FI115056B - Uusia välituotteena käytettäviä oksatsoliinisivuketjullisia taksaaneja ja menetelmä niiden valmistamiseksi - Google Patents

Uusia välituotteena käytettäviä oksatsoliinisivuketjullisia taksaaneja ja menetelmä niiden valmistamiseksi Download PDF

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Publication number
FI115056B
FI115056B FI943852A FI943852A FI115056B FI 115056 B FI115056 B FI 115056B FI 943852 A FI943852 A FI 943852A FI 943852 A FI943852 A FI 943852A FI 115056 B FI115056 B FI 115056B
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FI
Finland
Prior art keywords
mmol
ethyl acetate
solution
aryl
reaction mixture
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FI943852A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943852A0 (fi
FI943852A (fi
Inventor
John K Thottathil
Ivan D Trifunovich
David J Kucera
Shu-Hui Chen
Michael A Poss
Jianmei Wei
Jerome L Moniot
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Squibb Bristol Myers Co
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Publication of FI943852A0 publication Critical patent/FI943852A0/fi
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI943852A 1992-12-23 1994-08-22 Uusia välituotteena käytettäviä oksatsoliinisivuketjullisia taksaaneja ja menetelmä niiden valmistamiseksi FI115056B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99544392A 1992-12-23 1992-12-23
US99544392 1992-12-23
US9312173 1993-12-15
PCT/US1993/012173 WO1994014787A1 (en) 1992-12-23 1993-12-15 Novel sidechain-bearing taxanes and intermediates thereof

Publications (3)

Publication Number Publication Date
FI943852A0 FI943852A0 (fi) 1994-08-22
FI943852A FI943852A (fi) 1994-08-22
FI115056B true FI115056B (fi) 2005-02-28

Family

ID=25541806

Family Applications (2)

Application Number Title Priority Date Filing Date
FI943852A FI115056B (fi) 1992-12-23 1994-08-22 Uusia välituotteena käytettäviä oksatsoliinisivuketjullisia taksaaneja ja menetelmä niiden valmistamiseksi
FI20031464A FI20031464A (fi) 1992-12-23 2003-10-07 Uusia sivuketjullisia taksaaneja ja niiden välituotteita

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20031464A FI20031464A (fi) 1992-12-23 2003-10-07 Uusia sivuketjullisia taksaaneja ja niiden välituotteita

Country Status (22)

Country Link
EP (2) EP0626953A4 (de)
JP (2) JP3492690B2 (de)
KR (3) KR100327625B1 (de)
CN (4) CN1590386A (de)
AT (1) ATE309229T1 (de)
AU (3) AU679206B2 (de)
CA (1) CA2119261C (de)
CZ (1) CZ292993B6 (de)
DE (1) DE69333905T2 (de)
DK (1) DK1251127T3 (de)
ES (1) ES2252362T3 (de)
FI (2) FI115056B (de)
HK (1) HK1048310B (de)
HU (3) HU222175B1 (de)
IL (13) IL121542A (de)
NO (7) NO304521B1 (de)
NZ (1) NZ261070A (de)
PL (1) PL186176B1 (de)
RU (1) RU2125042C1 (de)
TW (1) TW247908B (de)
WO (1) WO1994014787A1 (de)
ZA (1) ZA939672B (de)

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US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
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US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5840929A (en) * 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
HU226325B1 (en) * 1995-09-12 2008-08-28 Cephalon Ltd Hydrolysis-promoting hydrophobic taxane derivatives, medicaments comprising them and the use of medicaments
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US5773629A (en) * 1996-06-14 1998-06-30 Industrial Technology Research Institute Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivative as taxol side-chain precursor
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
IL139218A0 (en) 1997-12-31 2001-11-25 Virginia Tech Intell Prop 2-aroyl-4-acyl-paclitaxel (taxol) analogs
DK1206461T3 (da) 1999-08-11 2004-08-16 Bristol Myers Squibb Co Fremgangsmåde til fremstilling af en paclitaxel C-4-methylcarbonatanalog
EP1391459A1 (de) * 1999-08-11 2004-02-25 Bristol-Myers Squibb Company Verfahren zur Herstellung eines Paclitaxel C-4 Methyl-Carbonat Analogen und Zwischenprodukte
AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
WO2002024178A2 (en) * 2000-09-22 2002-03-28 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
WO2002024179A2 (en) * 2000-09-22 2002-03-28 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
CN1688564A (zh) 2002-08-04 2005-10-26 天然医药品公司 用于将紫杉酰胺转化为紫杉醇或其他紫杉烷类化合物的方法及组合物
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
JP4499383B2 (ja) * 2003-07-11 2010-07-07 良明 木曽 水溶性プロドラッグ
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
TW200540164A (en) 2004-03-05 2005-12-16 Univ Florida State Res Found C7 lactyloxy-substituted taxanes
EP2428510A3 (de) 2005-03-31 2012-06-13 Accord Healthcare Inc. Herstellung von Taxanen aus 9-dehydro-13-acetylbaccatin III
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
WO2008122039A2 (en) 2007-04-02 2008-10-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selenocysteine mediated hybrid antibody molecules
CA2696856A1 (en) * 2007-08-22 2009-02-26 6570763 Canada Inc. Process for converting 9-dihydro-13-acetylbaccatin iii into docetaxel or paclitaxel
EA031986B1 (ru) 2012-04-04 2019-03-29 Галозим, Инк. Способ и комбинация для лечения солидной раковой опухоли и набор, содержащий комбинацию
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
CA2905509A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
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US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
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JP2503994B2 (ja) * 1986-09-02 1996-06-05 味の素株式会社 オキサゾリンカルボン酸誘導体及びその製造法
DE3825242A1 (de) * 1987-07-27 1989-02-09 Ciba Geigy Ag Durch schwefelhaltige gruppen substituierte histidinylamino-verbindungen
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
JP2847584B2 (ja) * 1991-06-21 1999-01-20 高砂香料工業株式会社 シクロヘキシル酪酸誘導体及びその製造法
HU226369B1 (en) * 1991-09-23 2008-09-29 Univ Florida State Process for preparing substituted isoserine-esters using metal alkoxides and beta-lactams
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NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater

Also Published As

Publication number Publication date
DE69333905D1 (de) 2005-12-15
CN1235973A (zh) 1999-11-24
CN1590386A (zh) 2005-03-09
NO973254L (no) 1994-08-16
CZ292993B6 (cs) 2004-01-14
AU715633B2 (en) 2000-02-10
NO20033865D0 (no) 2003-09-01
NO973253L (no) 1994-08-16
EP1251127A1 (de) 2002-10-23
EP0626953A1 (de) 1994-12-07
HK1048310B (zh) 2006-02-17
HU225294B1 (en) 2006-09-28
HUT75195A (en) 1997-04-28
CN1150178C (zh) 2004-05-19
PL186176B1 (pl) 2003-11-28
KR950700269A (ko) 1995-01-16
NO973256L (no) 1994-08-16
NO313802B1 (no) 2002-12-02
NO982744D0 (no) 1998-06-15
NO973255D0 (no) 1997-07-14
NO314355B1 (no) 2003-03-10
NO309426B1 (no) 2001-01-29
NZ261070A (en) 1997-10-24
CA2119261C (en) 2006-01-31
NO973253D0 (no) 1997-07-14
AU697836B2 (en) 1998-10-15
NO973254D0 (no) 1997-07-14
EP1251127B1 (de) 2005-11-09
AU679206B2 (en) 1997-06-26
HU222175B1 (hu) 2003-04-28
ES2252362T3 (es) 2006-05-16
IL121542A0 (en) 1998-02-08
DE69333905T2 (de) 2006-08-03
HU9401449D0 (en) 1994-09-28
CN1094725A (zh) 1994-11-09
NO943021D0 (no) 1994-08-16
NO304521B1 (no) 1999-01-04
KR100327625B1 (ko) 2002-11-07
CN1089761C (zh) 2002-08-28
IL122208A0 (en) 1998-04-05
CA2119261A1 (en) 1994-06-24
FI943852A0 (fi) 1994-08-22
IL121541A0 (en) 1998-02-08
EP0626953A4 (de) 1995-05-03
CN1230542A (zh) 1999-10-06
JPH07504444A (ja) 1995-05-18
IL108161A (en) 1999-03-12
NO20033865L (no) 1994-08-16
IL122209A0 (en) 1998-04-05
DK1251127T3 (da) 2006-03-06
JP3492690B2 (ja) 2004-02-03
ATE309229T1 (de) 2005-11-15
CZ146594A3 (en) 1995-06-14
HK1048310A1 (en) 2003-03-28
FI20031464A (fi) 2003-10-07
IL121540A (en) 2005-05-17
NO316071B1 (no) 2003-12-08
NO943021L (no) 1994-08-16
TW247908B (de) 1995-05-21
IL108161A0 (en) 1994-04-12
NO973256D0 (no) 1997-07-14
RU2125042C1 (ru) 1999-01-20
IL121540A0 (en) 1998-02-08
AU6014694A (en) 1994-07-19
NO982744L (no) 1994-08-16
IL121539A0 (en) 1998-02-08
IL145280A0 (en) 2002-06-30
IL121542A (en) 2001-03-19
KR100356448B1 (ko) 2002-10-19
IL121539A (en) 2004-07-25
AU3246397A (en) 1997-10-30
IL145280A (en) 2007-05-15
JP2003113166A (ja) 2003-04-18
ZA939672B (en) 1995-06-23
NO973255L (no) 1994-08-16
HU0203995D0 (en) 2003-04-28
AU3246497A (en) 1997-10-09
WO1994014787A1 (en) 1994-07-07
IL121541A (en) 2000-11-21
CN1109026C (zh) 2003-05-21
NO311217B1 (no) 2001-10-29
KR100378612B1 (ko) 2003-04-03
FI943852A (fi) 1994-08-22

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