IL102361A0 - Benzomorphan derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
Benzomorphan derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL102361A0 IL102361A0 IL102361A IL10236192A IL102361A0 IL 102361 A0 IL102361 A0 IL 102361A0 IL 102361 A IL102361 A IL 102361A IL 10236192 A IL10236192 A IL 10236192A IL 102361 A0 IL102361 A0 IL 102361A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- preparation
- pharmaceutical compositions
- compositions containing
- benzomorphan derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Benzomorphane derivs. of formula (I) are new. In (I), X = O or S; R1 = 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl or aryl; R2 = H, 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl, aryl or aralkyl; R3 = H or 1-6C alkyl; R4 and R5 = each 1-8C alkyl; R6 = 1-8C alkyl or aryl; R7 and R8 = each H, 1-8C alkyl, halogen, OH, 1-8C alkoxy, O-Acyl, CN, NO2, NH2, NH(1-8C alkyl), N(1-8C alkyl)2 (n which the alkyl gps. are opt. different), NH-acyl or N-acyl-(1-8C alkyl).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4121821A DE4121821A1 (en) | 1991-07-02 | 1991-07-02 | NEW BENZOMORPHANE AND ITS USE AS A MEDICAMENT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL102361A0 true IL102361A0 (en) | 1993-01-14 |
| IL102361A IL102361A (en) | 1997-02-18 |
Family
ID=6435223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10236192A IL102361A (en) | 1991-07-02 | 1992-06-30 | Benzomorphan derivatives their preparation and pharmaceutical compositions containing them |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0521422B1 (en) |
| JP (1) | JP3324785B2 (en) |
| KR (1) | KR100251256B1 (en) |
| AT (1) | ATE137749T1 (en) |
| AU (1) | AU657330B2 (en) |
| CA (1) | CA2072814C (en) |
| CZ (1) | CZ286949B6 (en) |
| DE (2) | DE4121821A1 (en) |
| DK (1) | DK0521422T3 (en) |
| ES (1) | ES2086585T3 (en) |
| FI (1) | FI105913B (en) |
| GR (1) | GR3020124T3 (en) |
| HK (1) | HK1003111A1 (en) |
| HU (1) | HU220873B1 (en) |
| IE (1) | IE74400B1 (en) |
| IL (1) | IL102361A (en) |
| MX (1) | MX9203845A (en) |
| NO (1) | NO178263C (en) |
| NZ (1) | NZ243388A (en) |
| PH (1) | PH31430A (en) |
| SG (1) | SG43001A1 (en) |
| SK (1) | SK280776B6 (en) |
| TW (1) | TW214547B (en) |
| ZA (1) | ZA924883B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19528472A1 (en) * | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | New process for the production of norbenzomorphan of an intermediate stage in the production of pharmaceutically valuable benzomorphan derivatives, in particular of (-) - (1R, 5S, S "R) -3'-hydroxy-2- (2-methoxypropyl -) - 5.9.9 -trimethyl-6.7 benzomorphan |
| DE19740110A1 (en) * | 1997-09-12 | 1999-03-18 | Boehringer Ingelheim Pharma | New hydroxy substituted benzomorphan derivatives |
| JPH1196519A (en) * | 1997-09-17 | 1999-04-09 | Alps Electric Co Ltd | Spin valve type thin-film element and its production |
| US6136980A (en) * | 1998-05-01 | 2000-10-24 | Boehringer Ingelheim Kg | Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane |
| DE19826365A1 (en) * | 1998-06-12 | 1999-12-16 | Gruenenthal Gmbh | Use of benzomorphan derivatives as an analgesic |
| DE19957156A1 (en) * | 1999-11-27 | 2001-05-31 | Boehringer Ingelheim Pharma | New amino and fluoro substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine derivatives useful in treatment of e.g. arrythmias, spasms, ischaemia, pain and neurodegenerative disorders |
| US6355652B1 (en) | 1999-11-27 | 2002-03-12 | Boehringer Ingelheim Pharma Kg | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions |
| DE10204276A1 (en) * | 2002-02-02 | 2003-08-07 | Boehringer Ingelheim Pharma | N-Allyloxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceuticals |
| EP2987788A1 (en) | 2002-05-17 | 2016-02-24 | Taiwanj Pharmaceuticals Co., Ltd. | Opioid and opioid-like compounds and uses thereof |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| CA2704628C (en) * | 2007-11-16 | 2016-11-29 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| EP3087079B1 (en) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7804509A (en) * | 1978-04-26 | 1979-10-30 | Acf Chemiefarma Nv | Novel 6,7-benzomorphan derivatives and their acid addition salts. |
| DE2828039A1 (en) * | 1978-06-26 | 1980-01-10 | Boehringer Sohn Ingelheim | 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF |
| NL7907800A (en) * | 1979-10-23 | 1981-04-27 | Acf Chemiefarma Nv | Novel 6,7-benzomorphan derivatives and their acid addition salts, pharmaceutical compositions containing such a compound, and process for the preparation of these compounds and their pharmaceutical compositions. |
-
1991
- 1991-07-02 DE DE4121821A patent/DE4121821A1/en not_active Withdrawn
-
1992
- 1992-06-03 TW TW081104377A patent/TW214547B/zh not_active IP Right Cessation
- 1992-06-27 DK DK92110923.7T patent/DK0521422T3/en active
- 1992-06-27 AT AT92110923T patent/ATE137749T1/en active
- 1992-06-27 EP EP92110923A patent/EP0521422B1/en not_active Expired - Lifetime
- 1992-06-27 SG SG1996002082A patent/SG43001A1/en unknown
- 1992-06-27 DE DE59206212T patent/DE59206212D1/en not_active Expired - Lifetime
- 1992-06-27 ES ES92110923T patent/ES2086585T3/en not_active Expired - Lifetime
- 1992-06-30 MX MX9203845A patent/MX9203845A/en unknown
- 1992-06-30 NZ NZ243388A patent/NZ243388A/en not_active IP Right Cessation
- 1992-06-30 IL IL10236192A patent/IL102361A/en not_active IP Right Cessation
- 1992-06-30 CA CA002072814A patent/CA2072814C/en not_active Expired - Lifetime
- 1992-06-30 AU AU18686/92A patent/AU657330B2/en not_active Expired
- 1992-07-01 KR KR1019920011664A patent/KR100251256B1/en not_active IP Right Cessation
- 1992-07-01 NO NO922603A patent/NO178263C/en not_active IP Right Cessation
- 1992-07-01 IE IE922144A patent/IE74400B1/en not_active IP Right Cessation
- 1992-07-01 ZA ZA924883A patent/ZA924883B/en unknown
- 1992-07-01 FI FI923050A patent/FI105913B/en not_active IP Right Cessation
- 1992-07-01 JP JP17447992A patent/JP3324785B2/en not_active Expired - Lifetime
- 1992-07-01 HU HU9202199A patent/HU220873B1/en unknown
- 1992-07-02 PH PH44606A patent/PH31430A/en unknown
- 1992-07-02 SK SK2075-92A patent/SK280776B6/en not_active IP Right Cessation
- 1992-07-02 CZ CS19922075A patent/CZ286949B6/en not_active IP Right Cessation
-
1996
- 1996-05-31 GR GR960401503T patent/GR3020124T3/en unknown
-
1998
- 1998-03-16 HK HK98102148A patent/HK1003111A1/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL102361A0 (en) | Benzomorphan derivatives,their preparation and pharmaceutical compositions containing them | |
| HUP0401174A2 (en) | Ecteinascidin analogues, their use in the preparation of a medicament for treatment of cancer and pharmaceutical compositions containing the compounds | |
| ATE201019T1 (en) | 9-DEOXOTAXANE COMPOUNDS | |
| IL128690A0 (en) | Cyclic amine derivatives pharmaceutical compositions containing the same and use thereof | |
| MX9805181A (en) | Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives. | |
| DK0671156T3 (en) | Cosmetic or pharmaceutical preparations containing liposomes | |
| NO912940D0 (en) | IMMUNE REPRESENTATIVE AGENT AND PROCEDURE FOR PREPARING THE SAME. | |
| IL94433A0 (en) | Aminophenol derivatives,their preparation and pharmaceutical compositions containing them | |
| ES2134801T3 (en) | CRYSTAL TIAGABINE HYDROCHLORIDE MONOHYDRATE, ITS PREPARATION AND USE. | |
| UA50711C2 (en) | Anthracyclinone derivatives, their use for amyloidosis treatment and pharmaceutical formulation | |
| RU2000102672A (en) | DERIVATIVES 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO [4,5-B] INDOL-1-ACETAMIDE, THEIR RECEIVING AND APPLICATION IN THERAPY | |
| MXPA02012426A (en) | Novel compounds. | |
| ES2145561T3 (en) | SUBSTITUTED BENCIL (S) DERIVATIVES (S) OF POLYALKYLENPOLIAMIDES AND ITS USE IN COSMETIC AND PHARMACEUTICAL COMPOSITIONS. | |
| NZ240280A (en) | Ergoline derivatives and pharmaceutical compositions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH | Patent void | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |