HUT71473A - Aromatic carboxylic acid derivatives, pharmaceutical compns. contg. them and process to prepare the said compds. - Google Patents

Aromatic carboxylic acid derivatives, pharmaceutical compns. contg. them and process to prepare the said compds.

Info

Publication number
HUT71473A
HUT71473A HU9402480A HU9402480A HUT71473A HU T71473 A HUT71473 A HU T71473A HU 9402480 A HU9402480 A HU 9402480A HU 9402480 A HU9402480 A HU 9402480A HU T71473 A HUT71473 A HU T71473A
Authority
HU
Hungary
Prior art keywords
compds
contg
prepare
carboxylic acid
acid derivatives
Prior art date
Application number
HU9402480A
Other languages
Hungarian (hu)
Other versions
HU9402480D0 (en
HU222345B1 (en
Inventor
Peter Mohr
Michael Klaus
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HU9402480D0 publication Critical patent/HU9402480D0/en
Publication of HUT71473A publication Critical patent/HUT71473A/en
Publication of HU222345B1 publication Critical patent/HU222345B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/618—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compounds of the formula <IMAGE> wherein R<1> is a radical of the formulae <IMAGE> and R<2>-R<10> have the meaning mentioned in the description, can be used as medicaments, particularly for dermatological and oncological indications.
HU9402480A 1993-09-02 1994-08-29 Aromatic carboxylic acid derivatives and pharmaceutical compositions containing them HU222345B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH261893 1993-09-02
CH196094 1994-06-21

Publications (3)

Publication Number Publication Date
HU9402480D0 HU9402480D0 (en) 1994-10-28
HUT71473A true HUT71473A (en) 1995-11-28
HU222345B1 HU222345B1 (en) 2003-06-28

Family

ID=25689113

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9402480A HU222345B1 (en) 1993-09-02 1994-08-29 Aromatic carboxylic acid derivatives and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (2) US5700836A (en)
EP (1) EP0641759B1 (en)
JP (1) JP2602629B2 (en)
KR (1) KR100335540B1 (en)
CN (1) CN1049423C (en)
AT (1) ATE174322T1 (en)
AU (1) AU680668B2 (en)
CA (1) CA2129773C (en)
CZ (1) CZ288426B6 (en)
DE (1) DE59407431D1 (en)
DK (1) DK0641759T3 (en)
ES (1) ES2126684T3 (en)
FI (1) FI113261B (en)
GR (1) GR3029437T3 (en)
HU (1) HU222345B1 (en)
IL (1) IL110808A (en)
NO (1) NO308579B1 (en)
NZ (1) NZ264327A (en)
RU (1) RU2130009C1 (en)
UA (1) UA43317C2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
DE4320920C1 (en) * 1993-06-24 1994-06-16 Goldschmidt Ag Th New silane cpds. used as surfactant in aq. media - comprise ether and hydrophilic gps., and are stable against hydrolysis in acid and alkali
FR2719041B1 (en) * 1994-04-26 1996-05-31 Cird Galderma New polyene compounds, pharmaceutical and cosmetic compositions containing them and uses.
US7115728B1 (en) 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
WO1997012853A1 (en) * 1995-10-06 1997-04-10 Ligand Pharmaceuticals Incorporated Dimer-selective rxr modulators and methods for their use
WO1999005161A1 (en) * 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
JO2178B1 (en) 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of emphysema using rar selective retinoid antagonists
KR100353310B1 (en) * 2000-03-27 2002-09-18 송웅재 A stone-tomb for constructing
KR100385492B1 (en) * 2000-08-10 2003-05-27 주식회사 지오지 Method of manufacturing a pipe connecting socket
DK1324970T3 (en) * 2000-10-02 2009-01-05 Hoffmann La Roche Retinoids for the treatment of emphysema
EP1935869A1 (en) * 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoids for the treatment of emphysema
EP1435894A4 (en) * 2001-07-23 2005-07-06 Galileo Pharmaceuticals Inc CYTOPROTECTIVE COMPOUNDS, METHODS AND PHARMACEUTICAL AND COSMETIC FORMULATIONS
EP1753861A4 (en) * 2004-02-17 2010-03-10 Dynamis Therapeutics Inc Fructoseamine 3 kinase and the formation of collagen and elastin
JP4683858B2 (en) 2004-05-14 2011-05-18 スリーエム イノベイティブ プロパティズ カンパニー Article support
CN102575220B (en) 2009-09-03 2015-09-16 贝克顿·迪金森公司 Methods and compositions for direct chemical lysis
HUE051664T2 (en) 2010-09-01 2021-03-29 Univ Jefferson Composition and method for muscle repair and regeneration
WO2012076842A1 (en) * 2010-12-09 2012-06-14 University Of Durham Synthetic retinoids for control of cell differentiation
WO2013019626A1 (en) * 2011-07-29 2013-02-07 Tempero Pharmaceuticals, Inc. Compounds and methods

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77254A1 (en) * 1977-05-04 1979-01-18
US4326055A (en) * 1977-12-22 1982-04-20 Hoffmann-La Roche Inc. Stilbene derivatives
DK159967C (en) * 1977-12-22 1991-06-03 Hoffmann La Roche ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE STYLE BENDER DERIVATIVES
DE3202100A1 (en) * 1982-01-23 1983-08-04 Basf Ag, 6700 Ludwigshafen SUBSTITUTED 4-HYDROXYANILIDES, ITS PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
ZA854828B (en) * 1984-07-27 1986-03-26 Hoffmann La Roche Phenyl nonatetraenoic acid derivatives
CH667868A5 (en) * 1984-09-05 1988-11-15 Oreal BENZONORBORNENE DERIVATIVES, PREPARATION METHODS THEREOF, AND MEDICINAL AND COSMETIC COMPOSITIONS CONTAINING THEM.
DE3434944A1 (en) * 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen L-SUBSTITUTED TETRALIN DERIVATIVES, THEIR PRODUCTION AND USE
SU1395139A3 (en) * 1984-09-29 1988-05-07 Байер Аг (Фирма) Method of producing derivatives of acrylic acid
US5019569A (en) * 1986-11-03 1991-05-28 Ortho Pharmaceutical Corporation Reversal of glucocorticoid-induced skin atrophy
US4889847A (en) * 1986-11-03 1989-12-26 Ortho Pharmaceutical Corporation Prevention of glucocorticoid-induced skin atrophy
CA1298309C (en) * 1987-11-06 1992-03-31 Michael Klaus Benzocycloheptene derivatives
ATE195716T1 (en) * 1992-04-22 2000-09-15 Ligand Pharm Inc RETINOID-X RECEPTOR SELECTIVE COMPOUNDS
US5324840A (en) * 1992-06-11 1994-06-28 Allergan, Inc. Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects
CA2153236A1 (en) * 1993-01-11 1995-02-09 Marcus F. Boehm Compounds having selective activity for retinoid x receptors, and means for modulation of processes mediated by retinoid x receptors

Also Published As

Publication number Publication date
FI113261B (en) 2004-03-31
KR100335540B1 (en) 2002-10-25
GR3029437T3 (en) 1999-05-28
CA2129773C (en) 2007-05-01
ATE174322T1 (en) 1998-12-15
CN1049423C (en) 2000-02-16
AU7148694A (en) 1995-03-16
NO943232L (en) 1995-03-03
IL110808A0 (en) 1994-11-11
CA2129773A1 (en) 1995-03-03
AU680668B2 (en) 1997-08-07
FI944045A0 (en) 1994-09-02
HU9402480D0 (en) 1994-10-28
JP2602629B2 (en) 1997-04-23
UA43317C2 (en) 2001-12-17
CZ210594A3 (en) 1995-06-14
CN1105981A (en) 1995-08-02
NO943232D0 (en) 1994-09-01
FI944045L (en) 1995-03-03
EP0641759A1 (en) 1995-03-08
NZ264327A (en) 1996-02-27
US5700836A (en) 1997-12-23
EP0641759B1 (en) 1998-12-09
KR950008468A (en) 1995-04-17
DE59407431D1 (en) 1999-01-21
CZ288426B6 (en) 2001-06-13
JPH07112952A (en) 1995-05-02
NO308579B1 (en) 2000-10-02
IL110808A (en) 2003-03-12
ES2126684T3 (en) 1999-04-01
HU222345B1 (en) 2003-06-28
US6610877B1 (en) 2003-08-26
DK0641759T3 (en) 1999-08-16
RU2130009C1 (en) 1999-05-10
RU94031754A (en) 1996-07-20

Similar Documents

Publication Publication Date Title
HUT71473A (en) Aromatic carboxylic acid derivatives, pharmaceutical compns. contg. them and process to prepare the said compds.
ATE149486T1 (en) SUBSTITUTED HETEROCYCLIC CARBOXYLIC AMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
AU697015B2 (en) Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals
FI96204C (en) Process for the preparation of therapeutically useful heterocyclic compounds
AU643489B2 (en) Antibacterial agents - II
AU7756694A (en) Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals
ZA934143B (en) 1,4-disubstituted piperazines, a process for their preparation and pharmaceutical compositions containing them
NZ242104A (en) Amides of aminoethylsubstituted benzothiazole, -thiazine, -oxazole and -oxazine derivatives; pharmaceutical compositions thereof
EP0614913A3 (en) Dynorphin derivatives.
AU1413788A (en) Dihydropyridinamides process for their preparation, and their use in medicaments
GR3020230T3 (en) Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments
WO1995022544A3 (en) Substituted 1,3,8-triaza-spiro(4,5)-decan-4-one derivatives useful as preliminary stages in the production of pharmaceuticals
DE59307401D1 (en) Alpha-aryl-alpha-hydroxy-beta-imidazolinyl propionic acid amides
AU4617193A (en) Heteroarenylpiperazines, a process for their preparation and their use as medicaments
EP0338494A3 (en) 3-anilino-2-hydroxycarbonyl-4-thiophen-acetic acids
EP0338493A3 (en) Tetrahydro-4-phenylimino-3-thiophen-acetic acids

Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20030408

MM4A Lapse of definitive patent protection due to non-payment of fees