ES8704443A1 - Un procedimiento para la preparacion de derivados sustituidos ester benzoato de 3-hidroximorfinanos. - Google Patents

Un procedimiento para la preparacion de derivados sustituidos ester benzoato de 3-hidroximorfinanos.

Info

Publication number
ES8704443A1
ES8704443A1 ES544852A ES544852A ES8704443A1 ES 8704443 A1 ES8704443 A1 ES 8704443A1 ES 544852 A ES544852 A ES 544852A ES 544852 A ES544852 A ES 544852A ES 8704443 A1 ES8704443 A1 ES 8704443A1
Authority
ES
Spain
Prior art keywords
hydroxymorphinans
intermediates
processes
prodrug derivatives
ester prodrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544852A
Other languages
English (en)
Spanish (es)
Other versions
ES544852A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES544852A0 publication Critical patent/ES544852A0/es
Publication of ES8704443A1 publication Critical patent/ES8704443A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES544852A 1984-07-05 1985-07-04 Un procedimiento para la preparacion de derivados sustituidos ester benzoato de 3-hidroximorfinanos. Expired ES8704443A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (2)

Publication Number Publication Date
ES544852A0 ES544852A0 (es) 1987-04-01
ES8704443A1 true ES8704443A1 (es) 1987-04-01

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544852A Expired ES8704443A1 (es) 1984-07-05 1985-07-04 Un procedimiento para la preparacion de derivados sustituidos ester benzoato de 3-hidroximorfinanos.

Country Status (18)

Country Link
US (1) US4668685A (OSRAM)
EP (1) EP0170090B1 (OSRAM)
AU (1) AU578391B2 (OSRAM)
CA (1) CA1301150C (OSRAM)
DE (1) DE3573251D1 (OSRAM)
DK (1) DK160501C (OSRAM)
ES (1) ES8704443A1 (OSRAM)
FI (1) FI83215C (OSRAM)
GR (1) GR851653B (OSRAM)
HK (1) HK39790A (OSRAM)
HU (1) HU193995B (OSRAM)
IE (1) IE58136B1 (OSRAM)
IL (1) IL75721A (OSRAM)
MX (1) MX160445A (OSRAM)
NO (1) NO171209C (OSRAM)
NZ (1) NZ212641A (OSRAM)
PT (1) PT80773B (OSRAM)
SU (2) SU1450742A3 (OSRAM)

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US6258360B1 (en) * 1989-05-04 2001-07-10 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
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US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US6323212B1 (en) * 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
TW372972B (en) * 1992-10-23 1999-11-01 Novartis Ag Antiretroviral acyl compounds
EP0615756B1 (en) * 1993-03-15 2001-06-27 National Science Council Nalbuphine esters and long-acting pharmaceutical compositions containing them
JP3843456B2 (ja) * 1993-07-23 2006-11-08 東レ株式会社 モルヒナン誘導体および医薬用途
US5376662A (en) * 1993-12-08 1994-12-27 Ockert; David M. Method of attenuating nerve injury induced pain
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US6225321B1 (en) * 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
PT1685839E (pt) 1997-12-22 2013-07-08 Euro Celtique Sa Forma de dosagem farmacêutica por via oral compreendendo uma combinação de um agonista opióide e de um antagonista opióide
ATE233264T1 (de) * 2000-04-27 2003-03-15 Oliver Yoa-Pu Hu Polynalbuphinderivat
US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
DE60238756D1 (de) 2001-05-11 2011-02-10 Endo Pharmaceuticals Inc Opioid enthaltende arzneiform gegen missbrauch
JP4559730B2 (ja) * 2001-08-23 2010-10-13 ナームローゼ・フエンノートチヤツプ・オルガノン １４−ヒドロキシノルモルフィノン誘導体の調製方法。
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
PT2425824T (pt) 2002-04-05 2017-08-23 Mundipharma Farmacêutica Lda Preparação farmacêutica contendo oxicodona e naloxona
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
JP2008514612A (ja) * 2004-09-23 2008-05-08 ミシャロウ、アレクサンダー 対抗適応を誘発することにより神経伝達物質系を調節する方法
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP3228308A1 (en) * 2005-01-28 2017-10-11 Euro-Celtique S.A. Alcohol resistant dosage forms
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
EP1928881A2 (en) 2005-08-19 2008-06-11 Pharmacofore, Inc. Prodrugs of active agents
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
US8178551B2 (en) * 2007-03-09 2012-05-15 Green Cross Corporation Orally bioavailable prodrugs of (+)-3-hydroxymorphinan for Parkinson'S disease prevention or treatment
MX2011000155A (es) * 2008-07-07 2011-03-01 Euro Celtique Sa Uso de antagonistas opioides para el tratamiento de retencion urinaria.
ME03298B (me) 2009-03-10 2019-07-20 Euro Celtique Sa Farmaceutske kombinacije sa trenutnim oslobađanjem које obuhvataju oksikodon i nalokson
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
WO2011008636A1 (en) * 2009-07-15 2011-01-20 Mallinckrodt Inc. 3-oxy-hydromorphone derivatives
RU2643807C1 (ru) 2010-11-12 2018-02-06 Сионоги Энд Ко., Лтд. Кристаллы производных 6,7-ненасыщенного-7-карбамоилморфинана и способ их получения
PH12014500791A1 (en) 2011-10-26 2022-12-02 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
CN105517551A (zh) 2013-07-23 2016-04-20 欧洲凯尔特公司 用于在患有疼痛和导致肠生态失调和/或提高肠细菌移位风险之疾病的患者中治疗疼痛的羟考酮与纳洛酮的组合
SG11201704178UA (en) 2014-11-25 2017-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
MX2017006935A (es) 2014-12-02 2017-08-10 Kempharm Inc * Acido benzoico, derivados de acido benzoico y conjugados de acido heteroaril carboxilico de oximorfona, profarmacos, metodos de elaboracion y uso de los mismos.
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
CA3149152A1 (en) 2019-08-11 2021-02-18 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates

Family Cites Families (14)

* Cited by examiner, † Cited by third party
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DE224197C (OSRAM) *
US3254088A (en) * 1961-03-14 1966-05-31 Lewenstein Morphine derivative
FR1602610A (en) * 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
GB1097167A (en) * 1966-05-31 1967-12-29 Shionogi & Co 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production
CH543514A (de) * 1967-08-25 1973-10-31 Hoffmann La Roche Verfahren zur Herstellung von Morphinanderivaten
US3654280A (en) * 1968-03-21 1972-04-04 Shionogi & Co L-n allylic-3-hydroxy-6-oxomorphinans
DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン
JPS59184163A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−１７−メチルモルヒナン
JPS59184183A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン
JPS59186987A (ja) * 1983-04-06 1984-10-23 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン

Also Published As

Publication number Publication date
CA1301150C (en) 1992-05-19
FI83215C (fi) 1991-06-10
HUT40132A (en) 1986-11-28
PT80773B (pt) 1987-10-20
US4668685A (en) 1987-05-26
FI852659L (fi) 1986-01-06
ES544852A0 (es) 1987-04-01
SU1508960A3 (ru) 1989-09-15
SU1450742A3 (ru) 1989-01-07
IE58136B1 (en) 1993-07-14
HK39790A (en) 1990-06-01
IL75721A (en) 1990-04-29
IL75721A0 (en) 1985-11-29
GR851653B (OSRAM) 1985-11-26
NZ212641A (en) 1988-10-28
DK306885A (da) 1986-01-06
FI83215B (fi) 1991-02-28
PT80773A (en) 1985-08-01
EP0170090A1 (en) 1986-02-05
AU578391B2 (en) 1988-10-20
DK306885D0 (da) 1985-07-04
NO852699L (no) 1986-01-06
HU193995B (en) 1987-12-28
EP0170090B1 (en) 1989-09-27
FI852659A0 (fi) 1985-07-04
AU4451685A (en) 1986-01-09
DK160501B (da) 1991-03-18
NO171209C (no) 1993-02-10
DE3573251D1 (en) 1989-11-02
IE851683L (en) 1986-01-05
DK160501C (da) 1991-08-26
MX160445A (es) 1990-03-02
NO171209B (no) 1992-11-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203