ES8205798A1 - Procedimiento para preparar derivados de indolizina - Google Patents
Procedimiento para preparar derivados de indolizinaInfo
- Publication number
- ES8205798A1 ES8205798A1 ES497504A ES497504A ES8205798A1 ES 8205798 A1 ES8205798 A1 ES 8205798A1 ES 497504 A ES497504 A ES 497504A ES 497504 A ES497504 A ES 497504A ES 8205798 A1 ES8205798 A1 ES 8205798A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- bromine
- iodine
- chlorine
- represents hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title 1
- HOBCFUWDNJPFHB-UHFFFAOYSA-N indolizine Chemical class C1=CC=CN2C=CC=C21 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 3
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000003406 indolizinyl group Chemical class C=1(C=CN2C=CC=CC12)* 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7942146 | 1979-12-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES497504A0 ES497504A0 (es) | 1982-06-16 |
| ES8205798A1 true ES8205798A1 (es) | 1982-06-16 |
Family
ID=10509659
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497504A Expired ES8205798A1 (es) | 1979-12-06 | 1980-12-05 | Procedimiento para preparar derivados de indolizina |
| ES508051A Expired ES8300108A1 (es) | 1979-12-06 | 1981-12-16 | Procedimiento para preparar derivados de indolizina. |
| ES508052A Granted ES508052A0 (es) | 1979-12-06 | 1981-12-16 | Procedimiento para preparar derivados de indolizina. |
| ES508053A Expired ES8300110A1 (es) | 1979-12-06 | 1981-12-16 | Procedimiento para preparar derivados de indolizina. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508051A Expired ES8300108A1 (es) | 1979-12-06 | 1981-12-16 | Procedimiento para preparar derivados de indolizina. |
| ES508052A Granted ES508052A0 (es) | 1979-12-06 | 1981-12-16 | Procedimiento para preparar derivados de indolizina. |
| ES508053A Expired ES8300110A1 (es) | 1979-12-06 | 1981-12-16 | Procedimiento para preparar derivados de indolizina. |
Country Status (40)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10065955B2 (en) * | 2014-12-10 | 2018-09-04 | Ono Pharmaceutical Co., Ltd. | Dihydroindolizinone derivative |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1518443A (en) | 1976-02-19 | 1978-07-19 | Labaz | Indolizine derivatives and process for preparing the same |
-
1980
- 1980-10-31 IL IL61385A patent/IL61385A/xx unknown
- 1980-11-04 GR GR63275A patent/GR70224B/el unknown
- 1980-11-05 IS IS2594A patent/IS1209B6/is unknown
- 1980-11-05 ZA ZA00806831A patent/ZA806831B/xx unknown
- 1980-11-07 CH CH8289/80A patent/CH651041A5/fr not_active IP Right Cessation
- 1980-11-12 AU AU64292/80A patent/AU536320B2/en not_active Ceased
- 1980-11-13 PH PH24853A patent/PH17028A/en unknown
- 1980-11-19 NL NLAANVRAGE8006310,A patent/NL184683C/xx not_active IP Right Cessation
- 1980-11-25 BR BR8007691A patent/BR8007691A/pt unknown
- 1980-11-26 ZW ZW285/80A patent/ZW28580A1/xx unknown
- 1980-12-01 BG BG062985A patent/BG37379A3/xx unknown
- 1980-12-01 BG BG049830A patent/BG35598A3/xx unknown
- 1980-12-01 CA CA000365859A patent/CA1152077A/en not_active Expired
- 1980-12-02 SE SE8008444A patent/SE441926B/sv not_active IP Right Cessation
- 1980-12-02 YU YU3041/80A patent/YU42366B/xx unknown
- 1980-12-03 MA MA19209A patent/MA19007A1/fr unknown
- 1980-12-03 IE IE2520/80A patent/IE50519B1/en unknown
- 1980-12-04 PL PL1980231829A patent/PL127865B1/pl unknown
- 1980-12-04 PL PL1980228265A patent/PL127999B1/pl unknown
- 1980-12-04 CS CS808517A patent/CS222697B2/cs unknown
- 1980-12-04 CS CS808517A patent/CS222692B2/cs unknown
- 1980-12-04 IN IN1344/CAL/80A patent/IN151241B/en unknown
- 1980-12-04 PL PL1980231828A patent/PL129365B1/pl unknown
- 1980-12-04 CS CS814016A patent/CS222698B2/cs unknown
- 1980-12-04 PT PT72151A patent/PT72151B/pt unknown
- 1980-12-04 NZ NZ195754A patent/NZ195754A/en unknown
- 1980-12-05 SU SU803213301A patent/SU1058505A3/ru active
- 1980-12-05 RO RO108948A patent/RO84707B/ro unknown
- 1980-12-05 IT IT26463/80A patent/IT1218424B/it active
- 1980-12-05 BE BE0/203053A patent/BE886511A/fr not_active IP Right Cessation
- 1980-12-05 DK DK521980A patent/DK146977C/da not_active IP Right Cessation
- 1980-12-05 NO NO803681A patent/NO157019C/no unknown
- 1980-12-05 FI FI803792A patent/FI67846C/fi not_active IP Right Cessation
- 1980-12-05 HU HU802915A patent/HU185019B/hu not_active IP Right Cessation
- 1980-12-05 ES ES497504A patent/ES8205798A1/es not_active Expired
- 1980-12-05 AT AT0596780A patent/AT376438B/de not_active IP Right Cessation
- 1980-12-05 DE DE3046017A patent/DE3046017C2/de not_active Expired
- 1980-12-05 RO RO108949A patent/RO85271B/ro unknown
- 1980-12-05 JP JP17252180A patent/JPS56103181A/ja active Granted
- 1980-12-05 RO RO102781A patent/RO81452B/ro unknown
- 1980-12-05 LU LU82983A patent/LU82983A1/fr unknown
- 1980-12-06 DD DD80225817A patent/DD155069A5/de unknown
- 1980-12-06 OA OA57269A patent/OA06711A/xx unknown
- 1980-12-06 AR AR283495A patent/AR227036A1/es active
-
1981
- 1981-12-16 ES ES508051A patent/ES8300108A1/es not_active Expired
- 1981-12-16 ES ES508052A patent/ES508052A0/es active Granted
- 1981-12-16 ES ES508053A patent/ES8300110A1/es not_active Expired
- 1981-12-22 SU SU813367150A patent/SU1109051A3/ru active
-
1982
- 1982-02-24 AR AR227094A patent/AR227094A1/es active
- 1982-02-24 AR AR288533A patent/AR227093A1/es active
- 1982-02-24 AR AR288535A patent/AR229692A1/es active
-
1983
- 1983-02-24 YU YU443/83A patent/YU42840B/xx unknown
- 1983-02-24 YU YU444/83A patent/YU42127B/xx unknown
-
1984
- 1984-04-25 SG SG33384A patent/SG33384G/en unknown
- 1984-08-13 KE KE3438A patent/KE3438A/xx unknown
- 1984-08-23 HK HK658/84A patent/HK65884A/xx unknown
- 1984-10-12 SU SU843801012A patent/SU1287751A3/ru active
Also Published As
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