FI105913B - Menetelmä farmaseuttisesti arvokkaiden bentsomorfaanien valmistamiseksi - Google Patents

Menetelmä farmaseuttisesti arvokkaiden bentsomorfaanien valmistamiseksi Download PDF

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Publication number
FI105913B
FI105913B FI923050A FI923050A FI105913B FI 105913 B FI105913 B FI 105913B FI 923050 A FI923050 A FI 923050A FI 923050 A FI923050 A FI 923050A FI 105913 B FI105913 B FI 105913B
Authority
FI
Finland
Prior art keywords
alkyl
trimethyl
hydroxy
benzomorphane
methoxypropyl
Prior art date
Application number
FI923050A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI923050A0 (fi
FI923050A (fi
Inventor
Helmut Ensinger
Matthias Grauert
Herbert Merz
Ilse Streller
Werner Stransky
Adrian Carter
Enzio Mueller
Franz Josefy Kuhn
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of FI923050A0 publication Critical patent/FI923050A0/fi
Publication of FI923050A publication Critical patent/FI923050A/fi
Application granted granted Critical
Publication of FI105913B publication Critical patent/FI105913B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI923050A 1991-07-02 1992-07-01 Menetelmä farmaseuttisesti arvokkaiden bentsomorfaanien valmistamiseksi FI105913B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4121821A DE4121821A1 (de) 1991-07-02 1991-07-02 Neue benzomorphane und ihre verwendung als arzneimittel
DE4121821 1991-07-02

Publications (3)

Publication Number Publication Date
FI923050A0 FI923050A0 (fi) 1992-07-01
FI923050A FI923050A (fi) 1993-01-03
FI105913B true FI105913B (fi) 2000-10-31

Family

ID=6435223

Family Applications (1)

Application Number Title Priority Date Filing Date
FI923050A FI105913B (fi) 1991-07-02 1992-07-01 Menetelmä farmaseuttisesti arvokkaiden bentsomorfaanien valmistamiseksi

Country Status (24)

Country Link
EP (1) EP0521422B1 (sk)
JP (1) JP3324785B2 (sk)
KR (1) KR100251256B1 (sk)
AT (1) ATE137749T1 (sk)
AU (1) AU657330B2 (sk)
CA (1) CA2072814C (sk)
CZ (1) CZ286949B6 (sk)
DE (2) DE4121821A1 (sk)
DK (1) DK0521422T3 (sk)
ES (1) ES2086585T3 (sk)
FI (1) FI105913B (sk)
GR (1) GR3020124T3 (sk)
HK (1) HK1003111A1 (sk)
HU (1) HU220873B1 (sk)
IE (1) IE74400B1 (sk)
IL (1) IL102361A (sk)
MX (1) MX9203845A (sk)
NO (1) NO178263C (sk)
NZ (1) NZ243388A (sk)
PH (1) PH31430A (sk)
SG (1) SG43001A1 (sk)
SK (1) SK280776B6 (sk)
TW (1) TW214547B (sk)
ZA (1) ZA924883B (sk)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JPH1196519A (ja) * 1997-09-17 1999-04-09 Alps Electric Co Ltd スピンバルブ型薄膜素子およびその製造方法
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
US6355652B1 (en) 1999-11-27 2002-03-12 Boehringer Ingelheim Pharma Kg Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE19957156A1 (de) * 1999-11-27 2001-05-31 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
DE10204276A1 (de) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
MXPA04011327A (es) 2002-05-17 2005-08-15 Jenken Biosciences Inc Opioides y compuestos similares a opioides y usos de los mismos.
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8859580B2 (en) * 2007-11-16 2014-10-14 Boehringer Ingelheim International Gmbh Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
WO2015097545A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
NL7907800A (nl) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.

Also Published As

Publication number Publication date
ES2086585T3 (es) 1996-07-01
SK280776B6 (sk) 2000-07-11
NO922603L (no) 1993-01-04
CA2072814C (en) 2003-09-23
AU657330B2 (en) 1995-03-09
JPH05201987A (ja) 1993-08-10
ATE137749T1 (de) 1996-05-15
FI923050A0 (fi) 1992-07-01
EP0521422A1 (de) 1993-01-07
IL102361A (en) 1997-02-18
DK0521422T3 (da) 1996-06-10
KR930002321A (ko) 1993-02-22
CZ286949B6 (cs) 2000-08-16
JP3324785B2 (ja) 2002-09-17
HU9202199D0 (en) 1992-10-28
CA2072814A1 (en) 1993-01-03
SG43001A1 (en) 1997-10-17
IE74400B1 (en) 1997-07-30
NZ243388A (en) 1994-11-25
EP0521422B1 (de) 1996-05-08
HK1003111A1 (en) 1998-10-09
HUT66410A (en) 1994-11-28
CZ207592A3 (en) 1993-08-11
MX9203845A (es) 1993-01-01
DE59206212D1 (de) 1996-06-13
SK207592A3 (en) 1997-01-08
NO922603D0 (no) 1992-07-01
KR100251256B1 (ko) 2000-05-01
IL102361A0 (en) 1993-01-14
ZA924883B (en) 1993-02-24
PH31430A (en) 1998-11-03
AU1868692A (en) 1993-01-07
DE4121821A1 (de) 1993-01-14
NO178263B (no) 1995-11-13
FI923050A (fi) 1993-01-03
NO178263C (no) 1996-02-21
GR3020124T3 (en) 1996-08-31
TW214547B (sk) 1993-10-11
IE922144A1 (en) 1993-01-13
HU220873B1 (en) 2002-06-29

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