NO852699L - Fremgangsmaate ved fremstilling av terapeutisk anvendelige substituerte benzoatesterderivater av 3-hydroxymorfinaner - Google Patents

Fremgangsmaate ved fremstilling av terapeutisk anvendelige substituerte benzoatesterderivater av 3-hydroxymorfinaner

Info

Publication number
NO852699L
NO852699L NO852699A NO852699A NO852699L NO 852699 L NO852699 L NO 852699L NO 852699 A NO852699 A NO 852699A NO 852699 A NO852699 A NO 852699A NO 852699 L NO852699 L NO 852699L
Authority
NO
Norway
Prior art keywords
hydroxymorphinanes
procedure
preparation
ester derivatives
benzoate ester
Prior art date
Application number
NO852699A
Other languages
English (en)
Other versions
NO171209C (no
NO171209B (no
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of NO852699L publication Critical patent/NO852699L/no
Publication of NO171209B publication Critical patent/NO171209B/no
Publication of NO171209C publication Critical patent/NO171209C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/28Morphinans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO852699A 1984-07-05 1985-07-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive morfinanestere NO171209C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (3)

Publication Number Publication Date
NO852699L true NO852699L (no) 1986-01-06
NO171209B NO171209B (no) 1992-11-02
NO171209C NO171209C (no) 1993-02-10

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
NO852699A NO171209C (no) 1984-07-05 1985-07-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive morfinanestere

Country Status (18)

Country Link
US (1) US4668685A (no)
EP (1) EP0170090B1 (no)
AU (1) AU578391B2 (no)
CA (1) CA1301150C (no)
DE (1) DE3573251D1 (no)
DK (1) DK160501C (no)
ES (1) ES8704443A1 (no)
FI (1) FI83215C (no)
GR (1) GR851653B (no)
HK (1) HK39790A (no)
HU (1) HU193995B (no)
IE (1) IE58136B1 (no)
IL (1) IL75721A (no)
MX (1) MX160445A (no)
NO (1) NO171209C (no)
NZ (1) NZ212641A (no)
PT (1) PT80773B (no)
SU (2) SU1450742A3 (no)

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PT1041987E (pt) 1997-12-22 2006-07-31 Euro Celtique Sa Forma farmaceutica de dosagem oral, compreendendo uma combinacao de um agonista de opioide e naltrexona
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
ATE233264T1 (de) * 2000-04-27 2003-03-15 Oliver Yoa-Pu Hu Polynalbuphinderivat
US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
EP1387673B1 (en) 2001-05-11 2010-12-29 Endo Pharmaceuticals Inc. Abuse-resistant controlled-release opioid dosage form
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ES2733051T1 (es) 2002-04-05 2019-11-27 Euro Celtique Sa Matriz para liberación sostenida, invariable e independiente de compuestos activos
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
US20060069086A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
GEP20105052B (en) * 2005-01-28 2010-07-26 Euro Celtique Sa Alcohol resistant dosage forms
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP1928881A2 (en) 2005-08-19 2008-06-11 Pharmacofore, Inc. Prodrugs of active agents
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
RU2430089C2 (ru) * 2007-03-09 2011-09-27 Грин Кросс Корпорейшн Перорально биодоступные пролекарства (+)-3- гидроксиморфинана для профилактики или лечения болезни паркинсона
CN105456267A (zh) * 2008-07-07 2016-04-06 欧洲凯尔特公司 阿片类拮抗剂治疗尿潴留的用途
MY152279A (en) 2009-03-10 2014-09-15 Euro Celtique Sa Immediate release pharmaceutical compositions comprising oxycodone and naloxone
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
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WO2011008636A1 (en) * 2009-07-15 2011-01-20 Mallinckrodt Inc. 3-oxy-hydromorphone derivatives
TWI597282B (zh) * 2010-11-12 2017-09-01 鹽野義製藥股份有限公司 6,7-不飽合-7-胺甲醯基嗎啡喃衍生物之結晶及其製造方法
WO2013063204A1 (en) 2011-10-26 2013-05-02 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
MY183489A (en) 2013-07-23 2021-02-22 Euro Celtique Sa A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
CA2967424C (en) 2014-11-25 2023-05-02 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
CA2969221C (en) 2014-12-02 2021-01-12 Travis Mickle Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods
EP4010078A4 (en) 2019-08-11 2023-08-09 Kappa-Pharma LLC COMPOSITIONS AND METHODS FOR ENHANCING OPIOID RECEPTOR MOBILIZATION BY OPIOID HEXADENOATES AND OPTIONALLY SUBSTITUTED HEXADIENATES

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JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev 3−ベンゾイルチオ−4、5α−エポキシ−7α−〔1(R)−ヒドロキシ−1−メチルベンチル〕−6−メトキシ−17−メチル−6、14−エンド−エタノモルヒナン
JPS59184163A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev 3−ベンゾイルチオ−17−メチルモルヒナン
JPS59184183A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev 3−ベンゾイルチオ−4、5α−エポキシ−7α−〔1(R)−ヒドロキシ−1−メチルブチル〕−6−メトキシ−17−メチル−6、14−エンド−エテノモルヒナン
JPS59186987A (ja) * 1983-04-06 1984-10-23 Res Inst For Prod Dev 3−ベンゾイルチオ−4、5α−エポキシ−7α−〔1(R)−ヒドロキシ−1−メチルブチル〕−6−メトキシ−17−メチル−6、14−エンド−エテノモルヒナン

Also Published As

Publication number Publication date
IE58136B1 (en) 1993-07-14
SU1450742A3 (ru) 1989-01-07
IE851683L (en) 1986-01-05
EP0170090A1 (en) 1986-02-05
DE3573251D1 (en) 1989-11-02
DK306885D0 (da) 1985-07-04
FI83215C (fi) 1991-06-10
ES8704443A1 (es) 1987-04-01
PT80773B (pt) 1987-10-20
AU578391B2 (en) 1988-10-20
DK160501C (da) 1991-08-26
SU1508960A3 (ru) 1989-09-15
ES544852A0 (es) 1987-04-01
FI852659A0 (fi) 1985-07-04
CA1301150C (en) 1992-05-19
EP0170090B1 (en) 1989-09-27
PT80773A (en) 1985-08-01
IL75721A (en) 1990-04-29
AU4451685A (en) 1986-01-09
HU193995B (en) 1987-12-28
IL75721A0 (en) 1985-11-29
FI83215B (fi) 1991-02-28
DK306885A (da) 1986-01-06
GR851653B (no) 1985-11-26
MX160445A (es) 1990-03-02
HUT40132A (en) 1986-11-28
DK160501B (da) 1991-03-18
US4668685A (en) 1987-05-26
FI852659L (fi) 1986-01-06
HK39790A (en) 1990-06-01
NZ212641A (en) 1988-10-28
NO171209C (no) 1993-02-10
NO171209B (no) 1992-11-02

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