ES2848705T3 - Amadoriasa modificada y método para producirla, agente para mejorar la resistencia a tensioactivos de la amadoriasa y composición para medir la HbA1c usando la misma - Google Patents
Amadoriasa modificada y método para producirla, agente para mejorar la resistencia a tensioactivos de la amadoriasa y composición para medir la HbA1c usando la misma Download PDFInfo
- Publication number
- ES2848705T3 ES2848705T3 ES14834684T ES14834684T ES2848705T3 ES 2848705 T3 ES2848705 T3 ES 2848705T3 ES 14834684 T ES14834684 T ES 14834684T ES 14834684 T ES14834684 T ES 14834684T ES 2848705 T3 ES2848705 T3 ES 2848705T3
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- Prior art keywords
- amino acid
- seq
- substitution
- position corresponding
- lysine
- Prior art date
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- 108010078123 amadoriase Proteins 0.000 title claims abstract description 482
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- 239000004472 Lysine Substances 0.000 claims abstract description 189
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- 150000001413 amino acids Chemical class 0.000 claims abstract description 86
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims abstract description 57
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 51
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- UJHVZVXYELCZLX-UHFFFAOYSA-M tributyl(dodecyl)phosphanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[P+](CCCC)(CCCC)CCCC UJHVZVXYELCZLX-UHFFFAOYSA-M 0.000 description 1
- RLZMYANQLOCZOB-UHFFFAOYSA-M tributyl(methyl)phosphanium;iodide Chemical compound [I-].CCCC[P+](C)(CCCC)CCCC RLZMYANQLOCZOB-UHFFFAOYSA-M 0.000 description 1
- PDSVZUAJOIQXRK-UHFFFAOYSA-N trimethyl(octadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)C PDSVZUAJOIQXRK-UHFFFAOYSA-N 0.000 description 1
- SZEMGTQCPRNXEG-UHFFFAOYSA-M trimethyl(octadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C SZEMGTQCPRNXEG-UHFFFAOYSA-M 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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- 239000012138 yeast extract Substances 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
- C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/723—Glycosylated haemoglobin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
- C12Y105/03—Oxidoreductases acting on the CH-NH group of donors (1.5) with oxygen as acceptor (1.5.3)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/795—Porphyrin- or corrin-ring-containing peptides
- G01N2333/805—Haemoglobins; Myoglobins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/906—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
- G01N2333/9065—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on CH-NH groups of donors (1.5)
- G01N2333/90672—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3) in general
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
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- Analytical Chemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013167005 | 2013-08-09 | ||
| JP2013221515 | 2013-10-24 | ||
| PCT/JP2014/071036 WO2015020200A1 (ja) | 2013-08-09 | 2014-08-08 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
Publications (1)
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| ES2848705T3 true ES2848705T3 (es) | 2021-08-11 |
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| ES14834684T Active ES2848705T3 (es) | 2013-08-09 | 2014-08-08 | Amadoriasa modificada y método para producirla, agente para mejorar la resistencia a tensioactivos de la amadoriasa y composición para medir la HbA1c usando la misma |
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| Country | Link |
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| US (2) | US10619183B2 (enExample) |
| EP (2) | EP3031914B1 (enExample) |
| JP (4) | JP6682268B2 (enExample) |
| CN (2) | CN105473715B (enExample) |
| ES (1) | ES2848705T3 (enExample) |
| WO (1) | WO2015020200A1 (enExample) |
Families Citing this family (9)
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| WO2015020200A1 (ja) * | 2013-08-09 | 2015-02-12 | キッコーマン株式会社 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
| KR102159807B1 (ko) | 2014-10-24 | 2020-09-25 | 기꼬만 가부시키가이샤 | 디히드로게나아제 활성이 향상된 아마도리아제 |
| EP3216865B1 (en) * | 2014-11-07 | 2020-09-30 | Kikkoman Corporation | Amadoriase having enhanced anionic-surfactant tolerance |
| CN109312312B (zh) * | 2016-04-22 | 2023-06-02 | 龟甲万株式会社 | HbA1c脱氢酶 |
| JP7352838B2 (ja) * | 2018-06-27 | 2023-09-29 | 東洋紡株式会社 | フルクトシルバリルヒスチジンオキシダーゼ活性を有するタンパク質 |
| JP7540890B2 (ja) * | 2020-01-10 | 2024-08-27 | キリンホールディングス株式会社 | 低毒性のポリマー粒子の製法 |
| JP7714520B2 (ja) | 2020-02-21 | 2025-07-29 | キッコーマン株式会社 | 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ |
| CN113773236B (zh) * | 2021-09-10 | 2023-03-14 | 上海奥威日化有限公司 | 用于制备烷基硫酸钠干燥物的前驱组合物 |
| WO2025018360A1 (ja) | 2023-07-19 | 2025-01-23 | 株式会社Provigate | フルクトシルアミノ酸オキシダーゼ、遺伝子、発現ベクター、糖化タンパク質センサ、糖化タンパク質の測定方法、及びフルクトシルアミノ酸オキシダーゼの製造方法 |
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| DE69635503T2 (de) * | 1995-04-11 | 2006-08-17 | Arkray, Inc. | Fructosyl-Aminosäureoxidase und Verfahren zu deren Herstellung |
| WO1997013872A1 (en) | 1995-10-12 | 1997-04-17 | Kyoto Daiichi Kagaku Co., Ltd. | Method and assaying amodori compounds |
| JP3949854B2 (ja) | 1999-10-01 | 2007-07-25 | キッコーマン株式会社 | 糖化蛋白質の測定方法 |
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| WO2002061119A1 (fr) * | 2001-01-31 | 2002-08-08 | Asahi Kasei Kabushiki Kaisha | Compositions pour analyse de glycoproteines |
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| JP4227820B2 (ja) | 2003-03-12 | 2009-02-18 | 旭化成ファーマ株式会社 | 新規な酵素 |
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| EP1626088B1 (en) * | 2003-05-21 | 2010-12-01 | Asahi Kasei Pharma Corporation | Method of measuring glycolated hemoglobin a1c, enzyme to be used therefor and process for producing the same |
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| DE102006021401A1 (de) * | 2006-05-08 | 2007-12-13 | Henkel Kgaa | Amadoriasen in Wasch- und Reinigungsmitteln |
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| JP5779118B2 (ja) | 2012-02-16 | 2015-09-16 | Ntn株式会社 | 転がり接触部品、転がり軸受、自在継手およびそれらの製造方法 |
| US20130269351A1 (en) | 2012-04-17 | 2013-10-17 | General Electric Company | Micromixer assembly of a turbine system and method of assembly |
| JP6401056B2 (ja) * | 2012-04-27 | 2018-10-03 | キッコーマン株式会社 | フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ |
| WO2015020200A1 (ja) * | 2013-08-09 | 2015-02-12 | キッコーマン株式会社 | 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 |
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| US11549134B2 (en) | 2023-01-10 |
| WO2015020200A1 (ja) | 2015-02-12 |
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| US20200263228A1 (en) | 2020-08-20 |
| EP3031914A4 (en) | 2017-01-11 |
| EP3760717A1 (en) | 2021-01-06 |
| JP6682268B2 (ja) | 2020-04-15 |
| US10619183B2 (en) | 2020-04-14 |
| CN111398605B (zh) | 2024-04-05 |
| CN105473715A (zh) | 2016-04-06 |
| EP3031914B1 (en) | 2020-12-23 |
| JP2022188182A (ja) | 2022-12-20 |
| EP3031914A1 (en) | 2016-06-15 |
| JP2024170623A (ja) | 2024-12-10 |
| JPWO2015020200A1 (ja) | 2017-03-02 |
| JP2020096596A (ja) | 2020-06-25 |
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