ES2520841T3 - Procedimiento para la producción de partículas - Google Patents
Procedimiento para la producción de partículas Download PDFInfo
- Publication number
- ES2520841T3 ES2520841T3 ES04712610.7T ES04712610T ES2520841T3 ES 2520841 T3 ES2520841 T3 ES 2520841T3 ES 04712610 T ES04712610 T ES 04712610T ES 2520841 T3 ES2520841 T3 ES 2520841T3
- Authority
- ES
- Spain
- Prior art keywords
- substance
- particles
- production
- procedure
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 abstract 4
- 239000002904 solvent Substances 0.000 abstract 3
- 239000000443 aerosol Substances 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
- B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0081—Use of vibrations, e.g. ultrasound
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la producción de partículas que comprende las etapas de i) formación de una solución de una sustancia deseada en un disolvente adecuado; ii) generación de un aerosol a partir de la solución de dicha sustancia; iii) recogida de las gotículas de aerosol en un recipiente que contiene un no disolvente de dicha sustancia; y iv) aplicación de ultrasonidos a las gotículas dispersadas en el no disolvente para efectuar la cristalización de dicha sustancia.
Description
Claims (1)
-
imagen1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0304037A GB0304037D0 (en) | 2003-02-21 | 2003-02-21 | Process for the production of particles for use in pharmaceutical formulations |
GB0304037 | 2003-02-21 | ||
GB0313129A GB0313129D0 (en) | 2003-06-06 | 2003-06-06 | Process for the production of particles |
GB0313129 | 2003-06-06 | ||
PCT/GB2004/000654 WO2004073827A1 (en) | 2003-02-21 | 2004-02-19 | Process for the production of particles |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2520841T3 true ES2520841T3 (es) | 2014-11-11 |
Family
ID=32910470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES04712610.7T Expired - Lifetime ES2520841T3 (es) | 2003-02-21 | 2004-02-19 | Procedimiento para la producción de partículas |
Country Status (11)
Country | Link |
---|---|
US (2) | US20070065372A1 (es) |
EP (1) | EP1610878B1 (es) |
JP (1) | JP5154078B2 (es) |
CA (1) | CA2516733C (es) |
DK (1) | DK1610878T3 (es) |
ES (1) | ES2520841T3 (es) |
NO (1) | NO20053796L (es) |
PL (1) | PL224720B1 (es) |
PT (1) | PT1610878E (es) |
SI (1) | SI1610878T1 (es) |
WO (1) | WO2004073827A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006032018A2 (en) * | 2004-09-14 | 2006-03-23 | Battelle Memorial Institute | Highly-aqueous non-respirable aerosols containing biologically-active ingredients method of making and device therefor |
CA2617620A1 (en) | 2005-08-04 | 2007-02-08 | Vladimir Berentsveig | Improved aerosol |
GB0525852D0 (en) * | 2005-12-20 | 2006-02-01 | Accentus Plc | Crystallisation apparatus and process |
FR2897281B1 (fr) * | 2006-02-14 | 2009-01-23 | Saint Louis Inst | Procede de fabrication par nanocristallisation de composes energetiques ou inertes |
JP4597107B2 (ja) * | 2006-03-02 | 2010-12-15 | 三井金属鉱業株式会社 | 砒素含有体からの砒素除去方法及び砒素除去装置 |
GB0610090D0 (en) * | 2006-05-20 | 2006-06-28 | Price Robert | Particulate drug compositions and their uses |
AU2008210270B8 (en) | 2007-02-02 | 2012-04-26 | Saban Ventures Pty Limited | Membrane vapour concentrator |
GB0705159D0 (en) * | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
ES2310131B1 (es) * | 2007-06-04 | 2009-12-04 | INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" | Procedimiento de cristalizacion a partir de solucion. |
GB0711680D0 (en) * | 2007-06-18 | 2007-07-25 | Prosonix Ltd | Process |
GB0806873D0 (en) * | 2008-04-16 | 2008-05-21 | Breath Ltd | Steroid nebuliser formulation |
BRPI0915783A2 (pt) * | 2008-07-18 | 2018-05-22 | Prosonix Ltd | processo para aumentar a cristalinidade de pelo menos um material sólido, partícula, composição farmacêutica ou agroquímica , e, inalador |
WO2010097188A1 (en) | 2009-02-25 | 2010-09-02 | Chiesi Farmaceutici S.P.A. | Inhalation particles comprising a salt of carmoterol and a corticosteroid |
GB0914240D0 (en) | 2009-08-14 | 2009-09-30 | Breath Ltd | Steroid solvates |
GB0914231D0 (en) * | 2009-08-14 | 2009-09-30 | Breath Ltd | Dry powder inhaler formulations |
GB0918431D0 (en) | 2009-10-21 | 2009-12-09 | Prosonix Ltd | Process for improving crystallinity |
MY162391A (en) | 2010-04-01 | 2017-06-15 | Chiesi Farm Spa | Process for preparing carrier particles for dry powders for inhalation |
EP2500072A1 (en) | 2011-03-15 | 2012-09-19 | LEK Pharmaceuticals d.d. | A novel process of residual solvent removal |
CN102166504B (zh) * | 2011-03-22 | 2013-03-06 | 中国人民解放军第三0九医院 | 一种凝胶微球快速成型装置及方法 |
CN102350280B (zh) * | 2011-06-23 | 2013-06-05 | 中国人民解放军第三0九医院 | 具有超声波振动装置的静电液滴发生装置及应用其制备载药凝胶微球的方法 |
US9643996B2 (en) | 2011-11-04 | 2017-05-09 | Battelle Memorial Institute | Processes for producing protein microparticles |
US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
RU2663117C2 (ru) | 2012-05-08 | 2018-08-01 | Никокс Офтэлмикс, Инк. | Препараты гидрофобных терапевтических средств, способы их получения и применения |
US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
CN104721052A (zh) * | 2015-02-10 | 2015-06-24 | 武汉工程大学 | 一种纳米药物制备装置 |
US10583085B2 (en) | 2017-05-17 | 2020-03-10 | Chiesi Farmaceutici S.P.A. | Carrier particles for dry powder formulations for inhalation |
KR102092068B1 (ko) * | 2018-03-26 | 2020-03-23 | 중앙대학교 산학협력단 | 약물 결정의 제조를 위한 비용매를 이용한 결정화 장치 및 이를 이용한 약물 결정의 제조 방법 |
BR112021001402A2 (pt) | 2018-07-27 | 2021-04-27 | Chiesi Farmaceutici S.P.A. | novas partículas carreadoras para formulações de pó seco para inalação |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE99546T1 (de) * | 1989-05-01 | 1994-01-15 | Alkermes Inc | Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen. |
US5376386A (en) * | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
GB9501841D0 (en) * | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
SE9501384D0 (sv) * | 1995-04-13 | 1995-04-13 | Astra Ab | Process for the preparation of respirable particles |
US5874029A (en) * | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
DE19617085A1 (de) * | 1996-04-29 | 1997-10-30 | Bayer Ag | Verfahren zur Herstellung von feinstteiligen Kristallisationsprodukten |
JP3447042B2 (ja) * | 1997-07-23 | 2003-09-16 | フロイント産業株式会社 | 単一物質球形粒の製造方法 |
GB9828721D0 (en) * | 1998-12-24 | 1999-02-17 | Glaxo Group Ltd | Novel apparatus and process |
US6522582B1 (en) * | 1999-03-05 | 2003-02-18 | Xilinx, Inc. | Non-volatile memory array using gate breakdown structures |
JP3490015B2 (ja) * | 1999-03-11 | 2004-01-26 | 関西ティー・エル・オー株式会社 | 化学的耐久性に優れた放射性微小球及びその製造方法 |
FR2797875B1 (fr) * | 1999-08-26 | 2001-10-19 | Hoechst Marion Roussel Inc | Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques |
GB9925934D0 (en) * | 1999-11-03 | 1999-12-29 | Glaxo Group Ltd | Novel apparatus and process |
CH694686A5 (it) * | 2000-03-04 | 2005-06-15 | Eco2 Sa | Prodotto di micronizzazione di sostanze farmaceutiche. |
GB0008411D0 (en) * | 2000-04-05 | 2000-05-24 | Vectura Ltd | Pharmaceutical preparations and their manufacture |
AU2001254995A1 (en) * | 2000-05-15 | 2001-11-26 | Vectura Limited | Method of manufacturing particles |
PT1409101E (pt) | 2001-05-05 | 2006-07-31 | Accentus Plc | Formacao de pequenos cristais |
BR0309625A (pt) * | 2002-04-29 | 2005-03-08 | Bristol Myers Squibb Co | Sistema de cristalização que utiliza atomização |
GB0219815D0 (en) * | 2002-08-24 | 2002-10-02 | Accentus Plc | Preparation of small crystals |
-
2004
- 2004-02-19 DK DK04712610.7T patent/DK1610878T3/da active
- 2004-02-19 EP EP04712610.7A patent/EP1610878B1/en not_active Revoked
- 2004-02-19 SI SI200432196T patent/SI1610878T1/sl unknown
- 2004-02-19 US US10/546,433 patent/US20070065372A1/en not_active Abandoned
- 2004-02-19 WO PCT/GB2004/000654 patent/WO2004073827A1/en active Application Filing
- 2004-02-19 JP JP2006502296A patent/JP5154078B2/ja not_active Expired - Fee Related
- 2004-02-19 PT PT47126107T patent/PT1610878E/pt unknown
- 2004-02-19 ES ES04712610.7T patent/ES2520841T3/es not_active Expired - Lifetime
- 2004-02-19 PL PL378127A patent/PL224720B1/pl unknown
- 2004-02-19 CA CA2516733A patent/CA2516733C/en not_active Expired - Fee Related
-
2005
- 2005-08-11 NO NO20053796A patent/NO20053796L/no not_active Application Discontinuation
-
2016
- 2016-10-23 US US15/331,872 patent/US20170143632A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20170143632A1 (en) | 2017-05-25 |
PT1610878E (pt) | 2014-12-03 |
WO2004073827A1 (en) | 2004-09-02 |
NO20053796D0 (no) | 2005-08-11 |
JP5154078B2 (ja) | 2013-02-27 |
PL224720B1 (pl) | 2017-01-31 |
US20070065372A1 (en) | 2007-03-22 |
PL378127A1 (pl) | 2006-03-06 |
EP1610878A1 (en) | 2006-01-04 |
CA2516733A1 (en) | 2004-09-02 |
NO20053796L (no) | 2005-11-03 |
SI1610878T1 (sl) | 2015-02-27 |
EP1610878B1 (en) | 2014-09-03 |
JP2006519780A (ja) | 2006-08-31 |
DK1610878T3 (da) | 2014-12-01 |
CA2516733C (en) | 2011-09-27 |
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