GB1097167A - 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production - Google Patents

3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production

Info

Publication number
GB1097167A
GB1097167A GB39695/66A GB3969566A GB1097167A GB 1097167 A GB1097167 A GB 1097167A GB 39695/66 A GB39695/66 A GB 39695/66A GB 3969566 A GB3969566 A GB 3969566A GB 1097167 A GB1097167 A GB 1097167A
Authority
GB
United Kingdom
Prior art keywords
oxo
cis
phenethylmorphinan
hydroxy
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39695/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB1097167A publication Critical patent/GB1097167A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel 3 - hydroxy - 6 - oxo - N - phenethyl-7 - dehydromorphinan(cis) and 3 - hydroxy - 6-oxo - N - phenethylmorphinan(cis) and acid addition salts thereof are prepared by subjecting the corresponding 3-methoxy-6-oxo-N-phenethylmorphinan(cis) compounds to hydrolytic fission, followed by optional conversion to an acid addition salt. Pharmaceutical compositions comprising as active ingredient 3-hydroxy-6-oxo-N-phenethyl-7 dehydromorphinan(cis), 3-hydroxy-6-oxo-N-phenethylmorphinan(cis) or acid addition salts thereof in combination with a pharmaceutical carrier are useful as analgesic agents. 3 - Methoxy - 6 - oxo - N - phenethyl - 7 - dehydromorphinan(cis) and 3 - methoxy - 6 - oxo-N-phenethylmorphinan(cis) are prepared by reacting the corresponding N-methyl compounds with cyanogen bromide, treating the resulting N-cyano compounds with hydrochloric acid and reacting the resulting N-unsubstituted compounds with phenethyl bromide.
GB39695/66A 1966-05-31 1966-09-06 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production Expired GB1097167A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3528966 1966-05-31

Publications (1)

Publication Number Publication Date
GB1097167A true GB1097167A (en) 1967-12-29

Family

ID=12437598

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39695/66A Expired GB1097167A (en) 1966-05-31 1966-09-06 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production

Country Status (3)

Country Link
CH (1) CH464947A (en)
FR (1) FR6147M (en)
GB (1) GB1097167A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6163658A (en) * 1984-07-05 1986-04-01 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー Substituted benzoate ester prodrug derivative of 3-hydroxymorphinanes
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
WO2016182840A1 (en) * 2015-05-08 2016-11-17 Nektar Therapeutics Morphinan derivatives for the treatment of neuropathic pain

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6163658A (en) * 1984-07-05 1986-04-01 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー Substituted benzoate ester prodrug derivative of 3-hydroxymorphinanes
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
WO2016182840A1 (en) * 2015-05-08 2016-11-17 Nektar Therapeutics Morphinan derivatives for the treatment of neuropathic pain
US10766864B2 (en) 2015-05-08 2020-09-08 Nektar Therapeutics Morphinan derivatives for the treatment of neuropathic pain

Also Published As

Publication number Publication date
DE1620407A1 (en) 1970-03-12
FR6147M (en) 1968-07-01
CH464947A (en) 1968-11-15

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