HK1003111A1 - Benzomorphanes and their use as pharmaceuticals - Google Patents

Benzomorphanes and their use as pharmaceuticals

Info

Publication number
HK1003111A1
HK1003111A1 HK98102148A HK98102148A HK1003111A1 HK 1003111 A1 HK1003111 A1 HK 1003111A1 HK 98102148 A HK98102148 A HK 98102148A HK 98102148 A HK98102148 A HK 98102148A HK 1003111 A1 HK1003111 A1 HK 1003111A1
Authority
HK
Hong Kong
Prior art keywords
alkyl
acyl
aryl
benzomorphanes
pharmaceuticals
Prior art date
Application number
HK98102148A
Inventor
Adrian Carter
Matthias Grauert
Herbert Merz
Werner Stransky
Helmut Ensinger
Franz Josef Kuhn
Enzio Muller
Ilse Streller
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of HK1003111A1 publication Critical patent/HK1003111A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Benzomorphane derivs. of formula (I) are new. In (I), X = O or S; R1 = 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl or aryl; R2 = H, 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl, aryl or aralkyl; R3 = H or 1-6C alkyl; R4 and R5 = each 1-8C alkyl; R6 = 1-8C alkyl or aryl; R7 and R8 = each H, 1-8C alkyl, halogen, OH, 1-8C alkoxy, O-Acyl, CN, NO2, NH2, NH(1-8C alkyl), N(1-8C alkyl)2 (n which the alkyl gps. are opt. different), NH-acyl or N-acyl-(1-8C alkyl).
HK98102148A 1991-07-02 1998-03-16 Benzomorphanes and their use as pharmaceuticals HK1003111A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4121821A DE4121821A1 (en) 1991-07-02 1991-07-02 NEW BENZOMORPHANE AND ITS USE AS A MEDICAMENT

Publications (1)

Publication Number Publication Date
HK1003111A1 true HK1003111A1 (en) 1998-10-09

Family

ID=6435223

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98102148A HK1003111A1 (en) 1991-07-02 1998-03-16 Benzomorphanes and their use as pharmaceuticals

Country Status (24)

Country Link
EP (1) EP0521422B1 (en)
JP (1) JP3324785B2 (en)
KR (1) KR100251256B1 (en)
AT (1) ATE137749T1 (en)
AU (1) AU657330B2 (en)
CA (1) CA2072814C (en)
CZ (1) CZ286949B6 (en)
DE (2) DE4121821A1 (en)
DK (1) DK0521422T3 (en)
ES (1) ES2086585T3 (en)
FI (1) FI105913B (en)
GR (1) GR3020124T3 (en)
HK (1) HK1003111A1 (en)
HU (1) HU220873B1 (en)
IE (1) IE74400B1 (en)
IL (1) IL102361A (en)
MX (1) MX9203845A (en)
NO (1) NO178263C (en)
NZ (1) NZ243388A (en)
PH (1) PH31430A (en)
SG (1) SG43001A1 (en)
SK (1) SK280776B6 (en)
TW (1) TW214547B (en)
ZA (1) ZA924883B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (en) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg New process for the production of norbenzomorphan of an intermediate stage in the production of pharmaceutically valuable benzomorphan derivatives, in particular of (-) - (1R, 5S, S "R) -3'-hydroxy-2- (2-methoxypropyl -) - 5.9.9 -trimethyl-6.7 benzomorphan
DE19740110A1 (en) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma New hydroxy substituted benzomorphan derivatives
JPH1196519A (en) * 1997-09-17 1999-04-09 Alps Electric Co Ltd Spin valve type thin-film element and its production
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
DE19826365A1 (en) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Use of benzomorphan derivatives as an analgesic
US6355652B1 (en) 1999-11-27 2002-03-12 Boehringer Ingelheim Pharma Kg Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE19957156A1 (en) * 1999-11-27 2001-05-31 Boehringer Ingelheim Pharma New amino and fluoro substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine derivatives useful in treatment of e.g. arrythmias, spasms, ischaemia, pain and neurodegenerative disorders
DE10204276A1 (en) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceuticals
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
WO2003097608A2 (en) 2002-05-17 2003-11-27 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
AR069545A1 (en) * 2007-11-16 2010-02-03 Boehringer Ingelheim Pharma DERIVATIVES OF ARIL AND HETEROARILCARBONILO OF RELATED BENZOMORPHANS AND RELATED STRUCTURES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, OBTAINING THEMSELVES, THEIR USE IN THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF THE HIDDEN AND DISEASE
US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (en) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Novel 6,7-benzomorphan derivatives and their acid addition salts.
DE2828039A1 (en) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF
NL7907800A (en) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Novel 6,7-benzomorphan derivatives and their acid addition salts, pharmaceutical compositions containing such a compound, and process for the preparation of these compounds and their pharmaceutical compositions.

Also Published As

Publication number Publication date
FI923050A (en) 1993-01-03
AU1868692A (en) 1993-01-07
CA2072814A1 (en) 1993-01-03
HU220873B1 (en) 2002-06-29
SG43001A1 (en) 1997-10-17
SK207592A3 (en) 1997-01-08
IE922144A1 (en) 1993-01-13
NZ243388A (en) 1994-11-25
ES2086585T3 (en) 1996-07-01
AU657330B2 (en) 1995-03-09
EP0521422B1 (en) 1996-05-08
CZ286949B6 (en) 2000-08-16
CA2072814C (en) 2003-09-23
KR100251256B1 (en) 2000-05-01
IE74400B1 (en) 1997-07-30
ZA924883B (en) 1993-02-24
TW214547B (en) 1993-10-11
FI105913B (en) 2000-10-31
NO922603D0 (en) 1992-07-01
IL102361A (en) 1997-02-18
DK0521422T3 (en) 1996-06-10
DE4121821A1 (en) 1993-01-14
NO178263B (en) 1995-11-13
NO178263C (en) 1996-02-21
HUT66410A (en) 1994-11-28
JPH05201987A (en) 1993-08-10
JP3324785B2 (en) 2002-09-17
CZ207592A3 (en) 1993-08-11
MX9203845A (en) 1993-01-01
ATE137749T1 (en) 1996-05-15
FI923050A0 (en) 1992-07-01
DE59206212D1 (en) 1996-06-13
EP0521422A1 (en) 1993-01-07
HU9202199D0 (en) 1992-10-28
KR930002321A (en) 1993-02-22
NO922603L (en) 1993-01-04
GR3020124T3 (en) 1996-08-31
IL102361A0 (en) 1993-01-14
PH31430A (en) 1998-11-03
SK280776B6 (en) 2000-07-11

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Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20120626