DE3573251D1 - Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, intermediates thereto, and processes - Google Patents

Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, intermediates thereto, and processes

Info

Publication number
DE3573251D1
DE3573251D1 DE8585108258T DE3573251T DE3573251D1 DE 3573251 D1 DE3573251 D1 DE 3573251D1 DE 8585108258 T DE8585108258 T DE 8585108258T DE 3573251 T DE3573251 T DE 3573251T DE 3573251 D1 DE3573251 D1 DE 3573251D1
Authority
DE
Germany
Prior art keywords
hydroxymorphinans
intermediates
processes
prodrug derivatives
ester prodrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585108258T
Other languages
English (en)
Inventor
Elie Gabriel Shami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of DE3573251D1 publication Critical patent/DE3573251D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
DE8585108258T 1984-07-05 1985-07-03 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, intermediates thereto, and processes Expired DE3573251D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (1)

Publication Number Publication Date
DE3573251D1 true DE3573251D1 (en) 1989-11-02

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585108258T Expired DE3573251D1 (en) 1984-07-05 1985-07-03 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, intermediates thereto, and processes

Country Status (18)

Country Link
US (1) US4668685A (de)
EP (1) EP0170090B1 (de)
AU (1) AU578391B2 (de)
CA (1) CA1301150C (de)
DE (1) DE3573251D1 (de)
DK (1) DK160501C (de)
ES (1) ES8704443A1 (de)
FI (1) FI83215C (de)
GR (1) GR851653B (de)
HK (1) HK39790A (de)
HU (1) HU193995B (de)
IE (1) IE58136B1 (de)
IL (1) IL75721A (de)
MX (1) MX160445A (de)
NO (1) NO171209C (de)
NZ (1) NZ212641A (de)
PT (1) PT80773B (de)
SU (2) SU1450742A3 (de)

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RU2241458C2 (ru) 1997-12-22 2004-12-10 Эро-Селтик, С.А. Комбинации агонист/антагонист опиоида
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US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
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US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
JP4620355B2 (ja) 2002-04-05 2011-01-26 ユーロ−セルティーク エス．エイ． 活性化合物の持続、不変及び独立放出のためのマトリクス
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US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604666A1 (de) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit
EP1604667A1 (de) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioide zur Behandlung des Restless Leg Syndroms
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
WO2006034343A2 (en) * 2004-09-23 2006-03-30 Alexander Michalow methods for regulating neurotransmitter systems by inducing counteradaptationS
AP2274A (en) * 2005-01-28 2011-08-19 Euro Celtiques Sa Alcohol resistant dosage forms.
EP1702558A1 (de) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Verfahren und Vorrichtung zur Darmtätigkeitserfassung
EP1695700A1 (de) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Darreichungsform enthaltend Oxycodon und Naloxon
US8163701B2 (en) 2005-08-19 2012-04-24 Signature Therapeutics, Inc. Prodrugs of active agents
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
CN101627014B (zh) * 2007-03-09 2013-04-24 株式会社绿十字 用于预防或治疗帕金森病的(+)-3-羟基吗啡喃的口服可生物利用前药
PE20110422A1 (es) * 2008-07-07 2011-07-01 Euro Celtique Sa Composicion farmaceutica que comprende antagonistas opioides
PT2405915T (pt) 2009-03-10 2019-01-29 Euro Celtique Sa Composições farmacêuticas de libertação imediata compreendendo oxicodona e naloxona
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US8623888B2 (en) * 2009-07-15 2014-01-07 Mallinckrodt Llc 3-oxy-hydromorphone derivatives
RU2643807C1 (ru) 2010-11-12 2018-02-06 Сионоги Энд Ко., Лтд. Кристаллы производных 6,7-ненасыщенного-7-карбамоилморфинана и способ их получения
CN105749294A (zh) 2011-10-26 2016-07-13 凯姆制药公司 氢吗啡酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物、其前药、制备和使用方法
AU2014295042B2 (en) 2013-07-23 2017-03-30 Mundipharma Pty Limited A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
KR20190049944A (ko) 2014-11-25 2019-05-09 켐팜 인코포레이티드 옥시코돈의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트
EP3226907A1 (de) 2014-12-02 2017-10-11 Kempharm, Inc. Benzoesäure, benzoesäurederivate und heteroarylcarbonsäurekonjugate aus oxymorphon, prodrugs, verfahren zur herstellung und verwendung davon
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods
JP2022544564A (ja) 2019-08-11 2022-10-19 カッパ－ファーマ・リミテッド・ライアビリティ・カンパニー オピオイドヘキサジエノエート及び選択的に置換されたヘキサジエノエートによってオピオイド受容体の結合を改善する組成物並びに方法

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CH560194A5 (de) * 1967-08-25 1975-03-27 Hoffmann La Roche
US3654280A (en) * 1968-03-21 1972-04-04 Shionogi & Co L-n allylic-3-hydroxy-6-oxomorphinans
DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
JPS59184163A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−１７−メチルモルヒナン
JPS59184183A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン
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Also Published As

Publication number Publication date
IE58136B1 (en) 1993-07-14
NO171209C (no) 1993-02-10
HU193995B (en) 1987-12-28
CA1301150C (en) 1992-05-19
DK160501B (da) 1991-03-18
HK39790A (en) 1990-06-01
NZ212641A (en) 1988-10-28
US4668685A (en) 1987-05-26
NO852699L (no) 1986-01-06
IL75721A (en) 1990-04-29
NO171209B (no) 1992-11-02
DK160501C (da) 1991-08-26
AU4451685A (en) 1986-01-09
ES544852A0 (es) 1987-04-01
EP0170090A1 (de) 1986-02-05
DK306885A (da) 1986-01-06
EP0170090B1 (de) 1989-09-27
PT80773A (en) 1985-08-01
FI852659A0 (fi) 1985-07-04
PT80773B (pt) 1987-10-20
FI852659L (fi) 1986-01-06
SU1450742A3 (ru) 1989-01-07
HUT40132A (en) 1986-11-28
AU578391B2 (en) 1988-10-20
ES8704443A1 (es) 1987-04-01
IE851683L (en) 1986-01-05
DK306885D0 (da) 1985-07-04
MX160445A (es) 1990-03-02
SU1508960A3 (ru) 1989-09-15
IL75721A0 (en) 1985-11-29
GR851653B (de) 1985-11-26
FI83215C (fi) 1991-06-10
FI83215B (fi) 1991-02-28

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: THE DU PONT MERCK PHARMACEUTICAL CO., WILMINGTON,

8328 Change in the person/name/address of the agent

Free format text: VON KREISLER, A., DIPL.-CHEM. SELTING, G., DIPL.-ING. WERNER, H., DIPL.-CHEM. DR.RER.NAT. FUES, J., DIPL.-CHEM. DR.RER.NAT. BOECKMANN GEN. DALLMEYER, G., DIPL.-ING. HILLERINGMANN, J., DIPL.-ING. JOENSSON, H., DIPL.-CHEM. DR.RER.NAT. MEYERS, H., DIPL.-CHEM. DR.RER.NAT., PAT.-ANWAELTE, 5000 KOELN

8339 Ceased/non-payment of the annual fee