KR950008468A - 방향족 카복실산 유도체 - Google Patents
방향족 카복실산 유도체 Download PDFInfo
- Publication number
- KR950008468A KR950008468A KR1019940021952A KR19940021952A KR950008468A KR 950008468 A KR950008468 A KR 950008468A KR 1019940021952 A KR1019940021952 A KR 1019940021952A KR 19940021952 A KR19940021952 A KR 19940021952A KR 950008468 A KR950008468 A KR 950008468A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- formula
- together form
- carboxylic acid
- acid derivatives
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
- C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
- C07C69/618—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
하기 일반식 (I)의 화합물은 약제, 구체적으로는 피부학적 및 종양학적 적용에 사용될 수 있다:
상기 식에서, R1은 상기 일반식(a) 또는 (b)의 잔기이고, R2-R10은 본 명세서에서 정의한 바와 같다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 하기 일반식 (I)의 화합물 및 일반식 (I)의 카복실산의 약학적으로 허용가능한 염:상기식에서, R1은 하기 일반식 (a) 또는 (b)의 잔기를 의미하고:R2는 C2-8-알카노일, C2-8-알킬, C2-8-알케닐, C2-8-알키닐 또는 -OCH2R3을 의미하고; R3은 수소, C1-6-알킬, C2-6-알케닐 또는 C2-6-알키닐을 의미하고; R4내지 R9는 각각 독립적으로 수소 또는 C1-5-알킬을 의미하거나; 또는 R8및 R9는 함께 (CRaRb)n를 형성하고, Ra및 Rb는 수소 또는 C1-5-알킬을 의미하고, n은 1, 2 또는 3을 의미하고, R4내지 R7은 상기 정의한 바와 같거나; 또는 R8및 R9는 함께 (CRaRb)n를 형성하고, R4및 R6은 함께 하이드록시에 의해 치환될 수 있는 메틸렌 또는 에틸렌을 형성하고, Ra, Rb, R5, R7및 n은 상기 정의한 바와 같고; R10은 카복실, C1-6-알콕시카보닐 또는 모노-또는 디-(C1-6-알킬)카바모일을 의미하고 일반식 (a)중의 점선으로 된 결합은 선택적이다.
- 제1항의 화합물 및 유용한 약학적 담체를 함유하는, 약학적 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH2618/93 | 1993-09-02 | ||
CH261893 | 1993-09-02 | ||
CH196094 | 1994-06-21 | ||
CH1960/94 | 1994-06-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR950008468A true KR950008468A (ko) | 1995-04-17 |
KR100335540B1 KR100335540B1 (ko) | 2002-10-25 |
Family
ID=25689113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940021952A KR100335540B1 (ko) | 1993-09-02 | 1994-09-01 | 방향족카복실산유도체및이를포함하는약학적제제 |
Country Status (20)
Country | Link |
---|---|
US (2) | US5700836A (ko) |
EP (1) | EP0641759B1 (ko) |
JP (1) | JP2602629B2 (ko) |
KR (1) | KR100335540B1 (ko) |
CN (1) | CN1049423C (ko) |
AT (1) | ATE174322T1 (ko) |
AU (1) | AU680668B2 (ko) |
CA (1) | CA2129773C (ko) |
CZ (1) | CZ288426B6 (ko) |
DE (1) | DE59407431D1 (ko) |
DK (1) | DK0641759T3 (ko) |
ES (1) | ES2126684T3 (ko) |
FI (1) | FI113261B (ko) |
GR (1) | GR3029437T3 (ko) |
HU (1) | HU222345B1 (ko) |
IL (1) | IL110808A (ko) |
NO (1) | NO308579B1 (ko) |
NZ (1) | NZ264327A (ko) |
RU (1) | RU2130009C1 (ko) |
UA (1) | UA43317C2 (ko) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100353310B1 (ko) * | 2000-03-27 | 2002-09-18 | 송웅재 | 축조용 돌묘 |
KR100385492B1 (ko) * | 2000-08-10 | 2003-05-27 | 주식회사 지오지 | 파이프 연결 소켓 제조 방법 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7655699B1 (en) | 1992-04-22 | 2010-02-02 | Eisai Inc. | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors |
DE4320920C1 (de) * | 1993-06-24 | 1994-06-16 | Goldschmidt Ag Th | Silane mit hydrophilen Gruppen, deren Herstellung und Verwendung als Tenside in wäßrigen Medien |
FR2719041B1 (fr) * | 1994-04-26 | 1996-05-31 | Cird Galderma | Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
US7115728B1 (en) * | 1995-01-30 | 2006-10-03 | Ligand Pharmaceutical Incorporated | Human peroxisome proliferator activated receptor γ |
KR100625255B1 (ko) * | 1995-10-06 | 2008-01-30 | 리간드 파마슈티칼스 인코포레이티드 | 다이머-선택적rxr변조물질및그의사용방법 |
AU8588798A (en) | 1997-07-25 | 1999-02-16 | Institut Pasteur | Human peroxisome proliferator activated receptor gamma (ppargamma) gene re gulatory sequences and uses therefor |
JO2178B1 (en) * | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of invasive diseases, using selected anti-PAR materials |
ATE413375T1 (de) * | 2000-10-02 | 2008-11-15 | Hoffmann La Roche | Retinoide zur behandlung von emphysem |
EP1935869A1 (en) * | 2000-10-02 | 2008-06-25 | F. Hoffmann-La Roche Ag | Retinoids for the treatment of emphysema |
JP4425628B2 (ja) * | 2001-07-23 | 2010-03-03 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | 細胞保護化合物、薬学的処方物および美容用処方物、ならびに方法 |
WO2005079463A2 (en) * | 2004-02-17 | 2005-09-01 | Dynamis Therapeutics, Inc. | Fructoseamine 3 kinase and the formation of collagen and elastin |
JP4683858B2 (ja) | 2004-05-14 | 2011-05-18 | スリーエム イノベイティブ プロパティズ カンパニー | 物品支持具 |
EP2473596B1 (en) | 2009-09-03 | 2017-12-13 | Becton, Dickinson and Company | Methods and compositions for direct chemical lysis |
EP2613776B1 (en) | 2010-09-01 | 2020-07-29 | Thomas Jefferson University | Composition and method for muscle repair and regeneration |
WO2012076842A1 (en) * | 2010-12-09 | 2012-06-14 | University Of Durham | Synthetic retinoids for control of cell differentiation |
EP2736332A4 (en) * | 2011-07-29 | 2015-03-18 | Tempero Pharmaceuticals Inc | CONNECTIONS AND METHODS |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU77254A1 (ko) * | 1977-05-04 | 1979-01-18 | ||
DK159967C (da) * | 1977-12-22 | 1991-06-03 | Hoffmann La Roche | Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater |
US4326055A (en) * | 1977-12-22 | 1982-04-20 | Hoffmann-La Roche Inc. | Stilbene derivatives |
DE3202100A1 (de) * | 1982-01-23 | 1983-08-04 | Basf Ag, 6700 Ludwigshafen | Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
ZA854828B (en) * | 1984-07-27 | 1986-03-26 | Hoffmann La Roche | Phenyl nonatetraenoic acid derivatives |
US4783549A (en) * | 1984-09-05 | 1988-11-08 | L'oreal | Benzonorbornene derivatives, processes for their preparation and medicinal and cosmetic compositions containing them |
DE3434944A1 (de) * | 1984-09-22 | 1986-04-03 | Basf Ag, 6700 Ludwigshafen | L-substituierte tetralinderivate, ihre herstellung und verwendung |
US4889847A (en) * | 1986-11-03 | 1989-12-26 | Ortho Pharmaceutical Corporation | Prevention of glucocorticoid-induced skin atrophy |
US5019569A (en) * | 1986-11-03 | 1991-05-28 | Ortho Pharmaceutical Corporation | Reversal of glucocorticoid-induced skin atrophy |
CA1298309C (en) * | 1987-11-06 | 1992-03-31 | Michael Klaus | Benzocycloheptene derivatives |
ATE307795T1 (de) * | 1992-04-22 | 2005-11-15 | Ligand Pharm Inc | Verbindungen mit retinoid x rezeptorselektivität |
US5324840A (en) * | 1992-06-11 | 1994-06-28 | Allergan, Inc. | Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects |
WO1995004036A1 (en) * | 1993-01-11 | 1995-02-09 | Ligand Pharmaceuticals Inc. | Compounds having selective activity for retinoid x receptors, and means for modulation of processes mediated by retinoid x receptors |
-
1994
- 1994-08-09 CA CA002129773A patent/CA2129773C/en not_active Expired - Fee Related
- 1994-08-18 DK DK94112886T patent/DK0641759T3/da active
- 1994-08-18 DE DE59407431T patent/DE59407431D1/de not_active Expired - Fee Related
- 1994-08-18 AT AT94112886T patent/ATE174322T1/de not_active IP Right Cessation
- 1994-08-18 ES ES94112886T patent/ES2126684T3/es not_active Expired - Lifetime
- 1994-08-18 EP EP94112886A patent/EP0641759B1/de not_active Expired - Lifetime
- 1994-08-25 AU AU71486/94A patent/AU680668B2/en not_active Ceased
- 1994-08-29 NZ NZ264327A patent/NZ264327A/en unknown
- 1994-08-29 HU HU9402480A patent/HU222345B1/hu not_active IP Right Cessation
- 1994-08-29 IL IL11080894A patent/IL110808A/xx not_active IP Right Cessation
- 1994-08-29 JP JP6203653A patent/JP2602629B2/ja not_active Expired - Fee Related
- 1994-09-01 UA UA94095764A patent/UA43317C2/uk unknown
- 1994-09-01 CZ CZ19942105A patent/CZ288426B6/cs not_active IP Right Cessation
- 1994-09-01 KR KR1019940021952A patent/KR100335540B1/ko not_active IP Right Cessation
- 1994-09-01 RU RU94031754A patent/RU2130009C1/ru not_active IP Right Cessation
- 1994-09-01 NO NO943232A patent/NO308579B1/no unknown
- 1994-09-01 CN CN94115650A patent/CN1049423C/zh not_active Expired - Fee Related
- 1994-09-02 FI FI944045A patent/FI113261B/fi active
-
1996
- 1996-10-21 US US08/734,222 patent/US5700836A/en not_active Expired - Fee Related
-
1997
- 1997-08-01 US US08/904,522 patent/US6610877B1/en not_active Expired - Fee Related
-
1999
- 1999-02-17 GR GR990400520T patent/GR3029437T3/el unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100353310B1 (ko) * | 2000-03-27 | 2002-09-18 | 송웅재 | 축조용 돌묘 |
KR100385492B1 (ko) * | 2000-08-10 | 2003-05-27 | 주식회사 지오지 | 파이프 연결 소켓 제조 방법 |
Also Published As
Publication number | Publication date |
---|---|
HU222345B1 (hu) | 2003-06-28 |
NO308579B1 (no) | 2000-10-02 |
KR100335540B1 (ko) | 2002-10-25 |
US6610877B1 (en) | 2003-08-26 |
ATE174322T1 (de) | 1998-12-15 |
RU2130009C1 (ru) | 1999-05-10 |
EP0641759B1 (de) | 1998-12-09 |
IL110808A0 (en) | 1994-11-11 |
DE59407431D1 (de) | 1999-01-21 |
NO943232L (no) | 1995-03-03 |
CZ288426B6 (en) | 2001-06-13 |
JPH07112952A (ja) | 1995-05-02 |
CA2129773A1 (en) | 1995-03-03 |
FI113261B (fi) | 2004-03-31 |
JP2602629B2 (ja) | 1997-04-23 |
GR3029437T3 (en) | 1999-05-28 |
RU94031754A (ru) | 1996-07-20 |
CN1049423C (zh) | 2000-02-16 |
NO943232D0 (no) | 1994-09-01 |
DK0641759T3 (da) | 1999-08-16 |
CZ210594A3 (en) | 1995-06-14 |
IL110808A (en) | 2003-03-12 |
AU680668B2 (en) | 1997-08-07 |
US5700836A (en) | 1997-12-23 |
HU9402480D0 (en) | 1994-10-28 |
NZ264327A (en) | 1996-02-27 |
FI944045A0 (fi) | 1994-09-02 |
ES2126684T3 (es) | 1999-04-01 |
FI944045A (fi) | 1995-03-03 |
AU7148694A (en) | 1995-03-16 |
EP0641759A1 (de) | 1995-03-08 |
CN1105981A (zh) | 1995-08-02 |
CA2129773C (en) | 2007-05-01 |
HUT71473A (en) | 1995-11-28 |
UA43317C2 (uk) | 2001-12-17 |
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