FI107384B - Menetelmä 5,6-dihydro-(S)-4-(etyyliamino)-(S)-6-metyyli-4H-tieno[2,3-b]tiopyran- 2-sulfonamidi-7,7-dioksidiyhdisteiden valmistamiseksi - Google Patents

Menetelmä 5,6-dihydro-(S)-4-(etyyliamino)-(S)-6-metyyli-4H-tieno[2,3-b]tiopyran- 2-sulfonamidi-7,7-dioksidiyhdisteiden valmistamiseksi Download PDF

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Publication number
FI107384B
FI107384B FI954438A FI954438A FI107384B FI 107384 B FI107384 B FI 107384B FI 954438 A FI954438 A FI 954438A FI 954438 A FI954438 A FI 954438A FI 107384 B FI107384 B FI 107384B
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FI
Finland
Prior art keywords
compound
formula
mixture
acid
sulfuric acid
Prior art date
Application number
FI954438A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI954438A0 (fi
FI954438A (fi
Inventor
Paul Sohar
David J Mathre
Thomas J Blacklock
Original Assignee
Merck & Co Inc
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Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI954438A0 publication Critical patent/FI954438A0/fi
Publication of FI954438A publication Critical patent/FI954438A/fi
Application granted granted Critical
Publication of FI107384B publication Critical patent/FI107384B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Seasonings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI954438A 1993-03-22 1995-09-20 Menetelmä 5,6-dihydro-(S)-4-(etyyliamino)-(S)-6-metyyli-4H-tieno[2,3-b]tiopyran- 2-sulfonamidi-7,7-dioksidiyhdisteiden valmistamiseksi FI107384B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US3552393A 1993-03-22 1993-03-22
US3552393 1993-03-22
US19588694A 1994-02-10 1994-02-10
US19588694 1994-02-10
PCT/US1994/002852 WO1994021645A1 (fr) 1993-03-22 1994-03-16 SYNTHESE ENANTIOSELECTIVE DU 5,6-DIHYDRO-(S)-4-(ETHYLAMINO)-(S)-6-METHYL-4H-THIENO[2,3-b]THIOPYRAN-2-SULFONAMIDE 7,7-DIOXYDE ET DE COMPOSES APPARENTES
US9402852 1994-03-16

Publications (3)

Publication Number Publication Date
FI954438A0 FI954438A0 (fi) 1995-09-20
FI954438A FI954438A (fi) 1995-09-20
FI107384B true FI107384B (fi) 2001-07-31

Family

ID=26712200

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954438A FI107384B (fi) 1993-03-22 1995-09-20 Menetelmä 5,6-dihydro-(S)-4-(etyyliamino)-(S)-6-metyyli-4H-tieno[2,3-b]tiopyran- 2-sulfonamidi-7,7-dioksidiyhdisteiden valmistamiseksi

Country Status (29)

Country Link
US (1) US5688968A (fr)
EP (1) EP0617037B1 (fr)
JP (1) JP3273096B2 (fr)
KR (1) KR0157162B1 (fr)
CN (1) CN1046732C (fr)
AT (1) ATE163291T1 (fr)
AU (1) AU673409B2 (fr)
BR (1) BR9406017A (fr)
CA (1) CA2119218C (fr)
CY (1) CY2108B1 (fr)
CZ (1) CZ281390B6 (fr)
DE (1) DE69408550T2 (fr)
DK (1) DK0617037T3 (fr)
ES (1) ES2112482T3 (fr)
FI (1) FI107384B (fr)
GR (1) GR3026178T3 (fr)
HK (1) HK1009063A1 (fr)
HR (1) HRP940182B1 (fr)
HU (1) HU217363B (fr)
NO (1) NO313240B1 (fr)
NZ (1) NZ263092A (fr)
PL (1) PL176373B1 (fr)
RO (1) RO115264B1 (fr)
SI (1) SI9420016B (fr)
SK (1) SK280831B6 (fr)
TW (1) TW265343B (fr)
UA (1) UA41921C2 (fr)
WO (1) WO1994021645A1 (fr)
YU (1) YU48951B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760249A (en) * 1995-08-29 1998-06-02 Merck & Co., Inc. Synthesis of hydroxysulfone and related compounds
ES2177415B1 (es) * 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
ES2204306B1 (es) * 2002-08-16 2005-08-01 Ragactives, S.L. Formas polimorficas de clorhidrato de dorzolamida, su obtencion y composiciones farmaceuticas que las contienen.
US7053115B2 (en) * 2003-04-07 2006-05-30 Hetero Drugs Limited Crystalline form of dorzolamide hydrochloride
AU2005290855B2 (en) * 2004-07-09 2010-08-19 Fdc Ltd An improved process for the preparation of 5,6 -dihydro -4H-4(S)-ethylamino-6(S)-methylthieno[2,3-b] thiopyran-2-sulfonamide- 7,7 -dioxide and its salt
ES2253112B1 (es) * 2004-11-05 2007-03-16 Ragactives, S.L. Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano.
US7109353B2 (en) 2004-12-28 2006-09-19 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl
MX2007007923A (es) * 2004-12-28 2007-11-14 Usv Ltd Procedimiento para preparar clorhidrato de 5,6-dihidro-4-(s)- (etilamino)-6-(s)metil-4h-tieno[2,3b]tiopiran-2-sulfonamida-7,7- dioxido.
CN101098874A (zh) * 2005-01-06 2008-01-02 特瓦药厂私人有限公司 制备盐酸多佐胺的方法
JP2008526780A (ja) * 2005-01-18 2008-07-24 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ ドルゾルアミド塩酸塩の非晶質および結晶質の形態およびそれらを製造する方法
US8263787B2 (en) 2007-05-07 2012-09-11 Cipla Limited Process for preparing dorzolamide
CN103415524B (zh) 2011-03-10 2015-11-25 Zach系统股份公司 不对称还原方法
ITMI20121165A1 (it) * 2012-07-03 2014-01-04 Zach System Spa Processo di riduzione asimmetrica
MX2016004940A (es) * 2013-10-17 2016-06-28 Dow Agrosciences Llc Proceso para la preparacion de compuestos plaguicidas.
CN105636445B (zh) * 2013-10-17 2018-12-07 美国陶氏益农公司 制备杀虫化合物的方法
CN103497202B (zh) * 2013-10-23 2015-12-02 武汉武药科技有限公司 盐酸多佐胺中间体的合成方法
CN108822127B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4968814A (en) * 1990-04-18 1990-11-06 Merck & Co., Inc. (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides

Also Published As

Publication number Publication date
HRP940182B1 (en) 2000-02-29
EP0617037B1 (fr) 1998-02-18
CN1119866A (zh) 1996-04-03
FI954438A0 (fi) 1995-09-20
HU217363B (hu) 2000-01-28
HU9502772D0 (en) 1995-11-28
PL310633A1 (en) 1995-12-27
JP3273096B2 (ja) 2002-04-08
DK0617037T3 (da) 1998-03-16
NO953733D0 (no) 1995-09-21
US5688968A (en) 1997-11-18
PL176373B1 (pl) 1999-05-31
YU48951B (sh) 2003-01-31
RO115264B1 (ro) 1999-12-30
AU5787194A (en) 1994-09-29
ATE163291T1 (de) 1998-03-15
FI954438A (fi) 1995-09-20
WO1994021645A1 (fr) 1994-09-29
SK280831B6 (sk) 2000-08-14
SK116995A3 (en) 1997-06-04
TW265343B (fr) 1995-12-11
CN1046732C (zh) 1999-11-24
BR9406017A (pt) 1995-12-19
YU13194A (sh) 1997-01-08
CY2108B1 (en) 2002-04-26
ES2112482T3 (es) 1998-04-01
DE69408550D1 (de) 1998-03-26
KR0157162B1 (ko) 1998-11-16
HK1009063A1 (en) 1999-05-21
GR3026178T3 (en) 1998-05-29
NO313240B1 (no) 2002-09-02
SI9420016A (en) 1996-06-30
CZ281390B6 (cs) 1996-09-11
EP0617037A1 (fr) 1994-09-28
NZ263092A (en) 1997-12-19
CA2119218A1 (fr) 1994-09-23
HUT72676A (en) 1996-05-28
HRP940182A2 (en) 1996-08-31
DE69408550T2 (de) 1998-08-27
AU673409B2 (en) 1996-11-07
CZ241895A3 (en) 1996-01-17
UA41921C2 (uk) 2001-10-15
SI9420016B (sl) 2002-12-31
NO953733L (no) 1995-09-21
JPH06298767A (ja) 1994-10-25
CA2119218C (fr) 2000-02-15

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