ES2950569T3 - (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-2-metoxi-n-(piridin-2-il)benzamida como inhibidor de la Btk - Google Patents

(S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-2-metoxi-n-(piridin-2-il)benzamida como inhibidor de la Btk Download PDF

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Publication number
ES2950569T3
ES2950569T3 ES18203086T ES18203086T ES2950569T3 ES 2950569 T3 ES2950569 T3 ES 2950569T3 ES 18203086 T ES18203086 T ES 18203086T ES 18203086 T ES18203086 T ES 18203086T ES 2950569 T3 ES2950569 T3 ES 2950569T3
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Spain
Prior art keywords
compound
disease
benzamide
btk
amino
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES18203086T
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English (en)
Spanish (es)
Inventor
Tjeerd A Barf
Christiaan Geradus Johannes Maria Jans
Man Adrianus Petrus Antonius De
Arthur A Oubrie
Hans C A Raaijmakers
Johannes Bernardus Maria Rewinkel
Jan-Gerard Sterrenburg
Jacobus C H M Wijkmans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp & Dohme BV
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Merck Sharp and Dohme Ltd
Merck Sharp & Dohme BV
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Application filed by Merck Sharp and Dohme Ltd, Merck Sharp & Dohme BV filed Critical Merck Sharp and Dohme Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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ES18203086T 2011-07-19 2012-07-11 (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-2-metoxi-n-(piridin-2-il)benzamida como inhibidor de la Btk Active ES2950569T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161509397P 2011-07-19 2011-07-19
EP11174578 2011-07-19

Publications (1)

Publication Number Publication Date
ES2950569T3 true ES2950569T3 (es) 2023-10-11

Family

ID=47557677

Family Applications (3)

Application Number Title Priority Date Filing Date
ES18203086T Active ES2950569T3 (es) 2011-07-19 2012-07-11 (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-2-metoxi-n-(piridin-2-il)benzamida como inhibidor de la Btk
ES12733505T Active ES2708224T3 (es) 2011-07-19 2012-07-11 4-Imidazopiridazín-1-il-benzamidas y 4-imidazotriazín-1-il-benzamidas como inhibidores de Btk
ES19215783T Active ES2904707T3 (es) 2011-07-19 2012-07-11 4-imidazopiridazin-1-il-benzamidas y 4-imidazotriazin-1-il-benzamidas como inhibidores de Btk

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES12733505T Active ES2708224T3 (es) 2011-07-19 2012-07-11 4-Imidazopiridazín-1-il-benzamidas y 4-imidazotriazín-1-il-benzamidas como inhibidores de Btk
ES19215783T Active ES2904707T3 (es) 2011-07-19 2012-07-11 4-imidazopiridazin-1-il-benzamidas y 4-imidazotriazin-1-il-benzamidas como inhibidores de Btk

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Country Link
US (8) US9290504B2 (enExample)
EP (4) EP4249076A3 (enExample)
JP (6) JP5826931B2 (enExample)
KR (2) KR101702727B1 (enExample)
CN (2) CN103889987B (enExample)
AU (4) AU2012285987C1 (enExample)
BR (1) BR112014001255B1 (enExample)
CA (1) CA2841886C (enExample)
CL (1) CL2014000130A1 (enExample)
CO (1) CO6940411A2 (enExample)
CR (1) CR20140030A (enExample)
CY (2) CY2021010I1 (enExample)
DK (2) DK3689878T3 (enExample)
DO (1) DOP2014000008A (enExample)
EA (2) EA034558B1 (enExample)
EC (1) ECSP14013217A (enExample)
ES (3) ES2950569T3 (enExample)
GT (1) GT201400009A (enExample)
HR (2) HRP20212021T1 (enExample)
HU (3) HUE056249T2 (enExample)
IL (3) IL230511B (enExample)
IN (1) IN2014CN00408A (enExample)
LT (1) LT2734522T (enExample)
MA (1) MA35348B1 (enExample)
MX (1) MX342983B (enExample)
MY (1) MY192354A (enExample)
PE (1) PE20141681A1 (enExample)
PH (2) PH12014500148A1 (enExample)
PL (2) PL3689878T3 (enExample)
PT (1) PT3689878T (enExample)
RS (2) RS62760B1 (enExample)
SG (1) SG10201605913VA (enExample)
SI (2) SI2734522T1 (enExample)
SM (2) SMT201900029T1 (enExample)
TN (1) TN2014000027A1 (enExample)
UA (1) UA115312C2 (enExample)
WO (1) WO2013010868A1 (enExample)
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Families Citing this family (121)

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Publication number Priority date Publication date Assignee Title
US8809273B2 (en) * 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
MX380504B (es) 2010-06-03 2025-03-12 Pharmacyclics Llc El uso de inhibidores de la tirosina quinasa de bruton (btk).
AU2012255860C1 (en) 2011-05-17 2015-12-10 Principia Biopharma Inc. Tyrosine kinase inhibitors
WO2012158795A1 (en) 2011-05-17 2012-11-22 Principia Biopharma Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
KR20140048968A (ko) 2011-07-13 2014-04-24 파마시클릭스, 인코포레이티드 브루톤형 티로신 키나제의 억제제
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