FI112476B - Menetelmä kohonneen verenpaineen ennalta ehkäisyyn ja hoitoon käyttökelpoisen 4'-(1H-imidatsol-1-yylimetyyli)-1,1'-bifenyylijohdannaisen valmistamiseksi - Google Patents

Menetelmä kohonneen verenpaineen ennalta ehkäisyyn ja hoitoon käyttökelpoisen 4'-(1H-imidatsol-1-yylimetyyli)-1,1'-bifenyylijohdannaisen valmistamiseksi Download PDF

Info

Publication number
FI112476B
FI112476B FI932492A FI932492A FI112476B FI 112476 B FI112476 B FI 112476B FI 932492 A FI932492 A FI 932492A FI 932492 A FI932492 A FI 932492A FI 112476 B FI112476 B FI 112476B
Authority
FI
Finland
Prior art keywords
group
phenyl
methyl
reaction
hydroxy
Prior art date
Application number
FI932492A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI932492A (fi
FI932492A0 (fi
Inventor
Hiroyuki Koike
Hiroaki Yanagisawa
Takuro Kanazaki
Yoshiya Amemiya
Yasuo Shimoji
Toshio Sada
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI932492A0 publication Critical patent/FI932492A0/fi
Publication of FI932492A publication Critical patent/FI932492A/fi
Application granted granted Critical
Publication of FI112476B publication Critical patent/FI112476B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI932492A 1992-06-02 1993-06-01 Menetelmä kohonneen verenpaineen ennalta ehkäisyyn ja hoitoon käyttökelpoisen 4'-(1H-imidatsol-1-yylimetyyli)-1,1'-bifenyylijohdannaisen valmistamiseksi FI112476B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14116092 1992-06-02
JP14116092 1992-06-02

Publications (3)

Publication Number Publication Date
FI932492A0 FI932492A0 (fi) 1993-06-01
FI932492A FI932492A (fi) 1993-12-03
FI112476B true FI112476B (fi) 2003-12-15

Family

ID=15285532

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932492A FI112476B (fi) 1992-06-02 1993-06-01 Menetelmä kohonneen verenpaineen ennalta ehkäisyyn ja hoitoon käyttökelpoisen 4'-(1H-imidatsol-1-yylimetyyli)-1,1'-bifenyylijohdannaisen valmistamiseksi

Country Status (22)

Country Link
EP (1) EP0573218B1 (ru)
JP (1) JP3461863B2 (ru)
KR (1) KR100300473B1 (ru)
CN (1) CN1051766C (ru)
AT (1) ATE199548T1 (ru)
AU (1) AU661153B2 (ru)
CA (1) CA2097444C (ru)
CZ (1) CZ287764B6 (ru)
DE (1) DE69329982T2 (ru)
DK (1) DK0573218T3 (ru)
ES (1) ES2155827T3 (ru)
FI (1) FI112476B (ru)
GR (1) GR3035624T3 (ru)
HK (1) HK1011983A1 (ru)
HU (1) HUT64329A (ru)
IL (1) IL105825A (ru)
NO (1) NO303872B1 (ru)
NZ (1) NZ247750A (ru)
PT (1) PT573218E (ru)
RU (1) RU2086541C1 (ru)
TW (1) TW228521B (ru)
ZA (1) ZA933824B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT398202B (de) * 1991-10-04 1994-10-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
RU2109736C1 (ru) * 1992-12-17 1998-04-27 Санкио Компани Лимитед Производные бифенила и способ их получения
RU2123847C1 (ru) * 1994-03-16 1998-12-27 Санкио Компани Лимитед Лекарственное средство и способ лечения повышенного глазного давления и/или глаукомы
KR100428725B1 (ko) * 1996-03-30 2004-07-07 주식회사 현대시스콤 디지탈이동통신교환기녹음안내장치의2단계자체루프백시험장치및방법
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
CN1197866C (zh) * 2003-03-21 2005-04-20 上海医药工业研究院 4，6－二氢呋喃并[3,4－d]咪唑－6－酮衍生物及其盐和制备方法
EP1614428A4 (en) * 2003-04-15 2010-01-06 Sankyo Co MEDICAMENT FOR THE PREVENTION OR TREATMENT OF ANGIOGENIC OCULAR DISEASES
US7692023B2 (en) 2004-02-11 2010-04-06 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
CN101024643A (zh) * 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101778842B (zh) * 2007-08-08 2014-10-29 力奇制药公司 制备或纯化奥美沙坦酯的方法
CN101481374B (zh) * 2008-01-09 2013-01-09 浙江华海药业股份有限公司 1-三苯甲基-5-(1，1｀-联苯基-2基)-1h-四唑类化合物脱去三苯甲基的方法
CN103319461A (zh) * 2013-07-02 2013-09-25 临海天宇药业有限公司 奥美沙坦酯中间体的制备方法以及奥美沙坦酯的合成方法
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法
CN104356069B (zh) * 2014-11-18 2016-09-14 黄冈鲁班药业有限公司 奥美沙坦酯中间体4-(1-羟基-1-甲基乙基)-2-丙基咪唑-5-羧酸乙酯的制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
WO1991000277A1 (en) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
CA2061607C (en) * 1991-02-21 1999-01-19 Hiroaki Yanagisawa 1-biphenylimidazole derivatives, their preparation and their therapeutic use
EP0505098A1 (en) * 1991-03-19 1992-09-23 Merck & Co. Inc. Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists

Also Published As

Publication number Publication date
CZ105093A3 (en) 1993-12-15
CN1085896A (zh) 1994-04-27
KR100300473B1 (ko) 2002-01-09
DE69329982D1 (de) 2001-04-12
JPH0649036A (ja) 1994-02-22
AU661153B2 (en) 1995-07-13
EP0573218A3 (en) 1994-06-01
CA2097444A1 (en) 1993-12-03
NO931980L (no) 1993-12-03
NO931980D0 (no) 1993-06-01
JP3461863B2 (ja) 2003-10-27
CN1051766C (zh) 2000-04-26
HUT64329A (en) 1993-12-28
TW228521B (ru) 1994-08-21
CA2097444C (en) 2005-03-29
ES2155827T3 (es) 2001-06-01
EP0573218A2 (en) 1993-12-08
CZ287764B6 (en) 2001-01-17
GR3035624T3 (en) 2001-06-29
IL105825A (en) 1998-01-04
FI932492A (fi) 1993-12-03
IL105825A0 (en) 1993-09-22
AU3988093A (en) 1993-12-09
NZ247750A (en) 1995-05-26
ATE199548T1 (de) 2001-03-15
RU2086541C1 (ru) 1997-08-10
EP0573218B1 (en) 2001-03-07
FI932492A0 (fi) 1993-06-01
DK0573218T3 (da) 2001-06-18
PT573218E (pt) 2001-06-29
HK1011983A1 (en) 1999-07-23
NO303872B1 (no) 1998-09-14
ZA933824B (en) 1993-12-27
KR940000455A (ko) 1994-01-03
HU9301600D0 (en) 1993-09-28
DE69329982T2 (de) 2001-09-27

Similar Documents

Publication Publication Date Title
FI112476B (fi) Menetelmä kohonneen verenpaineen ennalta ehkäisyyn ja hoitoon käyttökelpoisen 4'-(1H-imidatsol-1-yylimetyyli)-1,1'-bifenyylijohdannaisen valmistamiseksi
FI114983B (fi) Menetelmä bentsimidatsoli-7-karboksylaatin C-tyyppiä olevan kiteen valmistamiseksi
RU2152385C1 (ru) Гетероциклические соединения, применимые в качестве аллостерических эффекторов при мускариновых рецепторах
EP0442473B1 (en) Pyrimidinedione derivatives, their production and use
US4880804A (en) Angiotensin II receptor blocking benzimidazoles
US5459148A (en) Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease
KR20060056352A (ko) 안지오텐신ⅱ 수용체 차단제 유도체들
JPH0236175A (ja) ビス（アシルオキシメチル）イミダゾール誘導体
EP1142879B1 (en) Imidazole compounds and medicinal use thereof
WO1992004343A1 (en) Novel tetrahydrobenzazole derivative
US4665055A (en) Peptide renin inhibitors
JP2023513121A (ja) Ａｄａｍｔｓ阻害剤、その製造および医薬用途
DK164404B (da) 3-amino-2-oxo-azetidinderivater, analogifremgangsmaade til fremstilling deraf samt laegemidler indeholdende derivaterne
DE69813886T2 (de) Naphthalin derivate
IE59970B1 (en) 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
CA2131154A1 (en) Antiviral peptides
FR2710066A1 (fr) Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse.
JP3169413B2 (ja) イミダゾール誘導体
HU179219B (en) Process for preparing new phenyl-amino-imidazoline derivatives substituted with a halogen atom or alkyl group
GB1561704A (en) Azetidione derivatives
JPH0687833A (ja) ビニルイミダゾール誘導体
RU2092481C1 (ru) Производные 1-бифенилметилимидазола, их фармацевтически приемлемые соли или эфиры и способ их получения
KR100216428B1 (ko) 퀴녹살리논 유도체, 이의 제조방법 및 그를 함유한 안지오텐신 ii길항제 조성물
US5061808A (en) 2-oxo-1-pyrrolidine carboxylic acid esters
JPH06306077A (ja) ピラゾロトリアゾール誘導体

Legal Events

Date Code Title Description
MA Patent expired