FI113261B - Menetelmä terapeuttisesti käyttökelpoisten aromaattisten karboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten aromaattisten karboksyylihappojohdannaisten valmistamiseksi Download PDF

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Publication number
FI113261B
FI113261B FI944045A FI944045A FI113261B FI 113261 B FI113261 B FI 113261B FI 944045 A FI944045 A FI 944045A FI 944045 A FI944045 A FI 944045A FI 113261 B FI113261 B FI 113261B
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FI
Finland
Prior art keywords
tetramethyl
formula
tetrahydronaphthalen
methyl
vinyl
Prior art date
Application number
FI944045A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI944045A (fi
FI944045A0 (fi
Inventor
Michael Klaus
Peter Mohr
Original Assignee
Hoffmann La Roche
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Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI944045A0 publication Critical patent/FI944045A0/fi
Publication of FI944045A publication Critical patent/FI944045A/fi
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Publication of FI113261B publication Critical patent/FI113261B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/618—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI944045A 1993-09-02 1994-09-02 Menetelmä terapeuttisesti käyttökelpoisten aromaattisten karboksyylihappojohdannaisten valmistamiseksi FI113261B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH261893 1993-09-02
CH261893 1993-09-02
CH196094 1994-06-21
CH196094 1994-06-21

Publications (3)

Publication Number Publication Date
FI944045A0 FI944045A0 (fi) 1994-09-02
FI944045A FI944045A (fi) 1995-03-03
FI113261B true FI113261B (fi) 2004-03-31

Family

ID=25689113

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944045A FI113261B (fi) 1993-09-02 1994-09-02 Menetelmä terapeuttisesti käyttökelpoisten aromaattisten karboksyylihappojohdannaisten valmistamiseksi

Country Status (20)

Country Link
US (2) US5700836A (fr)
EP (1) EP0641759B1 (fr)
JP (1) JP2602629B2 (fr)
KR (1) KR100335540B1 (fr)
CN (1) CN1049423C (fr)
AT (1) ATE174322T1 (fr)
AU (1) AU680668B2 (fr)
CA (1) CA2129773C (fr)
CZ (1) CZ288426B6 (fr)
DE (1) DE59407431D1 (fr)
DK (1) DK0641759T3 (fr)
ES (1) ES2126684T3 (fr)
FI (1) FI113261B (fr)
GR (1) GR3029437T3 (fr)
HU (1) HU222345B1 (fr)
IL (1) IL110808A (fr)
NO (1) NO308579B1 (fr)
NZ (1) NZ264327A (fr)
RU (1) RU2130009C1 (fr)
UA (1) UA43317C2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
DE4320920C1 (de) * 1993-06-24 1994-06-16 Goldschmidt Ag Th Silane mit hydrophilen Gruppen, deren Herstellung und Verwendung als Tenside in wäßrigen Medien
FR2719041B1 (fr) * 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US7115728B1 (en) 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
ES2190479T3 (es) * 1995-10-06 2003-08-01 Ligand Pharm Inc Moduladores de rxr selectivos a dimeros y metodos para su uso.
WO1999005161A1 (fr) * 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated SEQUENCES REGULATRICES DU GENE HUMAIN PPARη (RECEPTEUR GAMMA ACTIVE DE LA PROLIFERATION DES PEROXYSOMES) ET LEURS UTILISATIONS
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of invasive diseases, using selected anti-PAR materials
KR100353310B1 (ko) * 2000-03-27 2002-09-18 송웅재 축조용 돌묘
KR100385492B1 (ko) * 2000-08-10 2003-05-27 주식회사 지오지 파이프 연결 소켓 제조 방법
BRPI0114344B8 (pt) * 2000-10-02 2021-05-25 Hoffmann La Roche composto retinóide, seu uso, sua composição farmacêutica e seu processo de preparação
EP1935869A1 (fr) * 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoides destines au traitement de l'emphyseme
MXPA04000695A (es) * 2001-07-23 2005-08-26 Galileo Pharmaceuticals Inc Compuestos citoprotectores, formulaciones farmaceuticas y cosmeticas y metodos.
AU2005214971A1 (en) * 2004-02-17 2005-09-01 Dynamis Therapeutics, Inc. Fructoseamine 3 kinase and the formation of collagen and elastin
JP4683858B2 (ja) 2004-05-14 2011-05-18 スリーエム イノベイティブ プロパティズ カンパニー 物品支持具
BR112012004699B1 (pt) 2009-09-03 2019-10-15 Becton, Dickinson And Company Métodos, composições e kits para lise química direta
WO2012030919A2 (fr) 2010-09-01 2012-03-08 Thomas Jefferson University Composition et méthode de réparation et de régénération musculaires
WO2012076842A1 (fr) * 2010-12-09 2012-06-14 University Of Durham Rétinoïdes synthétiques pour le contrôle de la différenciation des cellules
US20140155381A1 (en) * 2011-07-29 2014-06-05 Erkan Baloglu Compounds and methods

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77254A1 (fr) * 1977-05-04 1979-01-18
US4326055A (en) * 1977-12-22 1982-04-20 Hoffmann-La Roche Inc. Stilbene derivatives
DK159967C (da) * 1977-12-22 1991-06-03 Hoffmann La Roche Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater
DE3202100A1 (de) * 1982-01-23 1983-08-04 Basf Ag, 6700 Ludwigshafen Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
ZA854828B (en) * 1984-07-27 1986-03-26 Hoffmann La Roche Phenyl nonatetraenoic acid derivatives
CH667868A5 (fr) * 1984-09-05 1988-11-15 Oreal Derives du benzonorbornene, leurs procedes de preparation et compositions medicamenteuse et cosmetique les contenant.
DE3434944A1 (de) * 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen L-substituierte tetralinderivate, ihre herstellung und verwendung
US4889847A (en) * 1986-11-03 1989-12-26 Ortho Pharmaceutical Corporation Prevention of glucocorticoid-induced skin atrophy
US5019569A (en) * 1986-11-03 1991-05-28 Ortho Pharmaceutical Corporation Reversal of glucocorticoid-induced skin atrophy
CA1298309C (fr) * 1987-11-06 1992-03-31 Michael Klaus Derives du benzocyclooctene
ATE256653T1 (de) * 1992-04-22 2004-01-15 Ligand Pharm Inc Verbindungen mit retinoid x receptorselektivität
US5324840A (en) * 1992-06-11 1994-06-28 Allergan, Inc. Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects
AU5664294A (en) * 1993-01-11 1995-02-28 Ligand Pharmaceuticals, Inc. Compounds having selective activity for retinoid x receptors, and means for modulation of processes mediated by retinoid x receptors

Also Published As

Publication number Publication date
GR3029437T3 (en) 1999-05-28
IL110808A0 (en) 1994-11-11
IL110808A (en) 2003-03-12
CN1049423C (zh) 2000-02-16
AU680668B2 (en) 1997-08-07
DK0641759T3 (da) 1999-08-16
US6610877B1 (en) 2003-08-26
AU7148694A (en) 1995-03-16
CN1105981A (zh) 1995-08-02
JPH07112952A (ja) 1995-05-02
FI944045A (fi) 1995-03-03
CA2129773C (fr) 2007-05-01
NO943232L (no) 1995-03-03
JP2602629B2 (ja) 1997-04-23
HU222345B1 (hu) 2003-06-28
HUT71473A (en) 1995-11-28
HU9402480D0 (en) 1994-10-28
US5700836A (en) 1997-12-23
KR100335540B1 (ko) 2002-10-25
RU94031754A (ru) 1996-07-20
NO943232D0 (no) 1994-09-01
ES2126684T3 (es) 1999-04-01
KR950008468A (ko) 1995-04-17
NO308579B1 (no) 2000-10-02
EP0641759B1 (fr) 1998-12-09
EP0641759A1 (fr) 1995-03-08
CZ210594A3 (en) 1995-06-14
UA43317C2 (uk) 2001-12-17
CZ288426B6 (en) 2001-06-13
FI944045A0 (fi) 1994-09-02
ATE174322T1 (de) 1998-12-15
DE59407431D1 (de) 1999-01-21
NZ264327A (en) 1996-02-27
RU2130009C1 (ru) 1999-05-10
CA2129773A1 (fr) 1995-03-03

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