ES2712152T3 - Jeringa - Google Patents
Jeringa Download PDFInfo
- Publication number
- ES2712152T3 ES2712152T3 ES13701276T ES13701276T ES2712152T3 ES 2712152 T3 ES2712152 T3 ES 2712152T3 ES 13701276 T ES13701276 T ES 13701276T ES 13701276 T ES13701276 T ES 13701276T ES 2712152 T3 ES2712152 T3 ES 2712152T3
- Authority
- ES
- Spain
- Prior art keywords
- syringe
- stop
- filled
- plunger
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920002545 silicone oil Polymers 0.000 claims abstract description 26
- 230000001954 sterilising effect Effects 0.000 claims abstract description 20
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 18
- 239000002997 ophthalmic solution Substances 0.000 claims abstract description 16
- 238000002347 injection Methods 0.000 claims abstract description 15
- 239000007924 injection Substances 0.000 claims abstract description 15
- 229940054534 ophthalmic solution Drugs 0.000 claims abstract description 15
- 239000012530 fluid Substances 0.000 claims abstract description 12
- 239000002245 particle Substances 0.000 claims abstract description 10
- 229960003876 ranibizumab Drugs 0.000 claims abstract description 9
- 239000011521 glass Substances 0.000 claims abstract description 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 30
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 30
- 239000005557 antagonist Substances 0.000 claims description 27
- 229940071643 prefilled syringe Drugs 0.000 claims description 21
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 15
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims description 8
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims description 8
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims description 8
- 208000001309 degenerative myopia Diseases 0.000 claims description 8
- 230000004340 degenerative myopia Effects 0.000 claims description 8
- 201000011190 diabetic macular edema Diseases 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 7
- 208000022873 Ocular disease Diseases 0.000 claims description 5
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 4
- 208000001344 Macular Edema Diseases 0.000 claims description 4
- 206010025415 Macular oedema Diseases 0.000 claims description 4
- 206010038934 Retinopathy proliferative Diseases 0.000 claims description 4
- 206010058990 Venous occlusion Diseases 0.000 claims description 4
- 208000002780 macular degeneration Diseases 0.000 claims description 4
- 201000010230 macular retinal edema Diseases 0.000 claims description 4
- 230000002207 retinal effect Effects 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 238000006073 displacement reaction Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 description 19
- 239000003814 drug Substances 0.000 description 18
- 229940079593 drug Drugs 0.000 description 12
- 230000036512 infertility Effects 0.000 description 11
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 9
- 108010081667 aflibercept Proteins 0.000 description 8
- 238000007789 sealing Methods 0.000 description 8
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 7
- 239000007789 gas Substances 0.000 description 6
- 229920001296 polysiloxane Polymers 0.000 description 6
- 108020001507 fusion proteins Proteins 0.000 description 5
- 102000037865 fusion proteins Human genes 0.000 description 5
- 230000013595 glycosylation Effects 0.000 description 5
- 238000006206 glycosylation reaction Methods 0.000 description 5
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 102000008102 Ankyrins Human genes 0.000 description 3
- 108010049777 Ankyrins Proteins 0.000 description 3
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 description 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 3
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 3
- 229960002833 aflibercept Drugs 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 230000037452 priming Effects 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 description 2
- 108010001282 CT-322 Proteins 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229960000397 bevacizumab Drugs 0.000 description 2
- 102000023732 binding proteins Human genes 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229940051306 eylea Drugs 0.000 description 2
- 102000058223 human VEGFA Human genes 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 229940076783 lucentis Drugs 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 238000010845 search algorithm Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 101100381481 Caenorhabditis elegans baz-2 gene Proteins 0.000 description 1
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 1
- 108700022150 Designed Ankyrin Repeat Proteins Proteins 0.000 description 1
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 description 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 108700036276 KH902 fusion Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 101100372762 Rattus norvegicus Flt1 gene Proteins 0.000 description 1
- 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 description 1
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 description 1
- 102000009520 Vascular Endothelial Growth Factor C Human genes 0.000 description 1
- 102100038217 Vascular endothelial growth factor B Human genes 0.000 description 1
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 108010089411 angiocal protein Proteins 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000009455 aseptic packaging Methods 0.000 description 1
- 229940120638 avastin Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229950005748 conbercept Drugs 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 108020001756 ligand binding domains Proteins 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000012910 preclinical development Methods 0.000 description 1
- 229940076372 protein antagonist Drugs 0.000 description 1
- 108020001580 protein domains Proteins 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 108091008601 sVEGFR Proteins 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000012906 subvisible particle Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 239000012905 visible particle Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3104—Caps for syringes without needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
- A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12174860 | 2012-07-03 | ||
| EP12189649 | 2012-10-23 | ||
| AU2012101677A AU2012101677B4 (en) | 2012-07-03 | 2012-11-16 | Device |
| AU2012101678A AU2012101678B4 (en) | 2012-07-03 | 2012-11-16 | Use of device |
| DE202012011016U DE202012011016U1 (de) | 2012-07-03 | 2012-11-16 | Aflibercept-Spritze |
| DE202012011259U DE202012011259U1 (de) | 2012-07-03 | 2012-11-23 | Bevacizumab-Spritze |
| DE202012011260U DE202012011260U1 (de) | 2012-07-03 | 2012-11-23 | Ranibizumab-Spritze |
| EP12195360 | 2012-12-03 | ||
| DE201320000688 DE202013000688U1 (de) | 2012-07-03 | 2013-01-23 | Glas-Spritze |
| AU2013100071A AU2013100071C4 (en) | 2012-07-03 | 2013-01-23 | Device |
| AU2013100070A AU2013100070B4 (en) | 2012-07-03 | 2013-01-23 | Use of device |
| PCT/EP2013/051491 WO2014005728A1 (en) | 2012-07-03 | 2013-01-25 | Syringe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2712152T3 true ES2712152T3 (es) | 2019-05-09 |
Family
ID=48051683
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13701276T Active ES2712152T3 (es) | 2012-07-03 | 2013-01-25 | Jeringa |
| ES20159408T Active ES2906812T3 (es) | 2012-07-03 | 2013-01-25 | Jeringa |
| ES19210117T Active ES2912848T3 (es) | 2012-07-03 | 2013-01-25 | Jeringa |
| ES18162017T Active ES2882254T3 (es) | 2012-07-03 | 2013-01-25 | Jeringa. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES20159408T Active ES2906812T3 (es) | 2012-07-03 | 2013-01-25 | Jeringa |
| ES19210117T Active ES2912848T3 (es) | 2012-07-03 | 2013-01-25 | Jeringa |
| ES18162017T Active ES2882254T3 (es) | 2012-07-03 | 2013-01-25 | Jeringa. |
Country Status (39)
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2586459T3 (en) | 2005-03-25 | 2017-09-11 | Regeneron Pharma | VEGF antagonist formulations |
| RU2432155C3 (ru) | 2006-06-16 | 2017-11-17 | Ридженерон Фармасьютикалз, Инк. | Составы антагониста vegf, подходящие для интравитреального введения |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| CN103930595A (zh) | 2011-11-11 | 2014-07-16 | Sio2医药产品公司 | 用于药物包装的钝化、pH保护性或润滑性涂层、涂布方法以及设备 |
| AU2013269594C1 (en) | 2012-06-01 | 2020-12-17 | Novartis Ag | Syringe |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| WO2014164928A1 (en) | 2013-03-11 | 2014-10-09 | Sio2 Medical Products, Inc. | Coated packaging |
| US10251815B2 (en) * | 2013-03-13 | 2019-04-09 | Rush University Medical Center | Delivery device and storage system for oropharyngeal administration of mother's colostrum and milk |
| US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
| US10010447B2 (en) | 2013-12-18 | 2018-07-03 | Novartis Ag | Systems and methods for subretinal delivery of therapeutic agents |
| EP3122917B1 (en) | 2014-03-28 | 2020-05-06 | SiO2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| RU2702748C2 (ru) * | 2014-05-12 | 2019-10-11 | Формикон Аг | Предварительно заполненный пластиковый шприц, содержащий антагонист vegf |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| TWI806150B (zh) | 2014-11-07 | 2023-06-21 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
| EP3058974A1 (en) | 2015-02-19 | 2016-08-24 | Sanofi-Aventis Deutschland GmbH | Injection device with supplementary device |
| CN107743406B (zh) * | 2015-03-23 | 2020-12-11 | 赛诺菲-安万特德国有限公司 | 注射装置 |
| MA41906A (fr) | 2015-04-10 | 2018-02-13 | Dompe Farm Spa | Dispositif de distribution de gouttes oculaires |
| EP3377151A1 (en) * | 2015-11-18 | 2018-09-26 | Formycon AG | Pre-filled plastic syringe containing a vegf antagonist |
| MX382662B (es) * | 2015-11-18 | 2025-03-11 | Sio2 Medical Products Inc | Envase farmacéutico para formulaciones oftálmicas. |
| RU2734958C2 (ru) | 2015-11-18 | 2020-10-26 | Формикон Аг | Предварительно заполненная фармацевтическая упаковка, содержащая жидкий состав на основе антагониста vegf |
| DK3384049T3 (da) | 2015-12-03 | 2023-10-02 | Regeneron Pharma | Fremgangsmåder til associering af genetiske varianter med et klinisk resultat hos patienter, der lider af aldersrelateret makuladegeneration behandlet med anti-VEGF |
| JP7088454B2 (ja) | 2015-12-30 | 2022-06-21 | コディアック サイエンシーズ インコーポレイテッド | 抗体および抗体複合体 |
| CN109069754B (zh) * | 2016-04-15 | 2021-09-07 | 参天制药株式会社 | 准确、精确的微升剂量注射器 |
| US20170349313A1 (en) * | 2016-06-01 | 2017-12-07 | Centurion Medical Products Corporation | Methods for manufacturing non-glass prefilled syringes |
| WO2017217544A1 (ja) | 2016-06-17 | 2017-12-21 | 花王株式会社 | 水系インク |
| TWI737742B (zh) * | 2016-06-22 | 2021-09-01 | 德商梅茲製藥有限兩合公司 | 肉毒桿菌毒素的預填充式注射器系統、具有其之套組以及其之使用 |
| ITUA20162072A1 (it) * | 2016-06-30 | 2017-12-30 | Platinum Corp Srl | Dropper a volume controllato |
| JP6788677B2 (ja) | 2016-08-22 | 2020-11-25 | 株式会社Ｆｕｊｉ | 過酸化水素水の製造方法及び殺菌対象物の殺菌方法 |
| US10537683B2 (en) | 2016-11-03 | 2020-01-21 | Johnson & Johnson Surgical Vision, Inc. | Syringe finger grip |
| PL3600456T3 (pl) | 2017-03-27 | 2024-02-26 | Regeneron Pharmaceuticals, Inc. | Sposób sterylizacji |
| US11491179B2 (en) | 2017-04-12 | 2022-11-08 | Urigen Pharmaceuticals, Inc. | Article of manufacture comprising local anesthetic, buffer, and glycosaminoglycan in syringe with improved stability |
| WO2018203225A1 (en) | 2017-05-05 | 2018-11-08 | Novartis Ag | A syringe comprising a collapsible plunger |
| US20200171244A1 (en) | 2017-05-24 | 2020-06-04 | Sio2 Medical Products, Inc. | Sterilizable pharmaceutical package for ophthalmic formulations |
| US20200237997A1 (en) | 2017-05-24 | 2020-07-30 | Formycon Ag | Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist |
| WO2018232408A1 (en) | 2017-06-16 | 2018-12-20 | Credence Medsystems, Inc. | System and method for safety syringe |
| US11590175B2 (en) | 2017-08-23 | 2023-02-28 | Merakris Therapeutics Llc | Compositions containing amniotic components and methods for preparation and use thereof |
| FR3072297B1 (fr) * | 2017-10-17 | 2023-05-12 | Edix Sa | Dispositif d'injection manuelle |
| KR102695555B1 (ko) | 2017-12-13 | 2024-08-19 | 리제너론 파아마슈티컬스, 인크. | 정밀 도즈 전달을 위한 장치 및 방법 |
| JP2021511906A (ja) | 2018-02-02 | 2021-05-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | プレフィルドシリンジおよびプレフィルドシリンジを滅菌する方法 |
| CN112203679A (zh) | 2018-03-02 | 2021-01-08 | 科达制药股份有限公司 | Il-6抗体及其融合构建体和缀合物 |
| CA3096847A1 (en) * | 2018-04-09 | 2019-10-17 | Sio2 Medical Products, Inc. | Stretchable plunger assemblies |
| CN112312946B (zh) * | 2018-04-24 | 2023-01-10 | W.L.戈尔及同仁股份有限公司 | 具有抑制氧气渗透的医疗递送设备 |
| JP7235770B2 (ja) | 2018-05-10 | 2023-03-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 高濃度ｖｅｇｆ受容体融合タンパク質を含む製剤 |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| US20210260300A1 (en) * | 2018-06-01 | 2021-08-26 | Sun Pharma Advanced Research Company Limited | An injection device |
| WO2020086002A1 (en) * | 2018-10-26 | 2020-04-30 | Singapore Health Services Pte Ltd | Device and method for ophthalmic extraction and injection |
| CA3119277C (en) | 2018-11-13 | 2024-07-02 | Credence Medsystems, Inc. | SYSTEM AND METHOD FOR THE INJECTION OF MICRODOSES |
| WO2020109344A1 (en) | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Occular administration device for antisense oligonucleotides |
| WO2020109343A1 (en) | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Combination therapy for treatment of macular degeneration |
| US11945859B2 (en) | 2018-12-18 | 2024-04-02 | Novartis Ag | Protein solution formulation containing high concentration of an anti-VEGF antibody |
| CN109498264B (zh) * | 2018-12-21 | 2020-01-14 | 南通市第一人民医院 | 一种眼科手术用取硅油装置 |
| EP3689397B1 (de) * | 2019-01-31 | 2025-04-23 | SCHOTT Pharma Schweiz AG | Spritzenkörper, spritze und injektionsvorrichtung zum injizieren eines hochviskosen mediums |
| GB201902355D0 (en) * | 2019-02-21 | 2019-04-10 | New Injection Systems Ltd | Modular auto injector |
| FR3093004B1 (fr) * | 2019-02-21 | 2023-04-07 | Dev Techniques Plastiques | Procede de preparation d’une seringue |
| CA3131922A1 (en) | 2019-02-28 | 2020-09-03 | William Samuel Fagg, Iv | Amniotic fluid-derived extracellular vesicles and uses thereof for wound healing |
| LT3960702T (lt) * | 2019-03-29 | 2023-05-25 | Kortuc Inc. | Alyvos kompozicijos, apimančios silikoninę alyvą, panaudojimas vandenilio peroksido laikymo stabilizavimui |
| MX2021012683A (es) | 2019-04-18 | 2021-11-12 | Boehringer Ingelheim Int | Dispositivo de administracion para la administracion de un fluido. |
| CN118767254A (zh) | 2019-06-05 | 2024-10-15 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| JP2022542705A (ja) * | 2019-08-01 | 2022-10-06 | ジェノバ バイオファーマシューティカルズ リミテッド | ベバシズマブの眼科の組成物 |
| JP2022546082A (ja) * | 2019-09-03 | 2022-11-02 | アムジエン・インコーポレーテツド | 薬物送達のための注入デバイス及び注入デバイスのためのパッケージ |
| WO2021046245A1 (en) * | 2019-09-04 | 2021-03-11 | University Of Massachusetts | Adeno-associated virus vector platform for delivery of kh902 (conbercept) and uses thereof |
| US12233177B2 (en) | 2019-09-16 | 2025-02-25 | Amgen Inc. | Method for external sterilization of drug delivery device |
| WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| JP7779833B2 (ja) | 2019-11-14 | 2025-12-03 | コングルーエンス メディカル ソリューションズ，エルエルシー | 可変投薬注射器 |
| CN115335529A (zh) * | 2019-11-26 | 2022-11-11 | 马萨诸塞大学 | 用于递送kh902(康柏西普)的重组腺相关病毒及其用途 |
| JP2023505488A (ja) * | 2019-12-05 | 2023-02-09 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 注射器および気密性の試験方法 |
| JP7640549B2 (ja) * | 2019-12-12 | 2025-03-05 | ノバルティス アーゲー | 注射デバイス及び注射溶液移し替えシステム |
| EP4098298B1 (en) * | 2020-03-24 | 2025-08-27 | TERUMO Kabushiki Kaisha | Syringe-barrel grip, barrel assembly, and syringe |
| US11883635B2 (en) | 2020-06-17 | 2024-01-30 | Credence MedSystems | System and method for microdose injection |
| US20230390109A1 (en) * | 2020-10-30 | 2023-12-07 | Boehringer Ingelheim International Gmbh | Administration device for in particular intravitreal administration of a fluid |
| AU2021391499A1 (en) | 2020-12-01 | 2023-07-20 | Boehringer Ingelheim International Gmbh | Administration device for in particular intravitreal administration of a fluid |
| KR102720956B1 (ko) | 2020-12-15 | 2024-10-24 | 삼천당제약주식회사 | 안과용 제형을 포함하는 시린지 |
| JP7604663B2 (ja) * | 2020-12-29 | 2024-12-23 | ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド | 薄膜潤滑剤を有する薬剤注射ストッパ |
| KR102419910B1 (ko) * | 2021-04-15 | 2022-07-14 | 주식회사 알테오젠 | 저용량 약액 충전 사전 충전형 주사기 및 그 제조방법 |
| CN118575035A (zh) * | 2021-12-01 | 2024-08-30 | 赛诺菲-温思罗普工业公司 | 润滑梭 |
| CN114146220B (zh) | 2022-02-10 | 2022-04-29 | 中国远大集团有限责任公司 | 一种包含无菌pcl微球的美容产品 |
| CN120476003A (zh) | 2022-12-20 | 2025-08-12 | W.L.戈尔及同仁股份有限公司 | 低插入力注射器止挡件、组件及相关方法 |
| EP4480517A1 (de) | 2023-06-20 | 2024-12-25 | Ypsomed AG | Autoinjektor zur intravitrealen injektion |
| CA3237624A1 (en) * | 2023-07-28 | 2025-04-24 | Genentech, Inc. | NEW USES FOR OMALIZUMAB |
| CN117942456B (zh) * | 2024-03-27 | 2024-07-12 | 山东永聚医药科技股份有限公司 | 缓释型非牛顿流体制剂用预灌封注射器及其制备工艺 |
| KR102828906B1 (ko) * | 2024-11-18 | 2025-07-04 | 주식회사 비에스리서치 | 실리콘 오일이 미적용된 프리필드 시린지 |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US31789A (en) | 1861-03-26 | Bread-slicebi | ||
| DE2629557B2 (de) | 1976-07-01 | 1980-05-14 | Paul E. Dr.Med. 8000 Muenchen Doerr | Einmai-Injektionsspritze |
| JPH0747045B2 (ja) | 1986-10-15 | 1995-05-24 | 株式会社大協精工 | 積層した注射器用滑栓 |
| US4946441A (en) | 1988-07-21 | 1990-08-07 | Maurice Laderoute | Limited use hypodermic syringe |
| JPH0725963Y2 (ja) | 1989-11-06 | 1995-06-14 | 清坤 曽 | 緊急避難装置 |
| EP0511402B1 (en) * | 1990-11-17 | 1997-09-10 | Santen Seiyaku Kabushiki Kaisha | Double-chamber type syringe barrel |
| US5236604A (en) * | 1991-05-29 | 1993-08-17 | Sherwood Medical Company | Serum separation blood collection tube and the method of using thereof |
| JP3186422B2 (ja) | 1993-05-14 | 2001-07-11 | 武田薬品工業株式会社 | プラスチゾル |
| US5405326A (en) | 1993-08-26 | 1995-04-11 | Habley Medical Technology Corporation | Disposable safety syringe with retractable shuttle for luer lock needle |
| US5795337A (en) | 1994-02-14 | 1998-08-18 | Becton Dickinson And Company | Syringe assembly and syringe stopper |
| US5688252A (en) | 1994-09-30 | 1997-11-18 | Takeda Chemical Industries, Ltd. | Syringe |
| US5667495A (en) | 1995-04-21 | 1997-09-16 | Becton Dickinson France S.A. | Backstop device for a syringe |
| US5607400A (en) * | 1995-05-19 | 1997-03-04 | Becton, Dickinson And Company | Pre-fillable syringe and stopper assembly therefor |
| DE19622283A1 (de) | 1996-05-23 | 1997-11-27 | Schering Ag | Verfahren zur terminalen Sterilisierung von befüllten Spritzen |
| JP4078406B2 (ja) * | 1997-01-22 | 2008-04-23 | 有限会社コーキ・エンジニアリング | 注射器のシリンダの製造方法 |
| SI1325932T1 (enExample) | 1997-04-07 | 2005-08-31 | Genentech Inc | |
| JP3387775B2 (ja) | 1997-05-22 | 2003-03-17 | 株式会社大協精工 | 注射器用密封栓及びプレフィルド注射器 |
| US6200627B1 (en) * | 1998-03-17 | 2001-03-13 | Becton, Dickinson And Company | Low silicone glass prefillable syringe |
| JP2002515268A (ja) * | 1998-04-30 | 2002-05-28 | アボット・ラボラトリーズ | 注射器アセンブリ |
| USD430015S (en) | 1998-06-11 | 2000-08-29 | Pharmacia & Upjohn Ab | Blister pack for a syringe |
| JP2001104480A (ja) | 1999-10-05 | 2001-04-17 | Daikyo Seiko Ltd | プラスチック製プレフィルド注射器の密封に使用するゴム製ピストン |
| JP2001340455A (ja) | 2000-05-31 | 2001-12-11 | Yoshino Kogyosho Co Ltd | シリンジ容器 |
| JP2002177388A (ja) | 2000-12-15 | 2002-06-25 | Daikyo Seiko Ltd | 医薬・医療用既充填注射器 |
| JP2002241264A (ja) | 2001-02-19 | 2002-08-28 | Asahi Kasei Corp | エルカトニンのプレフィルドシリンジ製剤 |
| EP1477195A4 (en) * | 2001-12-27 | 2005-03-30 | Showa Pharm Chem Ind | CARTRIDGE SYRINGE, CARTRIDGE ASSEMBLY AND OPHTHALMIC SYRINGE CONTAINING SUCH A SYRINGE |
| JP4141156B2 (ja) * | 2002-03-15 | 2008-08-27 | 日本ベクトン・ディッキンソン株式会社 | プランジャ後退制限機構付きプレフィルドシリンジ |
| US6688252B1 (en) | 2002-12-11 | 2004-02-10 | Gary Caravella | Boat cover |
| WO2004075958A2 (en) | 2003-02-27 | 2004-09-10 | Baxter International Inc. | Piston assembly for syringe |
| JP2004313369A (ja) | 2003-04-15 | 2004-11-11 | Menicon Co Ltd | カートリッジ注入器、カートリッジ及び該注入器を備えた眼科用注入器セット |
| FR2855413B1 (fr) | 2003-05-26 | 2005-12-30 | Becton Dickinson France | Seringue pre-remplie avec coiffe anti effraction |
| KR20060130648A (ko) * | 2004-01-12 | 2006-12-19 | 아이싸이언스 인터벤셔날 코포레이션 | 점성 물질용 인젝터 |
| US8124207B2 (en) | 2004-03-02 | 2012-02-28 | Sakhrani Vinay G | Article with lubricated surface and method |
| DK1767546T3 (da) | 2004-06-08 | 2012-04-23 | Chengdu Kanghong Biotechnologies Co Ltd | Angiogenese-inhiberende kimært protein og dets anvendelse |
| PL1802334T3 (pl) * | 2004-10-21 | 2013-01-31 | Genentech Inc | Sposób leczenia wewnątrzgałkowych chorób neowaskularnych |
| WO2006088650A2 (en) * | 2005-02-02 | 2006-08-24 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a vegf inhibitor |
| EP1888150A1 (en) | 2005-05-31 | 2008-02-20 | Baxter International Inc. | Polypropylene hollow barrel with sliding coated rubber piston |
| US20060293270A1 (en) * | 2005-06-22 | 2006-12-28 | Adamis Anthony P | Methods and compositions for treating ocular disorders |
| US20070060887A1 (en) * | 2005-08-22 | 2007-03-15 | Marsh David A | Ophthalmic injector |
| FR2890316B1 (fr) * | 2005-09-02 | 2007-10-05 | Aguettant Soc Par Actions Simp | Seringue destinee a etre remplie puis sterilisee par autoclavage a la vapeur. |
| CA2622573A1 (en) * | 2005-09-16 | 2007-03-29 | (Osi) Eyetech, Inc. | Ophthalmic syringe |
| WO2007035623A1 (en) | 2005-09-17 | 2007-03-29 | Technology Group Northwest Inc. | System and method for foiling code-injection attacks in a computing device |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| CN101365456A (zh) * | 2005-10-14 | 2009-02-11 | 爱尔康公司 | 治疗原发性和继发性形式的青光眼的方法 |
| AT502791B1 (de) * | 2006-04-06 | 2007-05-15 | Pharma Consult Ges M B H & Co | Injektionsspritze |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| EP2012826B1 (en) * | 2006-05-04 | 2016-04-13 | Fovea Pharmaceuticals | Combination comprising a vegf inhibitor and a serine protease for treating neovascular diseases |
| RU2432155C3 (ru) * | 2006-06-16 | 2017-11-17 | Ридженерон Фармасьютикалз, Инк. | Составы антагониста vegf, подходящие для интравитреального введения |
| JP4131001B2 (ja) | 2006-07-28 | 2008-08-13 | 大成化工株式会社 | 定量吐出装置 |
| CN200973886Y (zh) * | 2006-11-20 | 2007-11-14 | 骆忠林 | 一种注射器 |
| WO2008077155A1 (en) | 2006-12-21 | 2008-06-26 | Genentech, Inc. | Sterilization of objects containing biological molecules |
| US8529521B2 (en) | 2007-04-23 | 2013-09-10 | Ultimed Inc. | Low-dosage syringe |
| CN100563736C (zh) * | 2007-06-02 | 2009-12-02 | 丁锐 | 一次性防刺伤注射器 |
| RU2488410C2 (ru) | 2007-06-12 | 2013-07-27 | Бектон, Дикинсон Энд Компани | Шприц с механизмом приведения его в неработоспособное состояние |
| ES2376761T3 (es) * | 2007-07-31 | 2012-03-16 | Al.Chi.Mi.A. S.R.L. | Método para realizar un dispositivo para tratamientos oftálmicos |
| WO2009030976A1 (en) | 2007-09-03 | 2009-03-12 | Becton Dickinson France | Medical device and smooth coating therefor |
| WO2009030975A1 (en) | 2007-09-03 | 2009-03-12 | Becton Dickinson France | Medical device comprising a siliconized chamber and a coated closure means |
| DE102008005938A1 (de) * | 2008-01-24 | 2009-07-30 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Vorgefüllte Spritze und Verfahren zum Verpacken einer Spritze |
| PL2235395T3 (pl) | 2008-01-24 | 2012-05-31 | Meflex Telecontrol Gmbh & Co Kg | Końcówka dla linki napędowej, linka napędowa, sposób wytwarzania końcówki, oraz sposób wytwarzania linki napędowej |
| EP2249801A2 (en) | 2008-02-07 | 2010-11-17 | Amgen Inc. | Stabilized protein compositions |
| EP2298392A4 (en) | 2008-06-17 | 2015-01-28 | Taisei Kako Co | INJECTION DEVICE |
| WO2009158613A1 (en) | 2008-06-26 | 2009-12-30 | West Pharmaceutical Services, Inc. | Method of coating polyxylylene onto flouropolymer surfaces and devices coated thereby |
| US8221353B2 (en) | 2008-10-21 | 2012-07-17 | KMG Pharma, Inc | Intravitreal injection device and system |
| WO2010060748A1 (en) | 2008-11-03 | 2010-06-03 | Molecular Partners Ag | Binding proteins inhibiting the vegf-a receptor interaction |
| US20110276005A1 (en) | 2008-12-03 | 2011-11-10 | Taisei Kako Co., Ltd. | Syringe |
| EP3028707A1 (en) * | 2009-05-01 | 2016-06-08 | Ophthotech Corporation | Methods for treating or preventing ophthalmological diseases |
| CN102458471A (zh) * | 2009-05-28 | 2012-05-16 | 葛兰素集团有限公司 | 用于治疗或预防眼病的TNFα拮抗剂和VEGF拮抗剂的组合 |
| EP2266647A1 (en) * | 2009-06-25 | 2010-12-29 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for drug delivery device |
| AR078060A1 (es) | 2009-07-14 | 2011-10-12 | Novartis Ag | Descontaminacion de superficie de contenedores previamente llenados en empaque secundario |
| EP3308816B1 (en) | 2009-10-29 | 2020-02-12 | W.L. Gore & Associates, Inc | Syringe stopper coated with densified expanded ptfe |
| CN201578690U (zh) | 2010-01-21 | 2010-09-15 | 王建友 | 一种注射器 |
| CA2795096C (en) | 2010-03-31 | 2021-10-26 | Ocuject, Llc | Device and method for intraocular drug delivery |
| US9408746B2 (en) | 2010-03-31 | 2016-08-09 | Ocuject, Llc | Device and method for intraocular drug delivery |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| JP2012045046A (ja) | 2010-08-24 | 2012-03-08 | Gc Corp | 歯科用シリンジ |
| FR2966044B1 (fr) | 2010-10-18 | 2012-11-02 | Sanofi Pasteur | Procede de conditionnement d'un vaccin contenant un adjuvant d'aluminium |
| US10034981B2 (en) | 2011-03-01 | 2018-07-31 | Terumo Kabushiki Kaisha | Syringe and syringe assembly |
| KR101978235B1 (ko) | 2011-04-25 | 2019-05-15 | 아이콘 바이오사이언스, 인크. | 주사기용 투여량 가이드 |
| US20130012918A1 (en) | 2011-07-07 | 2013-01-10 | Gary Foster | Steady grip ophthalmic surgical syringe and method |
| RU2621843C2 (ru) | 2011-09-27 | 2017-06-07 | Бектон Дикинсон Франс | Применение силиконового масла, обработанного плазмой, в качестве покрытия в медицинском инъекционном устройстве |
| US9421129B2 (en) | 2012-04-02 | 2016-08-23 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
| US10780228B2 (en) | 2012-05-07 | 2020-09-22 | Medline Industries, Inc. | Prefilled container systems |
| AU2013269594C1 (en) | 2012-06-01 | 2020-12-17 | Novartis Ag | Syringe |
| AU2013100071C4 (en) * | 2012-07-03 | 2013-05-02 | Novartis Ag | Device |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| AU2012101678B4 (en) | 2012-07-03 | 2013-01-24 | Novartis Ag | Use of device |
| US9662450B2 (en) * | 2013-03-01 | 2017-05-30 | Sio2 Medical Products, Inc. | Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus |
-
2012
- 2012-07-03 JO JOP/2020/0175A patent/JOP20200175A1/ar unknown
-
2013
- 2013-01-23 DE DE201320000688 patent/DE202013000688U1/de not_active Expired - Lifetime
- 2013-01-24 JO JOP/2013/0026A patent/JO3655B1/ar active
- 2013-01-25 EP EP18202752.4A patent/EP3470058A1/en active Pending
- 2013-01-25 FR FR1350671A patent/FR2983077B1/fr not_active Revoked
- 2013-01-25 ES ES13701276T patent/ES2712152T3/es active Active
- 2013-01-25 BR BR122020020290-4A patent/BR122020020290B1/pt active IP Right Grant
- 2013-01-25 NZ NZ702980A patent/NZ702980A/en unknown
- 2013-01-25 EP EP18162017.0A patent/EP3381444B1/en active Active
- 2013-01-25 KR KR1020227031067A patent/KR102487296B1/ko active Active
- 2013-01-25 CH CH00298/13A patent/CH706741B1/de unknown
- 2013-01-25 EP EP19210117.8A patent/EP3656373B1/en active Active
- 2013-01-25 HU HUE18162017A patent/HUE055227T2/hu unknown
- 2013-01-25 PL PL19210117T patent/PL3656373T3/pl unknown
- 2013-01-25 CN CN202110166906.0A patent/CN112972828A/zh active Pending
- 2013-01-25 HR HRP20220083TT patent/HRP20220083T1/hr unknown
- 2013-01-25 ES ES20159408T patent/ES2906812T3/es active Active
- 2013-01-25 HU HUE13701276A patent/HUE042652T2/hu unknown
- 2013-01-25 EA EA201590139A patent/EA031583B1/ru not_active IP Right Cessation
- 2013-01-25 DK DK18162017.0T patent/DK3381444T3/da active
- 2013-01-25 KR KR1020227014971A patent/KR102443606B1/ko active Active
- 2013-01-25 LT LTEP13701276.1T patent/LT2869813T/lt unknown
- 2013-01-25 MY MYPI2014003426A patent/MY164536A/en unknown
- 2013-01-25 KR KR1020207006794A patent/KR102299177B1/ko active Active
- 2013-01-25 PT PT13701276T patent/PT2869813T/pt unknown
- 2013-01-25 AR ARP130100235 patent/AR090059A1/es not_active Application Discontinuation
- 2013-01-25 HR HRP20190300TT patent/HRP20190300T1/hr unknown
- 2013-01-25 PL PL18162017T patent/PL3381444T3/pl unknown
- 2013-01-25 PL PL20159408T patent/PL3685826T3/pl unknown
- 2013-01-25 CA CA2803566A patent/CA2803566A1/en not_active Abandoned
- 2013-01-25 MA MA37740A patent/MA37740B2/fr unknown
- 2013-01-25 WO PCT/EP2013/051491 patent/WO2014005728A1/en not_active Ceased
- 2013-01-25 JP JP2013012497A patent/JP5744927B2/ja active Active
- 2013-01-25 EP EP13701276.1A patent/EP2869813B1/en not_active Revoked
- 2013-01-25 HR HRP20220535TT patent/HRP20220535T1/hr unknown
- 2013-01-25 LT LTEP20159408.2T patent/LT3685826T/lt unknown
- 2013-01-25 MX MX2014015743A patent/MX358323B/es active IP Right Grant
- 2013-01-25 SI SI201331979T patent/SI3656373T1/sl unknown
- 2013-01-25 LT LTEP19210117.8T patent/LT3656373T/lt unknown
- 2013-01-25 CN CN202010134846.XA patent/CN111249062A/zh active Pending
- 2013-01-25 DK DK19210117.8T patent/DK3656373T3/da active
- 2013-01-25 CN CN201380035900.3A patent/CN104427972A/zh active Pending
- 2013-01-25 SG SG11201408261UA patent/SG11201408261UA/en unknown
- 2013-01-25 BR BR112014032990-7A patent/BR112014032990B1/pt active IP Right Grant
- 2013-01-25 LT LTEP18162017.0T patent/LT3381444T/lt unknown
- 2013-01-25 PE PE2014002573A patent/PE20150196A1/es not_active Application Discontinuation
- 2013-01-25 KR KR1020217041316A patent/KR102395557B1/ko active Active
- 2013-01-25 ES ES19210117T patent/ES2912848T3/es active Active
- 2013-01-25 KR KR1020217028012A patent/KR102341670B1/ko active Active
- 2013-01-25 HU HUE20159408A patent/HUE057746T2/hu unknown
- 2013-01-25 KR KR1020147036866A patent/KR102092427B1/ko active Active
- 2013-01-25 US US13/750,352 patent/US9220631B2/en active Active
- 2013-01-25 TW TW102103005A patent/TWI632920B/zh active
- 2013-01-25 SI SI201331357T patent/SI2869813T1/sl unknown
- 2013-01-25 KR KR1020237000676A patent/KR20230013282A/ko not_active Ceased
- 2013-01-25 AU AU2013201624A patent/AU2013201624A1/en not_active Abandoned
- 2013-01-25 ES ES18162017T patent/ES2882254T3/es active Active
- 2013-01-25 SI SI201331917T patent/SI3381444T1/sl unknown
- 2013-01-25 CN CN201910358417.8A patent/CN110115657A/zh active Pending
- 2013-01-25 DK DK20159408.2T patent/DK3685826T3/da active
- 2013-01-25 EP EP20159408.2A patent/EP3685826B1/en active Active
- 2013-01-25 DK DK13701276.1T patent/DK2869813T3/en active
- 2013-01-25 PL PL13701276T patent/PL2869813T3/pl unknown
- 2013-01-25 SI SI201331963T patent/SI3685826T1/sl unknown
- 2013-12-25 JP JP2013266737A patent/JP6313038B2/ja active Active
-
2014
- 2014-12-11 ZA ZA2014/09411A patent/ZA201409411B/en unknown
- 2014-12-11 PH PH12014502785A patent/PH12014502785B1/en unknown
- 2014-12-12 TN TN2014000517A patent/TN2014000517A1/fr unknown
- 2014-12-15 IL IL236296A patent/IL236296B/en active IP Right Grant
- 2014-12-18 CO CO14278405A patent/CO7151483A2/es unknown
- 2014-12-29 GT GT201400300A patent/GT201400300A/es unknown
- 2014-12-31 CL CL2014003619A patent/CL2014003619A1/es unknown
-
2015
- 2015-02-03 EC ECIEPI20154005A patent/ECSP15004005A/es unknown
-
2019
- 2019-02-21 CY CY20191100225T patent/CY1121497T1/el unknown
-
2020
- 2020-02-26 IL IL272915A patent/IL272915B/en active IP Right Grant
-
2021
- 2021-07-27 HR HRP20211216TT patent/HRP20211216T1/hr unknown
- 2021-08-12 CY CY20211100725T patent/CY1124431T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2712152T3 (es) | Jeringa | |
| AU2013100071C4 (en) | Device | |
| AU2013100360A4 (en) | Device | |
| HK40031938B (en) | Syringe | |
| HK40031938A (en) | Syringe | |
| HK40030912A (en) | Syringe |