GR3029437T3 - Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives. - Google Patents

Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives.

Info

Publication number
GR3029437T3
GR3029437T3 GR990400520T GR990400520T GR3029437T3 GR 3029437 T3 GR3029437 T3 GR 3029437T3 GR 990400520 T GR990400520 T GR 990400520T GR 990400520 T GR990400520 T GR 990400520T GR 3029437 T3 GR3029437 T3 GR 3029437T3
Authority
GR
Greece
Prior art keywords
derivatives
preparation
carboxylic acid
aromatic carboxylic
drugs containing
Prior art date
Application number
GR990400520T
Other languages
English (en)
Inventor
Michael Klaus
Peter Mohr
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of GR3029437T3 publication Critical patent/GR3029437T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/618—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR990400520T 1993-09-02 1999-02-17 Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives. GR3029437T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH261893 1993-09-02
CH196094 1994-06-21

Publications (1)

Publication Number Publication Date
GR3029437T3 true GR3029437T3 (en) 1999-05-28

Family

ID=25689113

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990400520T GR3029437T3 (en) 1993-09-02 1999-02-17 Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives.

Country Status (20)

Country Link
US (2) US5700836A (el)
EP (1) EP0641759B1 (el)
JP (1) JP2602629B2 (el)
KR (1) KR100335540B1 (el)
CN (1) CN1049423C (el)
AT (1) ATE174322T1 (el)
AU (1) AU680668B2 (el)
CA (1) CA2129773C (el)
CZ (1) CZ288426B6 (el)
DE (1) DE59407431D1 (el)
DK (1) DK0641759T3 (el)
ES (1) ES2126684T3 (el)
FI (1) FI113261B (el)
GR (1) GR3029437T3 (el)
HU (1) HU222345B1 (el)
IL (1) IL110808A (el)
NO (1) NO308579B1 (el)
NZ (1) NZ264327A (el)
RU (1) RU2130009C1 (el)
UA (1) UA43317C2 (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
DE4320920C1 (de) * 1993-06-24 1994-06-16 Goldschmidt Ag Th Silane mit hydrophilen Gruppen, deren Herstellung und Verwendung als Tenside in wäßrigen Medien
FR2719041B1 (fr) * 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
US7115728B1 (en) * 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
KR100625255B1 (ko) * 1995-10-06 2008-01-30 리간드 파마슈티칼스 인코포레이티드 다이머-선택적rxr변조물질및그의사용방법
AU8588798A (en) 1997-07-25 1999-02-16 Institut Pasteur Human peroxisome proliferator activated receptor gamma (ppargamma) gene re gulatory sequences and uses therefor
JO2178B1 (en) * 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of invasive diseases, using selected anti-PAR materials
KR100353310B1 (ko) * 2000-03-27 2002-09-18 송웅재 축조용 돌묘
KR100385492B1 (ko) * 2000-08-10 2003-05-27 주식회사 지오지 파이프 연결 소켓 제조 방법
ATE413375T1 (de) * 2000-10-02 2008-11-15 Hoffmann La Roche Retinoide zur behandlung von emphysem
EP1935869A1 (en) * 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoids for the treatment of emphysema
JP4425628B2 (ja) * 2001-07-23 2010-03-03 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド 細胞保護化合物、薬学的処方物および美容用処方物、ならびに方法
WO2005079463A2 (en) * 2004-02-17 2005-09-01 Dynamis Therapeutics, Inc. Fructoseamine 3 kinase and the formation of collagen and elastin
JP4683858B2 (ja) 2004-05-14 2011-05-18 スリーエム イノベイティブ プロパティズ カンパニー 物品支持具
EP2473596B1 (en) 2009-09-03 2017-12-13 Becton, Dickinson and Company Methods and compositions for direct chemical lysis
EP2613776B1 (en) 2010-09-01 2020-07-29 Thomas Jefferson University Composition and method for muscle repair and regeneration
WO2012076842A1 (en) * 2010-12-09 2012-06-14 University Of Durham Synthetic retinoids for control of cell differentiation
EP2736332A4 (en) * 2011-07-29 2015-03-18 Tempero Pharmaceuticals Inc CONNECTIONS AND METHODS

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU77254A1 (el) * 1977-05-04 1979-01-18
DK159967C (da) * 1977-12-22 1991-06-03 Hoffmann La Roche Analogifremgangsmaade til fremstilling af terapeutisk aktive stilbenderivater
US4326055A (en) * 1977-12-22 1982-04-20 Hoffmann-La Roche Inc. Stilbene derivatives
DE3202100A1 (de) * 1982-01-23 1983-08-04 Basf Ag, 6700 Ludwigshafen Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
ZA854828B (en) * 1984-07-27 1986-03-26 Hoffmann La Roche Phenyl nonatetraenoic acid derivatives
US4783549A (en) * 1984-09-05 1988-11-08 L'oreal Benzonorbornene derivatives, processes for their preparation and medicinal and cosmetic compositions containing them
DE3434944A1 (de) * 1984-09-22 1986-04-03 Basf Ag, 6700 Ludwigshafen L-substituierte tetralinderivate, ihre herstellung und verwendung
US4889847A (en) * 1986-11-03 1989-12-26 Ortho Pharmaceutical Corporation Prevention of glucocorticoid-induced skin atrophy
US5019569A (en) * 1986-11-03 1991-05-28 Ortho Pharmaceutical Corporation Reversal of glucocorticoid-induced skin atrophy
CA1298309C (en) * 1987-11-06 1992-03-31 Michael Klaus Benzocycloheptene derivatives
ATE307795T1 (de) * 1992-04-22 2005-11-15 Ligand Pharm Inc Verbindungen mit retinoid x rezeptorselektivität
US5324840A (en) * 1992-06-11 1994-06-28 Allergan, Inc. Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects
WO1995004036A1 (en) * 1993-01-11 1995-02-09 Ligand Pharmaceuticals Inc. Compounds having selective activity for retinoid x receptors, and means for modulation of processes mediated by retinoid x receptors

Also Published As

Publication number Publication date
HU222345B1 (hu) 2003-06-28
NO308579B1 (no) 2000-10-02
KR100335540B1 (ko) 2002-10-25
US6610877B1 (en) 2003-08-26
ATE174322T1 (de) 1998-12-15
RU2130009C1 (ru) 1999-05-10
KR950008468A (ko) 1995-04-17
EP0641759B1 (de) 1998-12-09
IL110808A0 (en) 1994-11-11
DE59407431D1 (de) 1999-01-21
NO943232L (no) 1995-03-03
CZ288426B6 (en) 2001-06-13
JPH07112952A (ja) 1995-05-02
CA2129773A1 (en) 1995-03-03
FI113261B (fi) 2004-03-31
JP2602629B2 (ja) 1997-04-23
RU94031754A (ru) 1996-07-20
CN1049423C (zh) 2000-02-16
NO943232D0 (no) 1994-09-01
DK0641759T3 (da) 1999-08-16
CZ210594A3 (en) 1995-06-14
IL110808A (en) 2003-03-12
AU680668B2 (en) 1997-08-07
US5700836A (en) 1997-12-23
HU9402480D0 (en) 1994-10-28
NZ264327A (en) 1996-02-27
FI944045A0 (fi) 1994-09-02
ES2126684T3 (es) 1999-04-01
FI944045A (fi) 1995-03-03
AU7148694A (en) 1995-03-16
EP0641759A1 (de) 1995-03-08
CN1105981A (zh) 1995-08-02
CA2129773C (en) 2007-05-01
HUT71473A (en) 1995-11-28
UA43317C2 (uk) 2001-12-17

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