CN1082543C - 多环抗寄生虫剂,其制备的方法和菌株及其应用 - Google Patents
多环抗寄生虫剂,其制备的方法和菌株及其应用 Download PDFInfo
- Publication number
- CN1082543C CN1082543C CN99106438A CN99106438A CN1082543C CN 1082543 C CN1082543 C CN 1082543C CN 99106438 A CN99106438 A CN 99106438A CN 99106438 A CN99106438 A CN 99106438A CN 1082543 C CN1082543 C CN 1082543C
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- Prior art keywords
- compound
- compounds
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (2)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/146638 | 1993-11-01 | ||
US08/146,638 | 1993-11-01 | ||
US08/146,638 US5399582A (en) | 1993-11-01 | 1993-11-01 | Antiparasitic agents |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN94194524A Division CN1046943C (zh) | 1993-11-01 | 1994-10-27 | 多环抗寄生虫剂及其制备方法和含其的组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1236012A CN1236012A (zh) | 1999-11-24 |
CN1082543C true CN1082543C (zh) | 2002-04-10 |
Family
ID=22518283
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN94194524A Expired - Lifetime CN1046943C (zh) | 1993-11-01 | 1994-10-27 | 多环抗寄生虫剂及其制备方法和含其的组合物 |
CN99106438A Expired - Lifetime CN1082543C (zh) | 1993-11-01 | 1999-04-24 | 多环抗寄生虫剂,其制备的方法和菌株及其应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN94194524A Expired - Lifetime CN1046943C (zh) | 1993-11-01 | 1994-10-27 | 多环抗寄生虫剂及其制备方法和含其的组合物 |
Country Status (24)
Country | Link |
---|---|
US (2) | US5399582A (zh) |
EP (1) | EP0726902B1 (zh) |
JP (1) | JP3557212B2 (zh) |
KR (1) | KR100333017B1 (zh) |
CN (2) | CN1046943C (zh) |
AT (1) | ATE188476T1 (zh) |
AU (1) | AU688405B2 (zh) |
CA (1) | CA2174645C (zh) |
CZ (1) | CZ286032B6 (zh) |
DE (1) | DE69422526T2 (zh) |
DK (1) | DK0726902T3 (zh) |
ES (1) | ES2143558T3 (zh) |
FI (2) | FI110871B (zh) |
GR (1) | GR3032493T3 (zh) |
HU (1) | HU221276B1 (zh) |
NO (1) | NO315942B1 (zh) |
NZ (1) | NZ275339A (zh) |
PL (1) | PL178879B1 (zh) |
PT (1) | PT726902E (zh) |
RU (1) | RU2139874C1 (zh) |
SI (1) | SI0726902T1 (zh) |
SK (1) | SK281510B6 (zh) |
WO (1) | WO1995012599A1 (zh) |
ZA (1) | ZA948542B (zh) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399582A (en) * | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
US5541208A (en) * | 1994-01-24 | 1996-07-30 | Merck & Co., Inc. | Indole diterpene alkaloid compounds |
US6221894B1 (en) | 1995-03-20 | 2001-04-24 | Merck & Co., Inc. | Nodulisporic acid derivatives |
US5962499A (en) * | 1995-03-20 | 1999-10-05 | Merck & Co., Inc. | Nodulisporic acid derivatives |
US5595991A (en) * | 1995-03-20 | 1997-01-21 | Merck & Co., Inc. | Anthelmintic use of nodulisporic acid and analogs thereof |
CA2215982C (en) * | 1995-03-20 | 2001-06-12 | Merck & Co., Inc. | Nodulisporic acid derivatives |
US5834260A (en) * | 1996-08-30 | 1998-11-10 | Merck & Co., Inc. | Antiparasitic agents |
NZ334308A (en) * | 1996-09-19 | 2000-08-25 | Merck & Co Inc | Nodulosporic acid derivatives that are isolated from Nodulisporium sp. MF-5954 which are acaricidal, antiparasitic and anthelmintic agents |
AU1155499A (en) * | 1997-10-09 | 1999-05-03 | Rhone-Poulenc Agro | Pesticidal combination |
ES2359973T3 (es) * | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas. |
US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
US6399786B1 (en) * | 2000-07-14 | 2002-06-04 | Merck & Co., Inc. | Nonacyclic nodulisporic acid derivatives |
US6586452B1 (en) | 2000-07-14 | 2003-07-01 | Merck & Co., Inc. | C1 to C4 side chain modified nodulisporic acid analogs |
US20040077703A1 (en) * | 2002-10-02 | 2004-04-22 | Soll Mark D. | Nodulisporic acid derivative spot-on formulations for combating parasites |
US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
NZ573758A (en) | 2006-07-05 | 2012-01-12 | Aventis Agriculture | 1-Phenyl-3-cyano-pyrazole derivatives and pesticidal formulations containing them |
EP2155699B9 (en) | 2007-05-15 | 2016-09-14 | Merial, Inc. | Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof |
TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
AU2008340434B2 (en) | 2007-12-21 | 2014-02-06 | Boehringer Ingelheim Animal Health USA Inc. | The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals |
MX2011005011A (es) | 2008-11-14 | 2011-07-29 | Merial Ltd | Compuestos de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, metodo de elaboracion y de uso de los mismos. |
JP5755143B2 (ja) | 2008-11-19 | 2015-07-29 | メリアル リミテッド | アリールピラゾールおよび/またはホルムアミジンを含む組成物、それらの方法ならびに使用 |
NZ593184A (en) | 2008-12-04 | 2012-11-30 | Merial Ltd | Dimeric avermectin and milbemycin derivatives |
AU2010278948B2 (en) | 2009-07-30 | 2015-04-23 | Boehringer Ingelheim Animal Health USA Inc. | Insecticidal 4-Amino-thieno(2,3-d)-pyrimidine compounds and methods of their use |
ES2546100T3 (es) | 2009-12-04 | 2015-09-18 | Merial, Inc. | Compuestos pesticidas bis-organosulfurados |
WO2011075592A1 (en) | 2009-12-17 | 2011-06-23 | Merial Limited | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
EA021522B9 (ru) | 2009-12-17 | 2016-08-31 | Мериал Лимитед | Противопаразитарные дигидроазоловые соединения и содержащие их композиции |
CN102741252A (zh) | 2010-02-05 | 2012-10-17 | 英特维特国际股份有限公司 | 用作驱虫剂的螺吲哚啉化合物 |
UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
RU2596185C2 (ru) | 2010-09-29 | 2016-08-27 | Интервет Интернэшнл Б.В. | N-гетероарильные соединения |
AR083199A1 (es) | 2010-09-29 | 2013-02-06 | Intervet Internationale B V | Compuestos de n-heteroarilo con unidad de puente ciclico |
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WO2012177668A1 (en) | 2011-06-20 | 2012-12-27 | E. I. Du Pont De Nemours And Company | Heterocyclic compounds for treating helminth infections |
US20120329832A1 (en) | 2011-06-27 | 2012-12-27 | Jean Delaveau | Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use |
EP2723716B1 (en) | 2011-06-27 | 2017-01-11 | Merial, Inc. | Amido-pyridyl ether compounds and compositions and their use against parasites |
US9096599B2 (en) | 2011-08-04 | 2015-08-04 | Intervet Inc. | Spiroindoline compounds |
KR102081036B1 (ko) | 2011-09-12 | 2020-02-24 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 이속사졸 활성화제를 포함하는 구충 조성물, 이의 용도 및 구충 방법 |
US20130079394A1 (en) | 2011-09-23 | 2013-03-28 | Cnrs (Centre National Recherche Scientifique) | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods |
ES2642715T3 (es) | 2011-11-17 | 2017-11-17 | Merial, Inc. | Composiciones que comprenden un aril pirazol y un imidazol sustituido, procedimientos y utilizaciones de las mismas |
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DK2785719T3 (en) | 2011-12-02 | 2017-12-04 | Merial Inc | LONG-EFFECTIVE INJECTABLE MOXIDECTIN FORMULATIONS AND HIS UNKNOWN MOXIDECTIN CRYSTAL FORMS |
US9233100B2 (en) | 2012-02-06 | 2016-01-12 | Merial, Inc. | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
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AR090545A1 (es) | 2012-03-28 | 2014-11-19 | Intervet Int Bv | Compuesto heteroarilo con una unidad puente aciclica |
WO2013144180A1 (en) | 2012-03-28 | 2013-10-03 | Intervet International B.V. | Heteroaryl compounds with cyclic bridging unit for use in the treatment helminth infection |
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WO2014099837A1 (en) | 2012-12-18 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Sulfonamide anthelmintics |
AU2014342241B2 (en) | 2013-11-01 | 2017-09-14 | Boehringer Ingelheim Animal Health USA Inc. | Antiparasitic and pesticidal isoxazoline compounds |
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EP3145925B1 (en) | 2014-05-19 | 2020-11-04 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic compounds |
BR122020023385B1 (pt) | 2014-06-19 | 2021-05-25 | Merial, Inc | composições parasiticidas compreendendo derivados de indol, métodos e usos dos mesmos |
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WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
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US11560388B2 (en) | 2019-03-19 | 2023-01-24 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
US20230148316A1 (en) | 2019-12-18 | 2023-05-11 | Intervet Inc. | Anthelmintic compounds comprising a quinoline structure |
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AU2021395477A1 (en) | 2020-12-11 | 2023-06-22 | Intervet International B.V. | Anthelmintic compounds comprising a thienopyridine structure |
WO2022140728A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animam Health Usa Inc. | Parasiticidal collar comprising isoxazoline compounds |
WO2023156938A1 (en) | 2022-02-17 | 2023-08-24 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4801697A (en) * | 1985-04-02 | 1989-01-31 | Toyo Jozo Kabushiki Kaisha | Physiologically active substance TPI and production thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
US4199569A (en) * | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
JP2805564B2 (ja) * | 1992-08-13 | 1998-09-30 | 明治製菓株式会社 | 新規物質pf1101b物質及びその製造法 |
US5399582A (en) * | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
-
1993
- 1993-11-01 US US08/146,638 patent/US5399582A/en not_active Expired - Lifetime
-
1994
- 1994-10-27 CZ CZ961249A patent/CZ286032B6/cs not_active IP Right Cessation
- 1994-10-27 NZ NZ275339A patent/NZ275339A/en not_active IP Right Cessation
- 1994-10-27 WO PCT/US1994/012302 patent/WO1995012599A1/en active IP Right Grant
- 1994-10-27 CA CA002174645A patent/CA2174645C/en not_active Expired - Lifetime
- 1994-10-27 EP EP94932063A patent/EP0726902B1/en not_active Expired - Lifetime
- 1994-10-27 AT AT94932063T patent/ATE188476T1/de active
- 1994-10-27 SK SK539-96A patent/SK281510B6/sk not_active IP Right Cessation
- 1994-10-27 AU AU80929/94A patent/AU688405B2/en not_active Expired
- 1994-10-27 JP JP51328695A patent/JP3557212B2/ja not_active Expired - Lifetime
- 1994-10-27 SI SI9430297T patent/SI0726902T1/xx unknown
- 1994-10-27 PT PT94932063T patent/PT726902E/pt unknown
- 1994-10-27 RU RU96112175A patent/RU2139874C1/ru active
- 1994-10-27 DK DK94932063T patent/DK0726902T3/da active
- 1994-10-27 DE DE69422526T patent/DE69422526T2/de not_active Expired - Lifetime
- 1994-10-27 KR KR1019960702262A patent/KR100333017B1/ko not_active IP Right Cessation
- 1994-10-27 CN CN94194524A patent/CN1046943C/zh not_active Expired - Lifetime
- 1994-10-27 PL PL94314190A patent/PL178879B1/pl unknown
- 1994-10-27 HU HU9601138A patent/HU221276B1/hu unknown
- 1994-10-27 ES ES94932063T patent/ES2143558T3/es not_active Expired - Lifetime
- 1994-10-31 ZA ZA948542A patent/ZA948542B/xx unknown
- 1994-12-20 US US08/359,666 patent/US5614546A/en not_active Expired - Lifetime
-
1996
- 1996-04-30 NO NO19961748A patent/NO315942B1/no not_active IP Right Cessation
- 1996-04-30 FI FI961839A patent/FI110871B/fi not_active IP Right Cessation
-
1999
- 1999-04-24 CN CN99106438A patent/CN1082543C/zh not_active Expired - Lifetime
-
2000
- 2000-01-27 GR GR20000400187T patent/GR3032493T3/el unknown
-
2001
- 2001-11-27 FI FI20012318A patent/FI112503B/fi not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4801697A (en) * | 1985-04-02 | 1989-01-31 | Toyo Jozo Kabushiki Kaisha | Physiologically active substance TPI and production thereof |
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