FI101676B1 - Parannettu menetelmä stabiilin mikrohelmikoostumuksen valmistamiseksi - Google Patents

Parannettu menetelmä stabiilin mikrohelmikoostumuksen valmistamiseksi

Info

Publication number
FI101676B1
FI101676B1 FI911531A FI911531A FI101676B1 FI 101676 B1 FI101676 B1 FI 101676B1 FI 911531 A FI911531 A FI 911531A FI 911531 A FI911531 A FI 911531A FI 101676 B1 FI101676 B1 FI 101676B1
Authority
FI
Finland
Prior art keywords
producing
improved process
microsphere composition
stable microsphere
stable
Prior art date
Application number
FI911531A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI101676B (fi
FI911531A0 (fi
FI911531A (fi
Inventor
William Steber
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FI911531A0 publication Critical patent/FI911531A0/fi
Publication of FI911531A publication Critical patent/FI911531A/fi
Application granted granted Critical
Publication of FI101676B publication Critical patent/FI101676B/fi
Publication of FI101676B1 publication Critical patent/FI101676B1/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
FI911531A 1990-03-30 1991-03-28 Parannettu menetelmä stabiilin mikrohelmikoostumuksen valmistamiseksi FI101676B1 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50238290 1990-03-30
US07/502,382 US5213810A (en) 1990-03-30 1990-03-30 Stable compositions for parenteral administration and method of making same

Publications (4)

Publication Number Publication Date
FI911531A0 FI911531A0 (fi) 1991-03-28
FI911531A FI911531A (fi) 1991-10-01
FI101676B FI101676B (fi) 1998-08-14
FI101676B1 true FI101676B1 (fi) 1998-08-14

Family

ID=23997559

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911531A FI101676B1 (fi) 1990-03-30 1991-03-28 Parannettu menetelmä stabiilin mikrohelmikoostumuksen valmistamiseksi

Country Status (29)

Country Link
US (1) US5213810A (no)
EP (1) EP0448930B1 (no)
JP (1) JP2966564B2 (no)
KR (1) KR0159778B1 (no)
CN (1) CN1063941C (no)
AR (1) AR248085A1 (no)
AT (1) ATE106240T1 (no)
AU (1) AU641994B2 (no)
BG (1) BG60850B1 (no)
CA (1) CA2039491C (no)
CZ (1) CZ283053B6 (no)
DE (1) DE69102176T2 (no)
DK (1) DK0448930T3 (no)
ES (1) ES2054380T3 (no)
FI (1) FI101676B1 (no)
HK (1) HK1000004A1 (no)
HU (1) HU219584B (no)
IE (1) IE65970B1 (no)
IL (1) IL97145A (no)
MX (1) MX172602B (no)
NO (1) NO300717B1 (no)
NZ (1) NZ237509A (no)
PL (1) PL167692B1 (no)
PT (1) PT97160B (no)
RO (1) RO106191B1 (no)
RU (1) RU2011377C1 (no)
SK (1) SK279461B6 (no)
YU (1) YU47650B (no)
ZA (1) ZA912398B (no)

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US5599660A (en) * 1993-01-19 1997-02-04 Pharmacia Biotech Inc. Method and preparation for sequential delivery of wax-embedded, inactivated biological and chemical reagents
US6083430A (en) * 1994-10-28 2000-07-04 Fuisz Technologies Ltd. Method of preparing a dosage unit by direct tableting and product therefrom
US5683720A (en) * 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
AU2002300572B2 (en) * 1997-09-19 2004-11-25 Shire Laboratories, Inc. Solid Solution Beadlet
US6692767B2 (en) 1997-09-19 2004-02-17 Shire Laboratories Inc. Solid solution beadlet
US6117452A (en) * 1998-08-12 2000-09-12 Fuisz Technologies Ltd. Fatty ester combinations
TR200103188T2 (tr) * 1999-05-07 2002-04-22 Pharmasol Gmbh Sıvı ve katı lipit karışımları temelli lipid parçacıklar.
KR20020011985A (ko) * 1999-05-07 2002-02-09 파르마솔 게엠베하 액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법
CA2376202C (en) * 1999-06-07 2008-11-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel preparation and administration form comprising an acid-labile active compound
ATE364442T1 (de) 2000-04-27 2007-07-15 Verion Inc Nullte-ordnung-freisetzung und temperatur- kontrollierte mikrokapseln sowie herstellungsverfahren
AU7302801A (en) * 2000-06-26 2002-01-08 Omegatech Inc Improved methods of incorporating polyunsaturated fatty acids in milk
CA2423484A1 (en) 2000-09-27 2002-04-04 Verion Inc. Instant water dissolvable encapsulate and process
DE60133706T2 (de) * 2000-10-10 2009-07-02 Wyeth Holdings Corp. Stabilisierte Arzneizusammensetzungen zur parenteralen Vearbreichung
FR2852843B1 (fr) 2003-03-24 2008-05-23 Karim Ioualalen Systeme galenique permettant le masquage du gout
CA2547597A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
PT1691787E (pt) * 2003-12-04 2008-09-02 Pfizer Prod Inc Método de formação de multipartículas farmacêuticas
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
WO2005053640A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
EP1689368B1 (en) * 2003-12-04 2016-09-28 Bend Research, Inc Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions
AU2004294813A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US8221809B2 (en) * 2006-06-22 2012-07-17 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
KR101200728B1 (ko) 2006-08-09 2012-11-13 인타르시아 세라퓨틱스 인코포레이티드 삼투성 전달 시스템 및 피스톤 조립체
WO2008133908A2 (en) 2007-04-23 2008-11-06 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
CN102164597B (zh) * 2008-09-04 2014-09-03 安米林药品有限责任公司 使用非水性载体的持续释放制剂
JP5494957B2 (ja) 2009-06-11 2014-05-21 株式会社リコー 静電荷像現像用トナー、現像剤、画像形成方法及び画像形成装置
MX352878B (es) 2009-09-28 2017-12-13 Intarcia Therapeutics Inc Establecimiento y/o terminacion rapidos de suministro de estado estable sustancial de farmaco.
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9364549B2 (en) * 2011-11-30 2016-06-14 Andreas Voigt Hydrophobic drug-delivery material, method for manufacturing thereof and methods for delivery of a drug-delivery composition
US20160151286A1 (en) * 2013-05-29 2016-06-02 Therakine Biodelivery Gmbh Hydrophilic Microparticles, Drug-Delivery Material, Method For Manufacturing Thereof And Methods For Delivery of A Drug-Delivery Composition
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP4278996A3 (en) 2015-06-03 2024-01-24 i2o Therapeutics, Inc. Implant placement systems
EP3458084B1 (en) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Glucagon-receptor selective polypeptides and methods of use thereof
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
MX2019008006A (es) 2017-01-03 2019-08-29 Intarcia Therapeutics Inc Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco.
MX2021010043A (es) * 2019-02-21 2022-07-19 Chromadex Inc Uso de nicotinamida ribósido, ácido nicotinico ribósido, compuestos de nicotinil ribósido reducido y derivados de compuestos de nicotinil ribósido en formulaciones.

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US3147187A (en) * 1962-09-10 1964-09-01 Don Hall Lab Sustained release pharmaceutical
CH637297A5 (fr) * 1978-12-05 1983-07-29 Nestle Sa Microbille comprenant un microorganisme et son procede de fabrication.
JPS56140915A (en) * 1980-04-07 1981-11-04 Yamanouchi Pharmaceut Co Ltd Pharmaceutical preparation for solid drug
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
DE3024416C2 (de) * 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
US4666839A (en) * 1982-12-01 1987-05-19 Amgen Methods and materials for obtaining microbial expression of polypeptides including bovine prolactin
US4452775A (en) * 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4603044A (en) * 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4568536A (en) * 1985-02-08 1986-02-04 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4755387A (en) * 1985-03-21 1988-07-05 The Procter & Gamble Company Therapeutic particles
DE3527356A1 (de) * 1985-07-31 1987-02-05 Degussa Verfahren zur verbesserung der fruchtbarkeit von haustieren
SE462894B (sv) * 1985-10-28 1990-09-17 Biogram Ab Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning
US4837381A (en) * 1986-08-11 1989-06-06 American Cyanamid Company Compositions for parenteral administration and their use
US4911928A (en) * 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles

Also Published As

Publication number Publication date
FI101676B (fi) 1998-08-14
ES2054380T3 (es) 1994-08-01
NZ237509A (en) 1993-04-28
CN1055293A (zh) 1991-10-16
RU2011377C1 (ru) 1994-04-30
DE69102176D1 (de) 1994-07-07
BG60850B1 (bg) 1996-05-31
HU911054D0 (en) 1991-10-28
CA2039491A1 (en) 1991-10-01
US5213810A (en) 1993-05-25
KR0159778B1 (ko) 1998-12-01
SK279461B6 (sk) 1998-11-04
KR910016322A (ko) 1991-11-05
NO911228D0 (no) 1991-03-26
CA2039491C (en) 2001-09-04
NO911228L (no) 1991-10-01
IE911041A1 (en) 1991-10-09
IE65970B1 (en) 1995-11-29
IL97145A0 (en) 1992-05-25
PL289657A1 (en) 1992-01-13
DK0448930T3 (da) 1994-06-20
PL167692B1 (en) 1995-10-31
PT97160B (pt) 1998-07-31
HK1000004A1 (en) 1997-10-03
JPH04221319A (ja) 1992-08-11
FI911531A0 (fi) 1991-03-28
EP0448930A1 (en) 1991-10-02
AU641994B2 (en) 1993-10-07
YU57091A (sh) 1994-01-20
CZ283053B6 (cs) 1997-12-17
HU219584B (hu) 2001-05-28
MX172602B (es) 1993-01-03
BG93923A (bg) 1993-12-24
JP2966564B2 (ja) 1999-10-25
FI911531A (fi) 1991-10-01
NO300717B1 (no) 1997-07-14
AU7397291A (en) 1991-10-03
IL97145A (en) 1996-06-18
YU47650B (sh) 1995-12-04
AR248085A1 (es) 1995-06-30
PT97160A (pt) 1991-11-29
ZA912398B (en) 1992-01-29
EP0448930B1 (en) 1994-06-01
CN1063941C (zh) 2001-04-04
HUT59834A (en) 1992-07-28
DE69102176T2 (de) 1995-01-05
ATE106240T1 (de) 1994-06-15
RO106191B1 (ro) 1993-03-31

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