ES8304915A1 - Procedimiento para la obtencion de derivados de dioxibencenoeteres. - Google Patents

Procedimiento para la obtencion de derivados de dioxibencenoeteres.

Info

Publication number
ES8304915A1
ES8304915A1 ES513475A ES513475A ES8304915A1 ES 8304915 A1 ES8304915 A1 ES 8304915A1 ES 513475 A ES513475 A ES 513475A ES 513475 A ES513475 A ES 513475A ES 8304915 A1 ES8304915 A1 ES 8304915A1
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
alkylmercapto
trifluoromethyl
carboxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513475A
Other languages
English (en)
Other versions
ES513475A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8304915A1 publication Critical patent/ES8304915A1/es
Publication of ES513475A0 publication Critical patent/ES513475A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE DIOXIBENCENOETERES, DE FORMULA (I), EN LA QUE R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE DERIVADOS DE HIDROXIBENCENO DE FORMULA (II) CON COMPUESTOS DE FORMULA YR , EN LAS QUE X ES UN GRUPO PROTECTOR; Y ES UN GRUPO SALIENTE, Y R Y R SON LOS MISMOS QUE EN LA FORMULA (I), EN DISOLVENTES APROTICOS ORGANICOS INERTES, EN PRESENCIA DE UNA BASE FUERTE, A TEMPERATURAS ENTRE 0 C Y 150 C; SEGUIDA DE LA DISOCIACION DEL GRUPO PROTECTOR X, Y ESTERIFICACION CON COMPUESTOS DE FORMULA Y R , EN LA QUE R ES EL MISMO QUE EN LA FORMULA (I) E Y TIENE EL MISMO SIGNIFICADO QUE Y, PERO SIN SER IDENTICOS. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTITROMBOTICOS Y ANTIARTERIOESCLEROTICOS.
ES513475A 1981-06-26 1982-06-25 Procedimiento para la obtencion de derivados de dioxibencenoeteres. Granted ES513475A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813125059 DE3125059A1 (de) 1981-06-26 1981-06-26 Dioxybenzoletherderivate, diese enthaltende arzneimittel, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
ES8304915A1 true ES8304915A1 (es) 1983-03-16
ES513475A0 ES513475A0 (es) 1983-03-16

Family

ID=6135389

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513475A Granted ES513475A0 (es) 1981-06-26 1982-06-25 Procedimiento para la obtencion de derivados de dioxibencenoeteres.

Country Status (7)

Country Link
US (1) US4590291A (es)
EP (1) EP0068250B1 (es)
JP (1) JPS58928A (es)
AT (1) ATE18195T1 (es)
DE (2) DE3125059A1 (es)
DK (1) DK288382A (es)
ES (1) ES513475A0 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576030A (en) * 1983-08-31 1986-03-18 Wallace Expanding Machines, Inc. Stretch form die
CA1328279C (en) * 1987-10-01 1994-04-05 F. Hoffmann-La Roche Ag Catechol carboxylic acid derivatives
US4845277A (en) * 1988-08-22 1989-07-04 Mine Safety Appliances Company Method of preparing dialkoxybenzoic acid
US4845276A (en) * 1988-08-22 1989-07-04 Mine Safety Appliances Company Preparation of dialkoxybenzoic acid
JP3051145B2 (ja) * 1990-08-28 2000-06-12 住友製薬株式会社 新規なポリエチレングリコール誘導体修飾ペプチド
US5374772A (en) * 1992-12-08 1994-12-20 Hoffmann-Laroche Inc. Substituted benzoic acids, inhibitors of phospholipases A2
IL111613A0 (en) * 1993-11-12 1995-01-24 Rhone Poulenc Rorer Ltd Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them
DE19624155A1 (de) * 1996-06-18 1998-01-08 Hoechst Ag Substituierte Benzoesäurederivate, Verfahren zu ihrer Herstellung und die Anwendung der Verbindungen zur Behandlung von Krankheiten

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1076871A (en) * 1964-03-20 1967-07-26 Merck & Co Inc (phenoxy)phenylacetic acids and derivatives thereof
US3379752A (en) * 1964-05-20 1968-04-23 Merck & Co Inc Phenoxy substituted 3-hydroxyalkanoic acids and a method for their preparation
GB1262078A (en) * 1968-05-24 1972-02-02 Fisons Pharmaceuticals Ltd Preparation of phenoxy fumaric acid compounds and chromone-2-carboxylic acid compounds therefrom
GB1228731A (es) * 1969-01-06 1971-04-15
US3998874A (en) * 1971-03-23 1976-12-21 Gist-Brocades N.V. Phenylene di-ethers
NL7301246A (es) * 1972-02-14 1973-08-16
US3927118A (en) * 1973-12-21 1975-12-16 Crown Zellerbach Corp Process for monoetherification of polyhydric benzenes
ES437285A1 (es) * 1974-05-17 1977-04-01 Monsanto Co Un procedimiento para la preparacion de compuestos organi- cos.
JPS5214734A (en) * 1975-07-25 1977-02-03 Ube Ind Ltd Process for preparation of dioxybenzenem noalkylether
GB1565972A (en) * 1976-04-15 1980-04-23 Sori Soc Rech Ind M-substituted phenoxypropionic acid dervatives
US4096280A (en) * 1977-01-24 1978-06-20 Sterling Drug Inc. Arylenedioxy-bis-diketones
IT1075275B (it) * 1977-01-31 1985-04-22 Montedison Spa Alchil aril dieteri ad attivita' ormonica giovanile e acaricida
JPS557702A (en) * 1978-06-01 1980-01-19 Konishiroku Photo Ind Co Ltd Silver halide color photographic material
IT1096582B (it) * 1978-06-21 1985-08-26 Montedison Spa Dieteri idrochinonici aventi attivita' ormonica giovanile e acaricida
ZA794517B (en) * 1978-08-28 1980-09-24 Ciba Geigy Ag Phenylalkyl ethers
US4351950A (en) * 1980-01-02 1982-09-28 Warner-Lambert Company Anti-arteriosclerotic agents

Also Published As

Publication number Publication date
JPS58928A (ja) 1983-01-06
EP0068250B1 (de) 1986-02-26
DE3125059A1 (de) 1983-01-05
EP0068250A1 (de) 1983-01-05
US4590291A (en) 1986-05-20
ATE18195T1 (de) 1986-03-15
DE3269349D1 (en) 1986-04-03
DK288382A (da) 1982-12-27
ES513475A0 (es) 1983-03-16

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