FI110871B - Förfarande för framställning av polysykliska antiparasitiska ämnen och mikro-organism använd vid förfarandet - Google Patents

Förfarande för framställning av polysykliska antiparasitiska ämnen och mikro-organism använd vid förfarandet Download PDF

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Publication number
FI110871B
FI110871B FI961839A FI961839A FI110871B FI 110871 B FI110871 B FI 110871B FI 961839 A FI961839 A FI 961839A FI 961839 A FI961839 A FI 961839A FI 110871 B FI110871 B FI 110871B
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FI
Finland
Prior art keywords
compounds
compound
medium
fermentation
production
Prior art date
Application number
FI961839A
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English (en)
Finnish (fi)
Other versions
FI961839A (sv
FI961839A0 (sv
Inventor
Otto D Hensens
Deborah L Zink
Anne W Dombrowski
Richard G Endris
Gregory L Helms
John G Ondeyka
Dan A Ostlind
Jon D Polishook
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI961839A publication Critical patent/FI961839A/sv
Publication of FI961839A0 publication Critical patent/FI961839A0/sv
Application granted granted Critical
Publication of FI110871B publication Critical patent/FI110871B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Claims (3)

1. Förfarande för framställning av föreningar med formeln ''J xV-VkA“ ίο II 15 OHo^~~^Y OH och " 20 » * · • r t · I I t ^ 9H o :· Μβ'ΠΓ ^η II I Mel Me I H ·.·: 25 0AY^Tti^0H • Y Me Me OH λ-k/Me k^j O Me o/ y oh kännetecknat därav, att man i ett medium 30 omfattande koi-, kväve- och spärämneskällor fermenterar !/. en Nodulisporium sp. MF-5954, ATCC 74245-produktionsstam och isolerar föreningarna. • »
2. Biologiskt ren Nodulisporium sp. MF-5954, ATCC 74245-kultur, kännetecknad därav, att den 35 har förmäga att producera föreningar enligt patentkrav 1.
1 I »
FI961839A 1993-11-01 1996-04-30 Förfarande för framställning av polysykliska antiparasitiska ämnen och mikro-organism använd vid förfarandet FI110871B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/146,638 US5399582A (en) 1993-11-01 1993-11-01 Antiparasitic agents
US14663893 1993-11-01
PCT/US1994/012302 WO1995012599A1 (en) 1993-11-01 1994-10-27 Polycyclic antiparasitic agents, process and strain for their preparation and their use
US9412302 1994-10-27

Publications (3)

Publication Number Publication Date
FI961839A FI961839A (sv) 1996-04-30
FI961839A0 FI961839A0 (sv) 1996-04-30
FI110871B true FI110871B (sv) 2003-04-15

Family

ID=22518283

Family Applications (2)

Application Number Title Priority Date Filing Date
FI961839A FI110871B (sv) 1993-11-01 1996-04-30 Förfarande för framställning av polysykliska antiparasitiska ämnen och mikro-organism använd vid förfarandet
FI20012318A FI112503B (sv) 1993-11-01 2001-11-27 Polysykliska antiparasitiska ämnen och deras användning

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20012318A FI112503B (sv) 1993-11-01 2001-11-27 Polysykliska antiparasitiska ämnen och deras användning

Country Status (24)

Country Link
US (2) US5399582A (sv)
EP (1) EP0726902B1 (sv)
JP (1) JP3557212B2 (sv)
KR (1) KR100333017B1 (sv)
CN (2) CN1046943C (sv)
AT (1) ATE188476T1 (sv)
AU (1) AU688405B2 (sv)
CA (1) CA2174645C (sv)
CZ (1) CZ286032B6 (sv)
DE (1) DE69422526T2 (sv)
DK (1) DK0726902T3 (sv)
ES (1) ES2143558T3 (sv)
FI (2) FI110871B (sv)
GR (1) GR3032493T3 (sv)
HU (1) HU221276B1 (sv)
NO (1) NO315942B1 (sv)
NZ (1) NZ275339A (sv)
PL (1) PL178879B1 (sv)
PT (1) PT726902E (sv)
RU (1) RU2139874C1 (sv)
SI (1) SI0726902T1 (sv)
SK (1) SK281510B6 (sv)
WO (1) WO1995012599A1 (sv)
ZA (1) ZA948542B (sv)

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Also Published As

Publication number Publication date
PL178879B1 (pl) 2000-06-30
SK281510B6 (sk) 2001-04-09
DE69422526D1 (de) 2000-02-10
AU688405B2 (en) 1998-03-12
FI961839A (sv) 1996-04-30
JP3557212B2 (ja) 2004-08-25
HU221276B1 (en) 2002-09-28
ES2143558T3 (es) 2000-05-16
PL314190A1 (en) 1996-09-02
KR100333017B1 (ko) 2002-09-27
HU9601138D0 (en) 1996-06-28
NO315942B1 (no) 2003-11-17
CN1236012A (zh) 1999-11-24
ATE188476T1 (de) 2000-01-15
EP0726902B1 (en) 2000-01-05
AU8092994A (en) 1995-05-23
GR3032493T3 (en) 2000-05-31
PT726902E (pt) 2000-06-30
CN1082543C (zh) 2002-04-10
US5399582A (en) 1995-03-21
CN1046943C (zh) 1999-12-01
CZ124996A3 (en) 1996-10-16
NO961748L (no) 1996-07-01
SI0726902T1 (en) 2000-04-30
CZ286032B6 (cs) 1999-12-15
CA2174645C (en) 2004-09-07
KR960705828A (ko) 1996-11-08
CN1137796A (zh) 1996-12-11
US5614546A (en) 1997-03-25
RU2139874C1 (ru) 1999-10-20
FI961839A0 (sv) 1996-04-30
DE69422526T2 (de) 2000-07-27
CA2174645A1 (en) 1995-05-11
HUT74959A (en) 1997-03-28
ZA948542B (en) 1995-06-27
DK0726902T3 (da) 2000-05-01
WO1995012599A1 (en) 1995-05-11
EP0726902A1 (en) 1996-08-21
NO961748D0 (no) 1996-04-30
JPH09505567A (ja) 1997-06-03
NZ275339A (en) 1997-11-24
FI20012318A (sv) 2001-11-27
SK53996A3 (en) 1997-03-05
FI112503B (sv) 2003-12-15

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