PT80773B - Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT80773B PT80773B PT80773A PT8077385A PT80773B PT 80773 B PT80773 B PT 80773B PT 80773 A PT80773 A PT 80773A PT 8077385 A PT8077385 A PT 8077385A PT 80773 B PT80773 B PT 80773B
- Authority
- PT
- Portugal
- Prior art keywords
- profarmacles
- hydroxymorfinoan
- derivatives
- contain
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62792384A | 1984-07-05 | 1984-07-05 | |
US06/733,464 US4668685A (en) | 1984-07-05 | 1985-05-14 | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
PT80773A PT80773A (en) | 1985-08-01 |
PT80773B true PT80773B (pt) | 1987-10-20 |
Family
ID=27090564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT80773A PT80773B (pt) | 1984-07-05 | 1985-07-04 | Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem |
Country Status (18)
Country | Link |
---|---|
US (1) | US4668685A (pt) |
EP (1) | EP0170090B1 (pt) |
AU (1) | AU578391B2 (pt) |
CA (1) | CA1301150C (pt) |
DE (1) | DE3573251D1 (pt) |
DK (1) | DK160501C (pt) |
ES (1) | ES8704443A1 (pt) |
FI (1) | FI83215C (pt) |
GR (1) | GR851653B (pt) |
HK (1) | HK39790A (pt) |
HU (1) | HU193995B (pt) |
IE (1) | IE58136B1 (pt) |
IL (1) | IL75721A (pt) |
MX (1) | MX160445A (pt) |
NO (1) | NO171209C (pt) |
NZ (1) | NZ212641A (pt) |
PT (1) | PT80773B (pt) |
SU (2) | SU1450742A3 (pt) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
DK107688D0 (da) * | 1988-03-01 | 1988-03-01 | Novo Industri As | Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner |
US6702705B1 (en) | 1988-05-04 | 2004-03-09 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
DK24089D0 (da) * | 1989-01-20 | 1989-01-20 | Hans Bundgaard | Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups |
US6258360B1 (en) * | 1989-05-04 | 2001-07-10 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
KR100334695B1 (ko) * | 1991-08-05 | 2002-04-27 | 리차아드제이마세이 | 표적화된 촉매 단백질에 의해 활성화되는 선구 약제 |
US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
ATE172201T1 (de) * | 1992-01-23 | 1998-10-15 | Toray Industries | Morphinan-derivate und medizinische verwendung |
TW372972B (en) * | 1992-10-23 | 1999-11-01 | Novartis Ag | Antiretroviral acyl compounds |
EP0615756B1 (en) * | 1993-03-15 | 2001-06-27 | National Science Council | Nalbuphine esters and long-acting pharmaceutical compositions containing them |
DE69424853T2 (de) * | 1993-07-23 | 2000-10-05 | Toray Industries, Inc. | Morphinan-derivate und ihre medizinische verwendung |
US5376662A (en) * | 1993-12-08 | 1994-12-27 | Ockert; David M. | Method of attenuating nerve injury induced pain |
US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
US6225321B1 (en) * | 1997-06-05 | 2001-05-01 | Oliver Yoa-Pu Hu | Long analgesic acting nalbuphine polyester derivative and method of use |
US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
EP1685839B8 (en) | 1997-12-22 | 2013-06-26 | Euro-Celtique S.A. | Pharmaceutical oral dosage form comprising a combination of an opioid agonist and opioid antagonist |
ATE233264T1 (de) * | 2000-04-27 | 2003-03-15 | Oliver Yoa-Pu Hu | Polynalbuphinderivat |
US6569449B1 (en) | 2000-11-13 | 2003-05-27 | University Of Kentucky Research Foundation | Transdermal delivery of opioid antagonist prodrugs |
CA2446550C (en) | 2001-05-11 | 2012-03-06 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
US20040033253A1 (en) * | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
AU2003224041B2 (en) | 2002-04-05 | 2006-07-13 | Mundipharma Pty Limited | Matrix for sustained, invariant and independent release of active compounds |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
US20080020028A1 (en) * | 2003-08-20 | 2008-01-24 | Euro-Celtique S.A. | Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent |
EP1604667A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the restless leg syndrome |
EP1604666A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
EP1809104A4 (en) * | 2004-09-23 | 2009-04-29 | Alexander Michalow | METHODS FOR REGULATING NEUROTRANSMITTER SYSTEMS BY INDUCING COUNTER-ADAPTATIONS |
EA015615B1 (ru) * | 2005-01-28 | 2011-10-31 | Еуро-Селтик С.А. | Устойчивые к спиртам лекарственные формы |
EP1695700A1 (en) * | 2005-02-28 | 2006-08-30 | Euro-Celtique S.A. | Dosage form containing oxycodone and naloxone |
EP1702558A1 (en) * | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
US8163701B2 (en) | 2005-08-19 | 2012-04-24 | Signature Therapeutics, Inc. | Prodrugs of active agents |
GB0606124D0 (en) * | 2006-03-28 | 2006-05-03 | Reckitt Benckiser Healthcare | Buprenorphine derivatives and uses thereof |
RU2430089C2 (ru) * | 2007-03-09 | 2011-09-27 | Грин Кросс Корпорейшн | Перорально биодоступные пролекарства (+)-3- гидроксиморфинана для профилактики или лечения болезни паркинсона |
ES2635733T3 (es) * | 2008-07-07 | 2017-10-04 | Euro-Celtique S.A. | Uso de antagonistas opioideos para tratar la retención urinaria |
DK2405915T3 (en) | 2009-03-10 | 2019-02-11 | Euro Celtique Sa | PHARMACEUTICAL COMPOSITIONS WITH IMMEDIATE RELEASE INCLUDING OXYCODON AND NALOXON |
UA102916C2 (uk) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
US8623888B2 (en) * | 2009-07-15 | 2014-01-07 | Mallinckrodt Llc | 3-oxy-hydromorphone derivatives |
RS59256B1 (sr) * | 2010-11-12 | 2019-10-31 | Shionogi & Co | Kristalni derivat 6,7-nezasićenog-7-karbamoil morfinana, i postupak njegove proizvodnje |
JP5769889B2 (ja) | 2011-10-26 | 2015-08-26 | ケムファーム・インコーポレーテッド | ヒドロモルホンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体、そのプロドラッグ、製造法及び使用 |
MX2016000810A (es) | 2013-07-23 | 2016-08-05 | Euro Celtique Sa | Combinacion de oxicodona y naloxona para su uso en el tratamiento de dolor en pacientes que sufren de dolor y una enfermedad que resulta la disbiosis intestinal y/o aumento del riesgo de la translocacion bacteriana intestinal. |
JP6400848B2 (ja) | 2014-11-25 | 2018-10-03 | ケムファーム・インコーポレーテッド | オキシコドンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体 |
CA2969221C (en) | 2014-12-02 | 2021-01-12 | Travis Mickle | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof |
US10155771B2 (en) * | 2015-11-04 | 2018-12-18 | Noramco, Inc. | Selective reduction of morphinan alkaloids |
US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
WO2020012248A1 (en) | 2018-07-13 | 2020-01-16 | Alkermes Pharma Ireland Limited | Novel naphthylenyl compounds for long-acting injectable compositions and related methods |
US11186585B2 (en) | 2018-08-17 | 2021-11-30 | Kappa-Pharma LLC | Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates |
WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
MX2022001520A (es) | 2019-08-11 | 2022-07-21 | Kappa Pharma Llc | Composiciones y metodos para mejorar activacion de receptor de opioide por hexadienoatos opioides y hexadienoatos opcionalmente sustituidos. |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE224197C (pt) * | ||||
US3254088A (en) * | 1961-03-14 | 1966-05-31 | Lewenstein | Morphine derivative |
FR1602610A (en) * | 1962-10-10 | 1971-01-04 | 10.10.62.-17.4.63. 38445-15209 thebaine derivs | |
US3332950A (en) * | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
IL26896A (en) * | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
GB1097167A (en) * | 1966-05-31 | 1967-12-29 | Shionogi & Co | 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production |
CH543514A (de) * | 1967-08-25 | 1973-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Morphinanderivaten |
US3654280A (en) * | 1968-03-21 | 1972-04-04 | Shionogi & Co | L-n allylic-3-hydroxy-6-oxomorphinans |
DE2323192A1 (de) * | 1972-05-10 | 1973-12-13 | Endo Lab | Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte |
US4161597A (en) * | 1976-12-20 | 1979-07-17 | Research Corporation | N-alkyl-14-hydroxymorphinans and derivatives |
JPS59184182A (ja) * | 1983-04-02 | 1984-10-19 | Res Inst For Prod Dev | 3−ベンゾイルチオ−4、5α−エポキシ−7α−〔1(R)−ヒドロキシ−1−メチルベンチル〕−6−メトキシ−17−メチル−6、14−エンド−エタノモルヒナン |
JPS59184163A (ja) * | 1983-04-02 | 1984-10-19 | Res Inst For Prod Dev | 3−ベンゾイルチオ−17−メチルモルヒナン |
JPS59184183A (ja) * | 1983-04-02 | 1984-10-19 | Res Inst For Prod Dev | 3−ベンゾイルチオ−4、5α−エポキシ−7α−〔1(R)−ヒドロキシ−1−メチルブチル〕−6−メトキシ−17−メチル−6、14−エンド−エテノモルヒナン |
JPS59186987A (ja) * | 1983-04-06 | 1984-10-23 | Res Inst For Prod Dev | 3−ベンゾイルチオ−4、5α−エポキシ−7α−〔1(R)−ヒドロキシ−1−メチルブチル〕−6−メトキシ−17−メチル−6、14−エンド−エテノモルヒナン |
-
1985
- 1985-05-14 US US06/733,464 patent/US4668685A/en not_active Expired - Lifetime
- 1985-06-27 CA CA000485661A patent/CA1301150C/en not_active Expired - Lifetime
- 1985-07-03 EP EP85108258A patent/EP0170090B1/en not_active Expired
- 1985-07-03 AU AU44516/85A patent/AU578391B2/en not_active Ceased
- 1985-07-03 DE DE8585108258T patent/DE3573251D1/de not_active Expired
- 1985-07-04 NZ NZ212641A patent/NZ212641A/xx unknown
- 1985-07-04 PT PT80773A patent/PT80773B/pt not_active IP Right Cessation
- 1985-07-04 SU SU853920678A patent/SU1450742A3/ru active
- 1985-07-04 NO NO852699A patent/NO171209C/no unknown
- 1985-07-04 GR GR851653A patent/GR851653B/el unknown
- 1985-07-04 HU HU852607A patent/HU193995B/hu not_active IP Right Cessation
- 1985-07-04 ES ES544852A patent/ES8704443A1/es not_active Expired
- 1985-07-04 FI FI852659A patent/FI83215C/fi not_active IP Right Cessation
- 1985-07-04 IL IL75721A patent/IL75721A/xx not_active IP Right Cessation
- 1985-07-04 IE IE168385A patent/IE58136B1/en not_active IP Right Cessation
- 1985-07-04 DK DK306885A patent/DK160501C/da not_active IP Right Cessation
- 1985-07-05 MX MX6144A patent/MX160445A/es unknown
-
1987
- 1987-07-03 SU SU874202841A patent/SU1508960A3/ru active
-
1990
- 1990-05-24 HK HK397/90A patent/HK39790A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
GR851653B (pt) | 1985-11-26 |
HK39790A (en) | 1990-06-01 |
HUT40132A (en) | 1986-11-28 |
AU4451685A (en) | 1986-01-09 |
EP0170090A1 (en) | 1986-02-05 |
NO171209B (no) | 1992-11-02 |
MX160445A (es) | 1990-03-02 |
DK306885A (da) | 1986-01-06 |
DK160501C (da) | 1991-08-26 |
FI83215C (fi) | 1991-06-10 |
US4668685A (en) | 1987-05-26 |
FI852659L (fi) | 1986-01-06 |
ES8704443A1 (es) | 1987-04-01 |
IE58136B1 (en) | 1993-07-14 |
FI852659A0 (fi) | 1985-07-04 |
AU578391B2 (en) | 1988-10-20 |
IE851683L (en) | 1986-01-05 |
NZ212641A (en) | 1988-10-28 |
ES544852A0 (es) | 1987-04-01 |
SU1450742A3 (ru) | 1989-01-07 |
IL75721A0 (en) | 1985-11-29 |
NO852699L (no) | 1986-01-06 |
DK306885D0 (da) | 1985-07-04 |
CA1301150C (en) | 1992-05-19 |
FI83215B (fi) | 1991-02-28 |
HU193995B (en) | 1987-12-28 |
EP0170090B1 (en) | 1989-09-27 |
SU1508960A3 (ru) | 1989-09-15 |
DE3573251D1 (en) | 1989-11-02 |
IL75721A (en) | 1990-04-29 |
PT80773A (en) | 1985-08-01 |
DK160501B (da) | 1991-03-18 |
NO171209C (no) | 1993-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC3A | Transfer or assignment |
Free format text: 920721 DU PONT MERCK PHARMACEUTIVAL COMPANY,THE US |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19930930 |