AU1868692A - Benzomorphan derivatives - Google Patents

Benzomorphan derivatives

Info

Publication number
AU1868692A
AU1868692A AU18686/92A AU1868692A AU1868692A AU 1868692 A AU1868692 A AU 1868692A AU 18686/92 A AU18686/92 A AU 18686/92A AU 1868692 A AU1868692 A AU 1868692A AU 1868692 A AU1868692 A AU 1868692A
Authority
AU
Australia
Prior art keywords
alkyl
acyl
aryl
benzomorphan derivatives
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU18686/92A
Other versions
AU657330B2 (en
Inventor
Adrian Carter
Helmut Ensinger
Matthias Grauert
Franz Josef Kuhn
Herbert Merz
Enzio Muller
Werner Stransky
Ilse Streller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU1868692A publication Critical patent/AU1868692A/en
Application granted granted Critical
Publication of AU657330B2 publication Critical patent/AU657330B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

Benzomorphane derivs. of formula (I) are new. In (I), X = O or S; R1 = 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl or aryl; R2 = H, 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl, aryl or aralkyl; R3 = H or 1-6C alkyl; R4 and R5 = each 1-8C alkyl; R6 = 1-8C alkyl or aryl; R7 and R8 = each H, 1-8C alkyl, halogen, OH, 1-8C alkoxy, O-Acyl, CN, NO2, NH2, NH(1-8C alkyl), N(1-8C alkyl)2 (n which the alkyl gps. are opt. different), NH-acyl or N-acyl-(1-8C alkyl).
AU18686/92A 1991-07-02 1992-06-30 Benzomorphan derivatives Expired AU657330B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4121821A DE4121821A1 (en) 1991-07-02 1991-07-02 NEW BENZOMORPHANE AND ITS USE AS A MEDICAMENT
DE4121821 1991-07-02

Publications (2)

Publication Number Publication Date
AU1868692A true AU1868692A (en) 1993-01-07
AU657330B2 AU657330B2 (en) 1995-03-09

Family

ID=6435223

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18686/92A Expired AU657330B2 (en) 1991-07-02 1992-06-30 Benzomorphan derivatives

Country Status (24)

Country Link
EP (1) EP0521422B1 (en)
JP (1) JP3324785B2 (en)
KR (1) KR100251256B1 (en)
AT (1) ATE137749T1 (en)
AU (1) AU657330B2 (en)
CA (1) CA2072814C (en)
CZ (1) CZ286949B6 (en)
DE (2) DE4121821A1 (en)
DK (1) DK0521422T3 (en)
ES (1) ES2086585T3 (en)
FI (1) FI105913B (en)
GR (1) GR3020124T3 (en)
HK (1) HK1003111A1 (en)
HU (1) HU220873B1 (en)
IE (1) IE74400B1 (en)
IL (1) IL102361A (en)
MX (1) MX9203845A (en)
NO (1) NO178263C (en)
NZ (1) NZ243388A (en)
PH (1) PH31430A (en)
SG (1) SG43001A1 (en)
SK (1) SK280776B6 (en)
TW (1) TW214547B (en)
ZA (1) ZA924883B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (en) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg New process for the production of norbenzomorphan of an intermediate stage in the production of pharmaceutically valuable benzomorphan derivatives, in particular of (-) - (1R, 5S, S "R) -3'-hydroxy-2- (2-methoxypropyl -) - 5.9.9 -trimethyl-6.7 benzomorphan
DE19740110A1 (en) 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma New hydroxy substituted benzomorphan derivatives
JPH1196519A (en) * 1997-09-17 1999-04-09 Alps Electric Co Ltd Spin valve type thin-film element and its production
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
DE19826365A1 (en) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Use of benzomorphan derivatives as an analgesic
US6355652B1 (en) 1999-11-27 2002-03-12 Boehringer Ingelheim Pharma Kg Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE19957156A1 (en) * 1999-11-27 2001-05-31 Boehringer Ingelheim Pharma New amino and fluoro substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine derivatives useful in treatment of e.g. arrythmias, spasms, ischaemia, pain and neurodegenerative disorders
DE10204276A1 (en) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceuticals
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
JP5438250B2 (en) 2002-05-17 2014-03-12 ジェンケン バイオサイエンスィズ，インコーポレイテッド Opioids and opioid-like compounds and their use
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP2220048B1 (en) * 2007-11-16 2017-01-25 Boehringer Ingelheim International GmbH Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
WO2015097545A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (en) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Novel 6,7-benzomorphan derivatives and their acid addition salts.
DE2828039A1 (en) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF
NL7907800A (en) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Novel 6,7-benzomorphan derivatives and their acid addition salts, pharmaceutical compositions containing such a compound, and process for the preparation of these compounds and their pharmaceutical compositions.

Also Published As

Publication number Publication date
DE4121821A1 (en) 1993-01-14
IL102361A (en) 1997-02-18
NZ243388A (en) 1994-11-25
SK207592A3 (en) 1997-01-08
CA2072814C (en) 2003-09-23
TW214547B (en) 1993-10-11
SK280776B6 (en) 2000-07-11
KR100251256B1 (en) 2000-05-01
JP3324785B2 (en) 2002-09-17
AU657330B2 (en) 1995-03-09
EP0521422A1 (en) 1993-01-07
HK1003111A1 (en) 1998-10-09
HU9202199D0 (en) 1992-10-28
FI105913B (en) 2000-10-31
FI923050A0 (en) 1992-07-01
FI923050A (en) 1993-01-03
CA2072814A1 (en) 1993-01-03
DK0521422T3 (en) 1996-06-10
CZ286949B6 (en) 2000-08-16
DE59206212D1 (en) 1996-06-13
HUT66410A (en) 1994-11-28
NO178263B (en) 1995-11-13
IE922144A1 (en) 1993-01-13
KR930002321A (en) 1993-02-22
NO922603L (en) 1993-01-04
SG43001A1 (en) 1997-10-17
ES2086585T3 (en) 1996-07-01
EP0521422B1 (en) 1996-05-08
PH31430A (en) 1998-11-03
NO178263C (en) 1996-02-21
GR3020124T3 (en) 1996-08-31
CZ207592A3 (en) 1993-08-11
IE74400B1 (en) 1997-07-30
NO922603D0 (en) 1992-07-01
IL102361A0 (en) 1993-01-14
ZA924883B (en) 1993-02-24
HU220873B1 (en) 2002-06-29
MX9203845A (en) 1993-01-01
JPH05201987A (en) 1993-08-10
ATE137749T1 (en) 1996-05-15

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