ES2422433T3 - Procedimiento para la preparación de partículas esféricas a partir de una sustancia farmacéutica - Google Patents

Procedimiento para la preparación de partículas esféricas a partir de una sustancia farmacéutica

Info

Publication number
ES2422433T3
ES2422433T3 ES06776684T ES06776684T ES2422433T3 ES 2422433 T3 ES2422433 T3 ES 2422433T3 ES 06776684 T ES06776684 T ES 06776684T ES 06776684 T ES06776684 T ES 06776684T ES 2422433 T3 ES2422433 T3 ES 2422433T3
Authority
ES
Spain
Prior art keywords
particles
pharmaceutical substance
melt
procedure
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06776684T
Other languages
English (en)
Inventor
Michael Jacob
Annette Grave
Reinhard Nowak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glatt GmbH
Original Assignee
Glatt GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37650014&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2422433(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glatt GmbH filed Critical Glatt GmbH
Application granted granted Critical
Publication of ES2422433T3 publication Critical patent/ES2422433T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/16—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by suspending the powder material in a gas, e.g. in fluidised beds or as a falling curtain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Procedimiento para la preparación de partículas con una proporción de longitud-anchura inferior a 1,4, especialmenteinferior a 1,3, preferentemente inferior a 1,2, aún más preferentemente inferior a 1,1 y en particular inferior a 1,05, a partirde una sustancia farmacéutica, que comprende las siguientes etapas: (a) proporcionar una masa fundida de la sustancia farmacéutica; (b) generar gotas de la masa fundida mediante rociado en un espacio de procedimiento; (c) pasar repetidamente partículas sólidas por gotas rociadas en el espacio de procedimiento con ayuda de unchorro de gas de procedimiento dirigido de manera definida, cuya temperatura está determinada dependiendodel punto de solidificación de la masa fundida, de modo que al menos una parte de las gotas entre en contactocon partículas y solidifique en éstas; (d) extraer partículas del espacio de procedimiento dependiendo del tamaño de partícula.
ES06776684T 2005-08-09 2006-08-08 Procedimiento para la preparación de partículas esféricas a partir de una sustancia farmacéutica Active ES2422433T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005037630A DE102005037630A1 (de) 2005-08-09 2005-08-09 Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung
PCT/EP2006/007848 WO2007017254A2 (de) 2005-08-09 2006-08-08 Verfahren zur herstellung von teilchen aus pharmazeutischen substanzen, kollektiven von diesen teilchen sowie deren verwendung

Publications (1)

Publication Number Publication Date
ES2422433T3 true ES2422433T3 (es) 2013-09-11

Family

ID=37650014

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06776684T Active ES2422433T3 (es) 2005-08-09 2006-08-08 Procedimiento para la preparación de partículas esféricas a partir de una sustancia farmacéutica

Country Status (9)

Country Link
US (3) US8597685B2 (es)
EP (1) EP1915135B1 (es)
JP (1) JP5144513B2 (es)
DE (1) DE102005037630A1 (es)
DK (1) DK1915135T3 (es)
ES (1) ES2422433T3 (es)
PL (1) PL1915135T3 (es)
SI (1) SI1915135T1 (es)
WO (1) WO2007017254A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007012105A1 (de) * 2007-03-13 2008-09-18 Add Advanced Drug Delivery Technologies Ltd. Pellets enthaltend pharmazeutische Substanz, Verfahren zu deren Herstellung und deren Verwendung
CN101491483B (zh) * 2008-12-24 2011-12-28 烟台开发区博森制药机械有限公司 步进增压气冲微滴丸滴头
CN101518495B (zh) * 2009-03-26 2011-12-28 天津大学 一种振动破碎式滴丸机
US8754026B2 (en) 2010-09-27 2014-06-17 Basf Se Process for producing granules comprising one or more complexing agent salts
CA2809749A1 (en) 2010-09-27 2012-04-05 Basf Se Process for producing granules comprising one or more complexing agent salts
CN102078259A (zh) * 2010-12-29 2011-06-01 天津大学 一种制备均匀滴丸的设备及方法
EP2704696A1 (en) 2012-03-26 2014-03-12 Glatt AG Taste-masked ibuprofen granules
FR2996454B1 (fr) * 2012-10-05 2015-01-09 Roquette Freres Procede de granulation de 1,4-3,6 dianhydrohexitols, granules obtenus et leurs utilisations
WO2017085295A1 (en) 2015-11-18 2017-05-26 Hermes Arzneimittel Gmbh Ibuprofen compositions for direct oral administration
US11312847B2 (en) 2018-04-10 2022-04-26 Celanese International Corporation Thermoplastic vulcanizate compositions
WO2020016658A2 (en) 2018-07-18 2020-01-23 Glatt Gmbh Immediate release formulations of cannabinoids
EP3721871A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
WO2021263132A1 (en) 2020-06-26 2021-12-30 Aprecia Pharmaceuticals LLC Rapidly-orodispersible tablets having an interior cavity
US11896719B2 (en) 2022-01-24 2024-02-13 Calliditas Therapeutics Ab Pharmaceutical compositions
WO2024025868A1 (en) * 2022-07-25 2024-02-01 Spraying Systems Co. Fluidized bed coating apparatus
CN117398913B (zh) * 2023-12-12 2024-02-06 博德生物技术（德州）有限公司 一种牛蒡黄精鹿宝肽片生产用造粒装置

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FR1275463A (fr) * 1960-09-28 1961-11-10 Potasse & Engrais Chimiques Perfectionnements à la granulation et au séchage de produits fluides
US3382093A (en) * 1965-11-22 1968-05-07 Battelle Development Corp Fluidized bed coating of fragile bodies
US4086346A (en) * 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
US4092089A (en) * 1974-04-06 1978-05-30 Bayer Aktiengesellschaft Apparatus for the preparation of melt-sprayed spherical phenacetin granules
JPS5392715A (en) * 1977-01-27 1978-08-15 Tsukishima Kikai Co Method of granulating urea and apraratus therefor
JPH0660189B2 (ja) 1986-01-22 1994-08-10 財団法人微生物化学研究会 ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノ−ス又はその誘導体とその製造法
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JPH0745011B2 (ja) * 1986-09-09 1995-05-17 フアルマトロニク アクチエンゲゼルシヤフト 粒子を凝集しかつ／又は該粒子を被覆するための方法と装置
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CA2569961A1 (en) * 2004-06-10 2005-12-29 Glatt Air Techniques, Inc Controlled release pharmaceutical formulation

Also Published As

Publication number Publication date
US20140054808A1 (en) 2014-02-27
US9050254B2 (en) 2015-06-09
PL1915135T3 (pl) 2013-09-30
US9119788B2 (en) 2015-09-01
US20140056985A1 (en) 2014-02-27
SI1915135T1 (sl) 2013-08-30
JP2009504212A (ja) 2009-02-05
EP1915135A2 (de) 2008-04-30
US8597685B2 (en) 2013-12-03
US20100152486A1 (en) 2010-06-17
WO2007017254A2 (de) 2007-02-15
JP5144513B2 (ja) 2013-02-13
DE102005037630A1 (de) 2007-02-15
EP1915135B1 (de) 2013-04-24
WO2007017254A3 (de) 2008-05-15
DK1915135T3 (da) 2013-07-29

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