FI107384B - Menetelmä 5,6-dihydro-(S)-4-(etyyliamino)-(S)-6-metyyli-4H-tieno[2,3-b]tiopyran- 2-sulfonamidi-7,7-dioksidiyhdisteiden valmistamiseksi - Google Patents

Menetelmä 5,6-dihydro-(S)-4-(etyyliamino)-(S)-6-metyyli-4H-tieno[2,3-b]tiopyran- 2-sulfonamidi-7,7-dioksidiyhdisteiden valmistamiseksi Download PDF

Info

Publication number
FI107384B
FI107384B FI954438A FI954438A FI107384B FI 107384 B FI107384 B FI 107384B FI 954438 A FI954438 A FI 954438A FI 954438 A FI954438 A FI 954438A FI 107384 B FI107384 B FI 107384B
Authority
FI
Finland
Prior art keywords
compound
formula
mixture
acid
sulfuric acid
Prior art date
Application number
FI954438A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI954438A (fi
FI954438A0 (fi
Inventor
Paul Sohar
David J Mathre
Thomas J Blacklock
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI954438A publication Critical patent/FI954438A/fi
Publication of FI954438A0 publication Critical patent/FI954438A0/fi
Application granted granted Critical
Publication of FI107384B publication Critical patent/FI107384B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
FI954438A 1993-03-22 1995-09-20 Menetelmä 5,6-dihydro-(S)-4-(etyyliamino)-(S)-6-metyyli-4H-tieno[2,3-b]tiopyran- 2-sulfonamidi-7,7-dioksidiyhdisteiden valmistamiseksi FI107384B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US3552393A 1993-03-22 1993-03-22
US3552393 1993-03-22
US19588694A 1994-02-10 1994-02-10
US19588694 1994-02-10
US9402852 1994-03-16
PCT/US1994/002852 WO1994021645A1 (en) 1993-03-22 1994-03-16 ENANTIOSELECTIVE SYNTHESIS OF 5,6-DIHYDRO-(S)-4-(ETHYLAMINO)-(S)-6-METHYL-4H-THIENO[2,3-b]THIOPYRAN-2-SULFONAMIDE 7,7-DIOXIDE AND RELATED COMPOUNDS

Publications (3)

Publication Number Publication Date
FI954438A FI954438A (fi) 1995-09-20
FI954438A0 FI954438A0 (fi) 1995-09-20
FI107384B true FI107384B (fi) 2001-07-31

Family

ID=26712200

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954438A FI107384B (fi) 1993-03-22 1995-09-20 Menetelmä 5,6-dihydro-(S)-4-(etyyliamino)-(S)-6-metyyli-4H-tieno[2,3-b]tiopyran- 2-sulfonamidi-7,7-dioksidiyhdisteiden valmistamiseksi

Country Status (29)

Country Link
US (1) US5688968A (ro)
EP (1) EP0617037B1 (ro)
JP (1) JP3273096B2 (ro)
KR (1) KR0157162B1 (ro)
CN (1) CN1046732C (ro)
AT (1) ATE163291T1 (ro)
AU (1) AU673409B2 (ro)
BR (1) BR9406017A (ro)
CA (1) CA2119218C (ro)
CY (1) CY2108B1 (ro)
CZ (1) CZ281390B6 (ro)
DE (1) DE69408550T2 (ro)
DK (1) DK0617037T3 (ro)
ES (1) ES2112482T3 (ro)
FI (1) FI107384B (ro)
GR (1) GR3026178T3 (ro)
HK (1) HK1009063A1 (ro)
HR (1) HRP940182B1 (ro)
HU (1) HU217363B (ro)
NO (1) NO313240B1 (ro)
NZ (1) NZ263092A (ro)
PL (1) PL176373B1 (ro)
RO (1) RO115264B1 (ro)
SI (1) SI9420016B (ro)
SK (1) SK280831B6 (ro)
TW (1) TW265343B (ro)
UA (1) UA41921C2 (ro)
WO (1) WO1994021645A1 (ro)
YU (1) YU48951B (ro)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760249A (en) * 1995-08-29 1998-06-02 Merck & Co., Inc. Synthesis of hydroxysulfone and related compounds
ES2177415B1 (es) * 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
ES2204306B1 (es) * 2002-08-16 2005-08-01 Ragactives, S.L. Formas polimorficas de clorhidrato de dorzolamida, su obtencion y composiciones farmaceuticas que las contienen.
US7053115B2 (en) * 2003-04-07 2006-05-30 Hetero Drugs Limited Crystalline form of dorzolamide hydrochloride
MXPA06015274A (es) * 2004-07-09 2007-09-27 Fdc Ltd Un procedimiento mejorado para la preparacion de 5,6-dihidro-4h-4(s)-etilamino-6(s)-metiltieno [2,3-b] tiopiran-2-sulfonamida-7,7-dioxido y sus sales.
ES2253112B1 (es) * 2004-11-05 2007-03-16 Ragactives, S.L. Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano.
US7109353B2 (en) 2004-12-28 2006-09-19 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl
BRPI0419257A (pt) * 2004-12-28 2008-05-06 Usv Ltd processo para preparar cloridrato de 5,6-diidro-4-(s)-(ettilamino)-6-(s)-metil-4h-tieno{2,3b}tio pirano-2-sulfonamida-7,7-dióxido
WO2006074230A2 (en) * 2005-01-06 2006-07-13 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method of making dorzolamide hydrochloride
WO2006078731A2 (en) * 2005-01-18 2006-07-27 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same
KR20100031571A (ko) * 2007-05-07 2010-03-23 시플라 리미티드 도르졸라미드의 제조방법
HUE027183T2 (en) 2011-03-10 2016-08-29 Zach System Spa Asymmetric reduction process
ITMI20121165A1 (it) * 2012-07-03 2014-01-04 Zach System Spa Processo di riduzione asimmetrica
US9029554B1 (en) * 2013-10-17 2015-05-12 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
JP6487426B2 (ja) * 2013-10-17 2019-03-20 ダウ アグロサイエンシィズ エルエルシー 有害生物防除化合物の調製法
CN103497202B (zh) * 2013-10-23 2015-12-02 武汉武药科技有限公司 盐酸多佐胺中间体的合成方法
CN108822127B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4968814A (en) * 1990-04-18 1990-11-06 Merck & Co., Inc. (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides

Also Published As

Publication number Publication date
BR9406017A (pt) 1995-12-19
YU13194A (sh) 1997-01-08
WO1994021645A1 (en) 1994-09-29
DK0617037T3 (da) 1998-03-16
SK116995A3 (en) 1997-06-04
DE69408550T2 (de) 1998-08-27
HRP940182B1 (en) 2000-02-29
ES2112482T3 (es) 1998-04-01
ATE163291T1 (de) 1998-03-15
PL176373B1 (pl) 1999-05-31
UA41921C2 (uk) 2001-10-15
CN1046732C (zh) 1999-11-24
SI9420016A (en) 1996-06-30
NO953733L (no) 1995-09-21
CZ241895A3 (en) 1996-01-17
AU5787194A (en) 1994-09-29
TW265343B (ro) 1995-12-11
CZ281390B6 (cs) 1996-09-11
NO313240B1 (no) 2002-09-02
HRP940182A2 (en) 1996-08-31
HU9502772D0 (en) 1995-11-28
JP3273096B2 (ja) 2002-04-08
HU217363B (hu) 2000-01-28
JPH06298767A (ja) 1994-10-25
NZ263092A (en) 1997-12-19
PL310633A1 (en) 1995-12-27
CN1119866A (zh) 1996-04-03
SK280831B6 (sk) 2000-08-14
YU48951B (sh) 2003-01-31
US5688968A (en) 1997-11-18
EP0617037A1 (en) 1994-09-28
CA2119218C (en) 2000-02-15
EP0617037B1 (en) 1998-02-18
GR3026178T3 (en) 1998-05-29
FI954438A (fi) 1995-09-20
KR0157162B1 (ko) 1998-11-16
CY2108B1 (en) 2002-04-26
CA2119218A1 (en) 1994-09-23
NO953733D0 (no) 1995-09-21
RO115264B1 (ro) 1999-12-30
SI9420016B (sl) 2002-12-31
HK1009063A1 (en) 1999-05-21
DE69408550D1 (de) 1998-03-26
FI954438A0 (fi) 1995-09-20
HUT72676A (en) 1996-05-28
AU673409B2 (en) 1996-11-07

Similar Documents

Publication Publication Date Title
FI107384B (fi) Menetelmä 5,6-dihydro-(S)-4-(etyyliamino)-(S)-6-metyyli-4H-tieno[2,3-b]tiopyran- 2-sulfonamidi-7,7-dioksidiyhdisteiden valmistamiseksi
OA11567A (en) Polymorphic clopidogrel hydrogenesulphate form.
EP1656381B1 (en) Crystallisation of solid forms of clopidogrel addition salts
JP2019509308A (ja) １−（５−（２，４−ジフルオロフェニル）−１−（（３−フルオロフェニル）スルホニル）−４−メトキシ−１ｈ−ピロール−３−イル）−ｎ−メチルメタンアミン塩の新規な結晶形
EP2582711A1 (en) Process for the preparation of pteridine derivatives
JP2003522180A (ja) 新規な正のアロステリックａｍｐａ受容体モジュレーター（ｐａａｒｍ）、その製法及び医薬組成物としての使用
JP4681545B2 (ja) 血小板凝集阻害剤の結晶多形の製法
NO317997B1 (no) Fremgangsmate for fremstilling av et naftyridinkarboksylsyrederivat (metansulfonat-sesquihydrat)
RU2114851C1 (ru) Способ получения 7,7-диоксида 5,6-дигидро-(s)-4-(алкиламино)-(s)-6-алкил-4н-тиено(2,3-b)тиопиран-2- сульфонамида и 7,7-диоксида 5,6-дигидро-(s)-4-(ациламидо)-(s)-6-алкил-4н-тиено(2,3-b)тиопирана
US7834176B2 (en) Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
EP1730153B1 (en) Isopropanol water solvate of olanzapine
KR100834967B1 (ko) 여액의 라세미화 반응에 의한 ｓ-(＋)-클로피도그렐의고수율 제조방법
KR20060026121A (ko) 혈소판 응집 억제 약물의 무정형 형태를 제조하는 방법
AU2004326111A1 (en) Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCI
TW202116766A (zh) 有光學活性的1,4-苯并硫氮呯-1-氧化物衍生物的製造方法
AU2007227930A1 (en) Method for preparing clopidogrel 1,5-naphthalenedisulfonate or hydrate thereof
JPS62103088A (ja) ４，５，６，７−テトラヒドロチエノ〔３，２−ｃ〕ピリジン又はその塩の製造方法
PL204250B1 (pl) Sposób wytwarzania postaci amorficznej wodorosiarczanu klopidogrelu
KR20070113197A (ko) 5,6-디하이드로-4-(에스)-(에틸아미노)-6-(에스)메틸-4에이치-티에노[2,3비]티오피란-2-술폰아미드-7,7-디옥사이드염산의 제조 방법
HU226773B1 (en) Process for the production of clopidogrel hydrogensulfate polymorph 1

Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: MERCK SHARP & DOHME CORP.

Free format text: MERCK SHARP & DOHME CORP.

PC Transfer of assignment of patent

Owner name: MERCK SHARP & DOHME CORP.

MA Patent expired