DK306885A - Substituerede benzoatestere af 3-hydroxymorphinaner, deres fremstilling og anvendelse - Google Patents

Substituerede benzoatestere af 3-hydroxymorphinaner, deres fremstilling og anvendelse Download PDF

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Publication number
DK306885A
DK306885A DK306885A DK306885A DK306885A DK 306885 A DK306885 A DK 306885A DK 306885 A DK306885 A DK 306885A DK 306885 A DK306885 A DK 306885A DK 306885 A DK306885 A DK 306885A
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DK
Denmark
Prior art keywords
hydroxymorphinanes
preparation
substituted benzoates
benzoates
substituted
Prior art date
Application number
DK306885A
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English (en)
Other versions
DK160501C (da
DK306885D0 (da
DK160501B (da
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK306885D0 publication Critical patent/DK306885D0/da
Publication of DK306885A publication Critical patent/DK306885A/da
Publication of DK160501B publication Critical patent/DK160501B/da
Application granted granted Critical
Publication of DK160501C publication Critical patent/DK160501C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK306885A 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne DK160501C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US62792384 1984-07-05
US73346485 1985-05-14
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (4)

Publication Number Publication Date
DK306885D0 DK306885D0 (da) 1985-07-04
DK306885A true DK306885A (da) 1986-01-06
DK160501B DK160501B (da) 1991-03-18
DK160501C DK160501C (da) 1991-08-26

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
DK306885A DK160501C (da) 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne

Country Status (18)

Country Link
US (1) US4668685A (da)
EP (1) EP0170090B1 (da)
AU (1) AU578391B2 (da)
CA (1) CA1301150C (da)
DE (1) DE3573251D1 (da)
DK (1) DK160501C (da)
ES (1) ES8704443A1 (da)
FI (1) FI83215C (da)
GR (1) GR851653B (da)
HK (1) HK39790A (da)
HU (1) HU193995B (da)
IE (1) IE58136B1 (da)
IL (1) IL75721A (da)
MX (1) MX160445A (da)
NO (1) NO171209C (da)
NZ (1) NZ212641A (da)
PT (1) PT80773B (da)
SU (2) SU1450742A3 (da)

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US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
CA2580694A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
KR20090029856A (ko) * 2005-01-28 2009-03-23 유로-셀띠끄 소시에떼 아노님 알코올 저항성 제형
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1928881A2 (en) 2005-08-19 2008-06-11 Pharmacofore, Inc. Prodrugs of active agents
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
BRPI0808651A2 (pt) * 2007-03-09 2014-08-19 Green Cross Corp Pró-medicamentos oralmente biodisponíveis de (+)-3-hidroximorfinano para a prevenção ou o tratamento da doença de parkinson.
CN105456267A (zh) * 2008-07-07 2016-04-06 欧洲凯尔特公司 阿片类拮抗剂治疗尿潴留的用途
WO2010103039A1 (en) 2009-03-10 2010-09-16 Euro-Celtique S.A. Immediate release pharmaceutical compositions comprising oxycodone and naloxone
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
US8623888B2 (en) * 2009-07-15 2014-01-07 Mallinckrodt Llc 3-oxy-hydromorphone derivatives
MX348228B (es) 2010-11-12 2017-05-31 Shionogi & Co Cristal de derivados de 6,7-insaturado-7-carbamoil morfinano y metodo para producir el mismo.
RU2573388C2 (ru) 2011-10-26 2016-01-20 Кемфарм Инк. Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты с гидроморфоном, пролекарства, способы получения и их применение
AU2014295042B2 (en) 2013-07-23 2017-03-30 Mundipharma Pty Limited A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
JP6400848B2 (ja) 2014-11-25 2018-10-03 ケムファーム・インコーポレーテッド オキシコドンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体
RU2683274C2 (ru) 2014-12-02 2019-03-27 Кемфарм, Инк. Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты и оксиморфона, их пролекарства, способы получения и применение
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
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JP7535569B2 (ja) 2019-08-11 2024-08-16 カッパ－ファーマ・リミテッド・ライアビリティ・カンパニー オピオイドヘキサジエノエート及び選択的に置換されたヘキサジエノエートによってオピオイド受容体の結合を改善する組成物並びに方法

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Also Published As

Publication number Publication date
ES8704443A1 (es) 1987-04-01
NO171209C (no) 1993-02-10
SU1508960A3 (ru) 1989-09-15
HU193995B (en) 1987-12-28
AU578391B2 (en) 1988-10-20
AU4451685A (en) 1986-01-09
ES544852A0 (es) 1987-04-01
FI83215B (fi) 1991-02-28
FI83215C (fi) 1991-06-10
NZ212641A (en) 1988-10-28
MX160445A (es) 1990-03-02
DK160501C (da) 1991-08-26
FI852659L (fi) 1986-01-06
IL75721A (en) 1990-04-29
PT80773A (en) 1985-08-01
DK306885D0 (da) 1985-07-04
CA1301150C (en) 1992-05-19
IE58136B1 (en) 1993-07-14
PT80773B (pt) 1987-10-20
SU1450742A3 (ru) 1989-01-07
HUT40132A (en) 1986-11-28
EP0170090B1 (en) 1989-09-27
FI852659A0 (fi) 1985-07-04
DK160501B (da) 1991-03-18
HK39790A (en) 1990-06-01
IE851683L (en) 1986-01-05
IL75721A0 (en) 1985-11-29
US4668685A (en) 1987-05-26
DE3573251D1 (en) 1989-11-02
EP0170090A1 (en) 1986-02-05
NO171209B (no) 1992-11-02
GR851653B (da) 1985-11-26
NO852699L (no) 1986-01-06

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