CY2108B1 - Enantioselective synthesis of thieno (2,3-b) thiopyran-7, 7-dioxide compounds - Google Patents

Enantioselective synthesis of thieno (2,3-b) thiopyran-7, 7-dioxide compounds

Info

Publication number
CY2108B1
CY2108B1 CY9800020A CY9800020A CY2108B1 CY 2108 B1 CY2108 B1 CY 2108B1 CY 9800020 A CY9800020 A CY 9800020A CY 9800020 A CY9800020 A CY 9800020A CY 2108 B1 CY2108 B1 CY 2108B1
Authority
CY
Cyprus
Prior art keywords
thiopyran
thieno
enantioselective synthesis
dioxide compounds
dioxide
Prior art date
Application number
CY9800020A
Other languages
English (en)
Inventor
Paul Sohar
David J Mathre
Thomas J Blacklock
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CY2108B1 publication Critical patent/CY2108B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CY9800020A 1993-03-22 1998-07-23 Enantioselective synthesis of thieno (2,3-b) thiopyran-7, 7-dioxide compounds CY2108B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3552393A 1993-03-22 1993-03-22
US19588694A 1994-02-10 1994-02-10

Publications (1)

Publication Number Publication Date
CY2108B1 true CY2108B1 (en) 2002-04-26

Family

ID=26712200

Family Applications (1)

Application Number Title Priority Date Filing Date
CY9800020A CY2108B1 (en) 1993-03-22 1998-07-23 Enantioselective synthesis of thieno (2,3-b) thiopyran-7, 7-dioxide compounds

Country Status (29)

Country Link
US (1) US5688968A (fr)
EP (1) EP0617037B1 (fr)
JP (1) JP3273096B2 (fr)
KR (1) KR0157162B1 (fr)
CN (1) CN1046732C (fr)
AT (1) ATE163291T1 (fr)
AU (1) AU673409B2 (fr)
BR (1) BR9406017A (fr)
CA (1) CA2119218C (fr)
CY (1) CY2108B1 (fr)
CZ (1) CZ281390B6 (fr)
DE (1) DE69408550T2 (fr)
DK (1) DK0617037T3 (fr)
ES (1) ES2112482T3 (fr)
FI (1) FI107384B (fr)
GR (1) GR3026178T3 (fr)
HK (1) HK1009063A1 (fr)
HR (1) HRP940182B1 (fr)
HU (1) HU217363B (fr)
NO (1) NO313240B1 (fr)
NZ (1) NZ263092A (fr)
PL (1) PL176373B1 (fr)
RO (1) RO115264B1 (fr)
SI (1) SI9420016B (fr)
SK (1) SK280831B6 (fr)
TW (1) TW265343B (fr)
UA (1) UA41921C2 (fr)
WO (1) WO1994021645A1 (fr)
YU (1) YU48951B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760249A (en) * 1995-08-29 1998-06-02 Merck & Co., Inc. Synthesis of hydroxysulfone and related compounds
ES2177415B1 (es) * 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
ES2204306B1 (es) * 2002-08-16 2005-08-01 Ragactives, S.L. Formas polimorficas de clorhidrato de dorzolamida, su obtencion y composiciones farmaceuticas que las contienen.
US7053115B2 (en) * 2003-04-07 2006-05-30 Hetero Drugs Limited Crystalline form of dorzolamide hydrochloride
MXPA06015274A (es) * 2004-07-09 2007-09-27 Fdc Ltd Un procedimiento mejorado para la preparacion de 5,6-dihidro-4h-4(s)-etilamino-6(s)-metiltieno [2,3-b] tiopiran-2-sulfonamida-7,7-dioxido y sus sales.
ES2253112B1 (es) * 2004-11-05 2007-03-16 Ragactives, S.L. Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano.
US7109353B2 (en) 2004-12-28 2006-09-19 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl
MX2007007923A (es) * 2004-12-28 2007-11-14 Usv Ltd Procedimiento para preparar clorhidrato de 5,6-dihidro-4-(s)- (etilamino)-6-(s)metil-4h-tieno[2,3b]tiopiran-2-sulfonamida-7,7- dioxido.
US20060155132A1 (en) * 2005-01-06 2006-07-13 Kovacs Laszlo Z Method of making dorzolamide hydrochloride
TW200640450A (en) * 2005-01-18 2006-12-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same
AU2008247144B2 (en) * 2007-05-07 2013-02-28 Cipla Limited Process for preparing dorzolamide
EP2683724B1 (fr) 2011-03-10 2015-05-06 ZaCh System S.p.A. Procédé de réduction asymétrique
ITMI20121165A1 (it) * 2012-07-03 2014-01-04 Zach System Spa Processo di riduzione asimmetrica
KR20160075565A (ko) * 2013-10-17 2016-06-29 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
JP6487426B2 (ja) * 2013-10-17 2019-03-20 ダウ アグロサイエンシィズ エルエルシー 有害生物防除化合物の調製法
CN103497202B (zh) * 2013-10-23 2015-12-02 武汉武药科技有限公司 盐酸多佐胺中间体的合成方法
CN108822127B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4968814A (en) * 1990-04-18 1990-11-06 Merck & Co., Inc. (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides

Also Published As

Publication number Publication date
YU48951B (sh) 2003-01-31
ES2112482T3 (es) 1998-04-01
EP0617037A1 (fr) 1994-09-28
DE69408550D1 (de) 1998-03-26
FI107384B (fi) 2001-07-31
TW265343B (fr) 1995-12-11
NO953733L (no) 1995-09-21
HU217363B (hu) 2000-01-28
FI954438A0 (fi) 1995-09-20
HRP940182A2 (en) 1996-08-31
YU13194A (sh) 1997-01-08
DE69408550T2 (de) 1998-08-27
CN1046732C (zh) 1999-11-24
GR3026178T3 (en) 1998-05-29
JP3273096B2 (ja) 2002-04-08
CZ281390B6 (cs) 1996-09-11
SK280831B6 (sk) 2000-08-14
NO953733D0 (no) 1995-09-21
HUT72676A (en) 1996-05-28
HU9502772D0 (en) 1995-11-28
CN1119866A (zh) 1996-04-03
HRP940182B1 (en) 2000-02-29
KR0157162B1 (ko) 1998-11-16
DK0617037T3 (da) 1998-03-16
ATE163291T1 (de) 1998-03-15
US5688968A (en) 1997-11-18
CA2119218A1 (fr) 1994-09-23
JPH06298767A (ja) 1994-10-25
WO1994021645A1 (fr) 1994-09-29
NO313240B1 (no) 2002-09-02
AU5787194A (en) 1994-09-29
NZ263092A (en) 1997-12-19
SI9420016A (en) 1996-06-30
BR9406017A (pt) 1995-12-19
UA41921C2 (uk) 2001-10-15
EP0617037B1 (fr) 1998-02-18
RO115264B1 (ro) 1999-12-30
SI9420016B (sl) 2002-12-31
HK1009063A1 (en) 1999-05-21
CZ241895A3 (en) 1996-01-17
CA2119218C (fr) 2000-02-15
PL176373B1 (pl) 1999-05-31
AU673409B2 (en) 1996-11-07
PL310633A1 (en) 1995-12-27
FI954438A (fi) 1995-09-20
SK116995A3 (en) 1997-06-04

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