FI119676B - Pulver för användning i en torrpulverinhalator - Google Patents
Pulver för användning i en torrpulverinhalator Download PDFInfo
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- FI119676B FI119676B FI973151A FI973151A FI119676B FI 119676 B FI119676 B FI 119676B FI 973151 A FI973151 A FI 973151A FI 973151 A FI973151 A FI 973151A FI 119676 B FI119676 B FI 119676B
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
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- YZNWXXJZEDHRKB-UHFFFAOYSA-N octadecyl 2-hydroxypropanoate;sodium Chemical compound [Na].CCCCCCCCCCCCCCCCCCOC(=O)C(C)O YZNWXXJZEDHRKB-UHFFFAOYSA-N 0.000 description 1
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- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
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- 239000012086 standard solution Substances 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
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- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
- 229960005105 terbutaline sulfate Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Claims (42)
1. Pulver för användning i en torrpulverinhalator, varvid pulvret inkluderar aktiva partiklar, bärarpartiklar för att bära de aktiva partiklarna och partiklar av tillsatsma-terial fästade till bärarpartiklarnas ytor, varvid tillsatsmaterialets syfte är att främja 5 frisättning av de aktiva partiklarna frän bärarpartiklama vid utlösning av inhalatorn, kännetecknat av att tillsatsmaterialet innefattar ett ytaktivt material och inkluderar en kombination av material, varvid väsentligen samtliga bärarpartiklar har en aerodynamisk diameter som ligger mellan 20 pm och 1000 pm och massmedia-nen vad gäller tillsatspartiklarnas aerodynamiska diameter inte är mer än 10 pm.
2. Pulver enligt patentkrav 1, varvid pulvret inkluderar inte mer än 10 vikt% till- satsmaterial baserad pä pulvrets vikt.
3. Pulver enligt patentkrav 2, varvid pulvret inkluderar inte mer än 5 vikt% till-satsmaterial baserad pä pulvrets vikt.
4. Pulver enligt patentkrav 3, varvid pulvret inkluderar inte mer än 4 vikt% till-15 satsmaterial baserad pä pulvrets vikt.
5. Pulver enligt patentkrav 4, varvid pulvret inkluderar inte mer än 2 vikt% till-satsmaterial baserad pa pulvrets vikt. • "**: 6. Pulver enligt nägot av de föregäende patentkraven, varvid tillsatsmaterialet är ett fysiologisi godtagbart material. • · ..... 20 7. Pulver enligt nägot av de föregäende patentkraven, varvid tillsatsmaterialet I. ** innefattar partiklar av ytaktivt material, varvid det ytaktiva materialet valts ur grup- • · pen som bestär av: lecitin; fettsyror i fast fas säsom palmitinsyra, stearinsyra, eru- • · · *·* * kasyra, behensyra, och derivat därav; magnesiumstearat; natriumstearylfumarat; natriumstearyllaktylat; fosfatidylkoliner; fosfatidylglyceroler; liposomala formule- • · :.v 25 ringar; laurinsyra eller laurinsyrasalter; triglycerider; och sockerestrar. • · · • · • · *" 8. Pulver enligt nägot av de föregäende patentkraven, varvid tillsatsmaterialet ·.!:* valts ur gruppen som bestär av: en eller flera vattenlösliga substanser; en fosfoli- • · · pid eller ett derivat därav; palmitinsyra, stearinsyra, erukasyra, behensyra, mag- nesiumstearat, natriumstearylfumarat, natriumstearyllaktylat, en fosfatidyl koi in, en .···. 30 fosfatidylglycerol, en liposomal formulering, laurinsyra eller ett laurinsyrasalt, en • · triglycerid, eller en sockerester; en eller flera föreningar som valts bland aminosy-ror och derivat därav, och peptider och polypeptider som har en molekylvikt frän 0,25 till 1000 Kda, och derivat därav; och dipolara joner.
9. Pulver enligt patentkrav 7 eller 8, varvid tillsatsmaterialet innefattar lecitin.
10. Pulver enligt patentkrav 9, varvid tillsatsmaterialet innefattar sojalecitin.
11. Pulver enligt patentkrav 7 eller 8, varvid tillsatsmaterialet innefattar magnesi-5 umstearat i en mängd som utgör mindre än 1,5 vikt%. t
12. Pulver enligt patentkrav 8, varvid tillsatsmaterialet inkluderar en aminosyra.
13. Pulver enligt patentkrav 12, varvid tillsatsmaterialet inkluderar leucin.
14. Pulver enligt patentkrav 8, varvid tillsatsmaterialet bestär av zwitterjoner.
15. Pulver enligt nägot av de föregäende patentkraven, varvid tillsatsmaterialet 10 inkluderar en mangfald ytaktiva material.
16. Pulver enligt nägot av föregaende patentkrav, varvid pulvret bestär av inte mindre än 0,1 vikt% tillsatspartiklar baserad pä bärarpartiklamas vikt.
17. Pulver enligt nägot av de föregäende patentkraven, varvid partiklar av till-satsmaterial bildar en diskontinuerlig beläggning pä bärarpartiklamas ytor. ·:··: 15 18. Pulver enligt patentkrav 17, varvid tillsatsmaterialet, medan det bildar en dis- : .·. kontinuerlig beläggning pä bärarpartiklamas ytor, mättar bärarpartiklamas ytor. • ·· · ' ’ 19. Pulver enligt nägot av de föregäende patentkraven, varvid bärarpartiklarna : V innefattar ett eller flera kristallina sockerarter. • · • · • · ·
20. Pulver enligt patentkrav 19, varvid bärarpartiklarna är partiklar av laktos.
21. Pulver enligt nägot av de föregäende patentkraven, varvid massmedianen • · v.: vad gäller de aktiva partiklarnas aerodynamiska diameter inte är mer än 10 μίτι. ·♦· • · *** 22. Pulver enligt nägot av de föregäende patentkraven, varvid de aktiva partik- ···:* lama innefattar material som vanligen administreras oralt genom inhalation för ··· behandling av respiratoriska sjukdomar. • · • · ♦
24. Pulver enligt patentkrav 23, varvid de aktiva partiklarna inkluderar salbuta- *·)·* 25 23. Pulver enligt patentkrav 22, varvid de aktiva partiklarna inkluderar en β2- • · *·♦·’ agonist. mol, ett salt av salbutamol, salmeterol och/eller ett sait av salmeterol.
25. Pulver enligt patentkrav 22, varvid de aktiva partiklama inkluderar en steroid.
26. Pulver enigt patentkrav 25, varvid steroiden är beklometason-dipropionat el-ler flutikason.
27. Pulver enligt nägot av de föregaende patentkraven, varvid de aktiva partik- larna inte är benägna att frisättas frän bärarpartiklarna innan inhalatom utlöses.
28. Pulver enligt nägot av de föregäende patentkraven, varvid pulvret har en homogenitet efter vibration mätt som en procentuell variationskoefficient av mind-re än cirka 5 %, när den mäts med användning av förfarandet som beskrivits i Ex- 10 empel 12.
29. Förfarande för framställning av ett pulver enligt nagot av patentkraven 1 tili 28, varvid nämnda förfarande inkluderar stegen att man blandar bärarpartiklar som har en storlek som är lämplig för användning i en torrpulverinhalator med par-tiklar av tillsatsmaterial som fäster tili bärarpartiklarnas ytor, och att man blandar 15 de resulterande partiklarna med aktiva partiklar pä sä sätt att de aktiva partiklarna fäster tili bärarpartiklarnas ytor och/eller tillsatspartiklarnas ytor, kännetecknat av att tillsatsmaterialet innefattar ett ytaktivt material och inkluderar en kombination av material, och varvid väsentligen samtliga bärarpartiklar har en aerodynamisk • · diameter som ligger mellan 20 pm och 1000 pm och massmedianen vad gäller till- **' | 20 satspartiklarnas aerodynamiska diameter inte är mer än 10 pm. • ·
30. Förfarande enligt patentkrav 29, vidare innefattande steget att man ur ett prov av bärarpartiklar väljer ett fördelaktigt storleksintervall av bärarpartiklar före blandningssteget.
31. Förfarande enligt patentkrav 29 eller 30, varvid förfarandet vidare innefattar :.v 25 steget att man ur ett prov av tillsatspartiklar väljer ett fördelaktigt storleksintervall • · · av tillsatspartiklar före blandningssteget. • · · *"j 32. Förfarande enligt patentkrav 29 eller 30, varvid tillsatsmaterialet tillsatts i form av en suspension. • · • · · .*!:* 33. Förfarande enligt nagot av patentkraven 29 tili 32, varvid tillsatsmaterialet • ♦ *···* 30 och bärarpartiklarna blandas i mellan 0,1 timme och 0,5 timme.
34. Förfarande enligt nägot av patentkraven 29 tili 33, varvid bärarpartiklarna blandas med tillsatsmaterialet genom användning av en trumlingsblandare.
35. Förfarande enligt nägot av patentkraven 29 till 34, varvid förfarandet ytterli-gare inkluderar steget att man behandlar bärarpartiklarna för att avlägsna smä korn frän bärarpartiklarnas ytor, utan att väsentligen förändra storleken pä bärar- 5 partiklarna under behandlingen.
36. Förfarande enligt patentkrav 35, varvid blandningssteget är före behand-lingssteget.
37. Förfarande enligt patentkrav 35 eller patentkrav 36, varvid de sma kornen äter fäster tili ytorna pä bärarpartiklarna. 10 38. Förfarande enligt nägot av patentkraven 35 tili 37, varvid behandlingssteget är ett malningssteg.
39. Förfarande enligt patentkrav 38, varvid malningssteget utförs i en kulkvarn.
40. Förfarande enligt patentkrav 39, varvid partiklarna mals genom användning av plastkulor. 15 41. Förfarande enligt patentkrav 38, varvid behandlingssteget utförs i en ätercir- kulerande "low fluid energy”-kvam. .* 42. Förfarande enligt nägot av patentkraven 38 tili 41, varvid partiklarna mals i • · · ··· \ mellan cirka 0,25 timmar och 6 timmar. « · ·· · • · · ♦ « • · ·· • · • ♦· ··· • · · » · · • · • · · • · · • · ··· • · • · ··· m 9 9 99 9 9999 999 9 9 9 9 999 • • · • · · • · · 9 9 999 9 9 9 9 999
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9501841.2A GB9501841D0 (en) | 1995-01-31 | 1995-01-31 | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9501841 | 1995-01-31 | ||
| GBGB9521937.4A GB9521937D0 (en) | 1995-01-31 | 1995-10-26 | Improvementsin and relating to carrier particles for use in dry powder inhailers |
| GB9521937 | 1995-10-26 | ||
| GB9600215 | 1996-01-31 | ||
| PCT/GB1996/000215 WO1996023485A1 (en) | 1995-01-31 | 1996-01-31 | Carrier particles for use in dry powder inhalers |
Publications (3)
| Publication Number | Publication Date |
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| FI973151A0 FI973151A0 (sv) | 1997-07-30 |
| FI973151A FI973151A (sv) | 1997-09-30 |
| FI119676B true FI119676B (sv) | 2009-02-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI973151A FI119676B (sv) | 1995-01-31 | 1997-07-30 | Pulver för användning i en torrpulverinhalator |
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| EP (6) | EP2213279A3 (sv) |
| JP (1) | JP4042867B2 (sv) |
| KR (1) | KR100500694B1 (sv) |
| CN (1) | CN1303974C (sv) |
| AT (3) | ATE256450T1 (sv) |
| AU (1) | AU699131B2 (sv) |
| BG (1) | BG101858A (sv) |
| BR (3) | BRPI9612950B8 (sv) |
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| CZ (1) | CZ294259B6 (sv) |
| DE (2) | DE69631119T2 (sv) |
| DK (3) | DK1666023T3 (sv) |
| EA (1) | EA000352B1 (sv) |
| EE (1) | EE9700176A (sv) |
| ES (3) | ES2278828T3 (sv) |
| FI (1) | FI119676B (sv) |
| GB (2) | GB9501841D0 (sv) |
| GE (1) | GEP19991687B (sv) |
| HK (1) | HK1084897A1 (sv) |
| HU (1) | HU229965B1 (sv) |
| IS (1) | IS4531A (sv) |
| MX (1) | MX9705847A (sv) |
| NO (1) | NO324037B1 (sv) |
| NZ (1) | NZ300654A (sv) |
| PL (1) | PL186757B1 (sv) |
| PT (3) | PT806938E (sv) |
| SI (2) | SI1666023T1 (sv) |
| SK (1) | SK282630B6 (sv) |
| TR (1) | TR199700722T1 (sv) |
| UA (1) | UA61051C2 (sv) |
| WO (1) | WO1996023485A1 (sv) |
| ZA (1) | ZA96721B (sv) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6743777B1 (en) * | 1992-03-19 | 2004-06-01 | Eli Lilly And Company | Cyclic peptide antifungal agents and process for preparation thereof |
| GB9322014D0 (en) * | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9501841D0 (en) * | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9515182D0 (en) * | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| AUPN661995A0 (en) | 1995-11-16 | 1995-12-07 | Memtec America Corporation | Electrochemical cell 2 |
| US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5871010A (en) * | 1996-06-10 | 1999-02-16 | Sarnoff Corporation | Inhaler apparatus with modified surfaces for enhanced release of dry powders |
| US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
| GB9806477D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Improved crystals |
| US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| US20070212422A1 (en) * | 1999-11-10 | 2007-09-13 | Manfred Keller | Dry powder for inhalation |
| CZ303154B6 (cs) * | 1998-11-13 | 2012-05-09 | Jagotec Ag | Suchá prášková formulace k inhalaci obsahující stearát horecnatý |
| GB9827145D0 (en) | 1998-12-09 | 1999-02-03 | Co Ordinated Drug Dev | Improvements in or relating to powders |
| AU776782C (en) * | 1999-03-03 | 2005-04-07 | Eli Lilly And Company | Echinocandin pharmaceutical formulations containing micelle-forming surfactants |
| RU2001126723A (ru) * | 1999-03-03 | 2003-09-27 | Эли Лилли энд Компани (US) | Эхинокандин/углеводные комплексы |
| ATE363892T1 (de) | 1999-03-05 | 2007-06-15 | Chiesi Farma Spa | Verbesserte pulverformulierungen zur inhalation |
| IT1309592B1 (it) * | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| ITMI991582A1 (it) | 1999-07-16 | 2001-01-16 | Chiesi Farma Spa | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
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| GB9501841D0 (en) * | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| GB9515182D0 (en) * | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| ATE363892T1 (de) * | 1999-03-05 | 2007-06-15 | Chiesi Farma Spa | Verbesserte pulverformulierungen zur inhalation |
| PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| GB0009469D0 (en) * | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formalities for use in inhaler devices |
| EP1913939B1 (en) * | 2000-06-27 | 2017-05-31 | Vectura Limited | Formulations for use in inhaler devices |
| JP3486405B2 (ja) | 2001-08-10 | 2004-01-13 | 三菱重工業株式会社 | 減揺装置 |
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1995
- 1995-01-31 GB GBGB9501841.2A patent/GB9501841D0/en active Pending
- 1995-10-26 GB GBGB9521937.4A patent/GB9521937D0/en active Pending
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1996
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- 1996-01-31 DK DK06004066.4T patent/DK1666023T3/da active
- 1996-01-31 BR BRPI9612950A patent/BRPI9612950B8/pt unknown
- 1996-01-31 EP EP10075119A patent/EP2213279A3/en not_active Withdrawn
- 1996-01-31 AT AT96901439T patent/ATE256450T1/de active
- 1996-01-31 US US08/875,391 patent/US6153224A/en not_active Expired - Lifetime
- 1996-01-31 KR KR1019970705241A patent/KR100500694B1/ko active IP Right Grant
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- 1996-01-31 EP EP02007397A patent/EP1232745B1/en not_active Revoked
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- 1996-01-31 EP EP01120610A patent/EP1159955A1/en not_active Withdrawn
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- 1996-01-31 WO PCT/GB1996/000215 patent/WO1996023485A1/en active IP Right Grant
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1997
- 1997-07-25 IS IS4531A patent/IS4531A/is unknown
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- 1997-07-30 NO NO19973502A patent/NO324037B1/no not_active IP Right Cessation
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2000
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2002
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2005
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2006
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