02 2017-11-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to influenza ha and their use and identification
KR101879329B1 (ko) * 2016-06-13 2018-07-17 충북대학교 산학협력단 유전자 차별 발현 분석을 위한 RNA-seq 발현량 데이터 시뮬레이션 방법 및 이를 기록한 기록매체
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
US11854666B2 (en) 2016-09-29 2023-12-26 Myriad Women's Health, Inc. Noninvasive prenatal screening using dynamic iterative depth optimization
WO2018064629A1 (en) 2016-09-30 2018-04-05 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
EP3535415A4 (en) 2016-10-24 2020-07-01 The Chinese University of Hong Kong TUMOR DETECTION METHODS AND SYSTEMS
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
IL315032A (en) 2016-11-30 2024-10-01 Univ Hong Kong Chinese Analysis of cell-free dna in urine and other samples
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US20200255896A1 (en) * 2017-01-11 2020-08-13 Quest Diagnostics Investments Llc Method for non-invasive prenatal screening for aneuploidy
IL319365A (en) 2017-01-24 2025-05-01 Sequenom Inc Methods and processes for assessing genetic variations
CA3051509A1 (en) 2017-01-25 2018-08-02 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
US10894976B2 (en) 2017-02-21 2021-01-19 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
PT3596233T (pt) 2017-03-17 2022-08-22 Sequenom Inc Métodos e processos para avaliação de mosaicismo genético
CN110945136A (zh) 2017-06-20 2020-03-31 威斯康星州立大学医学院 使用总无细胞dna评估移植并发症风险
JP7776099B2 (ja) 2017-07-26 2025-11-26 ザ チャイニーズ ユニバーシティー オブ ホンコン 無細胞ウイルス核酸を用いる癌スクリーニングの強化
HRP20210826T1 (hr) 2017-07-26 2021-07-09 Trisomytest, S.R.O. Postupak neinvazivnog prenatalnog otkrivanja fetalnog kromosoma aneuploidija iz majčine krvi na temelju bayes mreže
CN111051511A (zh) 2017-08-04 2020-04-21 十亿至一公司 用于与生物靶相关的表征的靶相关分子
EP3662479A1 (en) 2017-08-04 2020-06-10 Trisomytest, s.r.o. A method for non-invasive prenatal detection of fetal sex chromosomal abnormalities and fetal sex determination for singleton and twin pregnancies
US11519024B2 (en) 2017-08-04 2022-12-06 Billiontoone, Inc. Homologous genomic regions for characterization associated with biological targets
SK862017A3 (sk) 2017-08-24 2020-05-04 Grendar Marian Doc Mgr Phd Spôsob použitia fetálnej frakcie a chromozómovej reprezentácie pri určovaní aneuploidného stavu v neinvazívnom prenatálnom testovaní
WO2019043656A1 (en) 2017-09-01 2019-03-07 Genus Plc METHODS AND SYSTEMS FOR ASSESSING AND / OR QUANTIFYING POPULATIONS OF SPERMATOZOIDS WITH SEXUAL ASYMMETRY
JP2021500883A (ja) 2017-10-27 2021-01-14 ジュノ ダイアグノスティックス，インク． 超微量リキッドバイオプシーのためのデバイス、システム、および方法
US11168356B2 (en) 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
WO2019118926A1 (en) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Assessing graft suitability for transplantation
CN112365927B (zh) * 2017-12-28 2023-08-25 安诺优达基因科技(北京)有限公司 Cnv检测装置
JP7164125B2 (ja) 2018-01-05 2022-11-01 ビリオントゥーワン，インコーポレイテッド シーケンシングベースのアッセイの妥当性を確保するための品質管理鋳型
CN108282396B (zh) * 2018-02-13 2022-02-22 湖南快乐阳光互动娱乐传媒有限公司 一种im集群中的多级消息广播方法及系统
US12398389B2 (en) 2018-02-15 2025-08-26 Natera, Inc. Methods for isolating nucleic acids with size selection
KR102099151B1 (ko) * 2018-03-05 2020-04-10 서강대학교산학협력단 마이크로웰 어레이를 이용한 dPCR 분석방법 및 분석장치
CA3095030A1 (en) 2018-03-30 2019-10-03 Juno Diagnostics, Inc. Deep learning-based methods, devices, and systems for prenatal testing
AU2019248635B2 (en) 2018-04-02 2022-01-27 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
CN112166199B (zh) 2018-04-02 2025-04-29 埃努梅拉分子股份有限公司 用于对核酸分子进行计数的方法、系统和组合物
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
CN112292458A (zh) * 2018-05-03 2021-01-29 香港中文大学 测量无细胞混合物特性的尺寸标记的优选末端和识别方向的分析
AU2019277698A1 (en) 2018-06-01 2020-11-19 Grail, Llc Convolutional neural network systems and methods for data classification
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
JP7637615B2 (ja) * 2018-09-04 2025-02-28 ガーダント ヘルス， インコーポレイテッド 無細胞核酸試料におけるアレル不均衡を検出するための方法およびシステム
WO2020051529A1 (en) 2018-09-07 2020-03-12 Sequenom, Inc. Methods, and systems to detect transplant rejection
WO2020076474A1 (en) 2018-10-12 2020-04-16 Nantomics, Llc Prenatal purity assessments using bambam
CA3116176A1 (en) * 2018-10-31 2020-05-07 Guardant Health, Inc. Methods, compositions and systems for calibrating epigenetic partitioning assays
CN109545379B (zh) * 2018-12-05 2021-11-09 易必祥 基于基因大数据的治疗系统
US11581062B2 (en) 2018-12-10 2023-02-14 Grail, Llc Systems and methods for classifying patients with respect to multiple cancer classes
JP6783437B2 (ja) * 2019-01-04 2020-11-11 株式会社大一商会 遊技機
JP2020108548A (ja) * 2019-01-04 2020-07-16 株式会社大一商会 遊技機
ES3013495T3 (en) 2019-01-31 2025-04-14 Guardant Health Inc Method for isolating and sequencing cell-free dna
US20220093208A1 (en) 2019-02-19 2022-03-24 Sequenom, Inc. Compositions, methods, and systems to detect hematopoietic stem cell transplantation status
KR20200109544A (ko) * 2019-03-13 2020-09-23 울산대학교 산학협력단 공통 유전자 추출에 의한 다중 암 분류 방법
TWI874374B (zh) 2019-03-25 2025-03-01 香港中文大學 確定循環核酸之線性及環狀形式
EP3947718A4 (en) 2019-04-02 2022-12-21 Enumera Molecular, Inc. METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
US12497662B2 (en) 2019-04-16 2025-12-16 Grail, Inc. Systems and methods for tumor fraction estimation from small variants
RU2717023C1 (ru) * 2019-04-24 2020-03-17 Общество с ограниченной ответственностью "ГЕНОТЕК ИТ" Способ определения кариотипа плода беременной женщины на основании секвенирования гибридных прочтений, состоящих из коротких фрагментов внеклеточной ДНК
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
CN116875669A (zh) 2019-08-16 2023-10-13 香港中文大学 测定核酸的碱基修饰
TWI724710B (zh) * 2019-08-16 2021-04-11 財團法人工業技術研究院 建構數位化疾病模組的方法及裝置
CN120473129A (zh) * 2019-09-30 2025-08-12 迈欧米公司 用于体外受精的多基因风险得分
CN114585749B (zh) * 2019-10-16 2024-09-03 斯蒂拉科技公司 核酸序列浓度的确定
WO2021137770A1 (en) 2019-12-30 2021-07-08 Geneton S.R.O. Method for fetal fraction estimation based on detection and interpretation of single nucleotide variants
AU2021205853A1 (en) * 2020-01-08 2023-11-23 Grail, Inc. Biterminal dna fragment types in cell-free samples and uses thereof
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
CA3173571A1 (en) 2020-02-28 2021-09-02 Laboratory Corporation Of America Holdings Compositions, methods, and systems for paternity determination
US12165374B2 (en) 2020-05-11 2024-12-10 Nec Corporation Determination device, determination method, and recording medium
JP7424476B2 (ja) * 2020-05-11 2024-01-30 日本電気株式会社 判定装置、判定方法およびプログラム
JP7424475B2 (ja) * 2020-05-11 2024-01-30 日本電気株式会社 判定装置、判定方法およびプログラム
WO2021237105A1 (en) * 2020-05-22 2021-11-25 Invitae Corporation Methods for determining a genetic variation
US20220010353A1 (en) * 2020-07-13 2022-01-13 The Chinese University Of Hong Kong Nuclease-associated end signature analysis for cell-free nucleic acids
CN116157869A (zh) * 2020-12-02 2023-05-23 伊鲁米纳软件公司 用于检测遗传改变的系统和方法
CN114645080A (zh) * 2020-12-21 2022-06-21 高嵩 一种利用多态性位点和靶位点测序检测胎儿遗传变异的方法
WO2022246291A1 (en) * 2021-05-21 2022-11-24 Invitae Corporation Methods for determining a genetic variation
US12252745B2 (en) 2021-09-02 2025-03-18 Enumerix, Inc. Detection and digital quantitation of multiple targets
CN113981062B (zh) * 2021-10-14 2024-02-20 武汉蓝沙医学检验实验室有限公司 以非生父和母亲dna评估胎儿dna浓度的方法及应用
EP4496900A2 (en) 2022-03-21 2025-01-29 BILLION ToONE, INC. Molecule counting of methylated cell-free dna for treatment monitoring
WO2024058850A1 (en) * 2022-09-16 2024-03-21 Myriad Women's Health, Inc. Rna-facs for rare cell isolation and detection of genetic variants
US20240384334A1 (en) * 2023-05-09 2024-11-21 Centre For Novostics Efficient digital measurement of long nucleic acid fragments
WO2024242641A1 (en) 2023-05-25 2024-11-28 Medirex Group Academy N.O. Method for detection of samples with insufficient amount of fetal and circulating tumor dna fragments for non-invasive genetic testing
WO2024253600A1 (en) 2023-06-07 2024-12-12 Univerzita Komenského v Bratislave Method for estimation of cell-free dna mixture proportions based on telomere-derived fragments
CN118098345B (zh) * 2024-04-28 2024-08-09 深圳市真迈生物科技有限公司 一种染色体非整倍体的检测方法、装置、设备及存储介质

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641628A (en) * 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
WO1993007296A1 (en) * 1991-10-03 1993-04-15 Indiana University Foundation Method for screening for alzheimer's disease
US6100029A (en) * 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US20010051341A1 (en) * 1997-03-04 2001-12-13 Isis Innovation Limited Non-invasive prenatal diagnosis
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6558901B1 (en) * 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
US6566101B1 (en) * 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
US20030022207A1 (en) * 1998-10-16 2003-01-30 Solexa, Ltd. Arrayed polynucleotides and their use in genome analysis
EP2177627B1 (en) * 1999-02-23 2012-05-02 Caliper Life Sciences, Inc. Manipulation of microparticles in microfluidic systems
AUPQ008799A0 (en) * 1999-04-30 1999-05-27 Tillett, Daniel Genome sequencing
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6440706B1 (en) * 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
AU776811C (en) * 1999-10-13 2005-07-28 Agena Bioscience, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
GB0009784D0 (en) * 2000-04-20 2000-06-07 Simeg Limited Methods for clinical diagnosis
US20030087231A1 (en) 2000-05-19 2003-05-08 Albertson Donna G. Methods and compositions for preparation of a polynucleotide array
GB0016742D0 (en) * 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
US6664056B2 (en) * 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
US8898021B2 (en) * 2001-02-02 2014-11-25 Mark W. Perlin Method and system for DNA mixture analysis
JP2002272497A (ja) 2001-03-15 2002-09-24 Venture Link Co Ltd 癌の診断方法、およびその診断用ベクター
US20020164816A1 (en) * 2001-04-06 2002-11-07 California Institute Of Technology Microfluidic sample separation device
US6960437B2 (en) * 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US7118907B2 (en) * 2001-06-06 2006-10-10 Li-Cor, Inc. Single molecule detection systems and methods
US20050037388A1 (en) * 2001-06-22 2005-02-17 University Of Geneva Method for detecting diseases caused by chromosomal imbalances
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
GT200200183A (es) * 2001-09-28 2003-05-23 Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol
EP2279742A3 (en) 2001-10-05 2011-04-20 Zalicus Inc. Combinations for the treatment of immunoinflammatory disorders
ATE428925T1 (de) * 2001-11-20 2009-05-15 Exact Sciences Corp Automatische probenvorbereitungsverfahren und - vorrichtungen
US7118910B2 (en) 2001-11-30 2006-10-10 Fluidigm Corporation Microfluidic device and methods of using same
US7691333B2 (en) * 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US20030180765A1 (en) 2002-02-01 2003-09-25 The Johns Hopkins University Digital amplification for detection of mismatch repair deficient tumor cells
CA2477611A1 (en) 2002-03-01 2003-09-12 Ravgen, Inc. Rapid analysis of variations in a genome
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) * 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
EP2236614A3 (en) 2002-08-15 2011-01-26 Genzyme Corporation Brain endothelial cell expression patterns
KR100500697B1 (ko) 2002-10-21 2005-07-12 한국에너지기술연구원 다단계 열회수형 물유동층 열교환기
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
ATE533857T1 (de) * 2003-01-17 2011-12-15 Univ Hong Kong Chinese Zirkulierende mrna als diagnostische marker für erkankungen die mit einer schwangerschaft zusammenhängen
CA2517017A1 (en) 2003-02-28 2004-09-16 Ravgen, Inc. Methods for detection of genetic disorders
EP1599608A4 (en) * 2003-03-05 2007-07-18 Genetic Technologies Ltd Identification of fetal DNA and fetal cell marker in maternal plasma or serum
US20040209299A1 (en) * 2003-03-07 2004-10-21 Rubicon Genomics, Inc. In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA
WO2004083816A2 (en) 2003-03-14 2004-09-30 John Wayne Cancer Institute Loss of heterozygosity of the dna markers in the 12q22-23 region
US7604965B2 (en) * 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US20050145496A1 (en) * 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US20040197832A1 (en) * 2003-04-03 2004-10-07 Mor Research Applications Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
EP1615721B1 (en) * 2003-04-03 2014-06-18 Fluidigm Corporation Microfluidic devices and methods of using same
RU2249820C1 (ru) * 2003-08-18 2005-04-10 Лактионов Павел Петрович Способ ранней диагностики заболеваний, связанных с нарушением функционирования генетического аппарата клетки
EP2354253A3 (en) * 2003-09-05 2011-11-16 Trustees of Boston University Method for non-invasive prenatal diagnosis
US20050282213A1 (en) * 2003-09-22 2005-12-22 Trisogen Biotechnology Limited Partnership Methods and kits useful for detecting an alteration in a locus copy number
CA2541706C (en) * 2003-10-08 2014-02-18 The Trustees Of Boston University Methods for prenatal diagnosis of chromosomal abnormalities
DE60328193D1 (de) * 2003-10-16 2009-08-13 Sequenom Inc Nicht invasiver Nachweis fötaler genetischer Merkmale
US20050221341A1 (en) 2003-10-22 2005-10-06 Shimkets Richard A Sequence-based karyotyping
WO2005044086A2 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal dna in amniotic fluid
US20100216151A1 (en) * 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20100216153A1 (en) * 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
US7709194B2 (en) 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
DE102004036285A1 (de) * 2004-07-27 2006-02-16 Advalytix Ag Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe
AU2005286876A1 (en) * 2004-09-20 2006-03-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Multiple mode multiplex reaction quenching method
CN1779688A (zh) * 2004-11-22 2006-05-31 寰硕数码股份有限公司 交互式医疗信息系统及方法
CA2894337C (en) 2005-03-18 2018-08-28 The Chinese University Of Hong Kong Markers for prenatal diagnosis of trisomy 18
US7645576B2 (en) * 2005-03-18 2010-01-12 The Chinese University Of Hong Kong Method for the detection of chromosomal aneuploidies
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
DE602005009324D1 (de) 2005-04-06 2008-10-09 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
EP2477029A1 (en) 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
WO2007001259A1 (en) * 2005-06-16 2007-01-04 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods and materials for identifying polymorphic variants, diagnosing susceptibilities, and treating disease
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20070122823A1 (en) 2005-09-01 2007-05-31 Bianchi Diana W Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis
WO2007062363A2 (en) * 2005-11-18 2007-05-31 Large Scale Biology Corporation Method for diagnosing a person having sjogren's syndrome
JP6121642B2 (ja) * 2005-11-26 2017-04-26 ナテラ， インコーポレイテッド 予測を行うための、遺伝子データを清浄化し、そして、そのデータを使用するためのシステムおよび方法
SI2385143T1 (sl) * 2006-02-02 2016-11-30 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Neinvazivni genetski presejalni test ploda z digitalno analizo
GB2449048A (en) 2006-02-15 2008-11-05 Agilent Technologies Inc Normalization probes for comparative genome hybridization arrays
ATE508209T1 (de) 2006-02-28 2011-05-15 Univ Louisville Res Found Erkennung von chromosomabnormalitäten im fötus mit hilfe der tandem-einzelnukleotid- polymorphismen
US20080038733A1 (en) * 2006-03-28 2008-02-14 Baylor College Of Medicine Screening for down syndrome
US8058055B2 (en) * 2006-04-07 2011-11-15 Agilent Technologies, Inc. High resolution chromosomal mapping
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
EP2061801A4 (en) * 2006-06-14 2009-11-11 Living Microsystems Inc DIAGNOSIS OF FETAL ANOMALIES BY COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS
WO2008111990A1 (en) * 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
US8137912B2 (en) * 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2029778B1 (en) 2006-06-14 2018-05-02 Verinata Health, Inc Diagnosis of fetal abnormalities
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) * 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (en) * 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
EP2366801B1 (en) 2006-06-14 2016-10-19 Verinata Health, Inc Methods for the diagnosis of fetal abnormalities
WO2007147063A2 (en) * 2006-06-16 2007-12-21 Sequenom, Inc. Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample
WO2008014516A2 (en) * 2006-07-28 2008-01-31 Living Microsystems, Inc. Selection of cells using biomarkers
JP4379742B2 (ja) 2006-10-23 2009-12-09 ソニー株式会社 再生装置および再生方法、並びにプログラム
WO2008094681A1 (en) * 2007-01-30 2008-08-07 Interdigital Technology Corporation Implicit drx cycle length adjustment control in lte_active mode
US8173370B2 (en) * 2007-02-08 2012-05-08 Sequenom, Inc. Nucleic acid-based tests for RHD typing, gender determination and nucleic acid quantification
US20100094562A1 (en) * 2007-05-04 2010-04-15 Mordechai Shohat System, Method and Device for Comprehensive Individualized Genetic Information or Genetic Counseling
PL2162534T3 (pl) 2007-05-24 2015-02-27 Apceth Gmbh & Co Kg Genetycznie zmodyfikowane, mezenchymalne komórki macierzyste CD34 negatywne do leczenia nowotworów
KR102222378B1 (ko) 2007-07-23 2021-03-04 더 차이니즈 유니버시티 오브 홍콩 핵산 서열 불균형의 결정
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
RU2010109698A (ru) 2007-09-19 2011-09-27 Плуристем Лтд. (Il) Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях
WO2009051842A2 (en) 2007-10-18 2009-04-23 The Johns Hopkins University Detection of cancer by measuring genomic copy number and strand length in cell-free dna
US20100000804A1 (en) 2008-07-02 2010-01-07 Ming-Hsiang Yeh Solar vehicle
CA2737643C (en) * 2008-09-20 2020-10-06 Hei-Mun Fan Noninvasive diagnosis of fetal aneuploidy by sequencing
WO2011054936A1 (en) 2009-11-06 2011-05-12 The Chinese University Of Hong Kong Size-based genomic analysis
KR20110072531A (ko) 2009-12-23 2011-06-29 재단법인대구경북과학기술원 전력 거래 서비스 방법 및 시스템
EP2569447A4 (en) 2010-05-14 2013-11-27 Fluidigm Corp ASSAYS FOR THE DETECTION OF GENOTYPES, MUTATIONS OR ANEUPLOIDY
KR101891847B1 (ko) 2010-11-30 2018-08-24 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
JP2012128587A (ja) 2010-12-14 2012-07-05 Mitsubishi Electric Corp 救援システム及び救援指示装置及び救援装置及び対象装置及びコンピュータプログラム及び救援指示方法
CA2840418C (en) 2011-07-26 2019-10-29 Verinata Health, Inc. Method for determining the presence or absence of different aneuploidies in a sample
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
JP2016131552A (ja) 2015-01-22 2016-07-25 クラシエフーズ株式会社 即席泡状固形ゼリーデザート用粉末
CN107867186B (zh) 2016-09-27 2021-02-23 华为技术有限公司 电动汽车以及电动汽车之间充电的方法

Also Published As

Publication number Publication date
HRP20140009T4 (hr) 2019-03-08
JP2016185162A (ja) 2016-10-27
EP2557519A3 (en) 2014-07-23
US8972202B2 (en) 2015-03-03
CN106886688A (zh) 2017-06-23
KR102112438B9 (ko) 2024-08-22
SI2183693T1 (sl) 2014-02-28
PL2514842T3 (pl) 2016-08-31
CN101849236A (zh) 2010-09-29
KR102561664B1 (ko) 2023-07-28
KR20250002752A (ko) 2025-01-07
KR102076438B1 (ko) 2020-02-11
PT2183693E (pt) 2014-01-14
SI2557520T1 (sl) 2021-08-31
CA2693081C (en) 2016-01-26
US20140329696A1 (en) 2014-11-06
EP2183693B2 (en) 2018-11-14
IL203311A (en) 2014-07-31
EP2527471A2 (en) 2012-11-28
KR20160113148A (ko) 2016-09-28
PT2557520T (pt) 2021-05-06
CA3076142C (en) 2023-01-03
US20090029377A1 (en) 2009-01-29
US20230323462A1 (en) 2023-10-12
US20140256560A1 (en) 2014-09-11
JP2024056078A (ja) 2024-04-19
KR20190114041A (ko) 2019-10-08
EP2557518A2 (en) 2013-02-13
JP2022173465A (ja) 2022-11-18
SI2514842T1 (sl) 2016-06-30
JP7457399B2 (ja) 2024-03-28
US20200056242A1 (en) 2020-02-20
CN107083425A (zh) 2017-08-22
KR102060911B1 (ko) 2019-12-30
KR102443163B1 (ko) 2022-09-14
JP7026303B2 (ja) 2022-02-28
CN103853916B (zh) 2018-07-27
JP7381116B2 (ja) 2023-11-15
US12054776B2 (en) 2024-08-06
KR102147626B9 (ko) 2024-08-22
JP6695392B2 (ja) 2020-05-20
KR20210130269A (ko) 2021-10-29
AU2008278839A1 (en) 2009-01-29
KR102197512B1 (ko) 2021-01-04
US20140045181A1 (en) 2014-02-13
EA028642B1 (ru) 2017-12-29
CA2900927A1 (en) 2009-01-29
KR20210006468A (ko) 2021-01-18
CY1124357T1 (el) 2022-07-22
JP2015142588A (ja) 2015-08-06
EP3540739B1 (en) 2025-07-30
EP2557520A2 (en) 2013-02-13
ZA201000524B (en) 2011-03-30
SI2183693T2 (sl) 2019-02-28
US8706422B2 (en) 2014-04-22
HRP20160493T1 (hr) 2016-07-15
JP2014073134A (ja) 2014-04-24
HUE030510T2 (hu) 2017-05-29
JP6383837B2 (ja) 2018-08-29
KR20190114039A (ko) 2019-10-08
KR101829565B1 (ko) 2018-03-29
JP5519500B2 (ja) 2014-06-11
EP2527471A3 (en) 2012-12-26
JP2010534069A (ja) 2010-11-04
PL2557520T3 (pl) 2021-10-11
JP6522554B2 (ja) 2019-05-29
KR20160113145A (ko) 2016-09-28
DK2514842T3 (en) 2016-05-30
CA3029497A1 (en) 2009-01-29
ES2441807T3 (es) 2014-02-06
CA3127930A1 (en) 2009-01-29
CN106886688B (zh) 2020-07-10
CN103902809A (zh) 2014-07-02
KR20170127073A (ko) 2017-11-20
CN103902809B (zh) 2017-11-28
KR20220127377A (ko) 2022-09-19
EA201000231A1 (ru) 2010-06-30
KR101972994B1 (ko) 2019-04-29
KR101896167B1 (ko) 2018-09-07
EP2557520A3 (en) 2015-04-29
EA201791612A3 (ru) 2018-03-30
CA3076159A1 (en) 2009-01-29
CA3076142A1 (en) 2009-01-29
ES2792802T3 (es) 2020-11-12
CA3200589A1 (en) 2009-01-29
ES2441807T5 (es) 2019-04-25
KR20200055151A (ko) 2020-05-20
KR102458210B1 (ko) 2022-10-24
DK2183693T4 (en) 2019-02-11
MX2010000846A (es) 2010-04-21
NZ600407A (en) 2013-12-20
IL233261A (en) 2016-07-31
HK1199067A1 (en) 2015-06-19
WO2009013496A1 (en) 2009-01-29
PL2183693T3 (pl) 2014-03-31
JP7634889B2 (ja) 2025-02-25
JP7761951B2 (ja) 2025-10-29
EA201791612A2 (ru) 2017-11-30
EP3770275A1 (en) 2021-01-27
EP2514842B1 (en) 2016-02-24
EP2557517A2 (en) 2013-02-13
CN101971178B (zh) 2014-03-26
JP6151739B2 (ja) 2017-06-21
US20250122566A1 (en) 2025-04-17
KR102128960B1 (ko) 2020-07-02
SI2557517T1 (sl) 2023-03-31
US12227804B2 (en) 2025-02-18
US20190136323A1 (en) 2019-05-09
US9051616B2 (en) 2015-06-09
CA2900927C (en) 2018-08-14
EA017966B1 (ru) 2013-04-30
KR20100075826A (ko) 2010-07-05
PL2557517T3 (pl) 2023-03-06
CA3029497C (en) 2023-08-08
AU2008278839B2 (en) 2013-04-04
PL2183693T5 (pl) 2019-04-30
KR20160113147A (ko) 2016-09-28
JP6629940B2 (ja) 2020-01-15
CN106834474A (zh) 2017-06-13
CY1117525T1 (el) 2017-04-26
CN106834481A (zh) 2017-06-13
KR20160113146A (ko) 2016-09-28
KR20180121695A (ko) 2018-11-07
BRPI0814670B8 (pt) 2021-07-27
KR20210028263A (ko) 2021-03-11
EP2557518B1 (en) 2017-03-15
CA3076159C (en) 2022-05-24
HK1144024A1 (en) 2011-01-21
ES2869347T3 (es) 2021-10-25
EP2557519B1 (en) 2020-08-19
HRP20140009T1 (hr) 2014-03-14
WO2009013492A1 (en) 2009-01-29
CN103849684A (zh) 2014-06-11
CA3009992C (en) 2021-10-19
ES2571738T3 (es) 2016-05-26
HRP20210983T1 (hr) 2021-09-17
CA3176319A1 (en) 2009-01-29
KR20180114251A (ko) 2018-10-17
EP3067807A1 (en) 2016-09-14
HRP20251164T3 (hr) 2025-12-19
CA2694007A1 (en) 2009-01-29
CN107083424A (zh) 2017-08-22
KR102147626B1 (ko) 2020-08-24
DK2557519T3 (da) 2020-09-21
EP3540739A1 (en) 2019-09-18
US11725245B2 (en) 2023-08-15
IL233261A0 (en) 2014-08-31
JP2019000113A (ja) 2019-01-10
CA2693081A1 (en) 2009-01-29
EA202192446A1 (ru) 2022-01-31
LT2557520T (lt) 2021-05-25
EP2183693B1 (en) 2014-01-01
MX341573B (es) 2016-08-25
ES3040072T3 (en) 2025-10-28
KR101916456B1 (ko) 2018-11-07
MX346069B (es) 2017-03-06
DK2527471T3 (da) 2020-05-18
CN106676188A (zh) 2017-05-17
EP2557519A2 (en) 2013-02-13
KR101966262B1 (ko) 2019-04-08
KR20200100860A (ko) 2020-08-26
JP2019013245A (ja) 2019-01-31
JP2010534068A (ja) 2010-11-04
JP2023178477A (ja) 2023-12-14
KR20190143494A (ko) 2019-12-30
CA3009992A1 (en) 2009-01-29
HUE054639T2 (hu) 2021-09-28
CY1114773T1 (el) 2016-12-14
EP2557517A3 (en) 2014-11-05
EP4134960A1 (en) 2023-02-15
EP2557517B1 (en) 2022-10-26
DK2557520T3 (da) 2021-05-31
EA201300072A1 (ru) 2014-11-28
EA035451B9 (ru) 2020-09-09
CN106834474B (zh) 2019-09-24
EA201201551A1 (ru) 2013-08-30
KR20180100713A (ko) 2018-09-11
EP2527471B1 (en) 2020-03-04
EA039167B1 (ru) 2021-12-13
CN107083425B (zh) 2025-08-05
US20250320558A1 (en) 2025-10-16
HK1182195A1 (en) 2013-11-22
EP2183693A1 (en) 2010-05-12
EP2183692A1 (en) 2010-05-12
HK1224033A1 (en) 2017-08-11
SG183062A1 (en) 2012-08-30
CA2694007C (en) 2019-02-26
EP2557520B1 (en) 2021-04-07
EP3745405A1 (en) 2020-12-02
JP2025069363A (ja) 2025-04-30
JP5736170B2 (ja) 2015-06-17
HUE061020T2 (hu) 2023-05-28
HRP20230033T3 (hr) 2023-03-03
JP2017148073A (ja) 2017-08-31
NZ582702A (en) 2012-07-27
US10208348B2 (en) 2019-02-19
AU2008278843A1 (en) 2009-01-29
KR101829564B1 (ko) 2018-02-14
KR102339760B1 (ko) 2021-12-14
BRPI0814670B1 (pt) 2019-10-01
EA201600280A1 (ru) 2016-07-29
KR20220146689A (ko) 2022-11-01
US20140256559A1 (en) 2014-09-11
KR20230117256A (ko) 2023-08-07
KR20100058503A (ko) 2010-06-03
EP3540739C0 (en) 2025-07-30
EP2514842A2 (en) 2012-10-24
JP2020031663A (ja) 2020-03-05
KR20230047215A (ko) 2023-04-06
EP2183692B1 (en) 2017-08-23
PL2183693T4 (pl) 2015-11-30
JP7490219B2 (ja) 2024-05-27
ES2820866T3 (es) 2021-04-22
KR101646978B1 (ko) 2016-08-09
EP3656870A1 (en) 2020-05-27
BRPI0814670A2 (pt) 2015-02-18
KR102222378B1 (ko) 2021-03-04
ES2933486T3 (es) 2023-02-09
JP2022040312A (ja) 2022-03-10
JP2020031664A (ja) 2020-03-05
DK2557517T3 (da) 2022-11-28
EP2557518A3 (en) 2014-10-08
HK1177768A1 (en) 2013-08-30
KR102112438B1 (ko) 2020-06-04
US20140329695A1 (en) 2014-11-06
EA035451B1 (ru) 2020-06-18
JP2020115887A (ja) 2020-08-06
PT2557517T (pt) 2023-01-04
JP7081829B2 (ja) 2022-06-07
CN103853916A (zh) 2014-06-11
DK2183693T5 (en) 2019-02-18
JP2022103371A (ja) 2022-07-07
EP2514842A3 (en) 2012-12-26
EP3892736A1 (en) 2021-10-13
KR20160030404A (ko) 2016-03-17
CN101971178A (zh) 2011-02-09
KR102516709B1 (ko) 2023-04-03
LT2557517T (lt) 2023-01-10
US20090087847A1 (en) 2009-04-02
DK2183693T3 (da) 2014-01-20

Similar Documents

Publication Publication Date Title
FI2557517T3 (fi) Nukleiinihapposekvenssiepätasapainon määrittäminen
KR102665592B1 (ko) 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
DK3241914T3 (en) Fetal genome analysis of a maternal biological sample
EP4258269A2 (en) Methods and processes for non-invasive assessment of genetic variations
US20220106642A1 (en) Multiplexed Parallel Analysis Of Targeted Genomic Regions For Non-Invasive Prenatal Testing
Hwa et al. A 1204-single nucleotide polymorphism and insertion–deletion polymorphism panel for massively parallel sequencing analysis of DNA mixtures
McIver et al. Population-scale analysis of human microsatellites reveals novel sources of exonic variation
EP2965243B1 (en) Non-invasive fetal sex determination
US11879157B2 (en) Target-enriched multiplexed parallel analysis for assessment of risk for genetic conditions
JP2025013900A (ja) 無細胞核酸試料におけるアレル不均衡を検出するための方法およびシステム
US12203132B2 (en) Method for determining fetal fraction in maternal sample
US20130143746A1 (en) Method for detecting gene region features based on inter-alu polymerase chain reaction
Helsmoortel et al. Multiplexed high resolution melting assay for versatile sample tracking in a diagnostic and research setting
Amr et al. Targeted hybrid capture for inherited disease panels
CA2907177A1 (en) Methods and compositions for evaluating genetic markers
WO2013073929A1 (en) Method and apparatus for detecting nucleic acid variation(s)
AU2013203448B2 (en) Determining fraction of fetal dna in maternal biological sample
HK40113543A (en) Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
HK40093249A (en) Methods and processes for non-invasive assessment of genetic variations
HK40032387A (en) Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
Uziela Making microarray and RNA-seq gene expression data comparable
HK1239751A1 (en) Method for analyzing genetic aberration
HK1237829A1 (en) Diagnosing fetal chromosomal aneuploidy using genomic sequencing
BR122020014914B1 (pt) Métodos para identificar uma mutação de novo no genoma de um feto não nascido de uma fêmea grávida, para determinar uma concentração fracionária de dna fetal em uma amostra biológica tirada de uma fêmea grávida e para determinar uma proporção de um genoma fetal que foi sequenciado a partir de uma amostra biológica tirada de uma fêmea grávida, e, meio legível por computador não transitório