ES2143558T3 - Agentes policiclicos antiparasitarios, procedimiento y cepa para su preparacion y su uso. - Google Patents

Agentes policiclicos antiparasitarios, procedimiento y cepa para su preparacion y su uso.

Info

Publication number
ES2143558T3
ES2143558T3 ES94932063T ES94932063T ES2143558T3 ES 2143558 T3 ES2143558 T3 ES 2143558T3 ES 94932063 T ES94932063 T ES 94932063T ES 94932063 T ES94932063 T ES 94932063T ES 2143558 T3 ES2143558 T3 ES 2143558T3
Authority
ES
Spain
Prior art keywords
antiparasitic
strain
polyclic
agents
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94932063T
Other languages
English (en)
Inventor
Anne W Dombrowski
Richard G Endris
Gregory L Helms
Otto D Hensens
John G Ondeyka
Dan A Ostlind
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2143558T3 publication Critical patent/ES2143558T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

SE PRESENTAN NUEVOS COMPUESTOS QUE TIENEN LAS FORMULAS (I-III) QUE SE DERIVAN DE LA FERMENTACION DE UNA CEPA DEL "NODULISPORIUM SP". LOS COMPUESTOS SON AGENTES ECTOPARASITICIDAS, ANTIPARASITARIOS E INSECTICIDAS ALTAMENTE POTENTES.
ES94932063T 1993-11-01 1994-10-27 Agentes policiclicos antiparasitarios, procedimiento y cepa para su preparacion y su uso. Expired - Lifetime ES2143558T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/146,638 US5399582A (en) 1993-11-01 1993-11-01 Antiparasitic agents

Publications (1)

Publication Number Publication Date
ES2143558T3 true ES2143558T3 (es) 2000-05-16

Family

ID=22518283

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94932063T Expired - Lifetime ES2143558T3 (es) 1993-11-01 1994-10-27 Agentes policiclicos antiparasitarios, procedimiento y cepa para su preparacion y su uso.

Country Status (24)

Country Link
US (2) US5399582A (es)
EP (1) EP0726902B1 (es)
JP (1) JP3557212B2 (es)
KR (1) KR100333017B1 (es)
CN (2) CN1046943C (es)
AT (1) ATE188476T1 (es)
AU (1) AU688405B2 (es)
CA (1) CA2174645C (es)
CZ (1) CZ286032B6 (es)
DE (1) DE69422526T2 (es)
DK (1) DK0726902T3 (es)
ES (1) ES2143558T3 (es)
FI (2) FI110871B (es)
GR (1) GR3032493T3 (es)
HU (1) HU221276B1 (es)
NO (1) NO315942B1 (es)
NZ (1) NZ275339A (es)
PL (1) PL178879B1 (es)
PT (1) PT726902E (es)
RU (1) RU2139874C1 (es)
SI (1) SI0726902T1 (es)
SK (1) SK281510B6 (es)
WO (1) WO1995012599A1 (es)
ZA (1) ZA948542B (es)

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US5541208A (en) * 1994-01-24 1996-07-30 Merck & Co., Inc. Indole diterpene alkaloid compounds
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
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US5595991A (en) * 1995-03-20 1997-01-21 Merck & Co., Inc. Anthelmintic use of nodulisporic acid and analogs thereof
US5962499A (en) * 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US5834260A (en) * 1996-08-30 1998-11-10 Merck & Co., Inc. Antiparasitic agents
NZ334308A (en) * 1996-09-19 2000-08-25 Merck & Co Inc Nodulosporic acid derivatives that are isolated from Nodulisporium sp. MF-5954 which are acaricidal, antiparasitic and anthelmintic agents
AU1155499A (en) * 1997-10-09 1999-05-03 Rhone-Poulenc Agro Pesticidal combination
US6733767B2 (en) 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
US6399786B1 (en) * 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
US6586452B1 (en) 2000-07-14 2003-07-01 Merck & Co., Inc. C1 to C4 side chain modified nodulisporic acid analogs
US20040077703A1 (en) * 2002-10-02 2004-04-22 Soll Mark D. Nodulisporic acid derivative spot-on formulations for combating parasites
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
CN101511795B (zh) 2006-07-05 2013-09-18 安万特农业公司 1-芳基-5-烷基吡唑衍生化合物、其制备方法和使用方法
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TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
WO2009080546A1 (en) 2007-12-21 2009-07-02 Basf Se The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals
CA2945453C (en) 2008-11-14 2021-03-02 Merial, Inc. Enantiomerically enriched aryloazol-2-yl cyanoethylamino paraciticidal compounds
AU2009316899B2 (en) 2008-11-19 2015-08-20 Boehringer Ingelheim Animal Health USA Inc. Compositions comprising 1-arylpyrazole alone or in combination with formamidine for the treatment of parasitic infection
US8426460B2 (en) 2008-12-04 2013-04-23 Merial Limited Dimeric avermectin and milbemycin derivatives
US9133209B2 (en) 2009-07-30 2015-09-15 Merial, Inc. Insecticidal 4-amino-thieno[2,3-D]-pyrimidine compounds and methods of their use
US8846569B2 (en) 2009-12-04 2014-09-30 Merial Limited Pesticidal bis-organosulfur compounds
MX2020001453A (es) 2009-12-17 2021-07-29 Merial Ltd Compuestos de dihidroazol antiparasiticos y composiciones que comprenden los mismos.
WO2011075592A1 (en) 2009-12-17 2011-06-23 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
WO2011095581A1 (en) 2010-02-05 2011-08-11 Intervet International B.V. S piroindoline compounds for use as anthelminthi cs
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
US8877934B2 (en) 2010-09-29 2014-11-04 Intervet Inc. N-heteroaryl compounds
PL2621923T3 (pl) 2010-09-29 2017-08-31 Intervet International B.V. Związki n-heteroarylu z mostkami cyklicznymi do leczenia chorób pasożytniczych
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KR20140038527A (ko) 2011-06-20 2014-03-28 이 아이 듀폰 디 네모아 앤드 캄파니 연충 감염을 치료하기 위한 복소환식 화합물
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US9096599B2 (en) 2011-08-04 2015-08-04 Intervet Inc. Spiroindoline compounds
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US20130079394A1 (en) 2011-09-23 2013-03-28 Cnrs (Centre National Recherche Scientifique) Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
ES2642715T3 (es) 2011-11-17 2017-11-17 Merial, Inc. Composiciones que comprenden un aril pirazol y un imidazol sustituido, procedimientos y utilizaciones de las mismas
TW201326128A (zh) 2011-11-28 2013-07-01 Du Pont 磺醯胺驅蟲劑
EP3351546B1 (en) 2011-12-02 2024-02-14 Boehringer Ingelheim Vetmedica GmbH Long-acting injectable moxidectin formulations
ES2515015B2 (es) 2012-02-06 2016-03-01 Merial Limited Composiciones veterinarias orales parasiticidas que comprenden agentes activos de acción sistémica, métodos y usos de las mismas
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Also Published As

Publication number Publication date
FI961839A0 (fi) 1996-04-30
CA2174645C (en) 2004-09-07
JPH09505567A (ja) 1997-06-03
CN1137796A (zh) 1996-12-11
DE69422526T2 (de) 2000-07-27
AU8092994A (en) 1995-05-23
FI110871B (fi) 2003-04-15
NO315942B1 (no) 2003-11-17
CZ124996A3 (en) 1996-10-16
KR100333017B1 (ko) 2002-09-27
AU688405B2 (en) 1998-03-12
EP0726902A1 (en) 1996-08-21
CN1082543C (zh) 2002-04-10
PL178879B1 (pl) 2000-06-30
DK0726902T3 (da) 2000-05-01
NZ275339A (en) 1997-11-24
KR960705828A (ko) 1996-11-08
HU9601138D0 (en) 1996-06-28
US5614546A (en) 1997-03-25
SK281510B6 (sk) 2001-04-09
GR3032493T3 (en) 2000-05-31
NO961748D0 (no) 1996-04-30
CN1046943C (zh) 1999-12-01
EP0726902B1 (en) 2000-01-05
CA2174645A1 (en) 1995-05-11
WO1995012599A1 (en) 1995-05-11
PT726902E (pt) 2000-06-30
JP3557212B2 (ja) 2004-08-25
FI112503B (fi) 2003-12-15
DE69422526D1 (de) 2000-02-10
FI20012318A (fi) 2001-11-27
SK53996A3 (en) 1997-03-05
SI0726902T1 (en) 2000-04-30
PL314190A1 (en) 1996-09-02
CN1236012A (zh) 1999-11-24
HUT74959A (en) 1997-03-28
HU221276B1 (en) 2002-09-28
FI961839A (fi) 1996-04-30
ZA948542B (en) 1995-06-27
RU2139874C1 (ru) 1999-10-20
CZ286032B6 (cs) 1999-12-15
ATE188476T1 (de) 2000-01-15
NO961748L (no) 1996-07-01
US5399582A (en) 1995-03-21

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