DK160501C - Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne - Google Patents

Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne

Info

Publication number
DK160501C
DK160501C DK306885A DK306885A DK160501C DK 160501 C DK160501 C DK 160501C DK 306885 A DK306885 A DK 306885A DK 306885 A DK306885 A DK 306885A DK 160501 C DK160501 C DK 160501C
Authority
DK
Denmark
Prior art keywords
hydroxymorphinanes
testers
sugar
pharmaceutical preparations
preparations containing
Prior art date
Application number
DK306885A
Other languages
Danish (da)
English (en)
Other versions
DK160501B (da
DK306885A (da
DK306885D0 (da
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK306885D0 publication Critical patent/DK306885D0/da
Publication of DK306885A publication Critical patent/DK306885A/da
Publication of DK160501B publication Critical patent/DK160501B/da
Application granted granted Critical
Publication of DK160501C publication Critical patent/DK160501C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK306885A 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne DK160501C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US62792384 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US73346485 1985-05-14

Publications (4)

Publication Number Publication Date
DK306885D0 DK306885D0 (da) 1985-07-04
DK306885A DK306885A (da) 1986-01-06
DK160501B DK160501B (da) 1991-03-18
DK160501C true DK160501C (da) 1991-08-26

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
DK306885A DK160501C (da) 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne

Country Status (18)

Country Link
US (1) US4668685A (OSRAM)
EP (1) EP0170090B1 (OSRAM)
AU (1) AU578391B2 (OSRAM)
CA (1) CA1301150C (OSRAM)
DE (1) DE3573251D1 (OSRAM)
DK (1) DK160501C (OSRAM)
ES (1) ES8704443A1 (OSRAM)
FI (1) FI83215C (OSRAM)
GR (1) GR851653B (OSRAM)
HK (1) HK39790A (OSRAM)
HU (1) HU193995B (OSRAM)
IE (1) IE58136B1 (OSRAM)
IL (1) IL75721A (OSRAM)
MX (1) MX160445A (OSRAM)
NO (1) NO171209C (OSRAM)
NZ (1) NZ212641A (OSRAM)
PT (1) PT80773B (OSRAM)
SU (2) SU1450742A3 (OSRAM)

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US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
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US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
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EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
CN101065014A (zh) * 2004-09-23 2007-10-31 亚历山大·米哈洛 通过诱导逆适应调节神经递质系统的方法
CN101132772B (zh) * 2005-01-28 2012-05-09 欧洲凯尔特公司 耐醇剂型
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
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CA2679973C (en) * 2007-03-09 2012-07-17 Green Cross Corporation Orally bioavailable prodrugs of (+)-3-hydroxymorphinan for parkinson's disease prevention or treatment
CA2730211C (en) * 2008-07-07 2016-11-08 Euro-Celtique S.A. Use of opioid antagonists for treating urinary retention
MX347106B (es) 2009-03-10 2017-04-12 Euro-Celtique S A * Coposiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona.
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
WO2011008636A1 (en) * 2009-07-15 2011-01-20 Mallinckrodt Inc. 3-oxy-hydromorphone derivatives
RU2607084C2 (ru) * 2010-11-12 2017-01-10 Сионоги Энд Ко., Лтд. Кристаллы производных 6,7-ненасыщенного-7-карбамоилморфинана и способ их получения
RU2573388C2 (ru) * 2011-10-26 2016-01-20 Кемфарм Инк. Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты с гидроморфоном, пролекарства, способы получения и их применение
UA116567C2 (uk) 2013-07-23 2018-04-10 Євро-Селтік С.А. Комбінація оксикодону та налоксону для застосування в лікуванні болю у пацієнтів, які страждають від болю та захворювання, що призводить до дисбактеріозу кишечнику та/або підвищує ризик кишкової бактеріальної транслокації
CN106999486A (zh) 2014-11-25 2017-08-01 凯姆制药公司 羟考酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物
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WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
MX2022001520A (es) 2019-08-11 2022-07-21 Kappa Pharma Llc Composiciones y metodos para mejorar activacion de receptor de opioide por hexadienoatos opioides y hexadienoatos opcionalmente sustituidos.

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CH543514A (de) * 1967-08-25 1973-10-31 Hoffmann La Roche Verfahren zur Herstellung von Morphinanderivaten
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Also Published As

Publication number Publication date
FI83215B (fi) 1991-02-28
EP0170090B1 (en) 1989-09-27
SU1450742A3 (ru) 1989-01-07
DK160501B (da) 1991-03-18
ES544852A0 (es) 1987-04-01
DE3573251D1 (en) 1989-11-02
NO852699L (no) 1986-01-06
PT80773B (pt) 1987-10-20
HK39790A (en) 1990-06-01
GR851653B (OSRAM) 1985-11-26
AU4451685A (en) 1986-01-09
SU1508960A3 (ru) 1989-09-15
MX160445A (es) 1990-03-02
EP0170090A1 (en) 1986-02-05
ES8704443A1 (es) 1987-04-01
NZ212641A (en) 1988-10-28
FI852659A0 (fi) 1985-07-04
IE851683L (en) 1986-01-05
IL75721A0 (en) 1985-11-29
NO171209B (no) 1992-11-02
DK306885A (da) 1986-01-06
IE58136B1 (en) 1993-07-14
FI83215C (fi) 1991-06-10
PT80773A (en) 1985-08-01
DK306885D0 (da) 1985-07-04
HU193995B (en) 1987-12-28
AU578391B2 (en) 1988-10-20
HUT40132A (en) 1986-11-28
NO171209C (no) 1993-02-10
CA1301150C (en) 1992-05-19
IL75721A (en) 1990-04-29
FI852659L (fi) 1986-01-06
US4668685A (en) 1987-05-26

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