ES2730737T3 - Material de soporte de partículas funcionalizado y métodos de fabricación y uso del mismo - Google Patents
Material de soporte de partículas funcionalizado y métodos de fabricación y uso del mismo Download PDFInfo
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- ES2730737T3 ES2730737T3 ES13837684T ES13837684T ES2730737T3 ES 2730737 T3 ES2730737 T3 ES 2730737T3 ES 13837684 T ES13837684 T ES 13837684T ES 13837684 T ES13837684 T ES 13837684T ES 2730737 T3 ES2730737 T3 ES 2730737T3
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- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
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- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
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- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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- Y10T428/00—Stock material or miscellaneous articles
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- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Mechanical Engineering (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Graft Or Block Polymers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| US201261702174P | 2012-09-17 | 2012-09-17 | |
| PCT/US2013/059995 WO2014043644A1 (en) | 2012-09-17 | 2013-09-16 | Functionalized particulate support material and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2730737T3 true ES2730737T3 (es) | 2019-11-12 |
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| ES13837684T Active ES2730737T3 (es) | 2012-09-17 | 2013-09-16 | Material de soporte de partículas funcionalizado y métodos de fabricación y uso del mismo |
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|---|---|
| US (1) | US11529610B2 (enExample) |
| EP (1) | EP2811983B1 (enExample) |
| JP (1) | JP6469574B2 (enExample) |
| KR (1) | KR102226564B1 (enExample) |
| CN (1) | CN104768536B (enExample) |
| CA (1) | CA2885264C (enExample) |
| ES (1) | ES2730737T3 (enExample) |
| IN (1) | IN2015DN01895A (enExample) |
| MY (1) | MY195756A (enExample) |
| PL (1) | PL2811983T3 (enExample) |
| RU (1) | RU2015114177A (enExample) |
| SG (1) | SG11201404684RA (enExample) |
| WO (1) | WO2014043644A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2015114177A (ru) | 2012-09-17 | 2016-11-10 | У.Р. Грейс Энд Ко.-Конн. | Функционализированный, состоящий из частиц материал носителя и способы его получения и применения |
| ES2887110T3 (es) | 2014-01-16 | 2021-12-21 | Grace W R & Co | Medios para cromatografía de afinidad y dispositivos para cromatografía |
| US11389783B2 (en) | 2014-05-02 | 2022-07-19 | W.R. Grace & Co.-Conn. | Functionalized support material and methods of making and using functionalized support material |
| JP6670039B2 (ja) * | 2014-11-07 | 2020-03-18 | 日鉄ケミカル＆マテリアル株式会社 | 表面修飾無機酸化物粒子及び樹脂組成物 |
| US10814319B2 (en) | 2016-09-30 | 2020-10-27 | Board Of Regents, University Of Texas System | Functionalized polyolefin capillaries for open tubular ion chromatography |
| US12403452B2 (en) * | 2018-08-30 | 2025-09-02 | Daicel Corporation | Stationary phase for chromatography |
| JP7310394B2 (ja) * | 2019-07-17 | 2023-07-19 | 株式会社豊田中央研究所 | 冷却液 |
| CN113063884B (zh) * | 2021-03-31 | 2021-11-16 | 中科微分科技发展(北京)有限公司 | 一种液相色谱柱复合填料及其应用 |
| EP4495174A1 (en) * | 2023-07-18 | 2025-01-22 | Sika Technology AG | Thermally conductive chemically curable composition |
Family Cites Families (183)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029583A (en) | 1975-02-28 | 1977-06-14 | Purdue Research Foundation | Chromatographic supports and methods and apparatus for preparing the same |
| US4118316A (en) | 1976-10-13 | 1978-10-03 | Calgon Corporation | Quaternized siliceous supports for gel permeation chromatography |
| US4397827A (en) | 1979-07-12 | 1983-08-09 | Mobil Oil Corporation | Silico-crystal method of preparing same and catalytic conversion therewith |
| ATE15378T1 (de) * | 1980-06-27 | 1985-09-15 | Akzo Nv | Mit einer unbeweglichen organischen phase ueberzogenes anorganisches poroeses traegermaterial, anwendung fuer die chromatographie und sein herstellungsverfahren. |
| US4517131A (en) | 1981-09-11 | 1985-05-14 | The Dow Chemical Company | High yield process for the cyanoalkylation or amidoalkylation or hydroxyaromatic compounds |
| SE8202544L (sv) | 1982-04-23 | 1983-10-24 | Larsson Per Olof | Lektinhaltigt separationsmedel |
| US4414372A (en) | 1982-06-17 | 1983-11-08 | E. I. Du Pont De Nemours & Co. | Process for preparing living polymers |
| JPS5950052A (ja) | 1982-09-17 | 1984-03-22 | Nippon Valqua Ind Ltd | ガラス及びガラス繊維の親水化方法 |
| JPS5950054A (ja) | 1982-09-17 | 1984-03-22 | Nippon Valqua Ind Ltd | 加工性及び親水性のすぐれたガラス繊維ストランドの製造方法 |
| FR2534486B1 (fr) | 1982-10-15 | 1987-11-20 | Commissariat Energie Atomique | Support particulaire greffe en surface, son procede de preparation et adsorbants pour chromatographie d'affinite incorporant ce support, ainsi que leur utilisation, notamment en biologie |
| US5059654A (en) * | 1983-02-14 | 1991-10-22 | Cuno Inc. | Affinity matrices of modified polysaccharide supports |
| SE451843B (sv) | 1983-05-09 | 1987-11-02 | Gambro Lundia Ab | Forfarande for utvinning av en forening |
| US4724207A (en) | 1984-02-02 | 1988-02-09 | Cuno Incorporated | Modified siliceous chromatographic supports |
| DE3407814A1 (de) | 1984-03-02 | 1985-09-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Phasentraeger fuer die verteilungschromatographie von makromolekuelen, verfahren zu ihrer herstellung und ihre verwendung |
| JPS61206689A (ja) | 1985-03-12 | 1986-09-12 | Fuji Photo Film Co Ltd | 感圧複写紙用マイクロカプセル塗布紙 |
| US4650784A (en) * | 1986-02-20 | 1987-03-17 | J. T. Baker Chemical Company | Bonded phase of silica for solid phase extraction |
| DE3619303A1 (de) | 1986-06-07 | 1987-12-10 | Merck Patent Gmbh | Optisch aktive adsorbentien |
| DE3639949A1 (de) | 1986-11-22 | 1988-06-09 | Diagen Inst Molekularbio | Verfahren zur trennung von langkettigen nukleinsaeuren |
| GB2201904B (en) | 1987-02-14 | 1990-12-19 | Domnick Hunter Filters Ltd | Device for liquid chromatography or immobilised enzyme reaction |
| IT1221982B (it) | 1987-07-08 | 1990-08-31 | Mini Ricerca Scient Tecnolog | Antibiotici ab 006 e processo per la loro produzione |
| DE3811042A1 (de) | 1988-03-31 | 1989-10-19 | Merck Patent Gmbh | Ionenaustauscher |
| US4917781A (en) | 1988-07-20 | 1990-04-17 | Southwestern Analytical Chemicals, Inc. | Process for preparing quaternary ammonium hydroxides |
| US5035803A (en) * | 1989-02-14 | 1991-07-30 | The Regents Of The University Of California | High yield water-soluble polymer silica separation resins |
| ATE118824T1 (de) | 1989-03-10 | 1995-03-15 | Amoco Corp | Immobilisierte oligonukleotidsonden und ihre verwendungen. |
| US5230833A (en) | 1989-06-09 | 1993-07-27 | Nalco Chemical Company | Low sodium, low metals silica polishing slurries |
| US6818259B1 (en) | 1989-10-31 | 2004-11-16 | The United States Of America As Represented By The National Aeronautics And Space Administration | Porous article with surface functionality and method for preparing same |
| WO1991011711A1 (fr) | 1990-01-26 | 1991-08-08 | Shiseido Company, Ltd. | Garniture a usage chromatographique et sa preparation |
| DE4029652A1 (de) | 1990-09-19 | 1992-03-26 | Hoechst Ag | Polymere ammoniumborate und verfahren zu ihrer herstellung |
| JP2558007B2 (ja) | 1990-10-31 | 1996-11-27 | 株式会社資生堂 | 液体クロマトグラフィー用充填剤およびその製造方法 |
| CA2057126A1 (en) | 1990-12-07 | 1992-06-08 | Naoya Yabuuchi | Production of surface-modified organic particles |
| US5152906A (en) | 1991-02-25 | 1992-10-06 | Nalco Chemical Company | Clay stabilizing composition for oil and gas well treatment |
| US5099923A (en) | 1991-02-25 | 1992-03-31 | Nalco Chemical Company | Clay stabilizing method for oil and gas well treatment |
| ATE120433T1 (de) | 1991-05-28 | 1995-04-15 | Nalco Chemical Co | Polierbreie aus silika mit geringem gehalt an natrium und an metallen. |
| EP0545677A1 (en) | 1991-12-06 | 1993-06-09 | Halliburton Company | Well drilling fluids and methods |
| US5306561A (en) | 1992-02-20 | 1994-04-26 | Cornell Research Foundation, Inc. | Preparation of surface-functional polymer particles |
| US5190660A (en) | 1992-06-04 | 1993-03-02 | Lindoy Leonard F | Ion complexation by silica-immobilized polyethyleneimines |
| US5805264A (en) | 1992-06-09 | 1998-09-08 | Ciba Vision Corporation | Process for graft polymerization on surfaces of preformed substates to modify surface properties |
| US5445732A (en) | 1992-06-19 | 1995-08-29 | Sepracor Inc. | Passivated porous polymer supports and methods for the preparation and use of same |
| WO1994000237A1 (en) | 1992-06-25 | 1994-01-06 | Monash University | Ion exchange resin |
| US5254322A (en) | 1992-08-10 | 1993-10-19 | Mobil Oil Corporation | Method for reducing automotive NOx emissions in lean burn internal combustion engine exhaust using a transition metal-containing zeolite catalyst which is in-situ crystallized |
| US6696585B1 (en) | 1993-04-13 | 2004-02-24 | Southwest Research Institute | Functionalized nanoparticles |
| US5451660A (en) | 1993-12-13 | 1995-09-19 | Genentech, Inc. | Method for purifying polypeptides |
| US6160054A (en) | 1995-05-08 | 2000-12-12 | Fmc Corporation | Hetero-telechelic polymers and processes for making same |
| WO1995025789A1 (en) | 1994-03-22 | 1995-09-28 | The Immune Response Corporation | Highly efficient production and isolation of viral particles |
| JP3376169B2 (ja) | 1994-06-17 | 2003-02-10 | キヤノン株式会社 | カラーフィルタの製造方法及びその方法により製造されたカラーフィルタ |
| AUPM632894A0 (en) | 1994-06-21 | 1994-07-14 | Alldredge, Robert Louis | Immobilised branched polyalkyleneimines |
| JPH08134138A (ja) | 1994-11-08 | 1996-05-28 | Dainippon Ink & Chem Inc | 重合性２−オキソ−１，３−ジオキソ−４−イル誘導体、該誘導体から得られる重合体及びこの重合体を用いた硬化性組成物 |
| TW434456B (en) | 1994-12-30 | 2001-05-16 | Novartis Ag | A compound as functionalized photoinitiator, its production process, its corresponding oligomers or polymers and its application in coating a substrate |
| US5763548A (en) | 1995-03-31 | 1998-06-09 | Carnegie-Mellon University | (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
| US5906747A (en) | 1995-11-13 | 1999-05-25 | Biosepra Inc. | Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates |
| JP3818689B2 (ja) * | 1996-01-16 | 2006-09-06 | 富士写真フイルム株式会社 | コロイド状シリカをコアとし、有機ポリマーをシェルとするコア／シェル状複合粒子の水性分散物及びその製造方法 |
| SE9600590D0 (sv) * | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| US5701956A (en) | 1996-04-17 | 1997-12-30 | Halliburton Energy Services, Inc. | Methods and compositions for reducing water production from subterranean formations |
| JP4031049B2 (ja) | 1996-11-27 | 2008-01-09 | ジェネンテック，インコーポレーテッド | タンパク質精製 |
| DE69810080T2 (de) | 1997-01-21 | 2003-10-09 | Grace W R & Co | Siliciumdioxidadsorbent auf magnetischem träger |
| SE9700383D0 (sv) * | 1997-02-04 | 1997-02-04 | Pharmacia Biotech Ab | An adsorption/separation method and a medium for adsorption/separation |
| SE9700768D0 (sv) * | 1997-03-04 | 1997-03-04 | Pharmacia Biotech Ab | Förfarande för att introducera funktionalitet |
| WO1998041534A2 (en) | 1997-03-19 | 1998-09-24 | Biosepra Inc. | Multifunctional ceramic particles as supports for solid phase and combinatorial synthesis |
| US6649572B2 (en) | 1997-05-27 | 2003-11-18 | B J Services Company | Polymer expansion for oil and gas recovery |
| GB2341625B (en) | 1997-05-27 | 2002-04-17 | Bj Services Co | Formation fracturing using a hydratable polymer |
| AUPP032897A0 (en) | 1997-11-12 | 1997-12-04 | University Of Queensland, The | Oligomer libraries |
| US20020104801A1 (en) | 1998-04-06 | 2002-08-08 | Nicolas Voute | Small dense microporous solid support materials, their preparation,and use for purification of large macromolecules and bioparticles |
| DE60029561T2 (de) | 1999-01-25 | 2007-07-19 | Micronas Holding Gmbh | Immobilisierung von molekülen auf oberflächen über polymerbürsten |
| US6692914B1 (en) | 1999-07-02 | 2004-02-17 | Symyx Technologies, Inc. | Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto |
| US6497964B1 (en) | 1999-07-22 | 2002-12-24 | Shin-Etsu Chemical Co., Ltd. | Coating compositions and method for the surface protection of plastic substrate |
| US6994964B1 (en) | 1999-09-01 | 2006-02-07 | Affymetrix, Inc. | Macromolecular arrays on polymeric brushes and methods for preparing the same |
| GB2355711B (en) | 1999-10-27 | 2003-12-24 | Agilent Technologies Inc | Porous silica microsphere scavengers |
| EP1095711B1 (en) * | 1999-10-27 | 2004-01-28 | Novartis AG | Process for coating a material surface |
| DE60024138T2 (de) | 1999-12-20 | 2006-07-20 | Akzo Nobel N.V. | Sole auf der basis von kieselsäure |
| US6689715B1 (en) | 2000-02-09 | 2004-02-10 | Hammen Corporation | Tethered polymer ligands |
| DE10009982A1 (de) | 2000-03-03 | 2001-09-06 | Qiagen Gmbh | Polymere Anionenaustauscher und deren Verwendung in chromatographischen Verfahren |
| US6946070B2 (en) | 2000-03-14 | 2005-09-20 | Hammen Richard F | Composite matrices with interstitial polymer networks |
| JP2003533694A (ja) | 2000-05-18 | 2003-11-11 | メドトロニック，インコーポレイテッド | イオン選択的固体状態ポリマー膜電極 |
| US6589665B2 (en) | 2000-05-30 | 2003-07-08 | Novartis Ag | Coated articles |
| GB0014225D0 (en) | 2000-06-09 | 2000-08-02 | Univ Warwick | Polymerisation initiator and use |
| US20020012982A1 (en) | 2000-07-13 | 2002-01-31 | Invitrogen Corporation | Methods and compositions for rapid protein and peptide extraction and isolation using a lysis matrix |
| ATE355525T1 (de) | 2000-07-27 | 2006-03-15 | Micronas Holding Gmbh | Auf einer oberfläche befestigte multifunktionelle polymere-netzwerke für sensorchips |
| WO2002028912A2 (en) | 2000-10-06 | 2002-04-11 | Carnegie Mellon University | Preparation of nanocomposite structures by controlled polymerization |
| SE0004932D0 (sv) * | 2000-12-31 | 2000-12-31 | Apbiotech Ab | A method for mixed mode adsorption and mixed mode adsorbents |
| AU2002246978A1 (en) | 2001-01-10 | 2002-07-24 | Symyx Technologies, Inc. | Polymer brushes for immobilizing molecules to a surface |
| DE60237251D1 (de) | 2001-01-29 | 2010-09-23 | Tosoh Corp | Kationenaustauscher, Verfahren zu dessen Herstellung und dessen Verwendung |
| JP3440419B2 (ja) | 2001-02-02 | 2003-08-25 | 株式会社フジミインコーポレーテッド | 研磨用組成物およびそれを用いた研磨方法 |
| WO2002065125A1 (en) | 2001-02-13 | 2002-08-22 | Invitrogen Corporation | Methods and compositions for isolation of biological macromolecules |
| US6966992B2 (en) | 2001-03-19 | 2005-11-22 | Akzo Nobel Nv | Method of purification of molecules using unbranched terminal alkyldiols |
| ATE500051T1 (de) * | 2001-04-06 | 2011-03-15 | Fluidigm Corp | Polymeroberflächenmodifikation |
| US7517496B2 (en) | 2001-07-17 | 2009-04-14 | Bio-Rad Laboratories, Inc. | Latex based adsorbent chip |
| US7250214B2 (en) * | 2001-08-09 | 2007-07-31 | Waters Investments Limited | Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation |
| US6867295B2 (en) | 2001-09-07 | 2005-03-15 | Dionex Corporation | Ion exchange cryptands covalently bound to substrates |
| SE0103084D0 (sv) | 2001-09-14 | 2001-09-14 | Amersham Pharm Biotech Ab | Generation of ion exchange media |
| US6916536B1 (en) | 2001-09-20 | 2005-07-12 | Christopher R. Hammen | Composites incorporating covalently bonded interstitial polymer resins |
| FI118061B (fi) | 2001-09-24 | 2007-06-15 | Beanor Oy | Menetelmä ja bioanturi analyysiä varten |
| US7135289B2 (en) | 2001-10-05 | 2006-11-14 | Transgenomic, Inc. | Methods and compositions for mutation analysis of polynucleotides by liquid chromatography |
| GB0124812D0 (en) | 2001-10-16 | 2001-12-05 | Polymer Lab Ltd | Material |
| US20040058059A1 (en) | 2001-11-07 | 2004-03-25 | Linford Mathew Richard | Funtionalized patterned surfaces |
| AU2002360298A1 (en) | 2001-12-10 | 2003-06-23 | Emembrane, Inc. | Functionalized materials and libraries thereof |
| US7192560B2 (en) | 2001-12-20 | 2007-03-20 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using anion exchange |
| ATE321078T1 (de) * | 2002-01-25 | 2006-04-15 | Phenomenex Inc | Oberflächenpfropfmodifizierte harze und deren herstellung |
| US6861103B2 (en) | 2002-02-07 | 2005-03-01 | The Regents Of The University Of California | Synthesis of functional polymers and block copolymers on silicon oxide surfaces by nitroxide-mediated living free radical polymerization in vapor phase |
| FR2835829B1 (fr) | 2002-02-13 | 2007-09-14 | Centre Nat Rech Scient | Nouveau procede de preparation de biopuces a adn ou a proteines et leurs applications |
| AU2003219910A1 (en) | 2002-02-25 | 2003-09-09 | Cabot Coproration | Compositions comprising continuous networks and monoliths |
| US6994791B2 (en) | 2002-06-27 | 2006-02-07 | Akzo Nobel N.V. | Adsorbent material and method of preparing an adsorbent material |
| DE10232695A1 (de) | 2002-07-18 | 2004-02-05 | Siemens Ag | Immobilisierungsschicht für Biosensoren |
| EP1578527A1 (en) * | 2002-09-13 | 2005-09-28 | Ciphergen Biosystems, Inc. | Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays |
| US7378479B2 (en) | 2002-09-13 | 2008-05-27 | Lubrizol Advanced Materials, Inc. | Multi-purpose polymers, methods and compositions |
| US7264728B2 (en) * | 2002-10-01 | 2007-09-04 | Dow Corning Corporation | Method of separating components in a sample using silane-treated silica filter media |
| DE10247359A1 (de) * | 2002-10-10 | 2004-04-29 | Basf Coatings Ag | Nanopartikel, Verfahren zur Modifizierung ihrer Oberfläche, Dispersion der Nanopartikel, Verfahren zu ihrer Herstellung und ihre Verwendung |
| WO2004041398A2 (en) * | 2002-10-30 | 2004-05-21 | Waters Investments Limited | Porous inorganic/organic hybrid materials and preparation thereof |
| US20040127648A1 (en) | 2002-12-31 | 2004-07-01 | Ciphergen Biosystems, Inc. | Sorbent and method for the separation of plasmid DNA |
| JP4791352B2 (ja) | 2003-02-07 | 2011-10-12 | ウオーターズ・テクノロジーズ・コーポレイシヨン | クロマトグラフィーナノカラム用ポリマー固体支持体 |
| US20070082019A1 (en) * | 2003-02-21 | 2007-04-12 | Ciphergen Biosystems Inc. | Photocrosslinked hydrogel surface coatings |
| EP1613737A4 (en) | 2003-03-28 | 2008-12-03 | Receptors Llc | ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS |
| DE112004000906T5 (de) | 2003-05-28 | 2006-10-19 | Waters Investments Ltd., New Castle | Neue Nanoverbundstoffe und ihre Anwendung als Monolithsäulen |
| EP1645597A1 (en) | 2003-07-09 | 2006-04-12 | Tokyo University of Science, Educational Foundation | Conjugate of fine porous particles with polymer molecules and utilization thereof |
| WO2005019263A1 (en) | 2003-08-26 | 2005-03-03 | Danmarks Tekniske Universitet | A continuous process for the assembly of macromolecular substances and the subsequent capture and isolation of a macromolecular assembly, and a system suitable for the process |
| US7198855B2 (en) | 2003-09-12 | 2007-04-03 | Becton, Dickinson And Company | Methods of surface modification of a flexible substrate to enhance cell adhesion |
| US20050106602A1 (en) | 2003-11-17 | 2005-05-19 | Hashem Akhavan-Tafti | Simplified methods for isolating nucleic acids from cellular materials |
| JP5105041B2 (ja) | 2004-01-16 | 2012-12-19 | Ｊｓｒ株式会社 | 絶縁膜形成用組成物およびその製造方法、ならびにシリカ系絶縁膜およびその形成方法 |
| US7479222B2 (en) | 2004-02-05 | 2009-01-20 | Millipore Corporation | Porous adsorptive or chromatographic media |
| JP4597870B2 (ja) | 2004-02-12 | 2010-12-15 | ジーエルサイエンス株式会社 | Ｄｎａなどの分離精製機構 |
| US7560258B2 (en) | 2004-02-24 | 2009-07-14 | Wisconsin Alumni Research Foundation | Glass-immobilized, protein-acrylamide copolymer and method of making thereof |
| FR2867479B1 (fr) | 2004-03-15 | 2007-11-02 | Commissariat Energie Atomique | Polymere de haut poids moleculaire a base de n,n- dimethylacrylamide et de monomeres fonctionnalises par des molecules sondes et ses utilisations |
| ATE547442T1 (de) | 2004-04-02 | 2012-03-15 | Nexttec Gmbh | Verfahren zur herstellung eines verbundsorptionsmaterials für die chromatographische trennung von biopolymeren |
| SE0400916D0 (sv) | 2004-04-05 | 2004-04-05 | Amersham Biosciences Ab | Polymeric ligands |
| US7323347B2 (en) | 2004-05-27 | 2008-01-29 | Sensata Technologies, Inc. | Biosensor surface structures and methods |
| DE102004032430A1 (de) * | 2004-07-03 | 2006-02-09 | Universität Dortmund | Verfahren zur Herstellung von molekular geprägten Polymeren |
| US7579081B2 (en) | 2004-07-08 | 2009-08-25 | Rohm And Haas Company | Opacifying particles |
| US8658277B2 (en) * | 2004-07-30 | 2014-02-25 | Waters Technologies Corporation | Porous inorganic/organic hybrid materials with ordered domains for chromatographic separations and processes for their preparation |
| DE102004038134B4 (de) | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| GB0420062D0 (en) | 2004-09-09 | 2004-10-13 | Akubio Ltd | Assay methods,materials and preparations |
| US7943046B2 (en) | 2004-10-01 | 2011-05-17 | Agilent Technologies, Inc | Methods and systems for on-column protein delipidation |
| EP1811295B1 (en) | 2004-11-10 | 2013-05-15 | Wako Pure Chemical Industries, Ltd. | Processes for production of silica gels carrying derivatization agents for carbonyl compounds |
| CN101076261B (zh) * | 2004-12-16 | 2011-10-05 | 道康宁公司 | 使用经硅烷处理的二氧化硅过滤介质避免或减少饮料中异味的方法 |
| US7354720B2 (en) | 2004-12-30 | 2008-04-08 | Affymetrix, Inc. | Label free analysis of nucleic acids |
| US20060257902A1 (en) | 2005-03-25 | 2006-11-16 | Ambion, Inc. | Methods and compositions for depleting abundant RNA transcripts |
| US20090035876A1 (en) | 2005-03-31 | 2009-02-05 | Inverness Medical Switzerland Gmbh | Electrochemical Assay |
| CA2608339A1 (en) | 2005-05-13 | 2006-11-16 | Protista Biotechnology Ab | Macroporous hydrogels, their preparation and their use |
| US7279147B2 (en) * | 2005-05-25 | 2007-10-09 | Selma Turkay | Method of producing an adsorbent from rice hull ash |
| US20090127501A1 (en) | 2005-05-27 | 2009-05-21 | Nissan Chemical Industries, Ltd. | Polishing Composition for Silicon Wafer |
| JP5475284B2 (ja) | 2005-08-03 | 2014-04-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 親水性架橋ポリマー |
| WO2007035527A2 (en) | 2005-09-15 | 2007-03-29 | Duke University | Non-fouling polymeric surface modification and signal amplification method for biomolecular detection |
| CN101321519A (zh) | 2005-09-30 | 2008-12-10 | 伊立普萨公司 | 制备含有交联壳的核-壳型复合物的方法及其得到的核-壳型复合物 |
| KR100727288B1 (ko) * | 2005-10-14 | 2007-06-13 | 한국과학기술원 | 메조다공성 골격을 갖는 미세다공성 결정성 분자체의제조방법 |
| DE102006001513B3 (de) | 2006-01-12 | 2007-08-16 | Daimlerchrysler Ag | Klappverdeck für einen Kraftwagen |
| US20070189944A1 (en) | 2006-02-13 | 2007-08-16 | Advanced Materials Technology, Inc. | Porous microparticles with solid cores |
| FR2898067B1 (fr) | 2006-03-03 | 2008-05-30 | Rhodia Recherches & Tech | Modification de surfaces solides par des associations de polymeres |
| US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
| EP1849845A1 (de) * | 2006-04-26 | 2007-10-31 | Sika Technology AG | Feuchtigkeitshärtende Zusammensetzungen enthaltend silanfunktionelle Polymere und Aminosilan-Addukte |
| US7981949B2 (en) * | 2006-05-23 | 2011-07-19 | 3M Innovative Properties Company | Curable hydrophilic compositions |
| GB0614316D0 (en) | 2006-07-19 | 2006-08-30 | Ge Healthcare Bio Sciences Ab | Axial Chromatography Columns and Methods |
| WO2008027262A1 (en) * | 2006-08-28 | 2008-03-06 | Massachusetts Institute Of Technology | Liquid supramolecular nanostamping (lisuns) |
| US7732383B2 (en) | 2006-12-21 | 2010-06-08 | E.I. Du Pont De Nemours And Company | Process for stabilized zirconium triethanolamine complex and uses in oil field applications |
| WO2008097616A1 (en) * | 2007-02-06 | 2008-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogel-metal assembly |
| US7758961B2 (en) * | 2007-03-22 | 2010-07-20 | Milliken & Company | Functionalized nanoparticles and their use in particle/bulk material systems |
| US7795188B2 (en) | 2007-03-30 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Zirconium-base cross-linker compositions and their use in high pH oil field applications |
| CN101678318B (zh) | 2007-05-25 | 2013-09-25 | 默克专利股份公司 | 用于阳离子交换色谱法的接枝共聚物 |
| SG149759A1 (en) | 2007-07-10 | 2009-02-27 | Millipore Corp | Media for affinity chromatography |
| WO2009020609A2 (en) * | 2007-08-06 | 2009-02-12 | Nanogen, Inc. | Isolation of nucleic acids molecules using modified solid supports |
| WO2009028944A1 (en) | 2007-08-29 | 2009-03-05 | Dolphys Technologies B.V. | Process for separating a charged species from an aqueous system |
| US20090074709A1 (en) | 2007-09-14 | 2009-03-19 | Koepsel Richard R | Methods, devices and systems for biocidal surface activity |
| KR20090055966A (ko) * | 2007-11-29 | 2009-06-03 | (주)석경에이.티 | 유기 실리카 미세입자 및 정전하상 현상용 토너 외첨제 |
| US7851417B2 (en) | 2007-12-11 | 2010-12-14 | E.I. Du Pont De Nemours And Company | Process to prepare borozirconate solution and use as cross-linker in hydraulic fracturing fluids |
| US7683011B2 (en) | 2007-12-12 | 2010-03-23 | Du Pont | Process to prepare borozirconate solution and use as cross-linker in hydraulic fracturing fluids |
| US7795190B2 (en) | 2007-12-14 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Process to prepare borozirconate solution and use as a cross-linker in hydraulic fracturing fluids |
| US7790657B2 (en) | 2007-12-17 | 2010-09-07 | E.I. Du Pont De Nemours And Company | Process to prepare borozirconate solution and use a cross-linker in hydraulic fracturing fluids |
| US7754660B2 (en) | 2007-12-18 | 2010-07-13 | E.I. Du Pont De Nemours And Company | Process to prepare zirconium-based cross-linker compositions and their use in oil field applications |
| KR101542637B1 (ko) | 2007-12-28 | 2015-08-06 | 쓰리엠 이노베이티브 프로퍼티즈 캄파니 | 나노입자, 비닐단량체 및 실리콘의 공중합체 |
| US7795189B2 (en) | 2007-12-28 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Zirconium-hydroxy alkylated amine-hydroxy carboxylic acid cross-linking composition for use with high pH polymer solutions |
| CN101939258B (zh) * | 2008-02-11 | 2014-05-14 | 纳诺洛吉卡股份公司 | 中孔材料的制造方法、这样生产的材料以及中孔材料的用途 |
| US20090294362A1 (en) | 2008-05-30 | 2009-12-03 | Persson Jonas Par | Stationary phase for hydrophilic interaction chromatography |
| US20090308599A1 (en) | 2008-06-13 | 2009-12-17 | Halliburton Energy Services, Inc. | Method of enhancing treatment fluid placement in shale, clay, and/or coal bed formations |
| US9333163B2 (en) * | 2008-10-06 | 2016-05-10 | Massachusetts Institute Of Technology | Particles with multiple functionalized surface domains |
| CN101381437B (zh) | 2008-10-15 | 2011-05-11 | 华南理工大学 | 一种具有壳-核结构的高选择性吸湿剂的制备方法 |
| EP2192409B1 (en) | 2008-11-26 | 2014-04-23 | Corning Incorporated | Label independent detection biosensor composition and methods thereof |
| EP2459308A1 (en) | 2009-07-28 | 2012-06-06 | instrAction GmbH | Specific sorbent for binding proteins and peptides, and separation method using the same |
| JP5894927B2 (ja) | 2009-12-17 | 2016-03-30 | インストラクション・ゲーエムベーハー | タンパク質及びペプチドを結合するための特定の溶媒、及び、それを用いた分離方法 |
| US8377672B2 (en) * | 2010-02-18 | 2013-02-19 | 3M Innovative Properties Company | Ligand functionalized polymers |
| JP5474881B2 (ja) | 2010-07-28 | 2014-04-16 | ローム アンド ハース カンパニー | 向上したクロマトグラフィー媒体の製造方法および使用方法 |
| SG10201604554WA (en) | 2011-06-08 | 2016-07-28 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| KR101348391B1 (ko) * | 2011-07-21 | 2014-01-14 | 한국에너지기술연구원 | 이미다졸륨염이 화학적으로 결합된 나노입자, 이의 제조방법 및 이를 포함하는 염료감응 태양전지용 나노젤형 전해질 |
| CN104245078B (zh) | 2012-04-25 | 2016-07-06 | 通用电气健康护理生物科学股份公司 | 分离方法和分离基质 |
| RU2015114177A (ru) | 2012-09-17 | 2016-11-10 | У.Р. Грейс Энд Ко.-Конн. | Функционализированный, состоящий из частиц материал носителя и способы его получения и применения |
| BR112015005937A2 (pt) * | 2012-09-17 | 2017-07-04 | Grace W R & Co | meios e dispositivos cromatográficos |
| CN103289030A (zh) | 2013-05-22 | 2013-09-11 | 中北大学 | Gma在硅胶表面高效接枝的新方法 |
-
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| CA2885264C (en) | 2021-10-26 |
| MY195756A (en) | 2023-02-09 |
| HK1204969A1 (en) | 2015-12-11 |
| EP2811983B1 (en) | 2019-05-01 |
| IN2015DN01895A (enExample) | 2015-08-07 |
| CN104768536B (zh) | 2019-03-29 |
| SG11201404684RA (en) | 2014-10-30 |
| CN104768536A (zh) | 2015-07-08 |
| EP2811983A1 (en) | 2014-12-17 |
| US20150251158A1 (en) | 2015-09-10 |
| RU2015114177A (ru) | 2016-11-10 |
| US11529610B2 (en) | 2022-12-20 |
| PL2811983T3 (pl) | 2019-10-31 |
| JP6469574B2 (ja) | 2019-02-13 |
| KR20150058095A (ko) | 2015-05-28 |
| KR102226564B1 (ko) | 2021-03-10 |
| CA2885264A1 (en) | 2014-03-20 |
| EP2811983A4 (en) | 2015-01-14 |
| WO2014043644A1 (en) | 2014-03-20 |
| JP2015531312A (ja) | 2015-11-02 |
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