DK0521422T3 - Benzomorphaner, fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler - Google Patents

Benzomorphaner, fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler

Info

Publication number
DK0521422T3
DK0521422T3 DK92110923.7T DK92110923T DK0521422T3 DK 0521422 T3 DK0521422 T3 DK 0521422T3 DK 92110923 T DK92110923 T DK 92110923T DK 0521422 T3 DK0521422 T3 DK 0521422T3
Authority
DK
Denmark
Prior art keywords
alkyl
benzomorphans
pharmaceuticals
processes
preparation
Prior art date
Application number
DK92110923.7T
Other languages
English (en)
Inventor
Franz Josef Dr Kuhn
Adrian Dr Carter
Helmut Dr Dipl-Chem Ensinger
Matthias Dr Dipl-Chem Grauert
Herbert Dr Dipl-Chem Merz
Enzio Prof Dr Mueller
Werner Dr Dipl-Chem Stransky
Ilse Dr Streller
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of DK0521422T3 publication Critical patent/DK0521422T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DK92110923.7T 1991-07-02 1992-06-27 Benzomorphaner, fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler DK0521422T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4121821A DE4121821A1 (de) 1991-07-02 1991-07-02 Neue benzomorphane und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DK0521422T3 true DK0521422T3 (da) 1996-06-10

Family

ID=6435223

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92110923.7T DK0521422T3 (da) 1991-07-02 1992-06-27 Benzomorphaner, fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler

Country Status (24)

Country Link
EP (1) EP0521422B1 (da)
JP (1) JP3324785B2 (da)
KR (1) KR100251256B1 (da)
AT (1) ATE137749T1 (da)
AU (1) AU657330B2 (da)
CA (1) CA2072814C (da)
CZ (1) CZ286949B6 (da)
DE (2) DE4121821A1 (da)
DK (1) DK0521422T3 (da)
ES (1) ES2086585T3 (da)
FI (1) FI105913B (da)
GR (1) GR3020124T3 (da)
HK (1) HK1003111A1 (da)
HU (1) HU220873B1 (da)
IE (1) IE74400B1 (da)
IL (1) IL102361A (da)
MX (1) MX9203845A (da)
NO (1) NO178263C (da)
NZ (1) NZ243388A (da)
PH (1) PH31430A (da)
SG (1) SG43001A1 (da)
SK (1) SK280776B6 (da)
TW (1) TW214547B (da)
ZA (1) ZA924883B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JPH1196519A (ja) * 1997-09-17 1999-04-09 Alps Electric Co Ltd スピンバルブ型薄膜素子およびその製造方法
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
DE19957156A1 (de) * 1999-11-27 2001-05-31 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6355652B1 (en) 1999-11-27 2002-03-12 Boehringer Ingelheim Pharma Kg Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE10204276A1 (de) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
MXPA04011327A (es) 2002-05-17 2005-08-15 Jenken Biosciences Inc Opioides y compuestos similares a opioides y usos de los mismos.
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
AR069545A1 (es) * 2007-11-16 2010-02-03 Boehringer Ingelheim Pharma Derivados de aril y heteroarilcarbonilo de benzomorfanos y estructuras relacionadas, composiciones farmaceuticas que contienen dichos compuestos, obtencion de las mismas, su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa (hsd) 1 y
WO2015097545A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (nl) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
NL7907800A (nl) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.

Also Published As

Publication number Publication date
NZ243388A (en) 1994-11-25
HU220873B1 (en) 2002-06-29
IE74400B1 (en) 1997-07-30
SG43001A1 (en) 1997-10-17
SK280776B6 (sk) 2000-07-11
DE4121821A1 (de) 1993-01-14
HU9202199D0 (en) 1992-10-28
DE59206212D1 (de) 1996-06-13
CA2072814A1 (en) 1993-01-03
ES2086585T3 (es) 1996-07-01
FI923050A0 (fi) 1992-07-01
FI923050A (fi) 1993-01-03
IL102361A (en) 1997-02-18
NO922603D0 (no) 1992-07-01
MX9203845A (es) 1993-01-01
TW214547B (da) 1993-10-11
NO178263C (no) 1996-02-21
NO922603L (no) 1993-01-04
IL102361A0 (en) 1993-01-14
FI105913B (fi) 2000-10-31
CZ286949B6 (cs) 2000-08-16
ATE137749T1 (de) 1996-05-15
AU1868692A (en) 1993-01-07
GR3020124T3 (en) 1996-08-31
KR930002321A (ko) 1993-02-22
EP0521422B1 (de) 1996-05-08
PH31430A (en) 1998-11-03
HUT66410A (en) 1994-11-28
HK1003111A1 (en) 1998-10-09
EP0521422A1 (de) 1993-01-07
CZ207592A3 (en) 1993-08-11
KR100251256B1 (ko) 2000-05-01
JPH05201987A (ja) 1993-08-10
SK207592A3 (en) 1997-01-08
JP3324785B2 (ja) 2002-09-17
NO178263B (no) 1995-11-13
ZA924883B (en) 1993-02-24
CA2072814C (en) 2003-09-23
AU657330B2 (en) 1995-03-09
IE922144A1 (en) 1993-01-13

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